KR920014784A - 비스테로이드성 항염증제로서의 피라졸 유도체 및 그 제조방법 - Google Patents

비스테로이드성 항염증제로서의 피라졸 유도체 및 그 제조방법 Download PDF

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KR920014784A
KR920014784A KR1019910000957A KR910000957A KR920014784A KR 920014784 A KR920014784 A KR 920014784A KR 1019910000957 A KR1019910000957 A KR 1019910000957A KR 910000957 A KR910000957 A KR 910000957A KR 920014784 A KR920014784 A KR 920014784A
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acetate
benzyl
ronazolac
organic solvent
acetic acid
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KR1019910000957A
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KR930006770B1 (ko
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정해수
최현웅
함광수
김재철
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정명진
태평양제약 주식회사
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음

Description

비스테로이드성 항염증제로서의 피라졸 유도체 및 그 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 LON,LCA 및 LAA의 UV흡광 스펙트럼이다. 제2도는 LON 및 LAA의 IR흡광 스펙트럼이다. 제3도는 DMSO내에서의 로나졸락의 1H-NMR 스펙트럼이다.

Claims (5)

  1. 3-(4-클로로페닐)-1-페닐-1H-피라졸-4-아세트산과 벤질-2-할로아세테이트를 유기용매내에서 알카리촉매제를 사용하여 합성된 벤질 로나졸락 아세테이트를 팔라듐/탄소촉매하에서 수소환원시킴으로써 생성된 로나졸락 아세트산 에스테르.
  2. 제1항에 있어서, 상기 벤질-2-할로 아세테이트가 벤질 2 클로로 아세테이트, 벤질 2-브로모 아세테이트 및 벤질 2 요드 아세테이트로 이루어진 군으로부터 선택된 하나인 것을 특징으로 하는 로나졸락 아세트산 에스테르.
  3. 제1항에 있어서, 상기 유기용매가 디메틸포름아미드, 아세톤, 메틸에틸케톤, 아세토니트릴, 피리딘, 클로로포름, 테트라히드로튜란 및 에틸아세테이트로 이루어진 군으로부터 선택된 하나인 것을 특징으로 하는 로나졸락 아세트산 에스테르.
  4. 제1항에 있어서, 상기 알카리촉매제가 수산화칼륨, 수산화나트륨, 탄산나트륨, 탄산칼슘, 트리에틸아민, 트리에탄올아민, 이소프로필아민 및 디에틸아민으로 이루어진 군으로부터 선택된 하나인 것을 특징으로 하는 로나졸락 아세트산 에스테르.
  5. 3-(4-클로로페닐)-1-페닐-1H-피라졸-4-아세트산과 벤질-2-할로 아세테이트를 유기용매내에서 알카리 촉매제를 사용하여 벤질 로나졸락 아세테이트를 합성하는 단계, 및 상기 재결정된 벤질 로나졸락 아세테이트에 유기용매와 팔마듐/탄소촉매를 가한 다음 수소환원반응기에서 환원반응시키는 단계로 구성되는 것을 특징으로하는 로나졸락 아세트산 에스테르의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910000957A 1991-01-21 1991-01-21 비스테로이드성 항염증제로서의 피라졸 유도체 및 그 제조방법 KR930006770B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019910000957A KR930006770B1 (ko) 1991-01-21 1991-01-21 비스테로이드성 항염증제로서의 피라졸 유도체 및 그 제조방법

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019910000957A KR930006770B1 (ko) 1991-01-21 1991-01-21 비스테로이드성 항염증제로서의 피라졸 유도체 및 그 제조방법

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KR920014784A true KR920014784A (ko) 1992-08-25
KR930006770B1 KR930006770B1 (ko) 1993-07-23

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