KR900013070A - 포유동물의 세포배양에서 암모니아제거방법 - Google Patents

포유동물의 세포배양에서 암모니아제거방법 Download PDF

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Publication number
KR900013070A
KR900013070A KR1019900002375A KR900002375A KR900013070A KR 900013070 A KR900013070 A KR 900013070A KR 1019900002375 A KR1019900002375 A KR 1019900002375A KR 900002375 A KR900002375 A KR 900002375A KR 900013070 A KR900013070 A KR 900013070A
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ammonia
cell culture
mammalian cell
aqueous
membrane
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KR1019900002375A
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반 아이케렌 파울
M. 라도비치 죤
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월터 C. 밥수
밴드리서치 인코퍼레이티드
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Publication of KR900013070A publication Critical patent/KR900013070A/ko

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/36—Pervaporation; Membrane distillation; Liquid permeation
    • B01D61/364—Membrane distillation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/38—Liquid-membrane separation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/10—Supported membranes; Membrane supports
    • B01D69/105—Support pretreatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/14—Dynamic membranes
    • B01D69/141—Heterogeneous membranes, e.g. containing dispersed material; Mixed matrix membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/26—Polyalkenes
    • B01D71/262—Polypropylene
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/30—Polyalkenyl halides
    • B01D71/32—Polyalkenyl halides containing fluorine atoms
    • B01D71/34—Polyvinylidene fluoride
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/30—Polyalkenyl halides
    • B01D71/32—Polyalkenyl halides containing fluorine atoms
    • B01D71/36—Polytetrafluoroethene
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/66—Polymers having sulfur in the main chain, with or without nitrogen, oxygen or carbon only
    • B01D71/68—Polysulfones; Polyethersulfones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/02—Percolation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/16—Hollow fibers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2257/00—Components to be removed
    • B01D2257/40—Nitrogen compounds
    • B01D2257/406—Ammonia
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/38—Hydrophobic membranes

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  • Chemical & Material Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
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  • Wood Science & Technology (AREA)
  • Water Supply & Treatment (AREA)
  • Sustainable Development (AREA)
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  • Biotechnology (AREA)
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  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)

Abstract

내용 없음

Description

포유동물의 세포배양에서 암모니아제거방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 이 발명의 전체과정을 표시하는 도면.
제2도는 이 발명의 대표적인 막을 통한 암모니아 확산을 표시하는 도면.
제3도는 전형적인 막 모듈.

Claims (10)

  1. 수성배양기에서 포유동물세포의 배양동안에 형성된 암모니아 제거공정에 있어서(a)양측 지지분비액막의 일축과 수성배양기를 접촉시키고 그 지지막이 미공성 소수성중합 매트릭스이며, (b)상기 지지분비액막의 다른쪽과 접촉하여 스트립용액을 유지하며 상기 스트립용액이 pH≤7.0을 가진 수성용액이 포유동물 세포배양에서 암모니아 제거방법.
  2. 제1항에 있어서, 지지분비액막의 분비액은 개스인 포유동물 세포뱅양에서 암모니아 제거방법.
  3. 제1항에 있어서, 상기 분비액은 디알킬 포스포릭산, 디알킬포스포닉산, 알릴 설포닉산, 알킬 설포닉산, 알릴 카복시릭산, 알킬 카복시릭산, 알릴 알콜, 알릴 아민, 아킬 아민, 트리 알킬 포스파인 옥상이드와 그 용액에서 선택되는 포유동물세포배양에서 암모니아 제거방법.
  4. 제1항에 있어서 미공성 소수성 중합 막 지지매트릭스는 적어도 하나가 속이 빈 섬유, 구슬, 구슬기질에 코팅한 것에서 선택되는 포유동물세포배양에서 암모니아 제거방법.
  5. 제4항에 있어서, 막 지지매트릭스는 적어도 한 개가 속이 빈섬유이며 상기 수성배양기는 적어도 한 개의 속이빈 섬유의 루멘에서 순환되는 포유동물세포배양에서 암모니아 제거방법.
  6. 제4항에 있어서, 상기의 적어도 한 개의 속이 빈 섬유는 상기 수성배양기와 스트립용액을 위하여 입구와 출구 구멍을 가진 적어도 하나의 모듈로 포트된 포유동물세포배양에서 암모니아 제거방법.
  7. 제4항에 있어서, 적어도 한 개의 미공성 속이 빈 섬유는 폴리프로필렌, 폴리 테트라 플로로에틸렌, 폴리(비닐리딘 플로라이드), 폴리 설폰과 폴리 에테르 설폰으로 이루어지는 중합체에서 선택되는 포유동물세포배양에서 암모니아 제거방법.
  8. 제4항에 있어서, 막 지지매트릭스는 암모니아 흡수물질의 구슬기질위에 적어도 하나의 코팅된 포유동물세포배양에서 암모니아 제거방법.
  9. 제8항에 있어서, 암모니아 흡수물질의 구슬기질은＋이온교환 수지 및 수소이온포함 다공세라믹에서 선택된 포유동물세포배양에서 암모니아 제거방법.
  10. 제1항 있어서, 수성배양기는 포유동물세포배양에서 더 사용되게 재순환되는 포유동물세포배양에서 암모니아 제거방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900002375A 1989-02-24 1990-02-24 포유동물의 세포배양에서 암모니아제거방법 KR900013070A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US315,477 1989-02-24
US07/315,477 US5071561A (en) 1989-02-24 1989-02-24 Ammonia removal from mammalian cell cultures

Publications (1)

Publication Number Publication Date
KR900013070A true KR900013070A (ko) 1990-09-03

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ID=23224621

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KR1019900002375A KR900013070A (ko) 1989-02-24 1990-02-24 포유동물의 세포배양에서 암모니아제거방법

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Country Link
US (1) US5071561A (ko)
EP (1) EP0385613A1 (ko)
JP (1) JPH02276571A (ko)
KR (1) KR900013070A (ko)
CA (1) CA2009761A1 (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091080A (en) * 1990-11-30 1992-02-25 Bend Research, Inc. Adsorbents for the removal of volatile substances from aqueous systems
KR100681811B1 (ko) * 2005-03-15 2007-02-12 성균관대학교산학협력단 생물학적 대사부산물의 효율적인 제거를 통한 유용 이차대사산물의 제조방법
GB0704025D0 (en) * 2007-03-02 2007-04-11 Ekb Technology Ltd Inhibitory product removal
US8906332B2 (en) * 2010-03-17 2014-12-09 The United States Of America, As Represented By The Secretary Of Agriculture Gaseous ammonia removal system
JP7075054B2 (ja) * 2018-09-06 2022-05-25 日機装株式会社 アンモニア吸着剤およびアンモニアの除去方法
JP7274170B2 (ja) * 2019-05-17 2023-05-16 日機装株式会社 被処理液の再生方法および被処理液の再生装置
CN115023493A (zh) 2020-01-30 2022-09-06 耶路撒冷希伯来大学伊森姆研究发展有限公司 过滤细胞培养基的方法和装置
EP4337755A1 (en) 2021-05-10 2024-03-20 Future Meat Technologies Ltd. Systems and methods for recycling cell culture medium

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3878564A (en) * 1972-04-14 1975-04-22 Shang J Yao Blood and tissue detoxification method
GB2047564B (en) * 1978-03-27 1983-01-26 Bend Res Inc Separator membrane and process using such membrane for removing ions from an aqueous solution
NL7904388A (nl) * 1978-06-15 1979-12-18 Mitsubishi Rayon Co Werkwijze en inrichting voor overdracht van gassen.
JPS551816A (en) * 1978-06-15 1980-01-09 Mitsubishi Rayon Co Ltd Vapor-liquid contactor
US4762535A (en) * 1987-06-02 1988-08-09 Air Products And Chemicals, Inc. Ammonia separation using semipermeable membranes

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EP0385613A1 (en) 1990-09-05
JPH02276571A (ja) 1990-11-13
US5071561A (en) 1991-12-10
CA2009761A1 (en) 1990-08-24

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