KR920010254B1 - Process for preparing soft gelatin capsule containing egg shells - Google Patents

Abstract

A process for preparing a soft capsule membrane comprises (a) mixing gelatin, glycerin and purifyed water, swelling the mixture, and dissolving it at 60-70 deg.C, (b) adding 70-325 mesh of egg shell, (c) agitating it for 20-30 mins. and removing air, and (d) molding it. The egg shell is pretreated in an alkali soln. to remove egg shell membrane. Pref. the weight ratio of the egg shell powder to gelatin is 1-30 wt.%.

Description

Manufacturing method of soft capsule film using egg shell

The present invention relates to a method for producing a soft capsule film using eggshell. More specifically, soft capsules disintegrate easily in gastric juice, facilitating the absorption of capsule contents into the body, preventing the adhesion between capsules during long-term preservation and high temperature and high humidity, and ingesting calcium having bioregulatory function. The present invention relates to a method for producing a soft capsule film using egg shells for the purpose of contributing to the utilization of waste resources by using egg shells treated with food by-products.

In general, soft capsule is a product form used in the field of medicines, health foods has the advantages of high stability of the contents and easy absorption in the digestive tract. And the film of the soft capsule is generally composed of 20 parts to 40 parts of glycerin for the gelatin 100 and a small amount of pigments and fragrance components, but has a disadvantage of poor disintegration due to the effect of glycerin used as a plasticizer.

Thus, attempts have been made to improve the disintegration and stability of soft capsules, for example, in U.S. Patent No. 4,708,834 (inventor Jonathan M. Cohen, filed on Nov. 24, 1987, Nov. 1, 1987; Prepatation of gelatin). In the -encapsulated controlled releare composition, polysaccharide gum and metal salts were added and US Patent No. 4,631,765 (inventor Paul C. Guley; patent application issued on September 1, 1984. In once daily antihypertensive use, the disintegration of the soft capsule film was controlled by adding methyl cellulose and metal salts. In addition, JP 61-115,019 [One person of the inventor 佐野 莊 仁; 1984.11.9. Application; Japanese Patent Application Laid-Open No. 61-115019 (published on June 1, 1986); In gelatin capsule film IX), calcium phosphate was added to increase disintegration.

In the above-cited patents, there is no suggestion regarding the manufacturing method of the soft capsule film according to the object of the present invention, and no technical means treated for achieving the above object can be found.

The present invention is to produce a soft capsule film by adding egg shell to improve the disintegration property of the soft capsule, to prevent adhesion, and to absorb calcium, which is a bioregulator, into the body, which is very nutritious as well as an egg shell processed as a food by-product. It also contributes to the utilization of waste resources. Eggshell is composed of 93.7% calcium carbonate and 1.3% magnesium carbonate, so that carbonic acid gas is generated under acidic conditions such as gastric juice, so that disintegration is faster than ordinary soft capsules. In addition, dissolved eggshell calcium and magnesium are absorbed into the body to prevent osteoporosis, stomach cancer, hypertension as well as bioregulatory function. Using this property, the egg shells from which egg shells were removed were pulverized, added to soft capsule coating solution, and then molded and tested for disintegration in artificial gastric juice. The control products without egg shells did not decompose after 1 hour, whereas egg shell powder The added film disintegrated in 40 minutes and was excellent in the adhesion test.

The egg shell powder used in the present invention was washed with water and then immersed in an alkaline solution to remove the egg shell membrane, and then washed again with water and dried. As a dry eggshell powder, more than 70 mesh and less than 325 mesh are most suitable. Above 70 meshes, eggshells break down in gastric juice at about the same time.

Eggshell powder according to the present invention is preferably 1 to 30wt% based on gelatin. At 1wt% or less, there is almost no eggshell addition effect, and when it is added (more than 30wt%), the contents leak out and there is a problem in capsule film formation.

The eggshell powder according to the present invention is mixed with gelatin, glycerin, and purified water as in Example 1, followed by swelling to dissolve in the temperature range of 60 to 70 ° C., and then the eggshell powder according to the present invention is added to the required range.

As described above, the production method of the present invention is a step of mixing, swelling and dissolving gelatin, glycerin and purified water, adding a preferred amount of egg shell powder by the treatment of the present invention, and depressurization after stirring. It is characterized by consisting of a combination of the process to make and forming process.

In the above process, the egg shell is decomposed into 70 mesh-325 mesh by a conventional centrifugal mill to prepare a required egg shell powder, and then gelatin and glycerin are mixed with a predetermined amount of purified water. After mixing, the mixture was swollen in a conventional manner for 1-2 hours and dissolved at a dissolution temperature of 60-70 ° C. The required amount of eggshell powder is added to the resultant dissolved gelatine coating liquid and stirred for 20-30 minutes with a high speed stirrer. After stirring, it is degassed by the usual method. The obtained solution is molded to a required thickness (about 2 mm) on a stainless steel plate. After molding, it is dried for about one day at 30 DEG C by a hot air dryer. It is then cut into the required shape to produce a soft capsule film.

Next, an Example demonstrates this invention.

EXAMPLE 1

The dried eggshell was ground with a 100 mesh raw mill to prepare an eggshell powder. Next, as shown in Table 1, 200 g of gelatin and 75 g of glycerin were mixed with 150 g of purified water, followed by swelling for 1 to 2 hours to dissolve at 60 to 70 ° C. 20 g of eggshell powder was added to the dissolved gelatin coating liquid, which was stirred for 20 to 30 minutes with a high speed stirrer and degassed under reduced pressure. The liquid was molded into a stainless steel plate to a thickness of 2 mm, dried at 30 ° C. for 24 hours with a hot air dryer, and cut into 1 cm squares to prepare a soft capsule film.

EXAMPLE 2

Ten films each prepared according to the method of Example 1 and no coating of eggshell powder were stored for 4 weeks at 75 ° C and 75% humidity for 4 weeks, and then dissolved in 1% pepsin solution dissolved in 37 ° C 0.1N hydrochloric acid to measure the disintegration time. One result is shown in Table 2.

TABLE 2

The soft capsule film containing 20 g of eggshell powder was 100% disintegrated within 40 minutes, whereas the capsule capsule film not added was more than 90% in 60 minutes.

EXAMPLE 3

The film prepared according to the method of Example 1 and the film without the addition of eggshell powder were added to each of 10 samples in a sample bottle and preserved for 4 weeks at 75 ° C humidity of 75%. The capsule film did not adhere but the egg shell powder was not attached to the container wall or the film.

Claims (3)

In the method for producing a soft capsule film using an egg shell, a process of mixing, swelling and dissolving gelatin, glycerin and purified water, adding a egg shell powder, degassing after stirring, and forming process The manufacturing method characterized in that the configuration. The method of claim 1, wherein the egg shell powder is washed with water, immersed in an alkaline solution to remove the egg shell membrane, and then used for washing and drying. The method according to claim 1, wherein the egg shell powder is added in an amount of 1 to 30 wt% based on gelatin, and the powder is used as 70 to 325 mesh.