NO137451B - PROCEDURES FOR THE MANUFACTURE OF LOW CARBON BAR MATERIAL} L - Google Patents

PROCEDURES FOR THE MANUFACTURE OF LOW CARBON BAR MATERIAL} L Download PDF

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Publication number
NO137451B
NO137451B NO742011A NO742011A NO137451B NO 137451 B NO137451 B NO 137451B NO 742011 A NO742011 A NO 742011A NO 742011 A NO742011 A NO 742011A NO 137451 B NO137451 B NO 137451B
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gelatin
drug
approx
copolymer
solution
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NO742011A
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Norwegian (no)
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NO137451C (en
NO742011L (en
Inventor
Theo Breedijk
Tiem Gezinus Meijering
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Hoogovens Ijmuiden Bv
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Publication of NO137451C publication Critical patent/NO137451C/en

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    • C—CHEMISTRY; METALLURGY
    • C21—METALLURGY OF IRON
    • C21D—MODIFYING THE PHYSICAL STRUCTURE OF FERROUS METALS; GENERAL DEVICES FOR HEAT TREATMENT OF FERROUS OR NON-FERROUS METALS OR ALLOYS; MAKING METAL MALLEABLE, e.g. BY DECARBURISATION OR TEMPERING
    • C21D1/00—General methods or devices for heat treatment, e.g. annealing, hardening, quenching or tempering
    • C21D1/18—Hardening; Quenching with or without subsequent tempering
    • C21D1/19—Hardening; Quenching with or without subsequent tempering by interrupted quenching
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B21—MECHANICAL METAL-WORKING WITHOUT ESSENTIALLY REMOVING MATERIAL; PUNCHING METAL
    • B21B—ROLLING OF METAL
    • B21B45/00—Devices for surface or other treatment of work, specially combined with or arranged in, or specially adapted for use in connection with, metal-rolling mills
    • B21B45/02—Devices for surface or other treatment of work, specially combined with or arranged in, or specially adapted for use in connection with, metal-rolling mills for lubricating, cooling, or cleaning
    • B21B45/0203—Cooling
    • B21B45/0209—Cooling devices, e.g. using gaseous coolants
    • B21B45/0215—Cooling devices, e.g. using gaseous coolants using liquid coolants, e.g. for sections, for tubes
    • B21B45/0224—Cooling devices, e.g. using gaseous coolants using liquid coolants, e.g. for sections, for tubes for wire, rods, rounds, bars
    • C—CHEMISTRY; METALLURGY
    • C21—METALLURGY OF IRON
    • C21D—MODIFYING THE PHYSICAL STRUCTURE OF FERROUS METALS; GENERAL DEVICES FOR HEAT TREATMENT OF FERROUS OR NON-FERROUS METALS OR ALLOYS; MAKING METAL MALLEABLE, e.g. BY DECARBURISATION OR TEMPERING
    • C21D8/00—Modifying the physical properties by deformation combined with, or followed by, heat treatment
    • C21D8/06—Modifying the physical properties by deformation combined with, or followed by, heat treatment during manufacturing of rods or wires
    • C21D8/08—Modifying the physical properties by deformation combined with, or followed by, heat treatment during manufacturing of rods or wires for concrete reinforcement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B21—MECHANICAL METAL-WORKING WITHOUT ESSENTIALLY REMOVING MATERIAL; PUNCHING METAL
    • B21B—ROLLING OF METAL
    • B21B1/00—Metal-rolling methods or mills for making semi-finished products of solid or profiled cross-section; Sequence of operations in milling trains; Layout of rolling-mill plant, e.g. grouping of stands; Succession of passes or of sectional pass alternations
    • B21B1/16—Metal-rolling methods or mills for making semi-finished products of solid or profiled cross-section; Sequence of operations in milling trains; Layout of rolling-mill plant, e.g. grouping of stands; Succession of passes or of sectional pass alternations for rolling wire rods, bars, merchant bars, rounds wire or material of like small cross-section
    • B21B1/163—Rolling or cold-forming of concrete reinforcement bars or wire ; Rolls therefor

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Thermal Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Organic Chemistry (AREA)
  • Manufacturing & Machinery (AREA)
  • Heat Treatment Of Steel (AREA)
  • Heat Treatment Of Strip Materials And Filament Materials (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Metal Rolling (AREA)

Abstract

Fremgangsmåte til fremstilling av stangmateriale fra lavcarbonstål..Process for the production of bar material from low-carbon steel.

Description

Fremgangsmåte ved fremstilling av en fast farmasøytisk bærer egnet til oral anvendelse. Process for the preparation of a solid pharmaceutical carrier suitable for oral use.

Foreliggende oppfinnelse angår en The present invention relates to a

fremgangsmåte ved fremstilling av en fast farmasøytisk bærer. Der erholdes en fast farmasøytisk bærer som når den inntas gjennom munnen sammen med et legemiddel stadig bevarer et terapeutisk effektivt nivå av legemidlet i legemet over lengere tidsrom. method in the preparation of a solid pharmaceutical carrier. A solid pharmaceutical carrier is obtained which, when taken orally together with a medicine, constantly preserves a therapeutically effective level of the medicine in the body over longer periods of time.

Legemiddelholdige produkter med en-teriske egenskaper har tidligere vært fremstillet. Slike produkter inneholder i alminnelighet en bærer som ikke oppløses i de sure mavesafter, men som lett oppløses i de alkaliske væsker i tarmen. Frigivelsen av legemidlet forhindres således i mavesekken, mens legemidlet hurtig frigis i tarmen. Det gjelder imidlertid mange legemidler at det ofte er meget ønskelig å regulere den hastighet med hvilken medikamentet frigis i fordøyelseskanalen innbefattet mavesekken, slik at der kontinuerlig kan bibeholdes en effektiv mengde av medikamentet i legemet over et lengere tidsrom, f. eks. 6 timer eller derover. Drug-containing products with enteric properties have previously been produced. Such products generally contain a carrier which does not dissolve in the acidic gastric juices, but which dissolves easily in the alkaline fluids in the intestine. The release of the drug is thus prevented in the stomach, while the drug is quickly released in the intestine. However, with many drugs it is often very desirable to regulate the rate at which the drug is released in the digestive tract, including the stomach, so that an effective amount of the drug can be continuously maintained in the body over a longer period of time, e.g. 6 hours or more.

Følgelig har der vært gjort mange for-søk på å finne en bærer som foruten å være Consequently, many attempts have been made to find a carrier that, in addition to being

egnet for oral inntagning sammen med medikamentet, også effektivt kunne kon-trollere den hastighet med hvilken medikamentet frigis i fordøyelseskanalen, hvorved en stadig effektiv konsentrasjon av medikamentet i legemet ville være tilstede over et forlenget tidsrom. De bærere som har vært foreslått eller anvendt hittil har suitable for oral intake together with the drug, could also effectively control the rate at which the drug is released in the digestive tract, whereby a constantly effective concentration of the drug in the body would be present over an extended period of time. The carriers that have been proposed or used so far have

for det meste vist seg å være utilfredsstillende av forskjellige grunner. Eksempelvis er enkelte kjente bærere utilfredsstilende fordi de absorberes i legemet så hurtig at det er umulig å oppnå en regulert frigivelse av legemidlet i fordøyelseskanalen over et tilfredsstillende langt tidsrom. Mange andre er utilfredsstillende fordi de ikke er tilstrekkelig motstandsdyktige mot angrep fra de i legemet forekommende væsker. Slike bærere har derfor en tendens til å ned-brytes i legemet temmelig hurtig med det resultat at en regulert frigivelse av medikamentet i fordøyelseskanalen over et tilstrekkelig langt tidsrom ikke erholdes. Andre bærere er utilfredsstillende fordi de ikke er istand til å regulere frigivelseshas-tigheten i tilstrekkelig grad. mostly proved unsatisfactory for various reasons. For example, some known carriers are unsatisfactory because they are absorbed into the body so quickly that it is impossible to achieve a regulated release of the drug in the digestive tract over a satisfactorily long period of time. Many others are unsatisfactory because they are not sufficiently resistant to attack from the fluids present in the body. Such carriers therefore tend to break down in the body rather quickly with the result that a regulated release of the drug in the digestive tract over a sufficiently long period of time is not obtained. Other carriers are unsatisfactory because they are not able to regulate the release rate to a sufficient extent.

Det vil da være klart at en farmasøy-tisk og medisinsk godtagbar bærer som egner seg for oral anvendelse sammen med legemidlet og som er istand til å regulere dettes frigivelseshastighet i fordøyelses-kanalen slik at en stadig effektiv konsentrasjon av legemidlet kan bibeholdes i legemet over et lengere tidsrom, eksempelvis 6 timer eller mere, er meget ønskelig i me-disinen. It will then be clear that a pharmaceutical and medically acceptable carrier which is suitable for oral use together with the drug and which is able to regulate its release rate in the digestive tract so that a constantly effective concentration of the drug can be maintained in the body over a longer periods of time, for example 6 hours or more, are very desirable in medicine.

Det er ifølge oppfinnelsen blitt funnet at kontinuerlig effektive konsentrasjoner av legemidler kan bibeholdes i legemet over tilfredsstillende lange tidsrom ved at man inkorporerer legemidlet i en fast, spiselig, farmasøytisk og medisinsk godtagbar bærer omfattende et sampolymerisat av glyoxal og delvis avbygget gelatin og presser den resulterende blanding til den får en passende hårdhet. Sampolymerisatet er en kjemisk modifisert form for gelatin, og som efter presning til tabletter eller lignende av passende hårdhet er meget mot-standsdyktig mot disintegrasjon i fordøyel-seskanalen og bare langsomt spaltes av fordøyelsesvæskene. Sampolymerisatet har imidlertid samtidig gelerings- og svelnings-egenskaper i likhet med gelatin og kan således tjene som en bærer med sådan struk-tur at medikamentet langsomt kan diffun-dere ut ved kontakt med mavens og tar-mens væsker og uavhengig av pH-verdien og temperaturen. According to the invention, it has been found that continuously effective concentrations of drugs can be maintained in the body over satisfactorily long periods of time by incorporating the drug in a solid, edible, pharmaceutically and medically acceptable carrier comprising a copolymer of glyoxal and partially degraded gelatin and pressing the resulting mixture until it reaches a suitable hardness. The copolymer is a chemically modified form of gelatin, and which, after pressing into tablets or the like of suitable hardness, is very resistant to disintegration in the digestive tract and is only slowly broken down by the digestive fluids. The copolymer, however, simultaneously has gelling and swelling properties similar to gelatin and can thus serve as a carrier with such a structure that the drug can slowly diffuse out upon contact with stomach and intestinal fluids and regardless of the pH value and the temperature.

Disse egenskaper hos sampolymerisatet kommer delvis av at i det minste en del av sampolymerisatet foreligger i sådan form at det blir mykt og klebrig i nærvær av vann, hvorved sampolymerisatet kleber til seg selv skjønt svelning kan finne sted. These properties of the copolymer result in part from the fact that at least part of the copolymer is in such a form that it becomes soft and sticky in the presence of water, whereby the copolymer sticks to itself although swelling may take place.

Sampolymerisatets kohesj onsegenska - per synes tildels å henge sammen med mengden av vann-ekstraherbart sampolymerisat som er tilstede i det med glyoxal omsatte avbyggede gelatin. Vanligvis har man funnet at slike sampolymerisater er tilfredsstillende når den vannoppløselige del er mellom 30 og 80 pst. Sampolymerisater med en vannoppløselig del på 40— 70 pst foretrekkes for oppnåelse av opti-male resultater. The cohesive properties of the copolymer seem to be partly related to the amount of water-extractable copolymer present in the glyoxal-reacted degraded gelatin. Generally, it has been found that such copolymers are satisfactory when the water-soluble part is between 30 and 80 percent. Copolymers with a water-soluble part of 40-70 percent are preferred for obtaining optimal results.

De produkter som fremstilles ifølge oppfinnelsen erholdes ved at man først oppløser gelatin i vann, om nødvendig under oppvarmning, for å bringe gelatinet i oppløsning. Den konsentrasjon av gelatin som brukes kan i alminnelighet variere innenfor vide grenser. Oppløsninger inneholdende opp til ca. 20 pst. (vektpst.) er tilfredsstillende. Oppløsninger inneholdende høyere konsentrasjoner kan brukes, dog kan man få noen vanskelighet med slike oppløsninger på grunn av deres høye viskositet og tendens til å gelere. Gelatin-oppløsningens pH innstilles da fortrinnsvis på ca. 4 (skjønt oppløsninger hvis pH ligger i området fra 2 til 7 er tilfredsstillende) ved tilsetning av saltsyre eller lignende, og oppløsningen hydrolyseres ved forhøyede temperaturer, dvs. fra 95 til 125° C, inntil oppløsningen får en viskositet på 8—16, fortrinnsvis 10—14, centipoise, målt ved 50°C (BrookfiekTs viskosimeter). Den nødvendige oppvarmningstid vil selvsagt variere avhengig av gelatinkonsentrasjo-nen, pH-verdien og temperaturen. Med en 20 pst.'s gelatinoppløsning med pH på ca. 4 erholdes tilfredsstillende resultater i løpet av ca. 15 minutter ved 120°C, mens lignende oppløsninger ved en pH på ca. 2 vil kreve ca. 30 minutter ved 95°C. The products produced according to the invention are obtained by first dissolving gelatin in water, if necessary during heating, to bring the gelatin into solution. The concentration of gelatin used can generally vary within wide limits. Solutions containing up to approx. 20 percent (weight percent) is satisfactory. Solutions containing higher concentrations can be used, however some difficulty may be encountered with such solutions due to their high viscosity and tendency to gel. The pH of the gelatin solution is then preferably set to approx. 4 (although solutions whose pH is in the range from 2 to 7 are satisfactory) by adding hydrochloric acid or the like, and the solution is hydrolysed at elevated temperatures, i.e. from 95 to 125° C, until the solution has a viscosity of 8-16, preferably 10-14, centipoise, measured at 50°C (BrookfiekT's viscometer). The necessary heating time will of course vary depending on the gelatin concentration, the pH value and the temperature. With a 20 percent gelatin solution with a pH of approx. 4, satisfactory results are obtained during approx. 15 minutes at 120°C, while similar solutions at a pH of approx. 2 will require approx. 30 minutes at 95°C.

Alternativt kan avbygningen om ønskes oppnåes ved at oppløsningen behand-les i autoklav ved en temperatur på ca. 120° C og et trykk på ca. 1,06 ato. Alternatively, if desired, the degradation can be achieved by treating the solution in an autoclave at a temperature of approx. 120° C and a pressure of approx. 1.06 ato.

Oppløsningen av delvis avbygget gelatin nøytraliseres derpå ved tilsetning av f. eks. natriumhydroxyd til en pH på ca. 7,5. Glyoxal tilsettes, og blandingen polymeriseres. Polymerisasjonen utføres vanligvis under stadig omrøring ved temperaturer på 40—50 °C og i løpet av 10—60 minutter avhengig av den anvendte glyoxalkon-sentrasjon. Det skal imidlertid bemerkes at betydelig høyere eller lavere temperaturer enn ovennevnte foretrukne temperatur-område kan anvendes forutsatt at reak-sjonstiden reguleres tilsvarende. Når høye-re temperaturer anvendes, kan reaksjons-tiden gjøres kortere. The solution of partially degraded gelatin is then neutralized by adding e.g. sodium hydroxide to a pH of approx. 7.5. Glyoxal is added and the mixture polymerized. The polymerization is usually carried out with constant stirring at temperatures of 40-50 °C and within 10-60 minutes depending on the glyoxal concentration used. However, it should be noted that significantly higher or lower temperatures than the above-mentioned preferred temperature range can be used provided that the reaction time is regulated accordingly. When higher temperatures are used, the reaction time can be shortened.

Når omsetningen har foregått i tilstrekkelig lang tid, tørres oppløsningen på i og for seg kjent måte slik at det faste sampolymerisat av glyoxal og avbygget gelatin dannes. Egnede tørremetoder for dette formål er f. eks. forstøvningstørring, frysetørring, trommeltørring under vakuum og lignende. Den mest bekvemme og økono-miske tørremetode er imidlertid trommel-tørring under vakuum. When the reaction has taken place for a sufficiently long time, the solution is dried in a manner known per se so that the solid copolymer of glyoxal and degraded gelatin is formed. Suitable drying methods for this purpose are e.g. spray drying, freeze drying, drum drying under vacuum and the like. However, the most convenient and economical drying method is drum drying under vacuum.

Hvilkensomhelst av de to hovedtyper av gelatin, type A eller type B, med gel-styrke i området fra 90 til 300 Bloom, og fortrinnsvis fra 200 til 250 Bloom, kan anvendes ved fremstillingen av den delvis avbyggede gelatin. Gelatin av type A fremstilles av syrebehandlet kollagen, og type B av kalkbehandlet kollagen. For det meste blir gelatin fra syrebehandlet utgangs-materiale (type A) fremstillet av frossen svinehud, og kalkbehandlet gelatin (type B) av kalvehud, oksehud samt av avmine-ralisert bensubstans fra kveg (ossein). Gelatin av 100 pst. svinehud (type A) og med gel-styrke på omkring 225 Bloom er særlig tilfredsstillende. Gel-styrken av gelatin bestemmes ved at man tilbereder en gela-tingel under standardiserte betingelser (6 % pst. konsentrasjon, 17 timer ved 10° C) , hvorefter testingen utføres med Bloom's gelometer, som er en slags penetrometer. Bloom-verdien er det antall gram som er nødvendig for å presse et y2-toms lodd 4 mm ned i gelen. Bloom-verdien er omtrent-lig proporsjonal med molekylvekten og også med viskositeten. Any of the two main types of gelatin, type A or type B, with a gel strength in the range from 90 to 300 Bloom, and preferably from 200 to 250 Bloom, can be used in the production of the partially degraded gelatin. Type A gelatin is produced from acid-treated collagen, and type B from lime-treated collagen. For the most part, gelatin from acid-treated starting material (type A) is produced from frozen pig skin, and lime-treated gelatin (type B) from calf skin, ox skin and from demineralized bone substance from cattle (ossein). Gelatin made from 100 percent pig skin (type A) and with a gel strength of around 225 Bloom is particularly satisfactory. The gel strength of gelatin is determined by preparing a gelatin gel under standardized conditions (6% concentration, 17 hours at 10° C), after which the testing is carried out with Bloom's gelometer, which is a type of penetrometer. The Bloom value is the number of grams required to push a y2-inch plumb bob 4 mm into the gel. The Bloom value is roughly proportional to the molecular weight and also to the viscosity.

Den konsentrasjon av glyoxal som anvendes ved fremstillingen av produktene ifølge foreliggende fremgangsmåte varierer avhengig av det anvendte gelatins konsentrasjon. I alminnelighet kan konsen-trasjonen av glyoxal variere fra 0,025 g til 0,07 g pr. gram gelatin. Man foretrekker dog glyoxalkonsentrasjoner i området 0,04 —0,05 g pr. gram gelatin. The concentration of glyoxal used in the production of the products according to the present method varies depending on the concentration of the gelatin used. In general, the concentration of glyoxal can vary from 0.025 g to 0.07 g per grams of gelatin. However, glyoxal concentrations in the range of 0.04 -0.05 g per grams of gelatin.

Som tidligere nevnt er produktene som fremstilles ifølge oppfinnelsen meget verdi-fulle som farmasøytiske bærere med sikte på å oppnå en forlenget varighet av den kontinuerlig effektive terapeutiske konsentrasjon av legemidler som inntas sammen med nevnte bærere. I alminnelighet kan et hvilketsomhelst fast legemiddel eller væskeformig legemiddel som kan over-føres til en terapeutisk effektiv fast form, anvendes med tilfredsstillende virkning. As previously mentioned, the products produced according to the invention are very valuable as pharmaceutical carriers with the aim of achieving an extended duration of the continuously effective therapeutic concentration of drugs that are taken together with said carriers. In general, any solid drug or liquid drug that can be transferred to a therapeutically effective solid form can be used with satisfactory effect.

Faste farmasøytiske preparater inneholdende både det ønskede legemiddel og bærer kan tilberedes på forskjellige i og for seg kjente måter. Fortrinnsvis blandes legemidlet og bæreren grundig og presses til tabletter med hårdhet på minst 10 kg målt med Monsanto-apparat. Andre faste preparater som f. eks. piller, pellets og lignende med egnede fysikalske egenskaper er også tilfredsstillende. Disse sistnevnte preparater kan brukes som de er, eller om ønskes innkapslet i gelatin på konvensjo-nell måte. Solid pharmaceutical preparations containing both the desired drug and carrier can be prepared in various ways known per se. Preferably, the drug and the carrier are thoroughly mixed and pressed into tablets with a hardness of at least 10 kg as measured by the Monsanto apparatus. Other solid preparations such as pills, pellets and the like with suitable physical properties are also satisfactory. These latter preparations can be used as they are, or if desired encapsulated in gelatin in the conventional way.

Følgende eksempel vil ytterligere be-lyse oppfinnelsen. The following example will further illustrate the invention.

Eksempel 1. Example 1.

1800 ml destillert vann ble oppvarmet til ca. 50°C. Under omrøring ble så 200 g U.S.P. gelatin (type A, 225 Bloom) tilsatt og oppløsningens pH innstillet på ca. 4,0 med konsentrert saltsyre. Oppløsningen ble så oppvarmet til 110°C og holdt på denne temperatur i 2 timer. Den således erholdte oppløsning av delvis avbygget gelatin med viskositet ved 50°C på ca. 10— 14 centipoise ble derpå avkjølt til 50°C og oppløsningens pH innstillet på ca. 7,5 med 1800 ml of distilled water was heated to approx. 50°C. While stirring, 200 g of U.S.P. gelatin (type A, 225 Bloom) added and the pH of the solution set to approx. 4.0 with concentrated hydrochloric acid. The solution was then heated to 110°C and held at this temperature for 2 hours. The thus obtained solution of partially degraded gelatin with a viscosity at 50°C of approx. 10-14 centipoise was then cooled to 50°C and the pH of the solution adjusted to approx. 7.5 incl

30 pst.'s natriumhydroxyd. Under omrøring 30 percent sodium hydroxide. While stirring

ved 50°C tilsattes derefter 33,3 ml av en vandig oppløsning inneholdende 30 vektpst. glyoxal, hvorefter reaksjonen pågikk i 10 minutter. Sampolymerisatet av glyoxal og avbygget gelatin erholdtes i hoved-sakelig tørr, fast form ved tørring av opp-løsningen i trommel under vakuum. Denne trommel hadde under tørringen en omdrei-ningshastighet på 2 omdreininger pr. mi-nutt, og der anvendtes et vakuum på ca. 685 mm/Hg. Trommelens damptrykk var ca. 1,4 ato. Sampolymerisatet ble derpå malt til en partikkelstørrelse på omkring 80 mesh. at 50°C, 33.3 ml of an aqueous solution containing 30% by weight were then added. glyoxal, after which the reaction continued for 10 minutes. The copolymer of glyoxal and degraded gelatin was obtained in mainly dry, solid form by drying the solution in a drum under vacuum. During drying, this drum had a rotational speed of 2 revolutions per second. minute, and a vacuum of approx. 685 mm/Hg. The steam pressure of the drum was approx. 1.4 ato. The copolymer was then ground to a particle size of about 80 mesh.

Eksempel 2. Example 2.

250 mg av det i henhold til eksempel 1 erholdte pulveriserte sampolymerisat og 250 mg procain-penicillin ble blandet i tørr tilstand og presset til tabletter med hårdhet på ca. 14 kg (Monsanto). Tablet-tene ble derpå ved 37 °C behandlet med en tilmålt mengde syntetisk mavesaft i 2 timer og derefter med en bestemt mengde syntetisk tarmsaft for resten av forsøket. Væskene ble fornyet hver time, og en ana-lyseprøve uttatt for bestemmelse av peni-cillininholdet. Det ble funnet at legemidlet forble intakt i nevnte væsker over et tidsrom på 7 uker. 250 mg of the powdered copolymer obtained according to Example 1 and 250 mg of procaine penicillin were mixed in a dry state and pressed into tablets with a hardness of approx. 14 kg (Monsanto). The tablets were then treated at 37°C with a measured amount of synthetic gastric juice for 2 hours and then with a determined amount of synthetic intestinal juice for the rest of the experiment. The liquids were renewed every hour, and an analytical sample taken to determine the penicillin content. It was found that the drug remained intact in said fluids over a period of 7 weeks.

Claims (1)

Fremgangsmåte ved fremstilling av en fast, farmasøytisk bærer egnet for oral anvendelse, karakterisert ved at hyd-rolysert gelatin polymeriseres med fra 2,5 til 7, fortrinnsvis 4—5, vektprosent glyoxal, beregnet på vekten av gelatinet, og at det erholdte sampolymerisat tørres.Process for the production of a solid, pharmaceutical carrier suitable for oral use, characterized in that hydrolyzed gelatin is polymerized with from 2.5 to 7, preferably 4-5, weight percent glyoxal, calculated on the weight of the gelatin, and that the copolymer obtained is dried .
NO742011A 1973-06-04 1974-06-04 PROCEDURE FOR MANUFACTURE OF BAR MATERIALS FROM LOW CARBON STEEL NO137451C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NLAANVRAGE7307718,A NL170159C (en) 1973-06-04 1973-06-04 METHOD FOR MANUFACTURING WELDABLE LOW CARBON STEEL MATERIAL BY CONTROLLED COOLING

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Publication Number Publication Date
NO742011L NO742011L (en) 1974-12-05
NO137451B true NO137451B (en) 1977-11-21
NO137451C NO137451C (en) 1978-03-01

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NO742011A NO137451C (en) 1973-06-04 1974-06-04 PROCEDURE FOR MANUFACTURE OF BAR MATERIALS FROM LOW CARBON STEEL

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BE (1) BE815881A (en)
DE (1) DE2426920C2 (en)
DK (1) DK138958B (en)
FR (1) FR2231758B1 (en)
GB (1) GB1471740A (en)
LU (1) LU70230A1 (en)
NL (1) NL170159C (en)
NO (1) NO137451C (en)
SE (1) SE421710B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE824100A (en) * 1975-01-03 1975-05-02 PLANT FOR PROCESSING LAMINATED STEEL PRODUCTS
DE2558832C2 (en) * 1975-01-03 1989-08-10 Centre de Recherches Métallurgiques-Centrum voor Research in de Metallurgie, Bruxelles Device for the treatment of rolled steel products
DE2602656C2 (en) * 1975-01-29 1986-09-11 Centre de Recherches Métallurgiques - Centrum voor Research in de Metallurgie - Association sans but lucratif - Vereniging zonder winstoogmerk, Brüssel/Bruxelles Process for the production of rolled steel for reinforcement purposes
NL7610472A (en) * 1975-09-30 1977-04-01 Arbed PROCESS FOR TREATMENT OF ROLLED STEEL.
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FR2231758A1 (en) 1974-12-27
SE7407267L (en) 1974-12-05
DE2426920A1 (en) 1974-12-19
BE815881A (en) 1974-12-04
NL170159C (en) 1982-10-01
FR2231758B1 (en) 1978-12-01
DE2426920C2 (en) 1983-12-29
SE421710B (en) 1982-01-25
DK138958C (en) 1979-06-05
NO137451C (en) 1978-03-01
LU70230A1 (en) 1974-10-17
DK138958B (en) 1978-11-20
NL170159B (en) 1982-05-03
DK295974A (en) 1975-02-03
NO742011L (en) 1974-12-05
GB1471740A (en) 1977-04-27
NL7307718A (en) 1974-12-06

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