KR920021138A - 콜레스테롤혈증 저하제 및 아테롬성동맥경화증 억제제로서의 깅게롤 및 깅게르디올 유도체 - Google Patents

콜레스테롤혈증 저하제 및 아테롬성동맥경화증 억제제로서의 깅게롤 및 깅게르디올 유도체 Download PDF

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KR920021138A
KR920021138A KR1019920009425A KR920009425A KR920021138A KR 920021138 A KR920021138 A KR 920021138A KR 1019920009425 A KR1019920009425 A KR 1019920009425A KR 920009425 A KR920009425 A KR 920009425A KR 920021138 A KR920021138 A KR 920021138A
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composition
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hydrogen
hydroxy
alkyl
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젠 탄 마오 시몬
리챠드 킹 치-신
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게리 디. 스트리트
메렐 다우 파마슈티칼스 인크.
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Publication of KR920021138A publication Critical patent/KR920021138A/ko

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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C—CHEMISTRY; METALLURGY
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with no unsaturation outside the aromatic ring
    • C07C39/11—Alkylated hydroxy benzenes containing also acyclically bound hydroxy groups, e.g. saligenol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C07C49/245—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음.

Description

콜레스테롤혈증 저하제 및 아테롬성동맥경화증 억제제로서의 깅게롤 및 깅게르디올 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (24)

  1. 혈중 콜레스테롤 저하 유효량의 하기 일반식의 화합물로 이루어지는 혈장 콜레스테롤 저하용 조성물.
    여기서, R1은 수소 또는 C1-C4알킬이고, R2는 C1-C12알킬이고, Y는 0 또는 OH이고, Z는 Y가 0일 때는 결합이고, Y가 OH일 때는 수소이다.
  2. 제1항에 있어서, R1이 메틸인 조성물.
  3. 제1항에 있어서, R2가 n-헵틸인 조성물.
  4. 제1항에 있어서, Y가 OH이고, Z가 수소인 조성물.
  5. 제1항에 있어서, Y가 0이고, Z가 결합인 조성물.
  6. 제1항에 있어서, 화합물이 1-(4'-히드록시-3'-메톡시페닐)-5-히드록시-3-도데카논인 조성물.
  7. 제1항에 있어서, 화합물이 안티-1-(4'-히드록시-3'-메톡시페닐)-3,5-도데칸 디올인 조성물.
  8. 아테롬성동맥경화 억제 유효량의 하기 일반식의 화합물로 이루어지는 아테롬성동맥경화중 전행 억제용 조성물.
    여기서, R1은 수소 또는 C1-C4알킬이고, R2는 C1-C12알킬이고, Y는 0 또는 0H이고, Z는 Y가 0일 때는 결합이고, Y가 OH일 때는 수소이다.
  9. 제8항에 있어서, R1이 메틸인 조성물.
  10. 제8항에 있어서, R2가 n-헵틸인 조성물.
  11. 제8항에 있어서, Y가 0H이고, Z가 수소인 조성물.
  12. 제8항에 있어서, Y가 0이고, Z가 결합인 조성물.
  13. 제8항에 있어서, 화합물이 1-(4'-히드록시-3'-메톡시페닐)-5-히드록시-3-도데카논인 조성물.
  14. 제8항에 있어서, 화합물이 안티-1-(4'-히드록시-3'-메톡시페닐)-3,5-도데칸 디올인 조성물.
  15. 산화방지 유효량의 하기 일반식의 화합물로 이루어지는 LDL지질의 과산화 억제용 조성물.
    여기서, R1은 수소 또는 C1-C4알킬이고, R2는 C1-C12알킬이고, Y는 0또는 OH이고, Z는 Y가0일 때는 결합이고, Y가 OH일 때는 수소이다.
  16. 제15항에 있어서, R1이 메틸인 조성물.
  17. 제15항에 있어서, R2가 n-헵틸인 조성물.
  18. 제15항에 있어서, Y가 OH이고, Z가 수소인 조성물.
  19. 제15항에 있어서, Y가 0이고, Z가 결합인 조성물.
  20. 제15항에 있어서, 화합물이 1-(4'-히드록시-3'-메톡시페닐)-5-히드록시-3-도데카논인 조성물.
  21. 제15항에 있어서, 화합물이 안티-1-(4'-히드록시-3'-메톡시페닐)-3,5-도데칸 디올인 조성물.
  22. 하기 일반식의 화합물.
    여기서, R1은 수소 또는 C1-C4알킬이고, R2는 C1-C12알킬이다.
  23. 제22항에 있어서, 안티-1-(4'-히드록시-3'-메톡시페닐)-3,5-도데칸 디올인 화합물.
  24. 보호된 신 및 안티 디올의 혼합물로부터 하기 일반식(6b)의 보호된 안티 디올을 분리하고, 이어서 안티 티올을 가수소 분해하는 것으로 이루어지는 하기 일반식(II)의 화합물의 제조방법.
    여기서, R1은 수소 또는 C1-C4알킬이고, R2는 C1-C12알킬이고, Pg는 적절한 보호기이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920009425A 1991-05-31 1992-05-30 콜레스테롤혈증 저하제 및 아테롬성동맥경화증 억제제로서의 깅게롤 및 깅게르디올 유도체 KR920021138A (ko)

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US70901291A 1991-05-31 1991-05-31
US709,012 1991-05-31

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EP (1) EP0516082A2 (ko)
JP (1) JPH05208929A (ko)
KR (1) KR920021138A (ko)
AU (1) AU1716092A (ko)
CA (1) CA2069548A1 (ko)
FI (1) FI922472A (ko)
HU (1) HUT61192A (ko)
IE (1) IE921768A1 (ko)
IL (1) IL102024A0 (ko)
NO (1) NO922151L (ko)
ZA (1) ZA923814B (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5446207A (en) * 1993-09-01 1995-08-29 Harbor Branch Oceanographic Institution, Inc. Anti-dyslipidemic agents
AU758911B2 (en) * 1997-10-21 2003-04-03 Zingotx Pty Ltd Medicinal uses of phenylalkanols and derivatives
US6518315B1 (en) 1997-10-21 2003-02-11 The University Of Sydney Medicinal uses of phenylaikanols and derivatives
AUPO990097A0 (en) * 1997-10-21 1997-11-13 University Of Sydney, The Medicinal uses of phenylalkanols and derivatives (gingerol analogues)
JP2005272384A (ja) * 2004-03-25 2005-10-06 Toagosei Co Ltd 低比重リポタンパクの酸化変性防止剤および抗アテローム性動脈硬化剤
JP4622310B2 (ja) * 2004-03-26 2011-02-02 東亞合成株式会社 低比重リポタンパクの酸化変性防止剤および抗アテローム性動脈硬化剤
FR2950884B1 (fr) * 2009-10-01 2011-11-11 Oreal Utilisation de derives de vanilline comme conservateur, procede de conservation, composes et composition
WO2021094268A1 (en) * 2019-11-11 2021-05-20 Firmenich Sa Gingerol compounds and their use as flavor modifiers

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HU9201804D0 (en) 1992-08-28
FI922472A (fi) 1992-12-01
FI922472A0 (fi) 1992-05-29
IE921768A1 (en) 1992-12-02
CA2069548A1 (en) 1992-12-01
AU1716092A (en) 1992-12-03
EP0516082A2 (en) 1992-12-02
IL102024A0 (en) 1992-12-30
NO922151L (no) 1992-12-01
HUT61192A (en) 1992-12-28
ZA923814B (en) 1993-01-27
JPH05208929A (ja) 1993-08-20
NO922151D0 (no) 1992-05-29

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