KR920002560A - 살균제 - Google Patents

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KR920002560A
KR920002560A KR1019910012964A KR910012964A KR920002560A KR 920002560 A KR920002560 A KR 920002560A KR 1019910012964 A KR1019910012964 A KR 1019910012964A KR 910012964 A KR910012964 A KR 910012964A KR 920002560 A KR920002560 A KR 920002560A
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KR1019910012964A
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KR100200936B1 (ko
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마틴 클러프 존
리차드 에이레스 갓프레이 크리스토퍼
토마스 스트리팅 아이언
치탐 렉스
존 드 프레인 폴
바폴로뮤 데이비드
존 에셀바이 제임스
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수잔 제인 젠틀
임페리알 케미칼 인더스트리스 피엘씨
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Priority claimed from GB909020748A external-priority patent/GB9020748D0/en
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Abstract

내용 없음

Description

살균제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 다음 구조식(Ⅰ)을 갖는 화합물 및 이것의 입체이성체.
    식중, K.L 및 M의 어떤 두개는 질소이고 그 나머지 것은 CB; T는 산소 또는 황; Z는 임의로 치환된 아릴 또는 임의로 치환된 헤테로시클릴; X는 O, S(O)n, NR4, N(CH0), CR1R2, CHR5, CO, CR1(OR2), C=CR1R2, CHR1CHR2, CR1=CR2, CHR1CR2=CH, C≡C, OCHR1, CHR1O, CH(CF3)O, CH(CN)O, OCHR1O, S(O)nCHR1, S(O)nCHR1O, CHR1S(O)n, CHR1OSO2, NR4CHR1, CHR1NR4, CO2, O2C, SO2O, OSO2, CO.CO, COCHR1, COCHR1O, CHR1CO, CHOH.CHR1, CHR1.CHOH,CONR4, OCHNR4, NR4CO, CSNR4, OCS.NR4, SCO.NR4, NR4CO2, NR4CS, NR4CSO, NR4COS, NR4CONR4, S(O)nNR4, NR4S(O)n, CS2, S2C, CO.S, SCO, N=N, N=CR1, CR1=N, CHR1CHR2CH(OH), CHR1OCO, CHR1SCO, CHR1NR4CO, CHR1NR4CONR4, CHR1CHR2CO, CR1=NO, C(NR1R2)=NO, ON=CR1, ON=C(NR1R2), CHR1O.N=CR2, CO.OCR1R2, CHR1CHR2CHR3, OCHR1CHR2, (CH2)mO, CHR1OCHR2, CHR1CHR2O, OCHR1CHR2O, S(O)nCHR1CHR2, SCHR1CHR2O, CHR1S(O)nCHR2, CHR1CHR2S(O)n, CR1=NNR4, NR4N=CR1, CHR1CONR2, CHR1OCO.NR2, CH=CHCH2O, C≡CCH2O, COCHR1CHR2O, 또는 (R5)2P+CHR2Q-; A, B 및 E는 같거나 다를수 있고 H, 하이드록시, 할로, C1-4알킬, C1-4알콕시, C1-4할로알킬, C1-4할로알콕시, C1-4알킬카보닐, C1-4알콕시카보닐, 페녹시, 니트로 또는 시아노; R1, R2및 R3는 같거나 다를수 있고, H, C1-4알킬 또는 페닐; R4는 H, C1-4알킬 또는 COR1; R5는 임의로 치환된 페닐; Q-는 할라이드 음이온; n은 0,1 또는 2: m은 3,4 또는 5: q는 0 또는 1인데, 단, q가 0이고 Z가 최소한 하나의 3가 질소 원자를 함유하는 임의로 치환된3-∼-6원 복소환식 고리일 경우, Z는 상기 3가 질소 원자에 의해 주요 피리미딘 고리에 결합되지 않고, q가 1이고 X가 0일 경우, Z는 임의로 치환된 페닐 또는 임의로 치환된 피리디닐이 아님.
  2. 제1항에 있어서, K 및 L이 질소이고 M이 CB인 화합물.
  3. 다음 구조식(Ⅰ)을 갖는 화합물 및 이것의 입체 이성체.
    식중, K.L 및 M의 어떤 두개는 질소이고 그 나머지 것은 CB; T는 산소 또는 황; Z는 임의로 치환된 아릴 또는 임의로 치환된 헤테로시클릴; X는 O, S(O)n, NR4, N(CH0), CR1R2, CHR5, CO, CR1(OR2), C=CR1R2, CHR1CHR2, CR1=CR2, CHR1CR2=CH, C≡C, OCHR1, CHR1O, CH(CF3)O, CH(CN)O, OCHR1O, S(O)nCHR1, S(O)nCHR1O, CHR1S(O)n, CHR1OSO2, NR4CHR1, CHR1NR4, CO2, O2C, SO2O, OSO2, CO.CO, COCHR1, COCHR1O, CHR1CO, CHOH.CHR1, CHR1.CHOH,CONR4, OCHNR4, NR4CO, CSNR4, OCS.NR4, SCO.NR4, NR4CO2, NR4CS, NR4CSO, NR4COS, NR4CONR4, S(O)nNR4, NR4S(O)n, CS2, S2C, CO.S, SCO, N=N, N=CR1, CR1=N, CHR1CHR2CH(OH), CHR1OCO, CHR1SCO, CHR1NR4CO, CHR1CHR2CO, O.N=CR1, CHR1O.N=CR2, CO.OCR1R2, CHR1CHR2CHR3, OCHR1CHR2, (CH2)mO, CHR1OCHR2, CHR1CHR2O, OCHR1CHR2O, S(O)nCHR1CHR2, SCHR1CHR2O, CHR1S(O)nCHR2, CHR1CHR2S(O)n, CR1=NNR4, NR4N=CR1, CHR1CONR2, CHR1OCO.NR2, CH=CHCH2O, C≡CCH2O, COCHR1CHR2O, 또는 (R5)2P+CHR2Q-; A, B 및 E는 같거나 다를수 있고 H, 하이드록시, 할로, C1-4알킬, C1-4알콕시, C1-4할로알킬, C1-4할로알콕시, C1-4알킬카보닐, C1-4알콕시카보닐, 페녹시, 니트로 또는 시아노; R1, R2및 R3는 같거나 다를수 있고, H, C1-4알킬 또는 페닐; R4는 H, C1-4알킬 또는 COR1; R5는 임의로 치환된 페닐; Q-는 할라이드 음이온; n은 0,1 또는 2: m은 3,4 또는 5: q는 0 또는 1인데, 단, q가 0이고 Z가 최소한 하나의 3가 질소 원자를 함유하는 임의로 치환된3-∼-6원 복소환식 고리일 경우, Z는 상기 3가 질소 원자에 의해 주요 피리미딘 고리에 결합되지 않음.
  4. 제3항에 있어서, 다음 구조식(Ⅰ.1)을 갖는 화합물.
    식중, K.L 및 M의 어떤 두개는 질소이고 그 나머지 것은 CB; X는 n이 0,1 또는 2인 S(O)n, NH, NCH3, NCH2CH3, NCOCH3, NCH(CH3)2, CH2, CH(CH3)2, CO, C=CH2, C=C(CH3)2, CH2CH2, CH(CH3)CH2, CH2CH(CH3), (E)-CH=CH, (Z)-CH=CH, (E)-C(CH3)=C(CH3), C≡C, C≡CCH2O, OCH2, OCH(CH3), p가 1-5의 정수인 (CH2)pO, CH(CH3)O, CH(CN)O, CH(CF3)O, SCH2, SCH(CH3), S(O)CH2, S(O)CH(CH3), S(O)2CH2, S(O)2CH(CH3), CH2S, CH(CH3)S, CH2S(O), CH(CH3)S(O), CH2S(O)2, CH(CH3)S(O)2, NHCH2, N(CHO), N(CH3)CH2, N(COCH3)CH2, NHCH(CH3), N(CH3)CH(CH3), N(COCH3)CH(CH3), CH2NH, CH2N(CH3), CH2N(COCH3), CH(CH3)NH, CH(CH3)N(CH3), CH(CH3)N(COCH3), CO2, O2C, SO2O, OSO2, CO.CO, COCH2, COCH(CH3), CON(COC6H5), CH2CO, CH(CH3)CO, CH(OH)CH2, CH(OH)CH(CH3), CH2CH(OH), CH(CH3)CH(OH), CONH, CON(CH3), CON(CH2CH2CH3), CON(CH)0, CON(COCH3), NHCO, N(CH3)CO, N(CH2CH3)CO, N(CHO)CO, N(COCH3)CO, CSN(CH3), CSNH, NHCS, N(CH3)CS, SO3NH, SO2NH, SO2N(CH3), NHSO2, N(CH3)SO2, N(CH2CH3)SO2, CS2, S2C, COS, SCO, (E)-N=N, (E)-N=CH, (E)-N=C(CH3), (E)-CH2=N, (E)-C(CH3)=N, CH2CH2CH2, CH(CH3)CH2CH2, CH2CH(CH3)CH2, CH2CH2CH(CH3), OCH2CH2, CH2OCH2, SCH2CH2, S(O)CH2CH2, S(O)2CH2CH2, SCH2CH2O, CH2SCH2, CH2S(O)CH2, CH2S(O)2CH2, CH2CH2S, CH2CHWS(O), CHWCHWS(O), (E)-CH=NNH, (E)-C(CH)3=NNH, (E)-CH=NN(CH3), (E)-NHN=CH, (E)-NHN=C(CH3), (E)-N(CH3)N=CH, CH2CONH, CH(CH3)CON(CH3), CH(CH3)CON(CH3), (E)-CH=CHCH2O, COCH2CH2O, 트랜스CH(C6H5), COCH2O, CH(OH), CO2CH2, (C6H5)2P+CH2Br-, CH2OCO, CH2NHCO, CH2SCO, OCH2O, OCH2CH2O, S(O)CH2O, COCH(CH3)O, (E)-CH2ON=CH, (Z)-CH2ON=CH, CH2CH2CH(OH), (E)-CH2CH=CH, C(CH3)(OH), CH2OSO2, CH2NHCO.NH, OCO.NH, NHCO.NH 또는 CH2OCO.NH; q는 0 또는 1: A 및 B는 독립적으로 H, 할로, C1-4알킬, C1-4알콕시, C1-4알킬티오 또는 아미노: E는 H 또는 할로: D는 H, 하이드록시, 할로, C1-4알킬, C1-4알콕시, 니트로, 시아노, 할로(C1-4)알킬 (특히 트리플루오로메틸), 할로(C1-4)알콕시 (특히 트리플루오로메톡시), 페닐, 페녹시, R6가 C1-4알킬(특히 메틸) 또는 페닐이고, R7및 R5가 독립적으로 H 또는 C1-4알킬인 NHCOR6, NHSO2R6NR7R8, CO2R7또는 CH3O2C.C=CH.OCH3; G는 H, 할로, C1-4알킬, C1-4알콕시 또는 니트로 : 이거나 D 및 G는 서로 인접해있을때 벤젠 고리나 피리딘 고리를 형성함.
  5. 식중, K.L 및 M의 어떤 두개는 질소이고 그 나머지 것은 CB; X는 n이 0,1 또는 2인 S(O)n, CH3, CH2CH3, OCH2, p가 1-5의 정수인 (CH2)pO, OCH2O, OCH2CH2O, SCH2CH2O, CH(OH), CO, CO2, O2C, COS, SCO, CO2CH2,SO2O, (Z)-CH=CH, (E)-CH=CH, (E)-CH=CHCH2O, C≡CCH2O, CH(CH3)O, SCH2, SCH2O, S(O)CH2, S(O)CH2O, CH(CN)O, CH(DF3)O, S(O)2CH2, CONH, CSNH, NH, NCH3, CH2NH, N(CH3)CH2, NHCO, N(CHO), CON(COC6H5), CH2OCONH, N(COCH3), NHSO2, (E)-N=N, (Z)-N=N, (E)-N=CH, (E)-N(CH3)O, CH2OCO, CH2NHCO, CH2SCO, 또는 (C6H5)2P+CH2Br-, q는 1:A,B 및 E는 모두 H:D는 H, 하이드록시, 할로, C1-4알킬, C1-4알콕시, 니트로, 시아노, 트리플루오로메틸, 트리풀루오로메톡시, 페닐, 페녹시, 아미노 또는 CH3O2C.C=CH.OCH3; G는 H, 할로, C1-4메틸, 니트로이거나 또는 D 및 G는 서로 인접해 있을 때 벤젠 고리나 피리딘 고리를 형성하는 구조식(Ⅰ,1)화합물.
  6. 다음 구조식(Ⅰ,2)를 갖는 화합물과 이것의 입체이성체 및 이들의 N-옥사이드 및 N-알킬염.
    식중, K, L 및 M의 어떤 두개는 질소이고 그 나머지 것은 CB; X는 산소 또는 황; Z는 임의로 치환된 5- 또는 6-원 복소환식 고리(피리딘 제외): A,B 및 E는 독립적으로 수소, 할로겐, C1-4알킬, C1-4알콕시, 시아노, 니트로 또는 트리플루오로메틸.
  7. 제6항에 있어서, K 및 L이 질소이고 M이 CH인 구조식(Ⅰ,2) 화합물.
  8. 구조식(Ⅱ), (Ⅴ) 및 (Ⅷ)의 화합물에서 Ⅴ가 수소일 경우 존재내에서 (a)다음 구조식(Ⅳ)또는(Ⅶ)의 피리미딘을
    다음 구조식(Ⅱ)의 화합물과 반응시키거나, 또는
    (b)다음 구조식(Ⅴ) 또는 (Ⅷ)의 피리미딘을
    다음 구조식(Ⅲ)의 치환된 벤젠과 반응시키고,
    식중, A, E, K, L, M, T, X 및 q는 제1항에 정의된 바와같고 : Z1은 Z또는 Z로 변환되는 그룹 : W는 CH3O2C.C=CH.OCH3또는 CH3O2C.C=CH.OCH3로 변환되는 그룹 : U는 이탈기 : V는 수소 또는 금속 : 및 Y는 공지된 방법에 의해 Z(X)q그룹으로 전환될 수 있는 그룹 구조식(Ⅶ) 또는 (Ⅷ)의 화합물을 사용하는 경우 계속해서 Y 그룹을 Z(X)q그룹으로 전환시키는 것으로 구성되는, 제1항의 화합물을 제조하는 방법.
  9. (E)-메틸 2-〔2-(6-하이드록시피리미딘-4-일옥시)페닐〕-3-메톡시프로페노에이트.
  10. 살균적으로 효과적인 양의 제1항의 화합물 및 살균적으로 허용가능한 이것의 담체 또는 희석제로 이루어진 살균 조성물.
  11. 제1항의 화합물 또는 제10항의 조성물을 식물에, 식물의 씨에 또는 식물이나 씨의 소재지에 사용하는 것으로 구성되는 균 퇴치 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910012964A 1990-07-27 1991-07-27 살균제 KR100200936B1 (ko)

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