AR245722A1 - Procedimiento para preparar un derivado 23-desoxi-27-halo de compuestos ll-f28249 y composicion para controlar insectos de las plantas excluyendo su aplicacion en animales y el hombre. - Google Patents

Procedimiento para preparar un derivado 23-desoxi-27-halo de compuestos ll-f28249 y composicion para controlar insectos de las plantas excluyendo su aplicacion en animales y el hombre.

Info

Publication number
AR245722A1
AR245722A1 AR88310221A AR31022188A AR245722A1 AR 245722 A1 AR245722 A1 AR 245722A1 AR 88310221 A AR88310221 A AR 88310221A AR 31022188 A AR31022188 A AR 31022188A AR 245722 A1 AR245722 A1 AR 245722A1
Authority
AR
Argentina
Prior art keywords
halo
compounds
ethyl
methyl
derivative
Prior art date
Application number
AR88310221A
Other languages
English (en)
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of AR245722A1 publication Critical patent/AR245722A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

UN PROCEDIMIENTO PARA PREPARAR UN DERIVADO 23-DESOXI-27-HALO DE COMPUESTOS LL-F28249 DE LA FORMULA (I), DONDE R1 ES METILO, ETILO O ISOPROPILO; R2 ES HIDROGENO; R3 ES METILO O ETILO; R4 ES METILO O ETILO; Y X ES CLORO, OBTENIDO POR HACER REACCIONAR UN COMPUESTO LL-F28249 DE FORMULA (II), CON DIAHALURO DE TRIFENILFOSFINA EN UN SOLVENTE INERTE PARA OBTENER EL DERIVADO 23-HALO CORRESPONDIENTE EL CUAL SE REDUCE CON HIDRURO DE TRIBUTILESTANO EN PRESENCIA DE AZOBISISOBUTIRONITRILO PARA PROPORCIONAR EL DERIVADO 23-DESOXI CORRESPONDIENTE, HACER REACCIONAR ESTE ULTIMO CON N-HALOSUCCINIMIDA PARA OBTENER 23-DESOXI-27-HALO-LL-F28249 EL QUE FINALMENTE SE HACE REACCIONAR CON N-HALOACETAMIDA EN ACETONA ACUOSA PARA OBTENER EL PRODUCTO DESEADO 23- DESOXI-27-HALO-LL-F28249 CON UN DOBLE ENLACE EN LA POSICION 26,26'.
AR88310221A 1987-03-06 1988-03-03 Procedimiento para preparar un derivado 23-desoxi-27-halo de compuestos ll-f28249 y composicion para controlar insectos de las plantas excluyendo su aplicacion en animales y el hombre. AR245722A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/022,848 US4956479A (en) 1987-03-06 1987-03-06 23-deoxy-27-chloro derivatives of LL-F28249 compounds

Publications (1)

Publication Number Publication Date
AR245722A1 true AR245722A1 (es) 1994-02-28

Family

ID=21811740

Family Applications (1)

Application Number Title Priority Date Filing Date
AR88310221A AR245722A1 (es) 1987-03-06 1988-03-03 Procedimiento para preparar un derivado 23-desoxi-27-halo de compuestos ll-f28249 y composicion para controlar insectos de las plantas excluyendo su aplicacion en animales y el hombre.

Country Status (17)

Country Link
US (1) US4956479A (es)
EP (1) EP0280928B1 (es)
JP (1) JPS63264586A (es)
KR (1) KR880011164A (es)
AR (1) AR245722A1 (es)
AT (1) ATE113049T1 (es)
AU (1) AU607190B2 (es)
BR (1) BR8800942A (es)
CA (1) CA1291128C (es)
DE (1) DE3851846T2 (es)
DK (1) DK118788A (es)
ES (1) ES2061529T3 (es)
HU (1) HU200774B (es)
IL (2) IL85450A (es)
NZ (1) NZ223643A (es)
PT (1) PT86902B (es)
ZA (1) ZA881576B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0238259B1 (en) * 1986-03-12 1993-09-29 American Cyanamid Company Macrolide compounds
SE8701019L (sv) * 1986-03-12 1987-09-13 Glaxo Group Ltd Makrolidforening
GB8905605D0 (en) * 1989-03-11 1989-04-26 Beecham Group Plc Novel compounds
US5830875A (en) * 1989-10-30 1998-11-03 Merck & Co., Inc. 24-and 25-substituted avermectin and milbemycin derivatives
WO1999017760A2 (en) 1997-10-02 1999-04-15 Microcide Pharmaceuticals, Inc. Fungal or mammalian cell efflux pump inhibitors for enhancing susceptibility of the cell to a drug

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US32034A (en) * 1861-04-09 Langdon sawyer
USRE32034E (en) 1977-12-19 1985-11-19 Merck & Co., Inc. 13-Halo and 13-deoxy derivatives of C-076 compounds
US4530921A (en) * 1983-10-03 1985-07-23 Merck & Co., Inc. Avermectin epoxide derivatives and method of use
US4584314A (en) * 1983-11-25 1986-04-22 Ciba-Geigy Corporation Lactone derivative, process for the preparation thereof, and use thereof in pest control
EP0170006B1 (en) * 1984-06-05 1992-07-08 American Cyanamid Company Method and compositions for helmintic, arthropod ectoparasitic and acaridal infections with novel agents
GB2166436B (en) * 1984-09-14 1989-05-24 Glaxo Group Ltd Antibiotic compounds and their preparation
US4696922A (en) * 1984-11-26 1987-09-29 Ciba-Geigy Corporation 5-azolylacetoxymilbemycins as ecto- and endoparasites
IL78621A (en) * 1985-04-30 1991-06-30 American Cyanamid Co Mylbemycin analogs,their preparation and pesticidal compositions containing them
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina
NZ217567A (en) * 1985-09-13 1988-07-28 Glaxo Group Ltd Avermectin/milbemycin derivatives
PH24355A (en) * 1986-03-12 1990-06-13 Glaxo Group Ltd Macrolide compounds,composition said compound and method of use thereof
ES2054664T3 (es) * 1986-03-12 1994-08-16 American Cyanamid Co Compuestos macrolidos.
US4876272A (en) * 1987-03-06 1989-10-24 American Cyanamid Company Mono- and diepoxide derivatives of LL-F28249 compounds

Also Published As

Publication number Publication date
IL85450A0 (en) 1988-07-31
EP0280928B1 (en) 1994-10-19
PT86902A (pt) 1988-04-01
ZA881576B (en) 1988-08-29
IL85451A (en) 1993-02-21
NZ223643A (en) 1991-01-29
US4956479A (en) 1990-09-11
DE3851846T2 (de) 1995-05-11
AU607190B2 (en) 1991-02-28
AU1271688A (en) 1988-09-08
KR880011164A (ko) 1988-10-27
BR8800942A (pt) 1988-10-11
PT86902B (pt) 1992-05-29
JPS63264586A (ja) 1988-11-01
DE3851846D1 (de) 1994-11-24
EP0280928A1 (en) 1988-09-07
HU200774B (en) 1990-08-28
ES2061529T3 (es) 1994-12-16
ATE113049T1 (de) 1994-11-15
DK118788D0 (da) 1988-03-04
DK118788A (da) 1988-09-07
IL85450A (en) 1994-05-30
CA1291128C (en) 1991-10-22

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