KR890014745A - Fr-900493화합물과 그 제조방법 및 그를 함유한 의약조성물 - Google Patents
Fr-900493화합물과 그 제조방법 및 그를 함유한 의약조성물 Download PDFInfo
- Publication number
- KR890014745A KR890014745A KR1019890002870A KR890002870A KR890014745A KR 890014745 A KR890014745 A KR 890014745A KR 1019890002870 A KR1019890002870 A KR 1019890002870A KR 890002870 A KR890002870 A KR 890002870A KR 890014745 A KR890014745 A KR 890014745A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- reaction
- pharmaceutical composition
- δppm
- chloroform
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/07—Bacillus
- C12R2001/085—Bacillus cereus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/832—Bacillus
- Y10S435/834—Bacillus cereus
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제 1도는 KBr에서 FR-900493화합물의 적외선 흡수스펙트럼이며,
제 2도는 D2O에서 FR-900493화합물의1H핵자기공명스펙트럼이며,
제 3도는 D2O에서 FR-900493화합물의13C핵자기공명스펙트럼이다.
Claims (8)
- 다음의 물리량 및 화학량을 가지는 FR-900493화합물(1) 외관 : 백색분말(2) 성질 : 양성(3) 용융짐 : 157-160℃(dec).(4) 광활성도 :: +27°(c 1.0, H2O)(5) 분자식 : C20H33N5O11,(6) 성분분석 : C20H33N5O112H2O에 대해 계산 : c 43.23, H 6.71, N 12.61(%)발견 C43.34, H 6.56, N 12.68(%)(9) 분자량 : SI-MS : m/z 520 ()+1)(8) 용해성 : 용해 ; 물, 비용해 ; 메탄올, 아세톤, 에틴아세데이트, 클로로포름.(7) 색반응 : 양성 ; 닌히드린, 요호드, 황산세륨 및 과망간산칼륨 각각과의 반응, 몰리시반응, 음성 ; 염화철 및 디아세틸제 각각과의 반응.(10) 박층크로마토그래피 : 정상상태 ; 실리카겔(키에셀겔 60 F-254, Merck제), 현상용매 ; n-부탄올 : 에탄올 : 클로로포름 : 28% 수성암모니아=4 : 7 : 2 : 7 v/v, Rf값 : 0.10.(11)(12) IR(KBr) : ν최대 : 3650-2200(br), 1670, 1620, 1570, 1555, 1540, 1500, 1495, 1390, 1350, 1340, 1270, 1240, 1170, 1100, 1050, 1000, 950, 920, 860, 820, 780cm-1.(13)1H NMR(D2O) : δppm ; 1.70∼2.00 (2H, m), 2.41 (3H, s). 2.44-2.68 (1H. m), 2.70-2.92 (1H, m), 3.00-3.31 (4H, m), 3.50 (1H, d. J=8Hz), 4.05-4.34 (8H, m), 5.21 (1H, br s), 5.75 (1H, d, J=2Hz), 5.82 (1H, d, J=8Hz), 7.79 (1H, d, J=8Hz).(14)13C NMR (D2O) δppm , 175.7. 171.3, 155.2, 141.9, 110.1, 102.4, 91.4. 83.7, 80.7, 78.5, 75.4, 74.2, 71,4, 71.3, 69.9, 52.3, 41.8, 39.0. 38.7, 25.0.
- 제 1항에 있어서, 영양물질내에서 바실루스종에 속하는 FR-900493화합물 생성균주를 배양한후 FR-900493화합물을 회복시키는 것으로 구성된 FR-900493화합물을 제조하는 방법.
- 제 1항에 있어서, 약제에 적합하고 본질적으로 비독성인 담체 또는 부형제에 활성성분으로 FR-900493화합물을 조합한 의약조성물.
- 제 1항에 있어서, FR-900493화합물을 약물로써 사용하는 방법.
- 제 1항에 있어서, FR-900493화합물을 항미생물제로써 사용하는 방법.
- 제 1항에 있어서, FR-900493화합물을 전염병치료 또는 예방약 제조에 사용하는 방법.
- 인간 또는 동물에게 FR-900493화합물을 주사하는 것으로 구성된 전염병치료 또는 예방방법.
- 미생물 바실루스 세레우스 No.2045(FERM BP-1791)의 생물학적 순수배양법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB888806429A GB8806429D0 (en) | 1988-03-18 | 1988-03-18 | Fr-900493 substance process for production & pharmaceutical composition containing same |
GB8806429 | 1988-03-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR890014745A true KR890014745A (ko) | 1989-10-25 |
Family
ID=10633652
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019890002870A KR890014745A (ko) | 1988-03-18 | 1989-03-09 | Fr-900493화합물과 그 제조방법 및 그를 함유한 의약조성물 |
Country Status (5)
Country | Link |
---|---|
US (1) | US4950605A (ko) |
EP (1) | EP0333177A3 (ko) |
JP (1) | JPH01296992A (ko) |
KR (1) | KR890014745A (ko) |
GB (1) | GB8806429D0 (ko) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19844469A1 (de) * | 1998-09-28 | 2000-03-30 | Herzog Mesmer Artur | Antimikrobielle Mittel, Verfahren zu deren Herstellung und deren Verwendung |
WO2007064985A2 (en) * | 2005-12-02 | 2007-06-07 | Terra Preta, Llc | Methods and compositions for improving plant growth |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4458078A (en) * | 1978-11-14 | 1984-07-03 | Fujisawa Pharmaceutical Company, Ltd. | Oxazole derivatives |
DE2963446D1 (en) * | 1978-11-14 | 1982-09-16 | Fujisawa Pharmaceutical Co | New lactyl tetrapeptide, processes for preparation thereof and pharmaceutical compositions containing it |
US4725582A (en) * | 1978-11-14 | 1988-02-16 | Fujisawa Pharmaceutical Company, Ltd. | Peptide, process for preparation thereof and use thereof |
DK156252C (da) * | 1979-07-31 | 1989-12-18 | Fujisawa Pharmaceutical Co | Analogifremgangsmaade til fremstilling af di-, tri- eller tetrapeptidderivater eller salte deraf |
JPS61134398A (ja) * | 1984-12-06 | 1986-06-21 | Microbial Chem Res Found | 新生理活性物質プリパスタチン及びその製造法 |
-
1988
- 1988-03-18 GB GB888806429A patent/GB8806429D0/en active Pending
-
1989
- 1989-03-06 US US07/319,042 patent/US4950605A/en not_active Expired - Fee Related
- 1989-03-09 KR KR1019890002870A patent/KR890014745A/ko not_active Application Discontinuation
- 1989-03-15 EP EP89104621A patent/EP0333177A3/en not_active Ceased
- 1989-03-16 JP JP1064889A patent/JPH01296992A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0333177A3 (en) | 1990-04-04 |
US4950605A (en) | 1990-08-21 |
JPH01296992A (ja) | 1989-11-30 |
GB8806429D0 (en) | 1988-04-20 |
EP0333177A2 (en) | 1989-09-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2997545B2 (ja) | 化粧用脱臭剤 | |
UA41446C2 (uk) | Застосування фумагілолу та його похідних для одержання ліків, призначених для боротьби з кишковими інфекціями, та фармацевтична композиція на їх основі | |
IL109526A0 (en) | Benzofuranyl- and thiophenyl-alkanecarboxylic acid derivatives, their preparation and pharmaceutical compositions containing them | |
NO166448C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive tiazolidindioner. | |
GR3026218T3 (en) | Antiviral 4-substituted-2-deoxy-2,3-didehydro derivatives of alpha D-neuraminic acid | |
CA2044746A1 (en) | Polypeptide compound and a process for preparation thereof | |
DE59009074D1 (de) | Diarylsubstituierte heterocyclische Verbindung, ihre Herstellung und Arzneimittel und Kosmetika daraus. | |
DE69815750D1 (de) | Verfahren zur Herstellung von Ascorbinsäurederivaten | |
HUP9802861A2 (hu) | Calendula glikozidok alkalmazása bőrsejtek túlburjánzásával kapcsolatos betegségek, így psoriasis kezelésére alkalmas gyógyászati készítmény előállítására, ezen vegyületek, valamint ezeket tartalmazó gyógyászati készítmények | |
SG46307A1 (en) | New pyrazine derivatives the preparation and use thereof | |
HUP0001741A2 (hu) | Antibakteriális hatású aza-biciklo-karbamoil-oxi-mutilin-származékok, eljárás ezek előállítására, ezeket tartalmazó készítmények és alkalmazásuk | |
KR830002510A (ko) | 생물학적 활성화합물과 하이드록시알킬 전분으로 구성되는 조성물 | |
AU3453493A (en) | Pharmaceutical preparation based on rhamnolipid against dermatological diseases, e.g. papilloma virus infections | |
CA2107485A1 (fr) | Nouveaux derives d'ellipticine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
KR890014745A (ko) | Fr-900493화합물과 그 제조방법 및 그를 함유한 의약조성물 | |
GEP20032970B (en) | Pharmaceutical Compositions of Tizoxanide and Nitazoxanide | |
WO2001017955A3 (en) | Hydroxyacetamidobenzenesulphonamide derivatives | |
DE69512419D1 (de) | IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZIN-2-CARBONSÄURE DERIVATE, IHRE HERSTELLUNG UND SIE ENTHALTENDE ARZNEIMITTEL | |
AP9801235A0 (en) | Erythromycin derivatives. | |
OA09665A (fr) | Esters d'aminoacides de l'hydroquinone, leur procédé de préparation et compositions pharmaceutiques ou cosmétiques les contenant | |
KR880009943A (ko) | 피리다지논 유도체 | |
ATE203903T1 (de) | Delta-aminolävulinsäure enthaltendes arzneimittel | |
KR940021524A (ko) | 1,2,5,6-테트라하이드로피리딘 유도체와 이의 제조 방법 및 치료시 이의 이용방법 | |
JPS5655397A (en) | Aminobenzoic acid ester derivative, and physiologically active agent containing said derivative | |
IE790857L (en) | Amino group-containing derivatives of 3-alkyl-5-(2-¹hydroxystyryl)-isoxazoles |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |