KR910000790A - 고리형 테트라펩티드 및 그의 제조방법 - Google Patents

고리형 테트라펩티드 및 그의 제조방법 Download PDF

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Publication number
KR910000790A
KR910000790A KR1019900009840A KR900009840A KR910000790A KR 910000790 A KR910000790 A KR 910000790A KR 1019900009840 A KR1019900009840 A KR 1019900009840A KR 900009840 A KR900009840 A KR 900009840A KR 910000790 A KR910000790 A KR 910000790A
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KR
South Korea
Prior art keywords
cyclic tetrapeptide
preparation
following formula
cyclic
helicoma
Prior art date
Application number
KR1019900009840A
Other languages
English (en)
Inventor
겐지 스기따
히로시 이따자끼
고이찌 마쓰모또
요시미 가와무라
Original Assignee
요시또시 가즈오
시오노기세이야꾸 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 요시또시 가즈오, 시오노기세이야꾸 가부시끼가이샤 filed Critical 요시또시 가즈오
Publication of KR910000790A publication Critical patent/KR910000790A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/126—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Abstract

내용 없음

Description

고리형 테트라펩티드 및 그의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제 1 도는 RF-1023-A의 UV흡수 스펙트럼을 나타내는 챠트이다.
제 2 도는 RF-1023-A의 IR흡수 스펙트럼을 나타내는 챠트이다.
제 3 도는 FR-1023-A의 NMR 스펙트럼(1H-NMR)을 나타내는 챠트이다.

Claims (5)

  1. 하기식(Ⅰ)로 표시되는 고리형 테트라펩티드.
    [상기 식중, n은 4 또는 3이다]
  2. 제1항에 있어서, n이 4인 고리형 테트라펩티드.
  3. 제1항에 있어서, n이 3인 고리형 테트라펩티드.
  4. 하기식(Ⅰ)로 표시되는 고리형 테트라펩티드를 생산할 수 있는 헬리코마 속 미생물을 배지에서 배양하고, 생산되는 하기식(Ⅰ)로 표시되는 고리형 테트라펩티드를 수거함을 특징으로 하는 하기식(Ⅰ)로 표시되는 고리형 테트라펩티드의 제조방법.
    [상기 식중, n은 4 또는 3이다]
  5. 제4항에 있어서, 헬리코마 속 미생물이 헬리코마 암비엔스 RF-1023(FERM BP-2751)인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900009840A 1988-06-30 1990-06-30 고리형 테트라펩티드 및 그의 제조방법 KR910000790A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP170930/1989 1988-06-30
JP1170930A JPH0334991A (ja) 1989-06-30 1989-06-30 環状テトラペプチドおよびその製造法

Publications (1)

Publication Number Publication Date
KR910000790A true KR910000790A (ko) 1991-01-30

Family

ID=15913999

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900009840A KR910000790A (ko) 1988-06-30 1990-06-30 고리형 테트라펩티드 및 그의 제조방법

Country Status (8)

Country Link
US (1) US5112944A (ko)
EP (1) EP0406725B1 (ko)
JP (1) JPH0334991A (ko)
KR (1) KR910000790A (ko)
AT (1) ATE102955T1 (ko)
DE (1) DE69007356T2 (ko)
DK (1) DK0406725T3 (ko)
ES (1) ES2053018T3 (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5620953A (en) * 1994-07-27 1997-04-15 Merck & Co., Inc. Antiprotozoal cyclic tetrapeptides
US6110697A (en) 1995-09-20 2000-08-29 Merck & Co., Inc. Histone deacetylase as target for antiprotozoal agents
US5922837A (en) * 1995-09-20 1999-07-13 Merck & Co., Inc. Antiprotozoal cyclic tetrapeptides
US6068987A (en) * 1996-09-20 2000-05-30 Merck & Co., Inc. Histone deacetylase as target for antiprotozoal agents
EP1010705A4 (en) * 1997-09-02 2004-09-15 Sumitomo Pharma NEW CYCLIC TETRAPEPTIDE DERIVATIVES AND THEIR MEDICAL USE
AUPP505798A0 (en) * 1998-08-04 1998-08-27 Fujisawa Pharmaceutical Co., Ltd. Novel compound fr225497 substance
PL219569B1 (pl) * 2010-02-19 2015-05-29 Peptaderm Spółka Z Ograniczoną Odpowiedzialnością Cykliczne tetrapeptydy i ich zastosowanie

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8427651D0 (en) * 1984-11-01 1984-12-05 Beecham Group Plc Compounds

Also Published As

Publication number Publication date
EP0406725B1 (en) 1994-03-16
DE69007356T2 (de) 1994-10-13
DE69007356D1 (de) 1994-04-21
JPH0334991A (ja) 1991-02-14
DK0406725T3 (da) 1994-05-02
EP0406725A1 (en) 1991-01-09
US5112944A (en) 1992-05-12
ATE102955T1 (de) 1994-04-15
ES2053018T3 (es) 1994-07-16

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