ES2126586T3 - Metabolitos de rapamicina. - Google Patents

Metabolitos de rapamicina.

Info

Publication number
ES2126586T3
ES2126586T3 ES92304293T ES92304293T ES2126586T3 ES 2126586 T3 ES2126586 T3 ES 2126586T3 ES 92304293 T ES92304293 T ES 92304293T ES 92304293 T ES92304293 T ES 92304293T ES 2126586 T3 ES2126586 T3 ES 2126586T3
Authority
ES
Spain
Prior art keywords
mass
charge ratio
virtue
useful
rapamycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92304293T
Other languages
English (en)
Inventor
Uwe Christians
Karl Friedrich Sewing
Martin Sattler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Application granted granted Critical
Publication of ES2126586T3 publication Critical patent/ES2126586T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

ESTE INVENTO MUESTRA METABOLITOS DE RAPAMICINA, EL PRIMERO DE LOS CUALES ES 41 MOLECULAR DIPROTONADO DETECTADO EN UNA MASA DE REGIMEN DE CARGA DE 899, Y UN MODELO DE FRAGMENTACION ESPECTROSCOPICA DE MASA DE IONIZACION QUIMICA DE DESORCION QUE COMPRENDE IONES DETECTADOS EN UNA MASA DE REGIMEN DE CARGA DE 591,569,559,543,529,421 Y 308. UN SEGUNDO COMPUESTO DE ESTE INVENTO ES UN METABOLITO HIDROXILADO DE RAPAMICINA CON UN ION MOLECULAR PROTONADO DETECTADO EN UN MASA DE REGIMEN DE CARGA DE 928, Y UN MODELO DE FRAGMENTACION ESPECTROSCOPICA DE MASA DE IONIZACION QUIMICA DE DESORCION QUE COMPRENDE IONES DETECTADOS EN UNA MASA DE 607,571,545,513,322,290 Y 241 AMU (UNIDAD DE MASA ATOMICA). LOS COMPUESTOS DE ESTE INVENTO, POR VIRTUD DE SU ACTIVIDAD INMUNOSUPRESORA SON UTILES EN EL TRATAMIENTO DE RECHAZOS DE TRASPLANTE, ENFERMEDAD HUESPED VERSUS ENFERMEDAD INJERTO, ENFERMEDADES AUTOINMUNES Y ENFERMEDADES DE INFLAMACION; POR VIRTUD DE SU ACTIVIDAD ANTITUMOR SON UTILES EN EL TRATAMIENTO DE TUMORES SOLIDOS; Y POR VIRTUD DE SU ACTIVIDAD ANTIHONGOS SON UTILES EN EL TRATAMIENTO DE INFECCION DE HONGOS.
ES92304293T 1991-05-14 1992-05-13 Metabolitos de rapamicina. Expired - Lifetime ES2126586T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/699,505 US5776943A (en) 1991-05-14 1991-05-14 Rapamycin metabolites

Publications (1)

Publication Number Publication Date
ES2126586T3 true ES2126586T3 (es) 1999-04-01

Family

ID=24809620

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92304293T Expired - Lifetime ES2126586T3 (es) 1991-05-14 1992-05-13 Metabolitos de rapamicina.

Country Status (13)

Country Link
US (1) US5776943A (es)
EP (1) EP0514144B1 (es)
JP (1) JP3183554B2 (es)
KR (1) KR920021552A (es)
AT (1) ATE174918T1 (es)
AU (1) AU659452B2 (es)
CA (1) CA2068349C (es)
DE (1) DE69227942T2 (es)
DK (1) DK0514144T3 (es)
ES (1) ES2126586T3 (es)
GR (1) GR3029767T3 (es)
HK (1) HK1010369A1 (es)
IE (1) IE921525A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9302569D0 (en) * 1993-02-10 1993-03-24 Smithkline Beecham Plc Novel compound
GB9315914D0 (en) * 1993-07-31 1993-09-15 Smithkline Beecham Plc Novel compound
US5849730A (en) * 1994-08-31 1998-12-15 Pfizer Inc. Process for preparing demethylrapamycins
US5922730A (en) * 1996-09-09 1999-07-13 American Home Products Corporation Alkylated rapamycin derivatives
IT1289815B1 (it) * 1996-12-30 1998-10-16 Sorin Biomedica Cardio Spa Stent per angioplastica e relativo procedimento di produzione
US6015809A (en) * 1998-08-17 2000-01-18 American Home Products Corporation Photocyclized rapamycin
CN100562570C (zh) * 2003-06-18 2009-11-25 吉恩勒克斯公司 修饰的重组痘苗病毒及其它微生物,及其应用
CA2571710A1 (en) 2004-06-24 2006-11-02 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
US8430055B2 (en) 2008-08-29 2013-04-30 Lutonix, Inc. Methods and apparatuses for coating balloon catheters
US8998846B2 (en) 2006-11-20 2015-04-07 Lutonix, Inc. Drug releasing coatings for balloon catheters
US9737640B2 (en) 2006-11-20 2017-08-22 Lutonix, Inc. Drug releasing coatings for medical devices
US9700704B2 (en) 2006-11-20 2017-07-11 Lutonix, Inc. Drug releasing coatings for balloon catheters
US20080175887A1 (en) 2006-11-20 2008-07-24 Lixiao Wang Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs
US20080276935A1 (en) 2006-11-20 2008-11-13 Lixiao Wang Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
US8425459B2 (en) 2006-11-20 2013-04-23 Lutonix, Inc. Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
US8414525B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8414910B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8414526B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA737247B (en) * 1972-09-29 1975-04-30 Ayerst Mckenna & Harrison Rapamycin and process of preparation
US3993749A (en) * 1974-04-12 1976-11-23 Ayerst Mckenna And Harrison Ltd. Rapamycin and process of preparation
US4885171A (en) * 1978-11-03 1989-12-05 American Home Products Corporation Use of rapamycin in treatment of certain tumors
US4316885A (en) * 1980-08-25 1982-02-23 Ayerst, Mckenna And Harrison, Inc. Acyl derivatives of rapamycin
US4401653A (en) * 1981-03-09 1983-08-30 Ayerst, Mckenna & Harrison Inc. Combination of rapamycin and picibanil for the treatment of tumors
US4650803A (en) * 1985-12-06 1987-03-17 University Of Kansas Prodrugs of rapamycin
US4981792A (en) * 1988-06-29 1991-01-01 Merck & Co., Inc. Immunosuppressant compound
US5100899A (en) * 1989-06-06 1992-03-31 Roy Calne Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof
EP0413532A3 (en) * 1989-08-18 1991-05-15 Fisons Plc Macrocyclic compounds
US5023264A (en) * 1990-07-16 1991-06-11 American Home Products Corporation Rapamycin oximes
US5023263A (en) * 1990-08-09 1991-06-11 American Home Products Corporation 42-oxorapamycin
US5023262A (en) * 1990-08-14 1991-06-11 American Home Products Corporation Hydrogenated rapamycin derivatives
JPH05112573A (ja) * 1991-04-17 1993-05-07 American Home Prod Corp ラパマイシンのカルバミン酸エステル類
US5091389A (en) * 1991-04-23 1992-02-25 Merck & Co., Inc. Lipophilic macrolide useful as an immunosuppressant
US5102876A (en) * 1991-05-07 1992-04-07 American Home Products Corporation Reduction products of rapamycin
JP3108192B2 (ja) * 1991-05-07 2000-11-13 アメリカン・ホーム・プロダクツ・コーポレイション 免疫抑制剤、抗炎症剤または抗真菌剤用ラパマイシンの還元生成物

Also Published As

Publication number Publication date
IE921525A1 (en) 1992-11-18
JP3183554B2 (ja) 2001-07-09
GR3029767T3 (en) 1999-06-30
EP0514144A2 (en) 1992-11-19
CA2068349A1 (en) 1992-11-15
DE69227942T2 (de) 1999-08-26
DK0514144T3 (da) 1999-08-23
JPH05130884A (ja) 1993-05-28
ATE174918T1 (de) 1999-01-15
AU659452B2 (en) 1995-05-18
AU1615492A (en) 1992-11-19
CA2068349C (en) 2002-04-09
US5776943A (en) 1998-07-07
HK1010369A1 (en) 1999-06-17
EP0514144A3 (en) 1993-03-03
DE69227942D1 (de) 1999-02-04
KR920021552A (ko) 1992-12-18
EP0514144B1 (en) 1998-12-23

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