KR900004755A - 노지리마이신 및 관련 화합물의 제조시 유용한 중간체의 합성 방법 - Google Patents

노지리마이신 및 관련 화합물의 제조시 유용한 중간체의 합성 방법 Download PDF

Info

Publication number
KR900004755A
KR900004755A KR1019890013193A KR890013193A KR900004755A KR 900004755 A KR900004755 A KR 900004755A KR 1019890013193 A KR1019890013193 A KR 1019890013193A KR 890013193 A KR890013193 A KR 890013193A KR 900004755 A KR900004755 A KR 900004755A
Authority
KR
South Korea
Prior art keywords
isopropylidene
nozirimycin
deoxy
preparation
methods
Prior art date
Application number
KR1019890013193A
Other languages
English (en)
Other versions
KR0135284B1 (ko
Inventor
비.안제베노 피터
Original Assignee
게리 디.스트리트
메렐 다우 파마슈티칼즈 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 게리 디.스트리트, 메렐 다우 파마슈티칼즈 인코포레이티드 filed Critical 게리 디.스트리트
Publication of KR900004755A publication Critical patent/KR900004755A/ko
Application granted granted Critical
Publication of KR0135284B1 publication Critical patent/KR0135284B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hydrogenated Pyridines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

내용 없음

Description

노지리마이신 및 관련 화합물의 제조시 유용한 중간체의 합성방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 5-아지도-5-데옥시-1,2-O-이소프로필리덴-α-D-글루쿠로노락톤을 하이드라이드 환원제로 환원시킴을 특징으로 하여, 5-아미노-5-데옥시-1,2-O-이소프로필리덴-α-D-글루코푸라노스를 제조하는 방법.
  2. 제1항에 있어서, 5-아지도-5-데옥시-1,2-O-이소프로필리덴-α-D-글루쿠로노락톤을 리튬 알루미늄 하이드라이드로 환원시켜 5-아미노-5-데옥시-1,2-O-이소프로필리덴-α-D-글루코푸라노스를 제조하는 방법
  3. 5-아지도-5-데옥시-1,2-O-이소프로필리덴-α-D-글루쿠로노락톤을 하이드라이드 환원제로 환원시켜 5-아미노-5-데옥시-1,2-O-이소프로필리덴-α-D-글루코푸라노스를 수득하고, 아미노 화합물을 수성 이산화황과 반응시켜 노지리마이신 중아황산염을 수득한후, 노지리마이신으로 전환시킴을 특징으로 하여, 노지리마이신을 제조하는 방법.
  4. 제3항에 있어서, 하이드라이드 환원제가 리튬 알루미늄 하이드라이드인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890013193A 1988-09-16 1989-09-12 노지리마이신 및 관련 화합물의 제조시 유용한 중간체의 합성방법 KR0135284B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US245,848 1988-09-16
US07/245,848 US4908439A (en) 1988-09-16 1988-09-16 Synthesis of intermediate useful in the preparation of nojirimycin and related compounds

Publications (2)

Publication Number Publication Date
KR900004755A true KR900004755A (ko) 1990-04-12
KR0135284B1 KR0135284B1 (ko) 1998-04-23

Family

ID=22928336

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890013193A KR0135284B1 (ko) 1988-09-16 1989-09-12 노지리마이신 및 관련 화합물의 제조시 유용한 중간체의 합성방법

Country Status (13)

Country Link
US (1) US4908439A (ko)
EP (1) EP0359263B1 (ko)
JP (1) JP2787344B2 (ko)
KR (1) KR0135284B1 (ko)
AT (1) ATE124413T1 (ko)
CA (1) CA1323626C (ko)
DE (1) DE68923235T2 (ko)
DK (1) DK170751B1 (ko)
ES (1) ES2076181T3 (ko)
HU (1) HU202545B (ko)
IE (1) IE67558B1 (ko)
IL (1) IL91612A (ko)
ZA (1) ZA896920B (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5227479A (en) * 1989-12-20 1993-07-13 Merrell Dow Pharmaceuticals Inc. Process for the preparation of nojirimycin and related compounds
KR100446483B1 (ko) 2000-03-31 2004-09-01 미시간 스테이트 유니버시티 옥심 또는 이민으로부터 1,5-디데옥시-1,5-이미노 헥시톨제조방법
WO2010004269A2 (en) * 2008-07-10 2010-01-14 Dextra Laboratories Limited Stereospecific synthesis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634765A (en) * 1984-12-18 1987-01-06 Merrell Dow Pharmaceuticals Inc. Homodisaccharide hypoglycemic agents
DE3628486A1 (de) * 1986-08-22 1988-02-25 Bayer Ag Piperidinderivate

Also Published As

Publication number Publication date
IL91612A0 (en) 1990-04-29
IE892961L (en) 1990-03-16
ATE124413T1 (de) 1995-07-15
EP0359263A3 (en) 1990-10-24
CA1323626C (en) 1993-10-26
ZA896920B (en) 1990-06-27
EP0359263B1 (en) 1995-06-28
DK454989A (da) 1990-03-17
US4908439A (en) 1990-03-13
EP0359263A2 (en) 1990-03-21
IL91612A (en) 1994-04-12
HU202545B (en) 1991-03-28
ES2076181T3 (es) 1995-11-01
KR0135284B1 (ko) 1998-04-23
DK170751B1 (da) 1996-01-08
DE68923235D1 (de) 1995-08-03
JPH02121999A (ja) 1990-05-09
DE68923235T2 (de) 1995-11-09
JP2787344B2 (ja) 1998-08-13
DK454989D0 (da) 1989-09-15
IE67558B1 (en) 1996-04-17
HUT51280A (en) 1990-04-28

Similar Documents

Publication Publication Date Title
KR840005083A (ko) 항고혈압제로서 유용한 아미노산유도체의 제조방법
DE3773089D1 (de) Verfahren zur herstellung von thiazolidinedion-derivaten.
ES2089416T3 (es) Procedimiento de produccion de intermedios para uso en la produccion de alcoxiiminoacetamidas.
KR830000214A (ko) 펩타이드 유도체의 제법
DE3376269D1 (en) Chlorosulphonated polysulphones and polysulphone sulphonamides
GB2283016A (en) Scavenging of hydrogen sulphide
AU4611589A (en) Enzyme-inhibiting amino acid derivatives, a process for the preparation thereof, agents containing these, and the use thereof.
KR900004755A (ko) 노지리마이신 및 관련 화합물의 제조시 유용한 중간체의 합성 방법
KR890001875A (ko) 제올라이트의 제조방법
KR830006286A (ko) 빈카민 사카리내이트의 제조방법
UA8032A1 (uk) Спосіб одержання 2-(4-метоксіфенілпропіоніл)аміно-6-н-пропіламіно-4,5,6,7-тетрагідробензотіазола у вигляді рацемата або (-)-енантіомера або його кислотно-аддітивної солі
SE8504093D0 (sv) Substituted 7-oxomitosanes
KR830001890A (ko) 카바졸 유도체의 제조방법
ES2125321T3 (es) Procedimiento para la preparacion de n-alquil- y n-cicloalquil-2-benzotiazol sulfonamidas.
ES536973A0 (es) Metodo de preparar dimetiloctenonas
KR830009044A (ko) 3,5-디-3급부틸-4-하이드록시페닐-치환 복소환 화합물의 제조방법
KR850001185A (ko) 프로판-2-올 유도체의 제조방법
GB1534242A (en) Derivatives of 2-imino-4-thiazolines and thiazolidines
KR890003290A (ko) 야채절임의 제조방법
KR840008335A (ko) 살충제의 제조방법
KR910000732A (ko) 피롤리진유도체 및 그 제조방법
KR870010025A (ko) 티아졸리딘 유도체의 제조방법
KR830006215A (ko) 4-저급알킬-3-페녹시피리딘-1-옥사이드의 제조방법
KR920009690A (ko) 안정화 이산화염소 수용액의 제조방법
KR910000733A (ko) 피롤리진 유도체 제조방법

Legal Events

Date Code Title Description
A201 Request for examination
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20111221

Year of fee payment: 15

EXPY Expiration of term