KR920019363A - 폴리아데닐산과 폴리우리딜산과의 복합물 - Google Patents

폴리아데닐산과 폴리우리딜산과의 복합물 Download PDF

Info

Publication number
KR920019363A
KR920019363A KR1019920006270A KR920006270A KR920019363A KR 920019363 A KR920019363 A KR 920019363A KR 1019920006270 A KR1019920006270 A KR 1019920006270A KR 920006270 A KR920006270 A KR 920006270A KR 920019363 A KR920019363 A KR 920019363A
Authority
KR
South Korea
Prior art keywords
poly
complex
acid
aids
complexes
Prior art date
Application number
KR1019920006270A
Other languages
English (en)
Other versions
KR100233393B1 (ko
Inventor
제.오바네시앙 아라
데샹 드 뺄레뜨 에블린
Original Assignee
게라르 보푸르
소시에떼 드 꽁세이으 드 르세르세 에 다쁠리까시옹 시앙띠피끄(에스.세.에르.아.에스)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 게라르 보푸르, 소시에떼 드 꽁세이으 드 르세르세 에 다쁠리까시옹 시앙띠피끄(에스.세.에르.아.에스) filed Critical 게라르 보푸르
Publication of KR920019363A publication Critical patent/KR920019363A/ko
Application granted granted Critical
Publication of KR100233393B1 publication Critical patent/KR100233393B1/ko

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV

Abstract

내용 없음

Description

폴리아데닐산과 폴리우리딜산과의 복합물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 세포 및 상징액에서 합성된 바이러스 단백질의 전기영동 분석결과를 나타낸 도면.

Claims (3)

  1. 폴리(A)·폴리(U)복합물 중의 하나의 상이한 기작에 따라서 HIV바이러스에 작용하는 다른 항-AIDS약제에 임의로 결합된 폴리(A)·폴리(U) 복합물 0.1 내지 100% 및 제약학상 허용되는 희석제 또는 담체로 이루어진, 후천성 면역 결핍증(AIDS) 및 관련된 감염증의 치료를 위한 치료학적 조성물.
  2. 제1항에 있어서, 폴리(A)·폴리(U)복합물 중의 하나의 상이한 기작에 따라서 HIV바이러스에 작용하는 다른 항-AIDS약제에 결합된 폴리(A)·폴리(U) 복합물 0.1 내지 99% 및 제약학상 허용되는 희석제 또는 담체로 이루어진, 후천성 면역 결핍증(AIDS) 및 관련된 감염증의 치료를 위한 치료학적 조성물.
  3. 제1항 또는 2항에 있어서, 폴리(A)·폴리(U)복합물 중의 하나의 상이한 기작에 따라서 HIV바이러스에 작용하는 -AIDS약제가 AZT, DDI 및 DDC로부터 선택된 치료학적 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920006270A 1991-04-16 1992-04-15 폴리아데닐산과 폴리우리딜산과의 복합물 KR100233393B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919108085A GB9108085D0 (en) 1991-04-16 1991-04-16 Complexes of polyadenylic acid with polyuridylic acid
GB9108085.3 1991-04-16

Publications (2)

Publication Number Publication Date
KR920019363A true KR920019363A (ko) 1992-11-19
KR100233393B1 KR100233393B1 (ko) 1999-12-01

Family

ID=10693367

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920006270A KR100233393B1 (ko) 1991-04-16 1992-04-15 폴리아데닐산과 폴리우리딜산과의 복합물

Country Status (19)

Country Link
US (2) US5756477A (ko)
EP (1) EP0509906A1 (ko)
JP (1) JPH05262653A (ko)
KR (1) KR100233393B1 (ko)
AU (1) AU656574B2 (ko)
BE (1) BE1004857A3 (ko)
CA (1) CA2066134C (ko)
CH (1) CH684521A5 (ko)
DK (1) DK51192A (ko)
DZ (1) DZ1570A1 (ko)
FR (1) FR2675384B1 (ko)
GB (2) GB9108085D0 (ko)
IE (1) IE921208A1 (ko)
LU (1) LU88102A1 (ko)
MY (1) MY108106A (ko)
NO (1) NO921513L (ko)
OA (1) OA09577A (ko)
SE (1) SE509801C2 (ko)
ZA (1) ZA922699B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6734192B1 (en) 1999-08-23 2004-05-11 Mp-1 Inc. Treatment of viral infections
US7875283B2 (en) * 2000-04-13 2011-01-25 Advanced Cardiovascular Systems, Inc. Biodegradable polymers for use with implantable medical devices
US7186789B2 (en) 2003-06-11 2007-03-06 Advanced Cardiovascular Systems, Inc. Bioabsorbable, biobeneficial polyester polymers for use in drug eluting stent coatings
US20060135253A1 (en) * 2004-09-10 2006-06-22 Jeffrey George Gaming system and method for providing entry to a contest

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4940954B1 (ko) * 1970-02-16 1974-11-06
US3796631A (en) * 1970-11-09 1974-03-12 Choay Sa Processes for preparing polynucleotides
IL37076A (en) * 1971-06-16 1974-05-16 Littauer U A method for stepwise synthesis of oligoribonucleotides of defined sequence using 2'(3')-o-acyl-nucleoside diphosphates and polynucleotide phosphorylase
US4124702A (en) * 1971-07-06 1978-11-07 Merck & Co., Inc. Polynucleotides active as inducers of interferon production in living animal cells
JPS524633B2 (ko) * 1972-07-21 1977-02-05
GB1435571A (en) * 1973-04-02 1976-05-12 Searle & Co Polynucleotides
DE2319495C2 (de) * 1973-04-17 1985-01-10 Yeda Research And Development Co., Ltd., Rehovot Verfahren zum selektiven, reversiblen Binden von Biomolekülen an ein Adsorbens in einer chromatographischen Säule
US4024222A (en) * 1973-10-30 1977-05-17 The Johns Hopkins University Nucleic acid complexes
FR2252350A1 (en) * 1973-11-22 1975-06-20 Choay Sa Polynucleotide phosphorylase - extraction from E coli, fixation on sepharose, and use in preparing polynucleotides
JPS50107187A (ko) * 1974-02-08 1975-08-23
US4006059A (en) * 1974-07-29 1977-02-01 Purdue Research Foundation Hydrophobic noncovalent binding of proteins to support materials
US4000098A (en) * 1974-08-16 1976-12-28 Palo Alto Medical Research Foundation Separation of proteins by hydrophobic adsorption
US4024241A (en) * 1974-09-27 1977-05-17 The United States Of America As Represented By The Secretary Of Health, Education And Welfare Nuclease-resistant hydrophilic complex of polyriboinosinic-polyribocytidylic acid
US4075195A (en) * 1976-08-31 1978-02-21 Kraft, Inc. Debittered protein product and method for manufacture
SU619508A1 (ru) * 1976-12-07 1978-08-15 Предприятие П/Я Г-4740 Способ получени полинуклеотидов, обладающих полирибонуклеотидфосфорилазной активностью
JPS5519239A (en) * 1978-07-28 1980-02-09 Green Cross Corp:The Interferon-producing attractant
JPS5618597A (en) * 1979-07-23 1981-02-21 Mitsubishi Chem Ind Ltd Production of oligonucleotide
US4379843A (en) * 1981-01-26 1983-04-12 Peter Cashion Immobilization of polynucleotides and polypeptides with tritylated polysaccharides
US4400375A (en) * 1981-11-23 1983-08-23 Eli Lilly And Company Tobramycin-double stranded RNA complex suitable for inducing interferon
EP0113162B1 (en) * 1982-09-16 1989-07-19 Hem Research, Inc. Anti-proliferative action of dsnras on tumor cells
US4617376A (en) * 1985-07-01 1986-10-14 Eli Lilly And Company Process for recovering glucagon from pancreas glands
US5063209A (en) * 1985-08-26 1991-11-05 Hem Research, Inc. Modulation of aids virus-related events by double-stranded RNAs
US4820696A (en) * 1985-08-26 1989-04-11 Hem Research, Inc. Modulation of aids virus-related events by double-stranded RNAS
CA1326450C (en) * 1985-08-26 1994-01-25 William A. Carter Modulation of aids virus-related events by double stranded rnas (dsrnas)
US4945082A (en) * 1985-08-26 1990-07-31 Hem Research, Inc. Controlled dsRNA therapy for human viral infections
US4795744A (en) * 1986-07-17 1989-01-03 Hem Research, Inc. Modulation of AIDS virus-related events by double-stranded RNAS
US4771128A (en) * 1986-10-10 1988-09-13 Cetus Corporation Method of purifying toxin conjugates using hydrophobic interaction chromatography
US4950652A (en) * 1987-03-23 1990-08-21 Hem Research, Inc. dsRNAs for combination therapy in the treatment of viral diseases
US5091374A (en) * 1987-07-17 1992-02-25 Hem Research Inc. Double-stranded RNA correction of abnormalities in circulating immune complexes and monocyte function
AU1820588A (en) * 1987-07-17 1989-01-19 Hem Research, Inc. Double-stranded rna correction of abnormalities in circulating immune complexes and monocyte function
AU1820388A (en) * 1987-07-17 1989-01-19 Hem Research, Inc. Double stranded rna correction of aberrant metabolic pathways associated with uncontrolled tumor cell and virus growth cycles
GB8725606D0 (en) * 1987-11-02 1987-12-09 Soc D Etudes Prod Chimique Preparation polynucleotides
US4963532A (en) * 1987-11-25 1990-10-16 Hem Research, Inc. dsRNA-based prevention of viral escape
DE68914201T2 (de) * 1988-07-07 1994-07-14 Hem Pharma Corp Diagnose und Behandlung chronischer Ermüdungserscheinungen.
JP2619710B2 (ja) * 1989-02-27 1997-06-11 日本製紙 株式会社 2′,3′−ジデオキシプリンヌクレオシド類の製造方法

Also Published As

Publication number Publication date
IE921208A1 (en) 1992-10-21
MY108106A (en) 1996-08-15
FR2675384B1 (fr) 1995-09-15
LU88102A1 (fr) 1992-10-15
DK51192A (da) 1992-10-17
AU1490992A (en) 1992-10-22
CA2066134C (en) 2002-11-19
US5756477A (en) 1998-05-26
CH684521A5 (fr) 1994-10-14
US5736525A (en) 1998-04-07
FR2675384A1 (fr) 1992-10-23
NO921513L (no) 1992-10-19
SE9201207L (sv) 1992-10-17
GB9108085D0 (en) 1991-06-05
GB2255504A (en) 1992-11-11
CA2066134A1 (en) 1992-10-17
ZA922699B (en) 1992-12-30
SE509801C2 (sv) 1999-03-08
KR100233393B1 (ko) 1999-12-01
BE1004857A3 (fr) 1993-02-09
GB9207798D0 (en) 1992-05-27
SE9201207D0 (sv) 1992-04-15
DK51192D0 (da) 1992-04-15
AU656574B2 (en) 1995-02-09
NO921513D0 (no) 1992-04-15
DZ1570A1 (fr) 2002-02-17
EP0509906A1 (fr) 1992-10-21
OA09577A (fr) 1993-01-31
JPH05262653A (ja) 1993-10-12

Similar Documents

Publication Publication Date Title
EA199901031A1 (ru) Производные бензимидазола
BR0013771A (pt) Composto, métodos de tratamento de uma infecção viral em um mamìfero, de inibir a transcriptase reversa do hiv, e de prevenção da infecção do hiv ou de tratar a infecção do hiv, uso de um composto, e, composição farmacêutica
MD1224B2 (en) Application of nucleoside analogues with 1,3-oxathiolan for treatment of hepatitis B
ATE87319T1 (de) Inklusionskomplexe von 7-isopropoxy-isoflavon mit cyclodextrinen, verfahren zu deren herstellung und diese inklusionskomplexe enthaltende pharmazeutische praeparate.
ES2150496T3 (es) Cicloalquilimidazopiridinas condensadas.
DK0951473T3 (da) Cyclosporinderivat, fremstilling af dette og farmaceutiske præparater indeholdende dette
RU93045710A (ru) Противовирусная нуклеозидная композиция, способ ее получения и способ лечения
DE68919146D1 (de) Ausgewählte Stämme von Lactobacillus enthaltende pharmazeutische Zusammensetzungen.
MD1233B1 (en) Erythromycin derivatives, process for their preparation and pharmaceutical composition on base thereof
KR930023370A (ko) 단백질 씨(c) 유도체
RU93043875A (ru) 1-(2-гидроксиметил)-1,3-оксатиолан-5-ил)-5-фторцитозин и способ лечения
DE3887014T2 (de) Nukleoside, ihre Herstellung und pharmazeutische Zusammenstellungen.
FI885454A (fi) Administrationssystem, som laongsamt frigoer substituerade dihydropyridiner.
KR970061246A (ko) 테스토스테론을 증가시키기 위한 약학 조성물
KR920019363A (ko) 폴리아데닐산과 폴리우리딜산과의 복합물
KR970061248A (ko) 알츠하이머병 치료용 1, 1, 2-트리페닐부트-1-엔 유도체
MC1930A1 (fr) Produit antiviral
NO983054L (no) Virale rekombinante pseudopartikler og anvendelse som vaksiner og som anti-tumormiddel
KR890001540A (ko) 심부전증 치료제
DE69208681D1 (de) Verwendungen von 1,1,1,3,3,3-hexafluoropropan
KR910000645A (ko) 개선된 경련치료제
PT89742A (pt) Processo de preparacao de 24r-cimnol e de suas composicoes farmaceuticas
KR900017587A (ko) 바이러스 감염증 치료제의 제조를 위한 티아졸 유도체 티프로티모드의 용도
KR890701582A (ko) 치료용 뉴클레오사이드
ES2078380T3 (es) Oligofosfatos de accion antiviral.

Legal Events

Date Code Title Description
A201 Request for examination
AMND Amendment
E902 Notification of reason for refusal
AMND Amendment
E601 Decision to refuse application
J201 Request for trial against refusal decision
B701 Decision to grant
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20030826

Year of fee payment: 5

LAPS Lapse due to unpaid annual fee