KR910002774A - 2-aminopentanoic acid compounds and how to use them as immunosuppressants - Google Patents

2-aminopentanoic acid compounds and how to use them as immunosuppressants Download PDF

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Publication number
KR910002774A
KR910002774A KR1019900010213A KR900010213A KR910002774A KR 910002774 A KR910002774 A KR 910002774A KR 1019900010213 A KR1019900010213 A KR 1019900010213A KR 900010213 A KR900010213 A KR 900010213A KR 910002774 A KR910002774 A KR 910002774A
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South Korea
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alkyl
aminopentanoic acid
immunosuppressants
acid compounds
compounds
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KR1019900010213A
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Korean (ko)
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KR950013101B1 (en
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데쯔로 후지다
다케시 이구모토
시게오 사사키
겐지 시바
유키오 호시노
Original Assignee
고오야 다다시
요시토미 세이야쿠 가부시기가이샤
다케이 노부오
다이토 가부시기가이샤
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Publication of KR910002774A publication Critical patent/KR910002774A/en
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Publication of KR950013101B1 publication Critical patent/KR950013101B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/36—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/40—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

내용 없음No content

Description

2-아미노펜탄 산 화합물 및 면역 억제제로 그들을 사용하는 방법2-aminopentanoic acid compounds and how to use them as immunosuppressants

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (3)

하기 일반식(I)로 표시되는 2-아미노펜탄 산, 그들의 염, 그들의 r-락톤 화합물 및 그것의 보호성기에 의해 보호된 화합물.2-aminopentanoic acid represented by the following general formula (I), their salts, their r-lactone compounds and compounds protected by their protecting groups. (상기식에서, R은 알킬, 히드록시 알킬, -CH=CH(CH2)nCH=CH-CH(OH)-(CH2)mCH3로 표시되는 기, -CH=CH(CH2)p-C-(=X)-(CH2)qCH3로 포시되는 기 또는 -CH=CH-Y로 표시되는 기이고, 여기에서 n 및 m은 각각 1 내지 10의 정수를 의미하며, >C=X 는 B는 수소 또는 알킬인 >C=N-OB, 또는 >CHNH2또는 A가 알킬렌인 >를 의미하며, p 및 q는 각각 1 내지 10의 정수이고, Y는 알킬이다).Wherein R is an alkyl, hydroxy alkyl, -CH = CH (CH 2 ) n CH = CH-CH (OH)-(CH 2 ) m CH 3 , -CH = CH (CH 2 ) p -C-(= X)-(CH 2 ) q is a group represented by CH 3 or a group represented by -CH = CH-Y, where n and m each represent an integer of 1 to 10,> C = X is> C = N-OB, where B is hydrogen or alkyl, or> CHNH 2 or A is alkylene> P and q are each an integer of 1 to 10, and Y is alkyl. 제1항에 있어서, 하기 화합물(a) 내지 (f)중에서 선택된 화합물, 또는 그들의 이성체 또는 그들의 약학적 허용염인 화합물.The compound according to claim 1, which is a compound selected from the following compounds (a) to (f), or an isomer thereof or a pharmaceutically acceptable salt thereof. 제1항 또는 제2항의 화합물을 포함하는 면역 억제제.An immunosuppressive agent comprising the compound of claim 1. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019900010213A 1989-07-07 1990-07-06 2-aminopentanoic acid compounds and their use as lmmunosuppressants KR950013101B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP176914 1989-07-07
JP17691489 1989-07-07
JP1-176914 1989-07-07

Publications (2)

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KR910002774A true KR910002774A (en) 1991-02-26
KR950013101B1 KR950013101B1 (en) 1995-10-24

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US (1) US5068247A (en)
EP (1) EP0410176A1 (en)
KR (1) KR950013101B1 (en)
CA (1) CA2020655A1 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5233062A (en) * 1992-03-16 1993-08-03 Merck & Co., Inc. Antibiotic eicosenoic acids
ES2126658T3 (en) * 1992-10-21 1999-04-01 Yoshitomi Pharmaceutical COMPOSED OF 2-AMINO-1,3-PROPANODIOL AND IMMUNOSUPPRESSOR.
US5948820A (en) * 1994-08-22 1999-09-07 Yoshitomi Pharmaceutical Industries, Ltd. Benzene compound and pharmaceutical use thereof
GB9518417D0 (en) * 1995-09-08 1995-11-08 Fujisawa Pharmaceutical Co Novel compound
US20030220234A1 (en) 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
EP1554572B1 (en) 2001-07-25 2009-10-14 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
WO2003033526A2 (en) 2001-10-19 2003-04-24 Isotechnika Inc. Synthesis of cyclosporin analogs
BR0306811A (en) * 2002-01-11 2004-10-26 Sankyo Co Compound, pharmacologically acceptable ester thereof, pharmaceutical composition and methods for the prevention or treatment of autoimmune diseases, rheumatoid arthritis and rejection caused by the transplantation of various organs in a mammal
AU2005215320B2 (en) 2004-02-24 2008-04-17 Sankyo Company, Limited Amino alcohol compound
BRPI0515992A (en) * 2004-10-12 2008-08-19 Forbes Medi Tech Res Inc compounds and methods for treating insulin resistance and cardiomyopathy
US20070135450A1 (en) * 2004-10-12 2007-06-14 Forbes Medi-Tech (Research), Inc. Compounds and Methods of Treating Insulin Resistance and Cardiomyopathy
EP3827747A1 (en) 2005-04-28 2021-06-02 Otsuka Pharmaceutical Co., Ltd. Pharma-informatics system
EP2063905B1 (en) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
ES2942923T3 (en) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Dermal delivery compositions comprising complexes of active agent-calcium phosphate particles and methods of use thereof
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

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US3928572A (en) * 1971-02-11 1975-12-23 Ayerst Mckenna & Harrison Myriocin and process of preparation
US3758529A (en) * 1971-03-23 1973-09-11 Sir Soc Italiana Resine Spa Antibiotic thermozymocidin and a process for its preparation
WO1990002727A1 (en) * 1988-09-14 1990-03-22 Yoshitomi Pharmaceutical Industries, Ltd. Immunosuppressant

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KR950013101B1 (en) 1995-10-24
US5068247A (en) 1991-11-26
CA2020655A1 (en) 1991-01-08
EP0410176A1 (en) 1991-01-30

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