KR900002797A - MAC-1 백혈구 점착 수용체의 α-아단위 - Google Patents

MAC-1 백혈구 점착 수용체의 α-아단위 Download PDF

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KR900002797A
KR900002797A KR1019890011971A KR890011971A KR900002797A KR 900002797 A KR900002797 A KR 900002797A KR 1019890011971 A KR1019890011971 A KR 1019890011971A KR 890011971 A KR890011971 A KR 890011971A KR 900002797 A KR900002797 A KR 900002797A
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알랜 스프링거 티모씨
코비 앤젤
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다나 파버 캔서 인스티튜트
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Abstract

내용 없음

Description

Mac-1 백혈구 점착 수용체의 α-아단위
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제 1 도는 Mac-1의 α아단위 cDNA 클론의 제한지도 및 서열분석 기획도이다.
제 2 도는 Mac-1의 α-아단위의 뉴클레오타이드 서열 및 cDNA-유도된 아미노산 서열을 나타낸다.
제 3 도는 Mac-1 α의 상동성 반복부를 나타낸다.

Claims (42)

  1. 천연 오염물이 실질직으로 없는 Mac-1 α-아단위 또는 이의 작용성 유도체.
  2. 제 1 항에 있어서, 언급된 Mac-1 α-아단위가 세포의 표면상에 존재하는 분자에 추가로 결합할 수 있는 Mac-1 α-아단위 또는 이의 작용성 유도체.
  3. 제 2 항에 있어서, 세포의 표면상에 존재하는 언급된 분가가 iC3b 또는 Mac-1의 다른 천연리간드인 Mac-1 α-아단위.
  4. 제 1 항에 있어서, 언급된 분자가 Mac-1 이종 이량체를 형성하기 위하여 Mac-1 β-아단위와 결합할 수 있는 Mac-1 α-아단위.
  5. 제 4 항에 있어서, 언급된 이종이량체가 iC3b 또는 Mac-1의 다른 천연리가드에 결합할 수 있는 Mac-1 α-아단위.
  6. 제 2 항에 있어서, 언급된 분자가 하기 a내지 n으로 이루어진 그룹중에서 선택되는 적어도 하나의 폴리펩타이드를 추가로 함유하는 Mac-1 α-아단위.
    a. A-N-Q-R-G-S-L ; h. Y-I-L-T-S-H-N ;
    b. M-E-Q-L-K-K-S ; i. C-Q-D-D-L-S-I ;
    c. T-D-G-E-K-F-G ; j. T-I-Q-N-Q-L-G ;
    d. G-V-F-L-Y-T-S ; l. Y-Q-H-I-G-L-V ;
    e. V-D-V-D-S-S-N-G-S-T ; m. L-F-T-A-L-F-P ;
    f. D-V-N-G-D-K-L-T-D-V-A ; n. F-S-L-V-G-T-P.
    g. D-L-T-M-D-G-L-V-D-L ;
  7. 제 2 항에 있어서, 언급된 작용성 유도체가 Mac-1 α-아단위의 단편인 Mac-1 α-아단위의 작용성 유도체.
  8. 제 2 항에 있어서, 언급된 작용성 유도체가 Mac-1 α-아단위의 변이체인 Mac-1 α-아단위의 작용성 유도체.
  9. 제 2 항에 있어서, 언급된 작용성 유도체가 Mac-1 α-아단위의 유사체인 Mac-1 α-아단위의 작용성 유도체.
  10. 제 2 항에 있어서, 언급된 작용성 유도체가 Mac-1 α-아단위의 화학적 유도체인 Mac-1 α-아단위의 작용성 유도체.
  11. Mac-1 α-아단위 또는 이의 작용성 유도체를 발현할 수 있는 재조합 DNA 분자.
  12. 제11항에 있어서, 언급된 Mac-1 α-아단위 또는 이의 작용성 유도체가 하기 a내지 n으로 이루어진 그룹중에서 선택되는 적어도 하나의 폴리펩타이드를 함유하는 DNA분자.
    a. A-N-Q-R-G-S-L ; h. Y-I-L-T-S-H-N ;
    b. M-E-Q-L-K-K-S ; i. C-Q-D-D-L-S-I ;
    c. T-D-G-E-K-F-G ; j. T-I-Q-N-Q-L-R ;
    d. G-V-F-L-Y-T-S ; k. V-Q-S-L-V-L-G ;
    e. V-D-V-D-S-S-N-G-S-T ; l. Y-Q-H-I-G-L-V ;
    f. D-V-N-G-D-K-L-T-D-V-A ; m. L-F-T-A-L-F-P ;
    g. D-L-T-M-D-G-L-V-D-L ; n. F-S-L-V-G-T-P.
  13. 제11항에 따른 재조합 분자의 발현에 의해 생성된 Mac-1 α 분자 또는 이의 작용성 유도체.
  14. Mac-1 α-아단위 및 이의 작용성 유도체로 이루어진 그룹중에서 선택되는 소염제를 염증을 억제하기에 충분한 양으로 이의 치료가 필요한 포유동물에 제공함을 특징으로 하여, 포유동물에서 비-특이적 방어계의 반응으로부터 발생하는 염증을 치료하는 방법.
  15. 제14항에 있어서, 언급된 소염제가 Mac-1 α-아단위인 방법.
  16. 제14항에 있어서, 언급된 소염제가 Mac-1 α-아단위의 작용성 유도체인 방법.
  17. 제14항에 있어서, Mac-1 β-아단위 또는 이의 작용성 유도체를 추가로 투여함을 특징으로 하는 방법.
  18. 제17항에 있어서, 언급된 Mac-1 α-아단위가 재조합 핵산 분자의 발현에 의해 생성되고, 언급된 β-아단위와 결합하여 Mac-1 이종이량체를 형성하는 방법.
  19. 제14항에 있어서, 언급된 소염제를 염증의 개시전에 포유동물에 제공하는 방법.
  20. 제14항에 있어서, 소염제를 장내 방법 및 비경구 방법으로 이루어진 그룹중에서 선택되는 방법으로 투여하는 방법.
  21. 제20항에 있어서, 비경구 방법이 근육내, 정맥내 피하 방법으로 이루어진 그룹중에서 선택되는 방법.
  22. 제14항에 있어서, 염증이 성인성 호흡곤란 증후군(adult respiratory distress syndrome), 아테롬성 동맥경화증(atherosclerosis), 패혈증에 따른 다발성 기관 손상 증후군(multiple organ injury syndrome secondary to septicemia), 외상에 따른 다발성 기관손상 증후군(multiple organ injury syndrome secondary to trauma), 조직의 재관류 손상(reperfusion injury of tissue), 급성 사구체신염(acute glomerulonephritis), 반응성 관절염(reactive arthritis), 급성 염증 성분에 의한 피부병(dermatosis with acute inflammatory components), 중추 신경계 염증 장애(central nervous system inflammatory disorder), 열상(thermal injury), 혈액투석증(hemodialysis), 류카페레시스(leukapheresis), 궤양성 대장염(ulcerative colitis), 크론 질환(Crohn's disease), 괴사성 소장결장염(necrotizing enterocolitis), 과립구 수혈 관련된 증후군(granulocyte transfusion associated syndrome), 사이토킨-유발된 독성(cytokin-induced toxicity), 및 아테롬성 동맥경화증(atherosclerosis)으로 이루어진 그룹중에서 선택된 증세와 관련되는 방법.
  23. 제22항에 있어서, 증세가 성인성 호흡 곤란 증후군인 방법.
  24. 제22항에 있어서, 증세가 패혈증에 따른 다발성 기관손상 증후군인 방법.
  25. 제22항에 있어서, 증세가 외상에 따른 다발성 기관손상 증후군인 방법.
  26. 제22항에 있어서, 증세가 조직의 재관류 손상인 방법.
  27. 제27항에 있어서, 재관류 손상이 심근조직의 재관류 손상인 방법.
  28. 제22항에 있어서, 증세가 급성 사구체신염인 방법.
  29. 제22항에 있어서, 증세가 반응성 관절염인 방법.
  30. 제22항에 있어서, 증세가 급성 염증 성분에 의한 피부병인 방법.
  31. 제22항에 있어서, 증세가 중추신경계 염증 장애인 방법.
  32. 제22항에 있어서, 중추신경계 염증 장애가 급성화농성 뇌막염인 방법.
  33. 제22항에 있어서, 증세가 열상인 방법.
  34. 제22항에 있어서, 증세가 혈액투석증인 방법.
  35. 제22항에 있어서, 증세가 류카페레시스인 방법.
  36. 제22항에 있어서, 증세가 궤양성 대장염인 방법.
  37. 제22항에 있어서, 증세가 크론 질환인 방법.
  38. 제22항에 있어서, 증세가 괴사성 소장결장염인 방법.
  39. 제22항에 있어서, 과립수 수혈 관련된 증후군인 방법.
  40. 제22항에 있어서, 증세가 사이토킨-유발된 독성인 방법.
  41. 제22항에 있어서, 증세가 아테롬성 동맥경화증인 방법.
  42. Mac-1 α-아단위, 또는 이의 작용성 유도체를 함유하는 조성물을 유효량으로 치료가 필요한 포유동물에 제공함을 특징으로 하여, 비루스 감염을 치료하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890011971A 1988-08-23 1989-08-23 MAC-1 백혈구 점착 수용체의 α-아단위 KR0185964B1 (ko)

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DK412489A (da) 1990-02-24
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EP0364690A2 (en) 1990-04-25
US20020022595A1 (en) 2002-02-21
PT91502B (pt) 1995-05-04
HU213014B (en) 1997-01-28
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