KR830001947A - Method of preparing the compound - Google Patents

Method of preparing the compound

Info

Publication number
KR830001947A
KR830001947A KR1019800000546A KR800000546A KR830001947A KR 830001947 A KR830001947 A KR 830001947A KR 1019800000546 A KR1019800000546 A KR 1019800000546A KR 800000546 A KR800000546 A KR 800000546A KR 830001947 A KR830001947 A KR 830001947A
Authority
KR
South Korea
Prior art keywords
group
general formula
compound
carboxy group
reacting
Prior art date
Application number
KR1019800000546A
Other languages
Korean (ko)
Other versions
KR830001903B1 (en
Inventor
올르 고츠프레드센 와근
본 대느 웰프
Original Assignee
에르링그 쥬을 니엘슨
레오 파마슈티칼 프로덕츠 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에르링그 쥬을 니엘슨, 레오 파마슈티칼 프로덕츠 리미티드 filed Critical 에르링그 쥬을 니엘슨
Publication of KR830001947A publication Critical patent/KR830001947A/en
Application granted granted Critical
Publication of KR830001903B1 publication Critical patent/KR830001903B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

내용 없음No content

Description

화합물의 제조방법Method of preparing the compound

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this content is publicly disclosed, the full text is not included.

Claims (1)

본문에 상술한 바와 같이 다음 일반식(5)의 화합물을 A 및 B 위치에서 접촉 수소화시키거나 가수분해시키고, 또는 다음 일반식(11)의 6-아미노페니실린산 에스테르를 다음 일반식(12)의 산반응성 유도체와 반응시키거나, 또는 다음 일반식(13)의 아미노페니실린을 다음 일반식(8)의 화합물과 반응시키는 것으로 구성된 다음 일반식(1)의 화합물을 제조하는 방법.The compound of the following general formula (5) is hydrogenated or hydrolyzed at positions A and B as described above in the text, or the 6-aminopenicillic acid ester of the following general formula (11) is A method for preparing a compound of general formula (1) consisting of reacting with an acid-reactive derivative or reacting an aminopenicillin of general formula (13) with a compound of general formula (8). 식 중,Where, R1은 페닐, 4-하이드록시페닐, 1,4-사이클로헥사디에닐 또는 3-티에닐기이고,R 1 is a phenyl, 4-hydroxyphenyl, 1,4-cyclohexadienyl or 3-thienyl group, R2는 1급 아미노 또는 카복시기이며,R 2 is a primary amino or carboxy group, R3는 수소원자, 또는 저급알킬, 아릴 또는 아랄킬기, 바람직하기는 메틸, 페닐 또는 벤질기이고,R 3 is a hydrogen atom, or a lower alkyl, aryl or aralkyl group, preferably a methyl, phenyl or benzyl group, A는 β-락탐환 뿐만 아니라 카복시기를 함유하는 β-락타마제 억제제의 기이며, A는 카복시기를 통하여 결합되고,A is a β-lactam ring as well as a group of β-lactamase inhibitors containing a carboxy group, A is bound through the carboxy group, B는 아지도기, 보호된 아미노기, 또는 보호된 카복시기이며,B is an azido group, a protected amino group, or a protected carboxy group, M은 양이온이고,M is a cation, X는 할로겐원자 또는 유사한 유리기이다.X is a halogen atom or a similar free group. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: Disclosure is based on the original application.
KR1019800000546A 1979-02-13 1980-02-12 Method for producing peniclanate derivative KR830001903B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB05020/79 1979-02-13
GB5020/79 1979-02-13
GB7905020 1979-02-13

Publications (2)

Publication Number Publication Date
KR830001947A true KR830001947A (en) 1983-05-21
KR830001903B1 KR830001903B1 (en) 1983-09-19

Family

ID=10503160

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019800000546A KR830001903B1 (en) 1979-02-13 1980-02-12 Method for producing peniclanate derivative

Country Status (4)

Country Link
JP (2) JPS55113790A (en)
KR (1) KR830001903B1 (en)
BE (1) BE881675A (en)
ZA (1) ZA80796B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020028298A (en) * 2000-10-09 2002-04-17 황해용 Underpaper and manufacturing apparatus thereof

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4714761A (en) * 1979-03-05 1987-12-22 Pfizer Inc. 6,6-dihalopenicillanic acid 1,1-dioxides and process
US4420426A (en) 1979-03-05 1983-12-13 Pfizer Inc. 6-Alpha-halopenicillanic acid 1,1-dioxides
US4309347A (en) 1979-05-16 1982-01-05 Pfizer Inc. Penicillanoyloxymethyl penicillanate 1,1,1',1'-tetraoxide
US4244951A (en) * 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4364957A (en) * 1979-09-26 1982-12-21 Pfizer Inc. Bis-esters of alkanediols as antibacterial agents
US4432970A (en) * 1979-11-23 1984-02-21 Pfizer Inc. 6-beta-Halopenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
IE51516B1 (en) * 1980-10-06 1987-01-07 Leo Pharm Prod Ltd 1,1-dioxapenicillanoyloxymethyl 6-(d-alpha-amino-alpha-phenylacetamido)penicillanate napsylate
IL64009A (en) * 1980-10-31 1984-09-30 Rech Applications Therap Crystalline 1,1-dioxopenicillanoyloxymethyl 6-(d-alpha-amino-alpha-phenylacetamido)penicillanate tosylate hydrates,their production and pharmaceutical compositions containing them
US4478748A (en) * 1981-02-20 1984-10-23 Pfizer Inc. Bis-esters of alkanediols
US4419284A (en) * 1981-03-23 1983-12-06 Pfizer Inc. Preparation of halomethyl esters (and related esters) of penicillanic acid 1,1-dioxide
IN159362B (en) * 1981-03-23 1987-05-09 Pfizer
ZA821903B (en) * 1981-03-23 1983-01-26 Pfizer Process for the preparation of penicillanic acid esters
US4582829A (en) * 1981-09-09 1986-04-15 Pfizer Inc. Antibacterial 6'-(2-amino-2-[4-acyloxyphenyl]acetamido)penicillanoyloxymethyl penicillanate 1,1-dioxide compounds
JPS5857384A (en) * 1981-09-09 1983-04-05 フアイザ−・インコ−ポレ−テツド Antibacterial penicillanic acid 6'-(2-amino- 2-(4-acyloxyphenyl)acetamide)penicillanoyloxymethyl- 1,1-dioxide compound
US4540687A (en) * 1981-09-09 1985-09-10 Pfizer Inc. Antibacterial 6'-(2-amino-2-[4-acyloxyphenyl]acetamido)penicillanoyloxymethyl penicillanate 1,1-dioxide compounds
US4351840A (en) * 1981-09-18 1982-09-28 Pfizer Inc. Antibacterial esters of resorcinol with ampicillin and penicillanic acid 1,1-dioxide derivatives
US4359472A (en) * 1981-12-22 1982-11-16 Pfizer Inc. Bis-hydroxymethyl carbonate bridged antibacterial agents
US4444686A (en) * 1982-01-25 1984-04-24 Pfizer Inc. Crystalline penicillin ester intermediate
US4432987A (en) * 1982-04-23 1984-02-21 Pfizer Inc. Crystalline benzenesulfonate salts of sultamicillin
PH20068A (en) * 1982-12-06 1986-09-18 Pfizer Process and intermediates for sultamicillin and analogs
US4835674A (en) * 1986-07-28 1989-05-30 Bull Hn Information Systems Inc. Computer network system for multiple processing elements
DE102004021281A1 (en) * 2004-04-29 2005-11-24 Boehringer Ingelheim Vetmedica Gmbh Use of meloxicam formulations in veterinary medicine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1578128A (en) * 1976-03-30 1980-11-05 Leo Pharm Prod Ltd Amidinopenicillanoyloxyalkyl amoxycillinates

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020028298A (en) * 2000-10-09 2002-04-17 황해용 Underpaper and manufacturing apparatus thereof

Also Published As

Publication number Publication date
KR830001903B1 (en) 1983-09-19
ZA80796B (en) 1981-02-25
JPS62281879A (en) 1987-12-07
BE881675A (en) 1980-08-12
JPH0470315B2 (en) 1992-11-10
JPS55113790A (en) 1980-09-02
JPS6259709B2 (en) 1987-12-12

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