KR870003122A - Method for preparing 3-vinyl cephalosporin derivative - Google Patents

Method for preparing 3-vinyl cephalosporin derivative Download PDF

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Publication number
KR870003122A
KR870003122A KR1019850006544A KR850006544A KR870003122A KR 870003122 A KR870003122 A KR 870003122A KR 1019850006544 A KR1019850006544 A KR 1019850006544A KR 850006544 A KR850006544 A KR 850006544A KR 870003122 A KR870003122 A KR 870003122A
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South Korea
Prior art keywords
formula
compound
preparing
syn
xii
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KR1019850006544A
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Korean (ko)
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KR870001807B1 (en
Inventor
정동인
이소영
안순길
안원준
Original Assignee
김동희
주식회사 종근당
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Priority to KR1019850006544A priority Critical patent/KR870001807B1/en
Publication of KR870003122A publication Critical patent/KR870003122A/en
Application granted granted Critical
Publication of KR870001807B1 publication Critical patent/KR870001807B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

내용 없음No content

Description

3-비닐 세팔로스포린 유도체의 제조방법Method for preparing 3-vinyl cephalosporin derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (3)

구조식(X)의 활성화된 카르복실산 유도체(Syn-이성체)와 구조식(XI) 또는 구조식(XII)의 3-비닐 세펨 유도체를 반응시켜 구조식(XIII)의 화합물을 만들고, 아연으로 보호기를 동시에 제거하여 구조식(Ⅰ)(Syn-이성체)의 화합물을 제조하는 방법.Reacting an activated carboxylic acid derivative (Syn-isomer) of formula (X) with a 3-vinyl cefem derivative of formula (XI) or formula (XII) to form a compound of formula (XIII), simultaneously removing the protecting group with zinc To prepare a compound of formula (I) (Syn-isomer). (상기구조식에서 R2는 수소 혹은 트리클로로 에틸기이다)(Wherein R 2 is hydrogen or trichloroethyl group) 제1항에 있어서, 구조식(XI)의 화합물은 구조식(XIV)의 화합물을 1,8-디아자비사이클로[5,4,0]운덱-7-엔과 같은 염기존재하에 구조식(XV)의 이미니움 염과 반응시킨후 생성된 구조식(XVI)의 화합물을 분리하지 않고 바로 탈리반응시킨후 탈아실화하여 제조하는 방법.The compound of formula (XI) according to claim 1, wherein the compound of formula (XI) is a compound of formula (XIV) in the presence of a base such as 1,8-diazabicyclo [5,4,0] undec-7-ene. A method of preparing by de-acylating the compound of the structural formula (XVI) after the reaction with the nitrile salt without detaching the compound immediately. 제1항에 있어서, 구조식(XII)의 화합물은 구조식(XVII)의 화합물을 아연으로 탈에스테르화하여 구조식 (XVIII)의 화합물을 만든후 아미다아제(Amisdae)로 탈아실화하여 제조하는 방법.The method of claim 1, wherein the compound of formula (XII) is prepared by deesterification of a compound of formula (XVII) with zinc to form a compound of formula (XVIII), followed by deacylation with amidase. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019850006544A 1985-09-07 1985-09-07 Process for preparing 3-vinyl-cephalosporin derivatives KR870001807B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019850006544A KR870001807B1 (en) 1985-09-07 1985-09-07 Process for preparing 3-vinyl-cephalosporin derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019850006544A KR870001807B1 (en) 1985-09-07 1985-09-07 Process for preparing 3-vinyl-cephalosporin derivatives

Publications (2)

Publication Number Publication Date
KR870003122A true KR870003122A (en) 1987-04-15
KR870001807B1 KR870001807B1 (en) 1987-10-13

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Application Number Title Priority Date Filing Date
KR1019850006544A KR870001807B1 (en) 1985-09-07 1985-09-07 Process for preparing 3-vinyl-cephalosporin derivatives

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Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100392409B1 (en) 2000-03-20 2003-07-22 한미정밀화학주식회사 A process for preparing cephalosporine derivatives using new thiazole compound

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Publication number Publication date
KR870001807B1 (en) 1987-10-13

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