KR900014360A - 피리딘카복실산 아미드 유도체 및 이를 함유하는 약학 조성물 - Google Patents

피리딘카복실산 아미드 유도체 및 이를 함유하는 약학 조성물 Download PDF

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Publication number
KR900014360A
KR900014360A KR1019900002605A KR900002605A KR900014360A KR 900014360 A KR900014360 A KR 900014360A KR 1019900002605 A KR1019900002605 A KR 1019900002605A KR 900002605 A KR900002605 A KR 900002605A KR 900014360 A KR900014360 A KR 900014360A
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South Korea
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compound
pharmaceutical composition
physiologically acceptable
effective amount
therapeutically effective
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KR1019900002605A
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English (en)
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KR0130758B1 (ko
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가쓰토시 미우라
히로야스 고야마
도시지 스가이
히로아키 야마다
에이노스케 사쿠라이
마사토 호리고메
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쇼다 오사무
닛신 세이훈 가부시키가이샤
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Publication of KR900014360A publication Critical patent/KR900014360A/ko
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Publication of KR0130758B1 publication Critical patent/KR0130758B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

내용 없음

Description

피리딘카복실산 아미드 유도체 및 이를 함유하는 약학 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 일반식(Ⅰ)의 화합물 및 생리학적으로 허용되는 이의 산 부가염.
    상기식에서, R1은 수소, C1-C6알킬, C3-C6사이클로알킬 또는 디페닐메틸이고, Y는 -NH(CH2)n-R2또는이며, R2는 OH 또는 -ONO2이며, ℓ은 2 또는 3이며, m은 0 또는 1이며, n은 2 내지 8이다.
  2. 제 1항에 있어서, R1이 메틸, 에틸, n-프로필, i-프로필, n-부틸, i-부틸, 3급-부틸, 헥실, 사이클로펜틸 또는 사이클로헥실인 화합물.
  3. 제 1항에 있어서, Y가 -NH(CH2)n-R2이고 R2가 OH 또는 -ONO2이며 n이 2 내지 8인 화합물.
  4. 제 1항에 있어서, Y가이고, R2가 OH 또는 -NO2인 화합물.
  5. 치료 유효량이 제 1항의 화합물 또는 생리학적으로 허용되는 이의 부가염과 약학적으로 허용되는 담체를 포함함을 특징으로 하는, 혈류증가작용과 혈압강하작용이 있는 약학 조성물.
  6. 치료 유효량의 제 2항의 화합물 또는 생리학적으로 허용되는 이의 부가염과 약학적으로 허용되는 담체를 포함함을 특징으로 하는, 혈류증가작용과 혈압강하작용이 있는 약학 조성물.
  7. 치료 유효량의 제 3항의 화합물 또는 생리학적으로 허용되는 이의 부가염과 약학적으로 허용되는 담체를 포함함을 특징으로 하는, 혈류증가작용과 혈압강하작용이 있는 약학 조성물.
  8. 치료 유효량의 제 4항의 화합물 또는 생리학적으로 허용되는 이의 부가염과 약학적으로 허용되는 담체를 포함함을 특징으로 하는, 혈류증가작용과 혈압강하작용이 있는 약학 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900002605A 1989-03-01 1990-02-28 피리딘카복실산 아미드 유도체 및 이를 포함하는 약제학적 조성물 KR0130758B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP1-46648 1989-03-01
JP4664889 1989-03-01
JP2027202A JP2843632B2 (ja) 1989-03-01 1990-02-08 ピリジンカルボン酸アミド誘導体
JP2-27202 1990-02-08

Publications (2)

Publication Number Publication Date
KR900014360A true KR900014360A (ko) 1990-10-23
KR0130758B1 KR0130758B1 (ko) 1998-04-09

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Application Number Title Priority Date Filing Date
KR1019900002605A KR0130758B1 (ko) 1989-03-01 1990-02-28 피리딘카복실산 아미드 유도체 및 이를 포함하는 약제학적 조성물

Country Status (3)

Country Link
JP (1) JP2843632B2 (ko)
KR (1) KR0130758B1 (ko)
CA (1) CA2011143C (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0882716B1 (en) * 1996-11-19 2002-04-10 Nisshin Pharma Inc. Pyridinecarboxamide derivatives
WO1999021834A1 (en) * 1997-10-27 1999-05-06 Neurosearch A/S Heteroaryl diazacycloalkanes as cholinergic ligands at nicotinic acetylcholine receptors
US9365553B2 (en) * 2010-05-27 2016-06-14 Aska Pharmaceutical Co., Ltd. Heterocyclic compound and H1 receptor antagonist

Also Published As

Publication number Publication date
JP2843632B2 (ja) 1999-01-06
CA2011143A1 (en) 1990-09-01
CA2011143C (en) 1999-02-23
KR0130758B1 (ko) 1998-04-09
JPH037258A (ja) 1991-01-14

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