KR910002774A - 2-아미노펜탄 산 화합물 및 면역 억제제로 그들을 사용하는 방법 - Google Patents
2-아미노펜탄 산 화합물 및 면역 억제제로 그들을 사용하는 방법 Download PDFInfo
- Publication number
- KR910002774A KR910002774A KR1019900010213A KR900010213A KR910002774A KR 910002774 A KR910002774 A KR 910002774A KR 1019900010213 A KR1019900010213 A KR 1019900010213A KR 900010213 A KR900010213 A KR 900010213A KR 910002774 A KR910002774 A KR 910002774A
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- aminopentanoic acid
- immunosuppressants
- acid compounds
- compounds
- Prior art date
Links
- SNDPXSYFESPGGJ-UHFFFAOYSA-N 2-aminopentanoic acid Chemical class CCCC(N)C(O)=O SNDPXSYFESPGGJ-UHFFFAOYSA-N 0.000 title claims 2
- 239000003018 immunosuppressive agent Substances 0.000 title claims 2
- 229960003444 immunosuppressant agent Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 229940125721 immunosuppressive agent Drugs 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
- C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C251/36—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C251/40—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (3)
- 하기 일반식(I)로 표시되는 2-아미노펜탄 산, 그들의 염, 그들의 r-락톤 화합물 및 그것의 보호성기에 의해 보호된 화합물.(상기식에서, R은 알킬, 히드록시 알킬, -CH=CH(CH2)nCH=CH-CH(OH)-(CH2)mCH3로 표시되는 기, -CH=CH(CH2)p-C-(=X)-(CH2)qCH3로 포시되는 기 또는 -CH=CH-Y로 표시되는 기이고, 여기에서 n 및 m은 각각 1 내지 10의 정수를 의미하며, >C=X 는 B는 수소 또는 알킬인 >C=N-OB, 또는 >CHNH2또는 A가 알킬렌인 >를 의미하며, p 및 q는 각각 1 내지 10의 정수이고, Y는 알킬이다).
- 제1항에 있어서, 하기 화합물(a) 내지 (f)중에서 선택된 화합물, 또는 그들의 이성체 또는 그들의 약학적 허용염인 화합물.
- 제1항 또는 제2항의 화합물을 포함하는 면역 억제제.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP176914 | 1989-07-07 | ||
JP17691489 | 1989-07-07 | ||
JP1-176914 | 1989-07-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR910002774A true KR910002774A (ko) | 1991-02-26 |
KR950013101B1 KR950013101B1 (ko) | 1995-10-24 |
Family
ID=16021968
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019900010213A KR950013101B1 (ko) | 1989-07-07 | 1990-07-06 | 2-아미노펜탄산 화합물 및 면역 억제제로 그들을 사용하는 방법 |
Country Status (4)
Country | Link |
---|---|
US (1) | US5068247A (ko) |
EP (1) | EP0410176A1 (ko) |
KR (1) | KR950013101B1 (ko) |
CA (1) | CA2020655A1 (ko) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5233062A (en) * | 1992-03-16 | 1993-08-03 | Merck & Co., Inc. | Antibiotic eicosenoic acids |
ES2126658T3 (es) * | 1992-10-21 | 1999-04-01 | Yoshitomi Pharmaceutical | Compuesto de 2-amino-1,3-propanodiol e inmunosupresor. |
US5948820A (en) * | 1994-08-22 | 1999-09-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzene compound and pharmaceutical use thereof |
GB9518417D0 (en) * | 1995-09-08 | 1995-11-08 | Fujisawa Pharmaceutical Co | Novel compound |
US20030220234A1 (en) | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
EP1554572B1 (en) | 2001-07-25 | 2009-10-14 | Raptor Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
WO2003033526A2 (en) | 2001-10-19 | 2003-04-24 | Isotechnika Inc. | Synthesis of cyclosporin analogs |
BR0306811A (pt) * | 2002-01-11 | 2004-10-26 | Sankyo Co | Composto, éster farmacologicamente aceitável do mesmo, composição farmacêutica e métodos para prevenção ou tratamento de doenças autoimunes, da artrite reumatóide e da rejeição causada pelo transplante de vários órgãos em um mamìfero |
AU2005215320B2 (en) | 2004-02-24 | 2008-04-17 | Sankyo Company, Limited | Amino alcohol compound |
BRPI0515992A (pt) * | 2004-10-12 | 2008-08-19 | Forbes Medi Tech Res Inc | compostos e métodos para o tratamento de resistência à insulina e cardiomiopatia |
US20070135450A1 (en) * | 2004-10-12 | 2007-06-14 | Forbes Medi-Tech (Research), Inc. | Compounds and Methods of Treating Insulin Resistance and Cardiomyopathy |
EP3827747A1 (en) | 2005-04-28 | 2021-06-02 | Otsuka Pharmaceutical Co., Ltd. | Pharma-informatics system |
EP2063905B1 (en) | 2006-09-18 | 2014-07-30 | Raptor Pharmaceutical Inc | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
ES2942923T3 (es) | 2009-05-06 | 2023-06-07 | Laboratory Skin Care Inc | Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3928572A (en) * | 1971-02-11 | 1975-12-23 | Ayerst Mckenna & Harrison | Myriocin and process of preparation |
US3758529A (en) * | 1971-03-23 | 1973-09-11 | Sir Soc Italiana Resine Spa | Antibiotic thermozymocidin and a process for its preparation |
WO1990002727A1 (en) * | 1988-09-14 | 1990-03-22 | Yoshitomi Pharmaceutical Industries, Ltd. | Immunosuppressant |
-
1990
- 1990-07-05 US US07/549,137 patent/US5068247A/en not_active Expired - Fee Related
- 1990-07-05 EP EP90112849A patent/EP0410176A1/en not_active Withdrawn
- 1990-07-06 KR KR1019900010213A patent/KR950013101B1/ko not_active IP Right Cessation
- 1990-07-06 CA CA002020655A patent/CA2020655A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
KR950013101B1 (ko) | 1995-10-24 |
US5068247A (en) | 1991-11-26 |
CA2020655A1 (en) | 1991-01-08 |
EP0410176A1 (en) | 1991-01-30 |
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LAPS | Lapse due to unpaid annual fee |