KR840009110A - Process for preparing ester compound of alpha-amino benzyl penicillin - Google Patents

Process for preparing ester compound of alpha-amino benzyl penicillin Download PDF

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Publication number
KR840009110A
KR840009110A KR1019830002338A KR830002338A KR840009110A KR 840009110 A KR840009110 A KR 840009110A KR 1019830002338 A KR1019830002338 A KR 1019830002338A KR 830002338 A KR830002338 A KR 830002338A KR 840009110 A KR840009110 A KR 840009110A
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KR
South Korea
Prior art keywords
alpha
formula
ester compound
benzyl penicillin
amino benzyl
Prior art date
Application number
KR1019830002338A
Other languages
Korean (ko)
Other versions
KR850000612B1 (en
Inventor
정재규, (외 1)
Original Assignee
김동회
주식회사 종근당
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 김동회, 주식회사 종근당 filed Critical 김동회
Priority to KR1019830002338A priority Critical patent/KR850000612B1/en
Publication of KR840009110A publication Critical patent/KR840009110A/en
Application granted granted Critical
Publication of KR850000612B1 publication Critical patent/KR850000612B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/28—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with modified 2-carboxyl group
    • C07D499/32—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음No content

Description

알파-아미노 벤질 페니실린의 에스테르 화합물의 제조방법Process for preparing ester compound of alpha-amino benzyl penicillin

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (5)

공지의 화합물인 구조식(Ⅲ)의 메틸렌-(비스)-알파-아미노 페닐 아세트 아미노 페니실란산의 염을 비프로톤성 극성 용매중 상간 이동 촉매 존재하에 공지의 화합물 구조식(Ⅳ)의 알파-클로로 디에틸 카르보네이트와 반응시켜 구조식(Ⅴ)의 에스테르 화합물을 만든 다음 공지의 방법으로 가수 분해하여 구조식(Ⅰ)의 1′-에톡시 카르보닐 옥시에틸-6-[디(-)알파-아미니 페닐 아세트 아미도] 페니실라-네이트 염산염을 제조하는 방법.The salt of the methylene- (bis) -alpha-amino phenyl acetamino peniclanic acid of formula (III) which is a known compound is subjected to the alpha-chloro di of formula (IV) Reaction with ethyl carbonate to produce an ester compound of formula (V), followed by hydrolysis by known methods to yield 1'-ethoxycarbonyl oxyethyl-6- [di (-) alpha-amini of formula (I). Phenyl acet amido] penicila-ate hydrochloride. (상기 구조식에서 M은 알칼리 금속을 나타낸다)(Wherein M represents an alkali metal) ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019830002338A 1983-05-27 1983-05-27 Process for preparing alpha-amino benzyl penicillin esters KR850000612B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019830002338A KR850000612B1 (en) 1983-05-27 1983-05-27 Process for preparing alpha-amino benzyl penicillin esters

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019830002338A KR850000612B1 (en) 1983-05-27 1983-05-27 Process for preparing alpha-amino benzyl penicillin esters

Publications (2)

Publication Number Publication Date
KR840009110A true KR840009110A (en) 1984-12-24
KR850000612B1 KR850000612B1 (en) 1985-05-01

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830002338A KR850000612B1 (en) 1983-05-27 1983-05-27 Process for preparing alpha-amino benzyl penicillin esters

Country Status (1)

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KR (1) KR850000612B1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1375492B1 (en) * 2001-03-30 2011-08-17 Nippon Soda Co., Ltd. Process for producing (dioxolenon-4-yl)methyl ester derivative

Also Published As

Publication number Publication date
KR850000612B1 (en) 1985-05-01

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