KR900011900A - 이.콜라이내에서 펩타이드를 분비시키기 위한 시그날 펩타이드 및 이를 암호화하는 유전자 - Google Patents

이.콜라이내에서 펩타이드를 분비시키기 위한 시그날 펩타이드 및 이를 암호화하는 유전자

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Publication number
KR900011900A
KR900011900A KR1019900000597A KR900000597A KR900011900A KR 900011900 A KR900011900 A KR 900011900A KR 1019900000597 A KR1019900000597 A KR 1019900000597A KR 900000597 A KR900000597 A KR 900000597A KR 900011900 A KR900011900 A KR 900011900A
Authority
KR
South Korea
Prior art keywords
peptides
coli
genes encoding
secreting
signal
Prior art date
Application number
KR1019900000597A
Other languages
English (en)
Other versions
KR0152996B1 (ko
Inventor
크납프 스테판
아만 에곤
아벨 칼-요셉
Original Assignee
베링베르케 아크티엔게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 베링베르케 아크티엔게젤샤프트 filed Critical 베링베르케 아크티엔게젤샤프트
Publication of KR900011900A publication Critical patent/KR900011900A/ko
Application granted granted Critical
Publication of KR0152996B1 publication Critical patent/KR0152996B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/034—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the periplasmic space of Gram negative bacteria as a soluble protein, i.e. signal sequence should be cleaved
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/825—Bacteria

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1019900000597A 1989-01-21 1990-01-19 이.콜라이내에서 펩타이드를 분비시키기 위한 시그날 펩타이드 및 이를 암호화하는 유전자 KR0152996B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3901681A DE3901681A1 (de) 1989-01-21 1989-01-21 Signalpeptid fuer die sekretion von peptiden in escherichia coli, verfahren zu seiner gewinnung und seine verwendung
DEP3901681.1 1989-01-21

Publications (2)

Publication Number Publication Date
KR900011900A true KR900011900A (ko) 1990-08-02
KR0152996B1 KR0152996B1 (ko) 1998-10-15

Family

ID=6372488

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900000597A KR0152996B1 (ko) 1989-01-21 1990-01-19 이.콜라이내에서 펩타이드를 분비시키기 위한 시그날 펩타이드 및 이를 암호화하는 유전자

Country Status (8)

Country Link
US (2) US5159062A (ko)
EP (1) EP0391022A3 (ko)
JP (2) JP2939283B2 (ko)
KR (1) KR0152996B1 (ko)
AU (1) AU619378B2 (ko)
CA (1) CA2008244A1 (ko)
DE (1) DE3901681A1 (ko)
PT (1) PT92886B (ko)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5356797A (en) * 1991-11-15 1994-10-18 Board Of Regents, The University Of Texas Membrane expression of heterologous genes
EP0613500A1 (en) * 1991-11-15 1994-09-07 The Board Of Regents, The University Of Texas System Membrane expression of heterologous genes
FR2690459B1 (fr) * 1992-04-23 1995-03-03 Pasteur Institut Plasmide de B. bronchiseptica, dérivés de ce plasmide et leur utilisation en tant que vecteurs pour la transformation de cellules hôtes.
JP2879303B2 (ja) * 1993-01-14 1999-04-05 佑 本庶 ｃＤＮＡライブラリーの作製方法、および新規なポリペプチドとそれをコードするＤＮＡ
US5753462A (en) * 1995-06-07 1998-05-19 Zymogenetics, Inc. Secretion leader trap cloning method
US6964861B1 (en) * 1998-11-13 2005-11-15 Invitrogen Corporation Enhanced in vitro recombinational cloning of using ribosomal proteins
US6720140B1 (en) 1995-06-07 2004-04-13 Invitrogen Corporation Recombinational cloning using engineered recombination sites
US6143557A (en) * 1995-06-07 2000-11-07 Life Technologies, Inc. Recombination cloning using engineered recombination sites
EP0832209A1 (en) * 1995-06-07 1998-04-01 ZymoGenetics, Inc. Secretion leader trap cloning method
US5851808A (en) 1997-02-28 1998-12-22 Baylor College Of Medicine Rapid subcloning using site-specific recombination
CN100342008C (zh) 1997-10-24 2007-10-10 茵维特罗根公司 利用具重组位点的核酸进行重组克隆
US7351578B2 (en) * 1999-12-10 2008-04-01 Invitrogen Corp. Use of multiple recombination sites with unique specificity in recombinational cloning
CN101125873A (zh) * 1997-10-24 2008-02-20 茵维特罗根公司 利用具重组位点的核酸进行重组克隆
CA2363924A1 (en) 1999-03-02 2000-09-08 Invitrogen Corporation Compositions and methods for use in recombinational cloning of nucleic acids
US6664386B1 (en) 1999-04-08 2003-12-16 The Research Foundation Of State University Of New York System for efficient secretion of recombinant proteins
AU785483B2 (en) 1999-12-10 2007-09-20 Invitrogen Corporation Use of multiple recombination sites with unique specificity in recombinational cloning
US7244560B2 (en) * 2000-05-21 2007-07-17 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
US7198924B2 (en) 2000-12-11 2007-04-03 Invitrogen Corporation Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites
EP1390394A4 (en) * 2001-04-19 2004-05-26 Invitrogen Corp COMPOSITIONS AND METHODS FOR RECOMBINANT CLONING OF NUCLEIC ACID MOLECULES
US7112434B2 (en) * 2001-05-02 2006-09-26 University Of South Florida Vector system for selection of genes encoding secreted proteins and membrane-bound proteins
WO2002095055A2 (en) * 2001-05-21 2002-11-28 Invitrogen Corporation Compositions and methods for use in isolation of nucleic acid molecules
DE602004027538D1 (de) 2003-12-01 2010-07-15 Life Technologies Corp Rekombinationsstellen enthaltende nukleinsäuremoleküle und verfahren zur verwendung davon
US20060234360A1 (en) * 2005-04-13 2006-10-19 Paola Branduardi Ascorbic acid production from D-glucose in yeast
EP2385065A1 (en) 2007-11-01 2011-11-09 Perseid Therapeutics LLC Immunosuppressive polypeptides and nucleic acids
WO2019099615A1 (en) 2017-11-17 2019-05-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Use of copeptin to modulate the immune response and hematopoiesis, and stimulate bone growth

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6030687A (ja) * 1983-08-01 1985-02-16 Wakunaga Seiyaku Kk Ｄνａ遺伝子，その製造法およびそれを含むプラスミド
ATE109828T1 (de) * 1987-04-23 1994-08-15 Monsanto Co Sekretion eines dem insulin ähnlichen wachstumsfaktors in e. coli.
DE3843894A1 (de) * 1988-12-24 1990-06-28 Behringwerke Ag Plasmide mit translations-start-stop-start codon-konfiguration zur expression von proteinen in e.coli
AU5966790A (en) * 1989-06-30 1991-01-17 Upjohn Company, The Genetic elements useful in production of active protein

Also Published As

Publication number Publication date
AU4862290A (en) 1990-08-16
EP0391022A2 (de) 1990-10-10
EP0391022A3 (de) 1992-01-29
US5580758A (en) 1996-12-03
JPH11346784A (ja) 1999-12-21
KR0152996B1 (ko) 1998-10-15
PT92886A (pt) 1990-07-31
DE3901681A1 (de) 1990-07-26
PT92886B (pt) 1995-11-30
CA2008244A1 (en) 1990-07-21
AU619378B2 (en) 1992-01-23
US5159062A (en) 1992-10-27
JPH02247198A (ja) 1990-10-02
JP2939283B2 (ja) 1999-08-25

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