JPH0427352A - Enteric soft capsule for health food - Google Patents
Enteric soft capsule for health foodInfo
- Publication number
- JPH0427352A JPH0427352A JP2131634A JP13163490A JPH0427352A JP H0427352 A JPH0427352 A JP H0427352A JP 2131634 A JP2131634 A JP 2131634A JP 13163490 A JP13163490 A JP 13163490A JP H0427352 A JPH0427352 A JP H0427352A
- Authority
- JP
- Japan
- Prior art keywords
- calcium
- soft capsule
- enteric
- water
- gelatin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007901 soft capsule Substances 0.000 title claims abstract description 54
- 235000013402 health food Nutrition 0.000 title claims abstract description 14
- 238000004519 manufacturing process Methods 0.000 claims abstract description 23
- 108010010803 Gelatin Proteins 0.000 claims abstract description 19
- 239000008273 gelatin Substances 0.000 claims abstract description 19
- 229920000159 gelatin Polymers 0.000 claims abstract description 19
- 235000019322 gelatine Nutrition 0.000 claims abstract description 19
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 19
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 17
- 239000011575 calcium Substances 0.000 claims abstract description 17
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229910001424 calcium ion Inorganic materials 0.000 claims abstract description 12
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 9
- 238000002156 mixing Methods 0.000 claims abstract description 6
- 239000004014 plasticizer Substances 0.000 claims abstract description 6
- 210000003278 egg shell Anatomy 0.000 claims abstract description 5
- 102000002322 Egg Proteins Human genes 0.000 claims abstract description 4
- 108010000912 Egg Proteins Proteins 0.000 claims abstract description 4
- 159000000007 calcium salts Chemical class 0.000 claims abstract 9
- 150000004676 glycans Chemical class 0.000 claims description 19
- 229920001282 polysaccharide Polymers 0.000 claims description 19
- 239000005017 polysaccharide Substances 0.000 claims description 19
- 239000002775 capsule Substances 0.000 claims description 16
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical group CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 9
- 235000010413 sodium alginate Nutrition 0.000 claims description 9
- 239000000661 sodium alginate Substances 0.000 claims description 9
- 229940005550 sodium alginate Drugs 0.000 claims description 9
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 5
- 239000002738 chelating agent Substances 0.000 claims description 5
- PYMYPHUHKUWMLA-UHFFFAOYSA-N 2,3,4,5-tetrahydroxypentanal Chemical compound OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims description 4
- 229920002148 Gellan gum Polymers 0.000 claims description 4
- 235000015278 beef Nutrition 0.000 claims description 4
- 235000010492 gellan gum Nutrition 0.000 claims description 4
- 239000000216 gellan gum Substances 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 210000000988 bone and bone Anatomy 0.000 claims description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 2
- 229910052751 metal Inorganic materials 0.000 claims description 2
- 239000002184 metal Substances 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 150000002500 ions Chemical class 0.000 claims 1
- 235000014214 soft drink Nutrition 0.000 claims 1
- 229940109850 royal jelly Drugs 0.000 abstract description 2
- 150000001720 carbohydrates Chemical class 0.000 abstract 2
- 239000007788 liquid Substances 0.000 description 16
- 238000000576 coating method Methods 0.000 description 15
- 239000011248 coating agent Substances 0.000 description 14
- 238000000034 method Methods 0.000 description 14
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 210000002784 stomach Anatomy 0.000 description 8
- 239000000243 solution Substances 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 210000004051 gastric juice Anatomy 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 239000007903 gelatin capsule Substances 0.000 description 5
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
- 229910021645 metal ion Inorganic materials 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 239000001509 sodium citrate Substances 0.000 description 4
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 4
- 229940038773 trisodium citrate Drugs 0.000 description 4
- 229920002494 Zein Polymers 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000000465 moulding Methods 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- 239000005019 zein Substances 0.000 description 3
- 229940093612 zein Drugs 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 229940036811 bone meal Drugs 0.000 description 2
- 239000002374 bone meal Substances 0.000 description 2
- 239000001569 carbon dioxide Substances 0.000 description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 108010025899 gelatin film Proteins 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000003002 pH adjusting agent Substances 0.000 description 2
- -1 sodium alginate Chemical class 0.000 description 2
- 240000002234 Allium sativum Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000186000 Bifidobacterium Species 0.000 description 1
- 235000010724 Wisteria floribunda Nutrition 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 239000003405 delayed action preparation Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000002702 enteric coating Substances 0.000 description 1
- 238000009505 enteric coating Methods 0.000 description 1
- 235000021323 fish oil Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 235000004611 garlic Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 150000004667 medium chain fatty acids Chemical class 0.000 description 1
- 238000006198 methoxylation reaction Methods 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Abstract
Description
【発明の詳細な説明】
（産業上の利用分野）
本発明は腸溶性軟カプセルに関し、更に詳しくは食品原
材料のみで製造し得る健康食品用腸溶性軟カプセルに関
するものである。DETAILED DESCRIPTION OF THE INVENTION (Field of Industrial Application) The present invention relates to enteric-coated soft capsules, and more particularly to enteric-coated soft capsules for health foods that can be manufactured only from food raw materials.
（従来の技術）
従来に於いては特に食品原料を用いる腸溶化技術として
、とうもろこし蛋白であるゼインをゼラチン軟カプセル
にコーティングする方法（特開昭５９−２２０１７５号
）やアルギン酸ナトリウムを皮膜に配合して滴下式軟カ
プセルを製造する方法（特開昭５８−１７２３１３号）
、アルギン酸ナトリウム溶液にゼラチン軟カプセルを浸
漬する方法等（特開昭６１−２０７３２８号）が知られ
ている。(Prior art) Conventionally, entericization techniques using food raw materials include a method in which soft gelatin capsules are coated with zein, a corn protein (Japanese Patent Laid-Open No. 59-220175), and a method in which sodium alginate is blended into the film. Method for producing drop-type soft capsules (Japanese Patent Application Laid-open No. 172313/1983)
, a method of immersing soft gelatin capsules in a sodium alginate solution (Japanese Unexamined Patent Publication No. 207328/1983) is known.
（発明が解決しようとする課題）
元来、腸溶性カプセルは胃酸で分解し、生理効果を消失
したり、胃に刺激を与えるような薬剤を胃では溶解せず
、腸内において溶解吸収すべく加工された医薬品におけ
る剤型の１つであるが一般に健康食品といわれるものの
中にも腸溶性カプセルに内包することで付加価値を高め
ることが出来るものが多い。(Problem to be solved by the invention) Originally, enteric-coated capsules were designed to dissolve and absorb drugs in the intestines, rather than in the stomach, because they would be broken down by stomach acid, causing loss of physiological effects or irritation to the stomach. Although it is one of the dosage forms for processed pharmaceuticals, there are also many products that are generally referred to as health foods that can be encapsulated in enteric-coated capsules to increase their added value.
例えば、ローヤルゼリー、乳酸菌、ビフィズス菌等は胃
酸によって分解し効力が低下することが知られているし
、ニンニク等は多量に摂取すると胃の粘膜を荒してしま
う、 又、スツポン粉末、魚油等は摂取後不快臭が胃よ
り口腔内に逆流して、本人及び周く実用化されている所
謂腸溶性基剤は、あくまで医薬品原料であって、このよ
うな健康食品には使用出来ないのである。For example, it is known that royal jelly, lactic acid bacteria, bifidobacteria, etc. are decomposed by stomach acid and their effectiveness decreases, garlic etc. can irritate the stomach mucosa if ingested in large quantities, and stupon powder, fish oil etc. Afterwards, the unpleasant odor flows back from the stomach into the oral cavity, and the so-called enteric base, which has been put into practical use around the world, is just a pharmaceutical raw material and cannot be used in such health foods.
又、ゼインで軟カプセルをコーティングする方法には次
のような問題点がある。Furthermore, the method of coating soft capsules with zein has the following problems.
（ａ）コーティング工程が増える為、時間及び費用が嵩
む。(a) Since the coating process is increased, time and cost increase.
（ｂ）コーティングにエタノールを用いるため、廃液の
回収手段や火災防止等に留意する必要がある。(b) Since ethanol is used for coating, it is necessary to pay attention to waste liquid collection methods and fire prevention.
（ｅ）ゼインは元来水に対し不溶性であるため、胃ばか
りか腸内においても溶解せずそのままの形で排出される
可能性がある。(e) Since zein is originally insoluble in water, it may not be dissolved in the stomach or intestines and may be excreted as is.
又、アルギン酸ナトリウムを皮膜に配合して滴下式軟カ
プセルを製造する方法には次のような問題点がある。Furthermore, the method of manufacturing drop-type soft capsules by incorporating sodium alginate into the film has the following problems.
（ａ）滴下式軟カプセル製造方式では製造可能であるが
、現在健康食品の製造で主流をしめるロータリー式軟カ
プセル製造方式では製造出来ない。(a) Although it is possible to produce soft capsules using the dropping method, it cannot be produced using the rotary soft capsule manufacturing method that is currently the mainstream in the production of health foods.
（ｂ）滴下式軟カプセルを成形後、そのカプセルに耐胃
液性を附与する工程が複雑且つ長時間を要す為商品化は
困難である。(b) Commercialization is difficult because the process of imparting gastric juice resistance to the drop-type soft capsules after molding is complicated and takes a long time.
アルギン酸ナトリウム溶液にゼラチン軟カプセルを浸ら
責する方法には次のような問題点がある。The method of soaking soft gelatin capsules in a sodium alginate solution has the following problems.
（ａ）ゼラチン軟カプセルの外観を著るしく低下させる
。(a) Significantly reduces the appearance of soft gelatin capsules.
（ｂ） ゼラチン軟カプセルを成形後そのカプセルに耐
胃液性を附与する工程が長時間を要し且つ大量生産には
不向きである為商品化は困難である。(b) Commercialization is difficult because the process of molding soft gelatin capsules and imparting gastric juice resistance to the capsules takes a long time and is unsuitable for mass production.
又、従来のロータリー式軟カプセルの製造方法にて、ア
ルギン酸ナトリウム等の、２価以上の陽イオンにより架
橋する水溶性多糖類を皮膜に配合した軟カプセルを製造
成しえなかった理由は概してこれらの架橋性多糖類の水
溶液は高粘性であって、製造後の軟カプセルの耐胃液性
が期待できるほどに該架橋性多糖類を皮膜液中に配合す
れば、その皮膜液の粘度は飛躍的に上昇し、ロータリー
式軟カプセル製造装置で軟カプセルを製造し得る限界の
粘度を大幅に越えてしまうことによる。 又、この時、
粘度の上昇を抑えるため皮膜液中の水の配合量を増やせ
ば、相対的にゼラチンの濃度が下がってしまって製造時
、帯状のゲルとなったゼラチン膜のヒートシール性が低
下し、完全な軟カプセルを製造し得ない欠点がある。In addition, these are the main reasons why it has not been possible to manufacture soft capsules containing a water-soluble polysaccharide that is crosslinked by divalent or higher cations, such as sodium alginate, in the shell using the conventional rotary-type soft capsule manufacturing method. The aqueous solution of the cross-linked polysaccharide is highly viscous, and if the cross-linked polysaccharide is incorporated into the coating liquid to the extent that the gastric juice resistance of the soft capsule after manufacture can be expected, the viscosity of the coating liquid will increase dramatically. This is due to the fact that the viscosity increases significantly and exceeds the limit viscosity that can be used to manufacture soft capsules using a rotary type soft capsule manufacturing apparatus. Also, at this time,
If the amount of water in the film solution is increased to suppress the increase in viscosity, the gelatin concentration will be relatively reduced, and the heat-sealability of the gelatin film, which becomes a band-shaped gel during manufacturing, will decrease, resulting in a complete failure. There is a drawback that soft capsules cannot be manufactured.
而して、本発明は滴下式軟カプセル製造方法のみならず
従来の技術では不可能であったロータリー式軟カプセル
製造方法による軟カプセルを食品用原料で腸溶化せしめ
ると共に、特別な後工程を増やすことなく、工業的に有
利に腸溶性カプセルを製造することを技術的課題とする
ものである。Therefore, the present invention enables enteric coating of soft capsules with food-grade raw materials not only by the drop-type soft capsule manufacturing method but also by the rotary-type soft capsule manufacturing method, which was impossible with conventional technology, and also increases the number of special post-processes. The technical problem is to industrially advantageously produce enteric-coated capsules without any problems.
（技術的手段）
上記目的を達成する為に、第一にゼラチンと可塑剤から
成る皮膜基剤に、炭酸カルシウム塩を主成分とする卵殻
、貝殻、牛骨粉等の天然カルシウムを配合しである。
好ましい配合比はゼラチンに対し３０〜６０重量％であ
る。 第二に該皮膜基剤にカルシウムイオンにより架橋
される水溶性多糖類を配合しである。 この場合の水溶
性多糖類とはアルギン酸ナトリウム、低メトキシルペク
チン、ジェランガムでありその何れでも良い、 但し、
好ましい配合比はゼラチンに対しアルギン酸ナトリウム
は２〜５重量％が好ましく、ジェランガムは０．５〜１
重量％が好ましい、 又、低メトキシルペクチンは分子
量１０００００〜２０００００、メトキシル化度３〜５
％のもので１０〜１５重量％が好ましい。(Technical means) In order to achieve the above purpose, firstly, natural calcium such as eggshell, seashell, and beef bone meal, which mainly contains calcium carbonate salt, is blended into the film base consisting of gelatin and a plasticizer. .
A preferred blending ratio is 30 to 60% by weight based on gelatin. Second, a water-soluble polysaccharide crosslinked by calcium ions is added to the film base. In this case, the water-soluble polysaccharide is sodium alginate, low methoxyl pectin, or gellan gum, and any of these may be used, however,
The preferred blending ratio is 2 to 5% by weight of sodium alginate to gelatin, and 0.5 to 1% by weight of gellan gum.
% by weight is preferable, and low methoxyl pectin has a molecular weight of 100,000 to 200,000 and a degree of methoxylation of 3 to 5.
%, preferably 10 to 15% by weight.
第三に該皮膜基剤にＰＨ調製剤を配合して粘度を低下せ
しめである。 該皮膜基剤のＰＨを中性にするものなら
制限はなく通常は水酸化ナトリウムが好ましい、 第四
に該皮膜基剤に金属イオンキレート剤を配合して粘度を
低下せしめである。Thirdly, a PH adjuster is added to the film base to lower the viscosity. There is no restriction as long as it neutralizes the pH of the film base, and sodium hydroxide is usually preferred.Fourthly, a metal ion chelating agent is blended into the film base to lower the viscosity.
健康食品に使用できるものなら制限はないが、通常はク
エン酸三ナトリウムが好ましい。There are no restrictions as long as it can be used in health foods, but trisodium citrate is usually preferred.
（作 用）
本発明によればゼラチン等の基剤から成る皮膜液中にカ
ルシウムイオンで架橋される水溶性多糖類を配合しても
、その粘度は飛躍的に上昇しない。(Function) According to the present invention, even if a water-soluble polysaccharide crosslinked with calcium ions is added to a coating liquid made of a base such as gelatin, the viscosity thereof does not increase dramatically.
何故ならＰＨ調製剤と金属イオンキレート剤を配合しで
あるからである。 ＰＨ調製剤は通常弱酸性を示す処の
ゼラチンを基剤とした皮膜液を中性に調製し、カルシウ
ムイオンで架橋される水溶性多糖類が酸性下で粘度上昇
したり、弱いゲル化をしたりするのを防ぐ、 又、金属
キレート剤はゼラチンを基剤とした皮膜液中の金属イオ
ンをキレートする。This is because it contains a PH adjusting agent and a metal ion chelating agent. The pH adjusting agent is prepared by adjusting the gelatin-based film solution, which is normally weakly acidic, to neutrality, and preventing water-soluble polysaccharides cross-linked with calcium ions from increasing in viscosity or forming a weak gel under acidic conditions. In addition, metal chelating agents chelate metal ions in gelatin-based coating liquids.
通常ゼラチン中には５０〜２００ｐｐｍのカルシウムイ
オンが存在するといわれており、これだけのカルシウム
イオンでもカルシウムイオンで架橋される水溶性多糖類
を粘度上昇させるには充分だからである。 以上２つの
方法により本発明では製造後の軟カプセルが充分な耐胃
液性をもつほどカルシウムで架橋する水溶性多糖類を軟
カプセル皮膜液中に配合しても、ロータリー式軟カプセ
ル製造装置で製造し得る。 又、本発明によれば皮膜液
中に配合したカルシウムで架橋する水溶性多糖類を、架
橋させる為に、軟カプセル成形後カルシウム溶液を軟カ
プセルに雰霧したり、又カルシウム溶液に軟カプセルを
浸漬する必要はない、 何故なら、軟カプセル皮膜中に
すでに炭酸カルシウム塩を主成分とする天然カルシウム
を配合しであるからである。 卵殻、貝殻、牛骨粉等の
天然カルシウム剤は水に不溶性である為軟カプセル皮膜
液を調製する際カルシウムで架橋する水溶性多糖類と同
時に配合しても、これを架橋することはない、 しか
し、本発明による軟カプセルは、製造後人に摂取された
時胃液中の酸に接触すると炭酸ガスを発泡しながらカル
シウムイオンを放出し、瞬時にして皮膜中に配合された
カルシウムで架橋する水溶性多糖類を架橋し、耐胃液性
が附与されるものである。 この際、皮膜に配合する天
然カルシウム剤の量を必要以上に増やせば、炭酸ガスの
発泡は軟カプセル内部においても活発に行われ、軟カプ
セルに浮力が生じ、胃内を浮遊するカプセルとなり、内
容物の選択次第では除放性の製剤としても利用可能であ
る。It is said that gelatin normally contains 50 to 200 ppm of calcium ions, and this amount of calcium ions is sufficient to increase the viscosity of water-soluble polysaccharides that are crosslinked with calcium ions. By using the above two methods, the present invention allows soft capsules to be produced using a rotary type soft capsule manufacturing apparatus even if a water-soluble polysaccharide cross-linked with calcium is added to the soft capsule coating liquid so that the manufactured soft capsules have sufficient gastric fluid resistance. It is possible. Further, according to the present invention, in order to crosslink the water-soluble polysaccharide that is crosslinked with calcium blended in the coating liquid, a calcium solution is sprayed into the soft capsule after forming the soft capsule, or the soft capsule is mixed with the calcium solution. There is no need for immersion because the soft capsule shell already contains natural calcium, the main component of which is calcium carbonate. Natural calcium agents such as eggshells, seashells, and beef bone powder are insoluble in water, so even if they are mixed with water-soluble polysaccharides that are crosslinked with calcium when preparing the soft capsule coating liquid, they will not be crosslinked. The soft capsule according to the present invention is a water-soluble capsule that, when ingested by a person after manufacture, releases calcium ions while foaming carbon dioxide gas when it comes into contact with acid in the gastric juice, and instantly crosslinks with the calcium contained in the capsule. It crosslinks polysaccharides and imparts gastric juice resistance. At this time, if the amount of natural calcium agent added to the film is increased more than necessary, carbon dioxide gas will bubble actively even inside the soft capsule, creating buoyancy in the soft capsule and making it float in the stomach, allowing the capsule to contain its contents. Depending on the material selected, it can also be used as a sustained-release preparation.
（実施例１）
次の処方で軟カプセル皮膜液を調製し、ロータリー式軟
カプセル製造装置にてＭＣＴ （中鎖脂肪酸トリグリセ
ライド）を内容物とした０ＶＡＬ７．５の軟カプセルを
調製した。(Example 1) A soft capsule coating liquid was prepared according to the following formulation, and soft capsules containing MCT (medium chain fatty acid triglyceride) and having a 0VAL of 7.5 were prepared using a rotary soft capsule manufacturing apparatus.
処方 ゼラチン １００部グリセリン
３０部
卵殻カルシウム ３０部
水酸化ナトリウム ０．２部
クエン酸三ナトリウム １．０部
アルギン酸ナトリウム ５．０部
精製水 １００部
（実施例２）
次の処方で軟カプセル皮膜液を調製し実施例１と同様な
方法及び内容物で０ＶＡＬ７．５の軟カプセルを調製し
た。Prescription Gelatin 100 parts Glycerin
30 parts Eggshell calcium 30 parts Sodium hydroxide 0.2 parts Trisodium citrate 1.0 parts Sodium alginate 5.0 parts Purified water 100 parts (Example 2) A soft capsule coating liquid was prepared using the following formulation. Example 1 Soft capsules with a 0VAL of 7.5 were prepared using the same method and contents.
処方 ゼラチン １００部グリセリン
３０部
牛骨粉 ３０部
水酸化ナトリウム ０．２部
クエン酸三ナトリウム １．０部
低メトキシルペクチン １０ｍ
精製水 １００部
（実施例３）
次の処方で軟カプセル皮膜液を調製し実施例１と同様な
方法及び内容物で０ＶＡＬ７．５の軟カプセルを調製し
た。Prescription Gelatin 100 parts Glycerin
30 parts Beef bone meal 30 parts Sodium hydroxide 0.2 parts Trisodium citrate 1.0 parts Low methoxyl pectin 10 m Purified water 100 parts (Example 3) Soft capsule coating liquid was prepared with the following formulation and the same as in Example 1. Soft capsules with a 0VAL of 7.5 were prepared using the same method and contents.
処方 ゼラチン １００部グリセリン
３０部
貝殻末 ３０部
水酸化ナトリウム ０．２部
クエン酸三ナトリウム １．０部
ジェランガム ０．８部
精製水 １００部
次いで、試験例について述べると、上述の実施例１〜３
で得た本発明による腸溶性カプセルを検体１〜３とし、
これについて日本薬局方による腸溶性崩壊試験を行った
ところこれに適合した。Prescription Gelatin 100 parts Glycerin
30 parts Shell powder 30 parts Sodium hydroxide 0.2 parts Trisodium citrate 1.0 parts Gellan gum 0.8 parts Purified water 100 parts Next, regarding test examples, Examples 1 to 3 described above
Specimens 1 to 3 are enteric-coated capsules according to the present invention obtained in
When this was subjected to an enteric disintegration test according to the Japanese Pharmacopoeia, it passed the test.
その結果は下表に示す。The results are shown in the table below.
供試カプセル数二６個
（実施例４）
次いで、ロータリー式軟カプセル製造方法の実施例につ
いて述べる。Number of test capsules: 26 (Example 4) Next, an example of a rotary type soft capsule manufacturing method will be described.
ｌはロータリー式自動軟カプセル製造機本体であり、主
として継目のある軟カプセルを造るものである。1 is the main body of a rotary automatic soft capsule making machine, which is mainly used to make soft capsules with seams.
２は円筒金型であり、加温して溶液状態を保ったゼラチ
ンを基剤とする皮膜液を帯状に成形し、冷却してゲル化
したシート状のゼラチン膜３を一対の噛合回転する該円
筒金型２の両側より挟間に送るように成しである。 ４
は内容液５を貯溜したポンプ器筐であり、前記円筒金型
２と連動するピストン６で該内容液５を前記両側一対の
シート状のゼラチン膜３の間に圧入して両円筒金型２の
圧切によってカプセル本体７を成型するように成しであ
る。Reference numeral 2 denotes a cylindrical mold, in which a gelatin-based coating liquid heated and maintained in a solution state is formed into a belt shape, and a gelatin film 3 in the form of a sheet, which is cooled and gelled, is meshed and rotated between a pair of molds. It is designed to be fed between both sides of the cylindrical mold 2. 4
is a pump housing storing a liquid content 5, and a piston 6 interlocking with the cylindrical mold 2 presses the liquid content 5 between the pair of sheet-like gelatin membranes 3 on both sides to form the cylindrical mold 2. The capsule body 7 is formed by pressure cutting.
然る時、該ポンプ器筺４により前記ゼラチンＭ３は適温
に熱せられ、圧力とヒートシールによって接着面の完全
なカプセルを造ることが出来る。At that time, the gelatin M3 is heated to an appropriate temperature by the pump housing 4, and a complete capsule of the adhesive surface can be created by pressure and heat sealing.
而して、前記皮膜液中にはその基剤配合物として、ＰＨ
調製剤又は金属イオンキレート剤を添加せしめであるの
で、低粘性の基剤が得られるためロータリー式に於いて
も接着の良好なカプセルが得られる。Therefore, the coating liquid contains PH as its base compound.
Since a preparation agent or a metal ion chelating agent is added, a base with low viscosity can be obtained, so that capsules with good adhesion can be obtained even in a rotary system.
（発明の効果）
而して、本発明は叙上の如き手段に基き下記の効果があ
る。(Effects of the Invention) The present invention has the following effects based on the above-mentioned means.
特に、水溶性多糖類を製造後の軟カプセルの耐胃液性が
期待でき得るほどに皮膜液中に配合することが出来、又
粘度を自由に下降せしめることも出来るので、ロータリ
ー式カプセル製造機でもって軟カプセルを製造すること
が出来、又、カプセル成形後の後処理を必要とせず製造
工程を簡略化出来る。In particular, water-soluble polysaccharides can be incorporated into the membrane liquid to the extent that the gastric juice resistance of the soft capsules after manufacturing can be expected, and the viscosity can be lowered freely, so rotary capsule manufacturing machines can be used. As a result, soft capsules can be manufactured, and the manufacturing process can be simplified without the need for post-treatment after capsule molding.
図面は本発明装置を示す構成概略図である。 特許出願人 富士カプセル株式会社 The drawing is a schematic diagram showing the configuration of the device of the present invention. Patent applicant: Fuji Capsule Co., Ltd.
Claims (7)
ム塩又は該カルシウム塩を主成分とする天然カルシウム
剤とカルシウムイオンで架橋される水溶性多糖類を配合
してなる健康食品用腸溶性軟カプセル(1) Enteric-coated soft drinks for health foods made by blending calcium salts or natural calcium agents containing calcium salts as main components and water-soluble polysaccharides cross-linked with calcium ions into a film base consisting of gelatin and a plasticizer. capsule
請求項１記載の健康食品用腸溶性軟カプセル(2) The enteric-coated soft capsule for health food according to claim 1, wherein the water-soluble polysaccharide is sodium alginate.
請求項１記載の健康食品用腸溶性軟カプセル(3) The enteric-coated soft capsule for health food according to claim 1, wherein the water-soluble polysaccharide is low methoxyl pectin.
記載の健康食品用腸溶性軟カプセル(4) Claim 1, wherein the water-soluble polysaccharide is gellan gum.
Enteric-coated soft capsules for health foods as described
分とする卵殻、貝殻、牛骨粉等の天然カルシウム剤であ
る請求項１記載の健康食品用腸溶性軟カプセル(5) The enteric-coated soft capsule for health food according to claim 1, wherein the natural calcium agent is a natural calcium agent such as eggshell, seashell, or beef bone powder containing calcium carbonate as a main component.
ム塩又は該カルシウム塩を主成分とする天然カルシウム
剤とカルシウムイオンで架橋される水溶性多糖類を配合
すると共に、該皮膜基剤にＰＨ調製剤を配合して、ロー
タリー式軟カプセル製造装置によりカプセルを得ること
を特徴とした健康食品用腸溶性軟カプセル(6) A calcium salt or a natural calcium agent containing the calcium salt as a main component and a water-soluble polysaccharide cross-linked with calcium ions are added to the film base consisting of gelatin and a plasticizer, and the film base has a PH Enteric-coated soft capsules for health foods, characterized by blending preparations and obtaining capsules using a rotary soft capsule manufacturing device.
ム塩又は該カルシウム塩を主成分とする天然カルシウム
剤とカルシウムイオンで架橋される水溶性多糖類を配合
すると共に、該皮膜基剤に金属イオンキレート剤を配合
して、ロータリー式軟カプセル製造装置によりカプセル
を得ることを特徴とする健康食品用腸溶性軟カプセル(7) A calcium salt or a natural calcium agent containing the calcium salt as a main component and a water-soluble polysaccharide crosslinked with calcium ions are added to a film base consisting of gelatin and a plasticizer, and a metal is added to the film base. Enteric-coated soft capsules for health foods, which are blended with an ion chelating agent and obtained by a rotary soft capsule manufacturing device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2131634A JPH0427352A (en) | 1990-05-22 | 1990-05-22 | Enteric soft capsule for health food |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2131634A JPH0427352A (en) | 1990-05-22 | 1990-05-22 | Enteric soft capsule for health food |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0427352A true JPH0427352A (en) | 1992-01-30 |
Family
ID=15062642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2131634A Pending JPH0427352A (en) | 1990-05-22 | 1990-05-22 | Enteric soft capsule for health food |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0427352A (en) |
Cited By (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0833463A (en) * | 1994-07-25 | 1996-02-06 | Micro Arujie Corp Kk | Health food containing calsium as main ingredient |
| WO1999001115A1 (en) * | 1997-07-03 | 1999-01-14 | Samyang Corporation | Colon selective drug delivery composition |
| WO2002017886A1 (en) * | 2000-09-01 | 2002-03-07 | Warner-Lambert Company Llc | Pectin film compositions |
| JP2005325081A (en) * | 2004-05-17 | 2005-11-24 | Medorekkusu:Kk | Oral enteric preparation |
| JP2006083081A (en) * | 2004-09-15 | 2006-03-30 | Taisho Pharmaceut Co Ltd | Solution for mucosa application |
| US7226613B2 (en) | 2002-12-05 | 2007-06-05 | Symrise Gmbh & Co. Kg | Seamless filled capsules |
| WO2007075475A3 (en) * | 2005-12-22 | 2007-12-13 | Banner Pharmacaps Inc | Gastric reflux resistant dosage forms |
| JP2008546756A (en) * | 2005-06-21 | 2008-12-25 | ヴェ． マヌ フィル | Gellan seamless collapsible capsule and method for producing the same |
| US7678817B2 (en) | 2005-06-03 | 2010-03-16 | Medrx Co., Ltd. | Enteric medicinal composition for oral use |
| JP2010116388A (en) * | 2009-03-10 | 2010-05-27 | Nr Laboratory:Kk | Pharmaceutical formulation soluble in alimentary canal |
| WO2013093630A3 (en) * | 2011-12-22 | 2013-12-27 | Pronova Biopharma Norge As | Gelatin/alginate delayed release capsules comprising omega-3 fatty acids, and methods and uses thereof |
| CN103750523A (en) * | 2014-01-28 | 2014-04-30 | 黄遂深 | Candy-type soft capsule |
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-
1990
- 1990-05-22 JP JP2131634A patent/JPH0427352A/en active Pending
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|---|---|---|---|---|
| JP2656448B2 (en) * | 1994-07-25 | 1997-09-24 | マイクロアルジェコーポレーション株式会社 | Health foods mainly composed of calcium |
| JPH0833463A (en) * | 1994-07-25 | 1996-02-06 | Micro Arujie Corp Kk | Health food containing calsium as main ingredient |
| WO1999001115A1 (en) * | 1997-07-03 | 1999-01-14 | Samyang Corporation | Colon selective drug delivery composition |
| WO2002017886A1 (en) * | 2000-09-01 | 2002-03-07 | Warner-Lambert Company Llc | Pectin film compositions |
| EP1315479B2 (en) † | 2000-09-01 | 2015-10-21 | Capsugel Belgium NV | Pectin film compositions |
| US7041315B2 (en) | 2000-09-01 | 2006-05-09 | Warner Lambert Company | Pectin film compositions |
| AU2002210449B2 (en) * | 2000-09-01 | 2006-10-26 | Warner-Lambert Company Llc | Pectin film compositions |
| EA007563B1 (en) * | 2000-09-01 | 2006-12-29 | Варнер-Ламберт Компани Ллс | Pectin film composition |
| US7226613B2 (en) | 2002-12-05 | 2007-06-05 | Symrise Gmbh & Co. Kg | Seamless filled capsules |
| JP2005325081A (en) * | 2004-05-17 | 2005-11-24 | Medorekkusu:Kk | Oral enteric preparation |
| JP4694145B2 (en) * | 2004-05-17 | 2011-06-08 | 株式会社 メドレックス | Oral enteric preparation |
| JP2006083081A (en) * | 2004-09-15 | 2006-03-30 | Taisho Pharmaceut Co Ltd | Solution for mucosa application |
| US7678817B2 (en) | 2005-06-03 | 2010-03-16 | Medrx Co., Ltd. | Enteric medicinal composition for oral use |
| US10278418B2 (en) | 2005-06-21 | 2019-05-07 | V. Mane Fils | Smoking device incorporating a breakable capsule, breakable capsule and process for manufacturing said capsule |
| JP2008546756A (en) * | 2005-06-21 | 2008-12-25 | ヴェ． マヌ フィル | Gellan seamless collapsible capsule and method for producing the same |
| US9339060B2 (en) | 2005-06-21 | 2016-05-17 | V. Mane Fils | Smoking device incorporating a breakable capsule, breakable capsule and process for manufacturing said capsule |
| US8820331B2 (en) | 2005-06-21 | 2014-09-02 | V. Mane Fils | Smoking device incorporating a breakable capsule, breakable capsule and process for manufacturing said capsule |
| EP2716283A1 (en) * | 2005-12-22 | 2014-04-09 | Banner Pharmacaps Inc. | Gastric reflux resistant dosage forms |
| US10182990B2 (en) | 2005-12-22 | 2019-01-22 | Patheon Softgels Inc. | Gastric reflux resistant dosage forms |
| JP2013209416A (en) * | 2005-12-22 | 2013-10-10 | Banner Pharmacaps Inc | Gastric reflux resistant dosage form |
| EP2923696A1 (en) * | 2005-12-22 | 2015-09-30 | Banner Life Sciences LLC | Gastric reflux resistant dosage forms |
| US9693966B2 (en) | 2005-12-22 | 2017-07-04 | Banner Life Sciences Llc | Gastric reflux resistant dosage forms |
| WO2007075475A3 (en) * | 2005-12-22 | 2007-12-13 | Banner Pharmacaps Inc | Gastric reflux resistant dosage forms |
| JP4630931B2 (en) * | 2009-03-10 | 2011-02-09 | 有限会社エヌアール・ラボラトリー | Gastrointestinal soluble dosage form |
| JP2010116388A (en) * | 2009-03-10 | 2010-05-27 | Nr Laboratory:Kk | Pharmaceutical formulation soluble in alimentary canal |
| WO2013093630A3 (en) * | 2011-12-22 | 2013-12-27 | Pronova Biopharma Norge As | Gelatin/alginate delayed release capsules comprising omega-3 fatty acids, and methods and uses thereof |
| US10449220B2 (en) * | 2013-08-30 | 2019-10-22 | Mimedx Group, Inc. | Micronized placental compositions comprising a chelator |
| CN103750523A (en) * | 2014-01-28 | 2014-04-30 | 黄遂深 | Candy-type soft capsule |
| JP2015189684A (en) * | 2014-03-27 | 2015-11-02 | 中日本カプセル 株式会社 | Soft capsule coating and soft capsule |
| US10357467B2 (en) | 2014-06-23 | 2019-07-23 | Patheon Softgels, Inc. | All-natural enteric soft capsules |
| US9987240B2 (en) | 2014-06-23 | 2018-06-05 | Patheon Softgels, Inc. | All-natural enteric soft capsules |
| JP2018183121A (en) * | 2017-04-27 | 2018-11-22 | 株式会社Ｍｒ．Ｏｒａｎｇｅ | Granular composition, method for producing the same and method for storing the same, and granular food |
| WO2018199234A1 (en) * | 2017-04-27 | 2018-11-01 | 株式会社Ｍｒ．Ｏｒａｎｇｅ | Granular composition, method for producing same and method for storing same, and granular food |
| JP6334029B1 (en) * | 2017-04-27 | 2018-05-30 | 株式会社Ｍｒ．Ｏｒａｎｇｅ | Granular composition, production method and storage method thereof, and granular food |
| CN108535067A (en) * | 2018-04-05 | 2018-09-14 | 中国家用电器研究院 | A kind of electricity toilet seat test standard analog excreta |
| JP2020029404A (en) * | 2018-08-20 | 2020-02-27 | 秀希 青木 | Enteric composition and method for producing the same |
| CN114845569A (en) * | 2019-10-28 | 2022-08-02 | R.P.谢勒技术有限公司 | Delayed release softgel capsules in higher PH environments |
| JP2023042392A (en) * | 2021-09-14 | 2023-03-27 | アピ株式会社 | Capsule coating composition and capsule |
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