KR890005120A - 마크롤리드 화합물 - Google Patents
마크롤리드 화합물 Download PDFInfo
- Publication number
- KR890005120A KR890005120A KR1019880011662A KR880011662A KR890005120A KR 890005120 A KR890005120 A KR 890005120A KR 1019880011662 A KR1019880011662 A KR 1019880011662A KR 880011662 A KR880011662 A KR 880011662A KR 890005120 A KR890005120 A KR 890005120A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- compound
- hydroxyl group
- general formula
- compound according
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Biochemistry (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pyrane Compounds (AREA)
- Devices For Conveying Motion By Means Of Endless Flexible Members (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (10)
- 하기 일반식(Ⅰ)의 화합물 및 그의 염상기식중, R1은 메틸, 에틸 또는 이소프로필기이고, R2는 산소 또는 황원자에 의해 단속되는 C2-7알칼기, 아릴, 아릴C1-7알킬 또는 헤테로아릴 C1-7알킬기를 나타내고, OR3는 히드록실기 또는 최대로 25개의 탄소원자를 갖는 치환된 히드록실기이고, =NOR2는 E배열이다.
- 제1항에 있어서, R1이 이소프로필기인 화합물.
- 제1 또는 2항에 있어서, R2가 메톡시메틸, 벤질, p-니트로벤질 또는 티에닐메틸기인 화합물.
- 상기 전항중 어느 하나의 항에 있어서, OR3가 메톡시 카르보닐옥시, 아세톡시 또는 히드록시기인 화합물.
- 제1항에 있어서, R1이 이소프로필기이고, R2가 p-니트로벤질기이고, OR3가 히드록시기인 화합물.
- 1종 이상의 담체 및(또는) 부형제와 함께 적어도 하나의 제1항에 의한 화합물 유효량을 함유하는 의약품용 조성물.
- 1종 이상으 담체 및(또는) 부형제와 함께 적어도 하나의 제1항에 의한 화합물 유효량을 함유하는 수의약품용 조성물.
- 1종 이상의 담체 및(또는) 부형제와 함께 적어도 하나의 제1항에 의한 화합물 유효량을 함유하는 해충 방제용 조성물.
- 1종 이상의 제1항에 의한 화합물 유효량을 식물 또는 기타 초목에 사용하거나, 또는 모충자체 또는 그 서식지에 시용하는 것으로 되는, 농업, 원예 또는 삼림지 또는 상점, 빌딩, 또는 기타 공공장소, 또는 모충 서식지중의 해충 박멸방법.
- (A)하기 일반식(Ⅱ)의 화합물.(여기에서, R1및 OR3는 제1항에서 정의된 바와같음) 또는 그의 염을 H2NOR2(여기에서 R2는 제1항에서 정의된 바와같음)과 반응시키고, 바람직한 경우, 이어서 OR3가 보호된 히드록실기인, 생성된 일반식(Ⅰ)의 화합물을 보호기 제거하거나, (B)OR3가 치환된 히드록실기인 일반식(Ⅰ)의 화합물을, OR3가 히드록실기인 대응하는 일반식(Ⅰ)의 화합물을 히드록실기를 치환된 히드록실기로 전환시키는 시약과 반응시켜서 제조하거나, (C)R2가 수소원자이고, OR3가 치환된 히드록실기인 일반식(Ⅰ)의 화합물을 에테르화제 R2Y(여기에서,Y는 이탈기임)과 반응시키고, 바람직한 경우, 이어서 OR3가 보호된 히드록실기인 일반식(Ⅰ)의 화합물을 보호기 제거하거나, 또는 (D)OR3가 히드록실기인 일반식(Ⅰ)의 화합물을, OR3가 보호된 히드록실기인 대응하는 일반식(Ⅰ)의 화합물을 보호기 제거하여 제조하는 것으로 되는, 제1항에 의한 화합물의 제조방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8721377 | 1987-09-11 | ||
GB878721377A GB8721377D0 (en) | 1987-09-11 | 1987-09-11 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
KR890005120A true KR890005120A (ko) | 1989-05-11 |
Family
ID=10623614
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880011662A KR890005120A (ko) | 1987-09-11 | 1988-09-09 | 마크롤리드 화합물 |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0307225B1 (ko) |
JP (1) | JPH01163181A (ko) |
KR (1) | KR890005120A (ko) |
AT (1) | ATE110384T1 (ko) |
AU (1) | AU621061B2 (ko) |
BR (1) | BR8804668A (ko) |
CA (1) | CA1329592C (ko) |
DD (1) | DD274225A5 (ko) |
DE (1) | DE3851190T2 (ko) |
DK (1) | DK505088A (ko) |
ES (1) | ES2058297T3 (ko) |
GB (1) | GB8721377D0 (ko) |
HU (1) | HU203352B (ko) |
NZ (1) | NZ226114A (ko) |
PT (1) | PT88463B (ko) |
ZA (1) | ZA886743B (ko) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ233680A (en) * | 1989-05-17 | 1995-02-24 | Beecham Group Plc | Avermectins and milbemycins and compositions thereof |
US4988824A (en) * | 1989-09-11 | 1991-01-29 | Maulding Donald R | Process for the preparation of 23-(C1-C6 alkyloxime)-LL-F28249 compounds |
US5478951A (en) * | 1994-06-22 | 1995-12-26 | American Cyanamid Company | Method for the purification of 23-E isomers of 23-imino derivatives of LL-F28249 compounds |
WO2012028556A1 (en) | 2010-08-31 | 2012-03-08 | Bayer Animal Health Gmbh | Macrocyclic lactones and their use and their combinations with other active substances |
DE102010064245A1 (de) | 2010-12-28 | 2012-06-28 | Bayer Animal Health Gmbh | Makrocylischen Lactone und deren Verwendung und deren Kombinationen mit anderen Wirkstoffen |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3532794A1 (de) * | 1984-09-14 | 1986-04-17 | Glaxo Group Ltd., London | Antibiotika, verfahren zu deren herstellung und diese verbindungen enthaltende mittel |
ES8802229A1 (es) * | 1985-04-30 | 1988-04-16 | Glaxo Group Ltd | Un procedimiento para preparar nuevos derivados lactonicos macrociclicos. |
CA1296329C (en) * | 1986-06-06 | 1992-02-25 | Derek R. Sutherland | Macrolide compounds |
EP0260537A1 (en) * | 1986-09-12 | 1988-03-23 | American Cyanamid Company | 13-Deoxy-23-oxo(keto) and 23-imino derivatives of 13-deoxy C-076-aglycone compounds |
ES2058082T3 (es) * | 1986-09-12 | 1994-11-01 | American Cyanamid Co | Derivados 23-oxo (ceto) y 23-imino de compuestos ll-f28249. |
-
1987
- 1987-09-11 GB GB878721377A patent/GB8721377D0/en active Pending
-
1988
- 1988-09-09 AT AT88308349T patent/ATE110384T1/de not_active IP Right Cessation
- 1988-09-09 DD DD88319664A patent/DD274225A5/de not_active IP Right Cessation
- 1988-09-09 BR BR8804668A patent/BR8804668A/pt active Search and Examination
- 1988-09-09 DK DK505088A patent/DK505088A/da not_active Application Discontinuation
- 1988-09-09 DE DE3851190T patent/DE3851190T2/de not_active Expired - Fee Related
- 1988-09-09 EP EP88308349A patent/EP0307225B1/en not_active Expired - Lifetime
- 1988-09-09 CA CA000576933A patent/CA1329592C/en not_active Expired - Fee Related
- 1988-09-09 AU AU22084/88A patent/AU621061B2/en not_active Ceased
- 1988-09-09 ZA ZA886743A patent/ZA886743B/xx unknown
- 1988-09-09 JP JP63224826A patent/JPH01163181A/ja active Pending
- 1988-09-09 ES ES88308349T patent/ES2058297T3/es not_active Expired - Lifetime
- 1988-09-09 NZ NZ226114A patent/NZ226114A/en unknown
- 1988-09-09 HU HU884654A patent/HU203352B/hu not_active IP Right Cessation
- 1988-09-09 KR KR1019880011662A patent/KR890005120A/ko not_active Application Discontinuation
- 1988-09-09 PT PT88463A patent/PT88463B/pt not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0307225B1 (en) | 1994-08-24 |
ES2058297T3 (es) | 1994-11-01 |
NZ226114A (en) | 1990-12-21 |
BR8804668A (pt) | 1989-04-18 |
DK505088D0 (da) | 1988-09-09 |
HU203352B (en) | 1991-07-29 |
JPH01163181A (ja) | 1989-06-27 |
DK505088A (da) | 1989-03-12 |
DE3851190T2 (de) | 1995-01-12 |
EP0307225A3 (en) | 1989-10-25 |
CA1329592C (en) | 1994-05-17 |
HUT48253A (en) | 1989-05-29 |
ZA886743B (en) | 1989-08-30 |
PT88463A (pt) | 1988-10-01 |
EP0307225A2 (en) | 1989-03-15 |
DD274225A5 (de) | 1989-12-13 |
AU621061B2 (en) | 1992-03-05 |
ATE110384T1 (de) | 1994-09-15 |
DE3851190D1 (de) | 1994-09-29 |
GB8721377D0 (en) | 1987-10-21 |
AU2208488A (en) | 1989-03-16 |
PT88463B (pt) | 1992-11-30 |
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A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E601 | Decision to refuse application |