KR890014455A - Separation and Purification Method of 11a-chloro-5-hydroxy-6-methylene tetracycline - Google Patents

Separation and Purification Method of 11a-chloro-5-hydroxy-6-methylene tetracycline Download PDF

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Publication number
KR890014455A
KR890014455A KR1019880002793A KR880002793A KR890014455A KR 890014455 A KR890014455 A KR 890014455A KR 1019880002793 A KR1019880002793 A KR 1019880002793A KR 880002793 A KR880002793 A KR 880002793A KR 890014455 A KR890014455 A KR 890014455A
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South Korea
Prior art keywords
general formula
chloro
compound
hydroxy
eluted
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KR1019880002793A
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Korean (ko)
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유용걸
신연호
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채영복
재단법인 한국화학연구소
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Priority to KR1019880002793A priority Critical patent/KR890014455A/en
Publication of KR890014455A publication Critical patent/KR890014455A/en

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Abstract

내용 없음.No content.

Description

11a-클로로-5-히드록시-6-메틸렌 테트라사이클린의 분리 정제방법Separation and Purification Method of 11a-chloro-5-hydroxy-6-methylene tetracycline

내용없음No content

Claims (5)

하기 일반식(II)의 11a-클로로-5-히드록시테트라사이클린-6,12-헤미케타 또는 그의 산부가염을 황산과 반응시켜 탈수화반응액을 얻고, 탈수화반응액중에 존재하는 일반식(I)의 11a-클로로-5-히드록시-6-메틸렌 테트라 사이클린을 다공성수지에 흡착시고, 흡착된 일반식(I) 화합물을 용매로 용출시켜 고순도의 일반식(I)의 화합물의 분리, 정제방법.11a-Chloro-5-hydroxytetracycline-6,12-hemiketa of Formula (II) or acid addition salt thereof is reacted with sulfuric acid to obtain a dehydration reaction solution, and a general formula present in the dehydration reaction solution ( I) 11a-chloro-5-hydroxy-6-methylene tetracycline was adsorbed on the porous resin, and the adsorbed General Formula (I) compound was eluted with a solvent to separate and purify the compound of General Formula (I) of high purity. Way. 제1항에 있어서, 정제된 일반식(II)의 염산염을 황산과 반응시킴이 특징인 방법.A process according to claim 1, characterized in that the purified hydrochloride of general formula (II) is reacted with sulfuric acid. 제1항에 있어서, 용출용매가 저급알칸올임이 특징인 방법.The method of claim 1 wherein the eluting solvent is a lower alkanol. 제1항에 있어서, 용출된 일반식(I)화합물을 염형태로 만든후 공지의 방법에 따라 재결정함이 특징인 방법.A method according to claim 1, characterized in that the eluted compound of formula (I) is made into a salt form and then recrystallized according to a known method. 제1항 또는 제3항에 있어서, 용출된 일반식(I)화합물을 파라톨루엔술폰산염의 형태로 제조하여 분리, 정제하는 방법.4. The method according to claim 1 or 3, wherein the eluted general formula (I) compound is prepared in the form of paratoluene sulfonate, and separated and purified. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019880002793A 1988-03-17 1988-03-17 Separation and Purification Method of 11a-chloro-5-hydroxy-6-methylene tetracycline KR890014455A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019880002793A KR890014455A (en) 1988-03-17 1988-03-17 Separation and Purification Method of 11a-chloro-5-hydroxy-6-methylene tetracycline

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019880002793A KR890014455A (en) 1988-03-17 1988-03-17 Separation and Purification Method of 11a-chloro-5-hydroxy-6-methylene tetracycline

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KR890014455A true KR890014455A (en) 1989-10-23

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