KR900012882A - 광학 활성 화합물 및 이의 제조방법 - Google Patents

광학 활성 화합물 및 이의 제조방법 Download PDF

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KR900012882A
KR900012882A KR1019900001988A KR900001988A KR900012882A KR 900012882 A KR900012882 A KR 900012882A KR 1019900001988 A KR1019900001988 A KR 1019900001988A KR 900001988 A KR900001988 A KR 900001988A KR 900012882 A KR900012882 A KR 900012882A
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optically active
compound
ester
active compound
carbon atoms
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KR1019900001988A
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KR930002029B1 (ko
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가즈토시 미야지와
나오유키 요시다
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노기 사다오
칫소 가부시키가이샤
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

광학 활성 화합물 및 이의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. R-또는 S-에스테르인 일반식(Ⅰ)의 광학활성 화합물.
    상기식에서,R1은 수소 또는 탄소수 2 내지 20의 아실이고, R2는 탄소수 3 내지 40의 알킬, 알케닐 또는 알키닐이며,*로 표시된 탄소는 비대칭 탄소 원자이다.
  2. 제1항에 있어서, R2가 탄소수 3 내지 40의 알킬인 광학활성 화합물.
  3. 제1항에 있어서, R2가 프로필인 광학활성 화합물.
  4. 제1항에 있어서, R2가 1,1-디메틸에틸인 광학활성 화합물.
  5. 에스테르를 일반식(Ⅱ)의 (R,S)-화합물과 가수분해 효소의 존재하에 실질적으로 A수 조건하에서 반응시켜 에스테르와 (R,S)-화합물 사이의 에스테르 교환반응을 수행하고, R-또는 S-화합물이 강화된 혼합물을수득한 다음, 혼합물을 상응하는 광학활성 R-또는 S-화합물이 강화된 혼합물을 수득한 다음, 혼합물을 상응하는 광학활성 R-또는 S-알코올 및 일반식(Ⅰ)의 에스테르로 분할함을 특징으로 하여, 광학활성 화합물을 제조하는 방법.
    상기식에서, R1은 수소 또는 탄소수 2 내지 20의 아실이고, R2는 탄소수 3 내지 40의 알킬, 알케닐 또는 알키닐이며,*로 표시된 탄소는 비대칭 탄소 원자이다.
  6. 제5항에 있어서, 에스테르가 트리글리세라이드인 방법.
  7. 제5항에 있어서, 사용된 에스테르가 지방산 비닐에스테르인 방법.
  8. 제5항에 있어서, 강수분해효소가 리파아제인 방법.
  9. 제5항에 있어서, 가수분해효소가 슈도모나스 종(Pseudomonas sp.)으로부터 유도된 리파아제인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900001988A 1989-02-21 1990-02-19 광학활성 화합물 및 이의 제조방법 KR930002029B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1-39297 1989-02-21
JP1039297A JP2578658B2 (ja) 1989-02-21 1989-02-21 光学活性化合物及びその製造法

Publications (2)

Publication Number Publication Date
KR900012882A true KR900012882A (ko) 1990-09-03
KR930002029B1 KR930002029B1 (ko) 1993-03-22

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Country Link
US (1) US5128252A (ko)
EP (1) EP0384189A3 (ko)
JP (1) JP2578658B2 (ko)
KR (1) KR930002029B1 (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2852545B2 (ja) * 1989-11-14 1999-02-03 チッソ株式会社 複数の不斉点を持つ光学活性化合物および製造法
DE4037440A1 (de) * 1990-11-24 1992-05-27 Basf Ag Verfahren zur herstellung von (6s)-6,8-dihydroxyoctansaeureestern
JP3704731B2 (ja) * 1994-10-17 2005-10-12 チッソ株式会社 光学活性３−ヒドロキシヘキサン酸類の製造方法
AU2017278099B2 (en) 2016-06-07 2021-03-11 Ithaca College Medium chain fatty acid esters of beta-hydroxybutyrate and butanediol and compositions and methods for using same
CN111050764A (zh) 2017-07-21 2020-04-21 巴克老年研究所 β-羟基丁酸酯和丁二醇的S对映异构体及其使用方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4272437A (en) * 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates
DE3163939D1 (en) * 1980-03-08 1984-07-12 Fuji Oil Co Ltd Method for enzymatic interesterification of lipid and enzyme used therein
IE54838B1 (en) * 1982-04-30 1990-02-28 Unilever Plc Improvements in and relating to interesterification of triglycerides of fatty acids
US4940845A (en) * 1984-05-30 1990-07-10 Kao Corporation Esterification process of fats and oils and enzymatic preparation to use therein
US4735900A (en) * 1984-12-21 1988-04-05 Kao Corporation Enzyme preparation for interesterification
JPS6261589A (ja) * 1985-09-10 1987-03-18 Fuji Oil Co Ltd グリセリド油脂の加工法
JPH0740956B2 (ja) * 1986-01-21 1995-05-10 チッソ株式会社 生化学的手法による光学活性なアルコ−ルの製造法
SE452166B (sv) * 1986-03-10 1987-11-16 Berol Kemi Ab Forfarande for transesterifiering av triglycerider
US4916074A (en) * 1986-10-30 1990-04-10 Chisso Corporation Process for producing optically active compounds
JPH0755158B2 (ja) * 1986-10-30 1995-06-14 チッソ株式会社 光学活性エステルの製造法
JP2707076B2 (ja) * 1987-05-01 1998-01-28 チッソ株式会社 光学活性化合物の製造法
JP2869650B2 (ja) * 1987-05-15 1999-03-10 チッソ株式会社 光学活性化合物およびその製造方法
JP2691986B2 (ja) * 1987-08-28 1997-12-17 チッソ株式会社 ピリジン骨格を有する光学活性化合物の製造法
DE3743824C2 (de) * 1987-12-23 1997-03-06 Hoechst Ag Verfahren zur enzymatischen Racematspaltung von racemischen Alkoholen mit/in Vinylestern durch Umesterung
US4996158A (en) * 1987-12-26 1991-02-26 Junichi Oda Optical resolution of racemic alcohols
GB2236537A (en) * 1989-09-13 1991-04-10 Unilever Plc Transesterification

Also Published As

Publication number Publication date
JPH02219598A (ja) 1990-09-03
JP2578658B2 (ja) 1997-02-05
US5128252A (en) 1992-07-07
KR930002029B1 (ko) 1993-03-22
EP0384189A3 (en) 1990-11-28
EP0384189A2 (en) 1990-08-29

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