KR920019363A - 폴리아데닐산과 폴리우리딜산과의 복합물 - Google Patents
폴리아데닐산과 폴리우리딜산과의 복합물 Download PDFInfo
- Publication number
- KR920019363A KR920019363A KR1019920006270A KR920006270A KR920019363A KR 920019363 A KR920019363 A KR 920019363A KR 1019920006270 A KR1019920006270 A KR 1019920006270A KR 920006270 A KR920006270 A KR 920006270A KR 920019363 A KR920019363 A KR 920019363A
- Authority
- KR
- South Korea
- Prior art keywords
- poly
- complex
- acid
- aids
- complexes
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 세포 및 상징액에서 합성된 바이러스 단백질의 전기영동 분석결과를 나타낸 도면.
Claims (3)
- 폴리(A)·폴리(U)복합물 중의 하나의 상이한 기작에 따라서 HIV바이러스에 작용하는 다른 항-AIDS약제에 임의로 결합된 폴리(A)·폴리(U) 복합물 0.1 내지 100% 및 제약학상 허용되는 희석제 또는 담체로 이루어진, 후천성 면역 결핍증(AIDS) 및 관련된 감염증의 치료를 위한 치료학적 조성물.
- 제1항에 있어서, 폴리(A)·폴리(U)복합물 중의 하나의 상이한 기작에 따라서 HIV바이러스에 작용하는 다른 항-AIDS약제에 결합된 폴리(A)·폴리(U) 복합물 0.1 내지 99% 및 제약학상 허용되는 희석제 또는 담체로 이루어진, 후천성 면역 결핍증(AIDS) 및 관련된 감염증의 치료를 위한 치료학적 조성물.
- 제1항 또는 2항에 있어서, 폴리(A)·폴리(U)복합물 중의 하나의 상이한 기작에 따라서 HIV바이러스에 작용하는 -AIDS약제가 AZT, DDI 및 DDC로부터 선택된 치료학적 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919108085A GB9108085D0 (en) | 1991-04-16 | 1991-04-16 | Complexes of polyadenylic acid with polyuridylic acid |
GB9108085.3 | 1991-04-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR920019363A true KR920019363A (ko) | 1992-11-19 |
KR100233393B1 KR100233393B1 (ko) | 1999-12-01 |
Family
ID=10693367
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019920006270A KR100233393B1 (ko) | 1991-04-16 | 1992-04-15 | 폴리아데닐산과 폴리우리딜산과의 복합물 |
Country Status (19)
Country | Link |
---|---|
US (2) | US5756477A (ko) |
EP (1) | EP0509906A1 (ko) |
JP (1) | JPH05262653A (ko) |
KR (1) | KR100233393B1 (ko) |
AU (1) | AU656574B2 (ko) |
BE (1) | BE1004857A3 (ko) |
CA (1) | CA2066134C (ko) |
CH (1) | CH684521A5 (ko) |
DK (1) | DK51192A (ko) |
DZ (1) | DZ1570A1 (ko) |
FR (1) | FR2675384B1 (ko) |
GB (2) | GB9108085D0 (ko) |
IE (1) | IE921208A1 (ko) |
LU (1) | LU88102A1 (ko) |
MY (1) | MY108106A (ko) |
NO (1) | NO921513L (ko) |
OA (1) | OA09577A (ko) |
SE (1) | SE509801C2 (ko) |
ZA (1) | ZA922699B (ko) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6734192B1 (en) | 1999-08-23 | 2004-05-11 | Mp-1 Inc. | Treatment of viral infections |
US7875283B2 (en) * | 2000-04-13 | 2011-01-25 | Advanced Cardiovascular Systems, Inc. | Biodegradable polymers for use with implantable medical devices |
US7186789B2 (en) | 2003-06-11 | 2007-03-06 | Advanced Cardiovascular Systems, Inc. | Bioabsorbable, biobeneficial polyester polymers for use in drug eluting stent coatings |
US20060135253A1 (en) * | 2004-09-10 | 2006-06-22 | Jeffrey George | Gaming system and method for providing entry to a contest |
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JPS4940954B1 (ko) * | 1970-02-16 | 1974-11-06 | ||
US3796631A (en) * | 1970-11-09 | 1974-03-12 | Choay Sa | Processes for preparing polynucleotides |
IL37076A (en) * | 1971-06-16 | 1974-05-16 | Littauer U | A method for stepwise synthesis of oligoribonucleotides of defined sequence using 2'(3')-o-acyl-nucleoside diphosphates and polynucleotide phosphorylase |
US4124702A (en) * | 1971-07-06 | 1978-11-07 | Merck & Co., Inc. | Polynucleotides active as inducers of interferon production in living animal cells |
JPS524633B2 (ko) * | 1972-07-21 | 1977-02-05 | ||
GB1435571A (en) * | 1973-04-02 | 1976-05-12 | Searle & Co | Polynucleotides |
DE2319495C2 (de) * | 1973-04-17 | 1985-01-10 | Yeda Research And Development Co., Ltd., Rehovot | Verfahren zum selektiven, reversiblen Binden von Biomolekülen an ein Adsorbens in einer chromatographischen Säule |
US4024222A (en) * | 1973-10-30 | 1977-05-17 | The Johns Hopkins University | Nucleic acid complexes |
FR2252350A1 (en) * | 1973-11-22 | 1975-06-20 | Choay Sa | Polynucleotide phosphorylase - extraction from E coli, fixation on sepharose, and use in preparing polynucleotides |
JPS50107187A (ko) * | 1974-02-08 | 1975-08-23 | ||
US4006059A (en) * | 1974-07-29 | 1977-02-01 | Purdue Research Foundation | Hydrophobic noncovalent binding of proteins to support materials |
US4000098A (en) * | 1974-08-16 | 1976-12-28 | Palo Alto Medical Research Foundation | Separation of proteins by hydrophobic adsorption |
US4024241A (en) * | 1974-09-27 | 1977-05-17 | The United States Of America As Represented By The Secretary Of Health, Education And Welfare | Nuclease-resistant hydrophilic complex of polyriboinosinic-polyribocytidylic acid |
US4075195A (en) * | 1976-08-31 | 1978-02-21 | Kraft, Inc. | Debittered protein product and method for manufacture |
SU619508A1 (ru) * | 1976-12-07 | 1978-08-15 | Предприятие П/Я Г-4740 | Способ получени полинуклеотидов, обладающих полирибонуклеотидфосфорилазной активностью |
JPS5519239A (en) * | 1978-07-28 | 1980-02-09 | Green Cross Corp:The | Interferon-producing attractant |
JPS5618597A (en) * | 1979-07-23 | 1981-02-21 | Mitsubishi Chem Ind Ltd | Production of oligonucleotide |
US4379843A (en) * | 1981-01-26 | 1983-04-12 | Peter Cashion | Immobilization of polynucleotides and polypeptides with tritylated polysaccharides |
US4400375A (en) * | 1981-11-23 | 1983-08-23 | Eli Lilly And Company | Tobramycin-double stranded RNA complex suitable for inducing interferon |
EP0113162B1 (en) * | 1982-09-16 | 1989-07-19 | Hem Research, Inc. | Anti-proliferative action of dsnras on tumor cells |
US4617376A (en) * | 1985-07-01 | 1986-10-14 | Eli Lilly And Company | Process for recovering glucagon from pancreas glands |
US5063209A (en) * | 1985-08-26 | 1991-11-05 | Hem Research, Inc. | Modulation of aids virus-related events by double-stranded RNAs |
US4820696A (en) * | 1985-08-26 | 1989-04-11 | Hem Research, Inc. | Modulation of aids virus-related events by double-stranded RNAS |
CA1326450C (en) * | 1985-08-26 | 1994-01-25 | William A. Carter | Modulation of aids virus-related events by double stranded rnas (dsrnas) |
US4945082A (en) * | 1985-08-26 | 1990-07-31 | Hem Research, Inc. | Controlled dsRNA therapy for human viral infections |
US4795744A (en) * | 1986-07-17 | 1989-01-03 | Hem Research, Inc. | Modulation of AIDS virus-related events by double-stranded RNAS |
US4771128A (en) * | 1986-10-10 | 1988-09-13 | Cetus Corporation | Method of purifying toxin conjugates using hydrophobic interaction chromatography |
US4950652A (en) * | 1987-03-23 | 1990-08-21 | Hem Research, Inc. | dsRNAs for combination therapy in the treatment of viral diseases |
US5091374A (en) * | 1987-07-17 | 1992-02-25 | Hem Research Inc. | Double-stranded RNA correction of abnormalities in circulating immune complexes and monocyte function |
AU1820588A (en) * | 1987-07-17 | 1989-01-19 | Hem Research, Inc. | Double-stranded rna correction of abnormalities in circulating immune complexes and monocyte function |
AU1820388A (en) * | 1987-07-17 | 1989-01-19 | Hem Research, Inc. | Double stranded rna correction of aberrant metabolic pathways associated with uncontrolled tumor cell and virus growth cycles |
GB8725606D0 (en) * | 1987-11-02 | 1987-12-09 | Soc D Etudes Prod Chimique | Preparation polynucleotides |
US4963532A (en) * | 1987-11-25 | 1990-10-16 | Hem Research, Inc. | dsRNA-based prevention of viral escape |
DE68914201T2 (de) * | 1988-07-07 | 1994-07-14 | Hem Pharma Corp | Diagnose und Behandlung chronischer Ermüdungserscheinungen. |
JP2619710B2 (ja) * | 1989-02-27 | 1997-06-11 | 日本製紙 株式会社 | 2′,3′−ジデオキシプリンヌクレオシド類の製造方法 |
-
1991
- 1991-04-16 GB GB919108085A patent/GB9108085D0/en active Pending
-
1992
- 1992-04-09 GB GB9207798A patent/GB2255504A/en not_active Withdrawn
- 1992-04-10 CH CH1177/92A patent/CH684521A5/fr not_active IP Right Cessation
- 1992-04-12 DZ DZ920036A patent/DZ1570A1/fr active
- 1992-04-13 ZA ZA922699A patent/ZA922699B/xx unknown
- 1992-04-15 CA CA002066134A patent/CA2066134C/en not_active Expired - Fee Related
- 1992-04-15 IE IE120892A patent/IE921208A1/en unknown
- 1992-04-15 FR FR9204606A patent/FR2675384B1/fr not_active Expired - Fee Related
- 1992-04-15 MY MYPI92000650A patent/MY108106A/en unknown
- 1992-04-15 NO NO92921513A patent/NO921513L/no unknown
- 1992-04-15 KR KR1019920006270A patent/KR100233393B1/ko not_active IP Right Cessation
- 1992-04-15 BE BE9200348A patent/BE1004857A3/fr not_active IP Right Cessation
- 1992-04-15 SE SE9201207A patent/SE509801C2/sv not_active IP Right Cessation
- 1992-04-15 EP EP92401045A patent/EP0509906A1/fr not_active Withdrawn
- 1992-04-15 DK DK051192A patent/DK51192A/da not_active Application Discontinuation
- 1992-04-15 JP JP4095140A patent/JPH05262653A/ja not_active Ceased
- 1992-04-15 AU AU14909/92A patent/AU656574B2/en not_active Ceased
- 1992-04-16 OA OA60187A patent/OA09577A/fr unknown
- 1992-04-16 LU LU88102A patent/LU88102A1/fr unknown
-
1996
- 1996-01-04 US US08/582,658 patent/US5756477A/en not_active Expired - Fee Related
-
1997
- 1997-03-13 US US08/816,643 patent/US5736525A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
IE921208A1 (en) | 1992-10-21 |
MY108106A (en) | 1996-08-15 |
FR2675384B1 (fr) | 1995-09-15 |
LU88102A1 (fr) | 1992-10-15 |
DK51192A (da) | 1992-10-17 |
AU1490992A (en) | 1992-10-22 |
CA2066134C (en) | 2002-11-19 |
US5756477A (en) | 1998-05-26 |
CH684521A5 (fr) | 1994-10-14 |
US5736525A (en) | 1998-04-07 |
FR2675384A1 (fr) | 1992-10-23 |
NO921513L (no) | 1992-10-19 |
SE9201207L (sv) | 1992-10-17 |
GB9108085D0 (en) | 1991-06-05 |
GB2255504A (en) | 1992-11-11 |
CA2066134A1 (en) | 1992-10-17 |
ZA922699B (en) | 1992-12-30 |
SE509801C2 (sv) | 1999-03-08 |
KR100233393B1 (ko) | 1999-12-01 |
BE1004857A3 (fr) | 1993-02-09 |
GB9207798D0 (en) | 1992-05-27 |
SE9201207D0 (sv) | 1992-04-15 |
DK51192D0 (da) | 1992-04-15 |
AU656574B2 (en) | 1995-02-09 |
NO921513D0 (no) | 1992-04-15 |
DZ1570A1 (fr) | 2002-02-17 |
EP0509906A1 (fr) | 1992-10-21 |
OA09577A (fr) | 1993-01-31 |
JPH05262653A (ja) | 1993-10-12 |
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