KR890002228A - 태반조직 단백질 pp 4의 정제방법 - Google Patents
태반조직 단백질 pp 4의 정제방법 Download PDFInfo
- Publication number
- KR890002228A KR890002228A KR1019880009268A KR880009268A KR890002228A KR 890002228 A KR890002228 A KR 890002228A KR 1019880009268 A KR1019880009268 A KR 1019880009268A KR 880009268 A KR880009268 A KR 880009268A KR 890002228 A KR890002228 A KR 890002228A
- Authority
- KR
- South Korea
- Prior art keywords
- sulfate
- carrier
- mol
- calcium ions
- purifying
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4721—Lipocortins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/85—Reproductive organs or embryos
- Y10S530/851—Placenta; amniotic fluid
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cleaning Implements For Floors, Carpets, Furniture, Walls, And The Like (AREA)
- Detergent Compositions (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Saccharide Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (7)
- 칼슘이온의 존재하에서, PP 4-함유 용액을 담체-결합된 삭카라이드 폴리설페이트 또는 설페이트화된 당과 접촉시키고, 상등액을 제거한 다음, 경우에 따라 PP 4가 함유된 담체기질을 세척한 후, PP 4를 용출시킴을 특징으로 하여, PP 4를 정제하는 방법.
- 제1항에 있어서, 담체물질이 불용성 아가로스, 댁스트란, 폴리아크릴아미드, 아미노-작용GHK된 담체 수지 또는, 폴리에틸렌 글리콜, 펜타에스쓰리톨 및 메타크릴레이트의 공중합체, 또는 이의 혼합물인 방법.
- 제1항에 있어서, 삭카라이드 폴리설페이트가 헤파린, 텍스트란 설페이트, GP파란 설페치트, 콘도로이틴 설페이트, 케라탄 설페이트 또는 테르마탄 설페이트인 방법.
- 제1항에 있어서, 담체-결합된 헤파린 또는 텍스트란 설페이트, 바람직하게는 담체-결합된 헤파린을 사용하는 방법.
- 제1항에 있어서, 칼슘이온 0.001 내지 0.2mol/l가 존재하는 방법.
- 제1항에 있어서, 담체-결합된 헤파린, 댁스트란 설페이트, 헤파란 설페이트, 콘드로이틴 설페이트, 케라탄설페이트 또는 데르마탄 설페이트를 사용하는 방법.
- 제1항에 있어서, 칼슘이온 0.01 내지 0.2mal/l, 바람직하게는 0.003 내지 0.02mol/l 및, Nacl, Kcl 또는 Licl 0.001 내지 0.4 mol/l, 바람직하게는 0.05 내지 0.3mal/l를 합유하면 pH가 5.5 내지 0.6인 완충제를 사용하여 세척하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEP3724726.3 | 1987-07-25 | ||
DE19873724726 DE3724726A1 (de) | 1987-07-25 | 1987-07-25 | Verfahren zur reinigung des plazentaren gewebeproteins pp4 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR890002228A true KR890002228A (ko) | 1989-04-10 |
KR970001810B1 KR970001810B1 (ko) | 1997-02-15 |
Family
ID=6332384
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880009268A KR970001810B1 (ko) | 1987-07-25 | 1988-07-23 | 태반조직 단백질 pp4의 정제방법 |
Country Status (13)
Country | Link |
---|---|
US (1) | US4990597A (ko) |
EP (1) | EP0301374B1 (ko) |
JP (1) | JP2511500B2 (ko) |
KR (1) | KR970001810B1 (ko) |
AT (1) | ATE85344T1 (ko) |
AU (1) | AU620553B2 (ko) |
CA (1) | CA1327675C (ko) |
DE (2) | DE3724726A1 (ko) |
DK (1) | DK411088A (ko) |
ES (1) | ES2038721T3 (ko) |
FI (1) | FI90553C (ko) |
GR (1) | GR3007613T3 (ko) |
PT (1) | PT88067B (ko) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3643182A1 (de) * | 1986-12-18 | 1988-06-30 | Behringwerke Ag | Arzneimittel enthaltend das gewebeprotein pp4, verfahren zur herstellung von pp4 und zu seiner pasteurisierung sowie die verwendung von pp4 |
US5225330A (en) * | 1988-08-01 | 1993-07-06 | The United States Of America As Represented By The Department Of Health And Human Services | Diagnostic kit and diagnostic method utilizing carbohydrate receptors |
US5136026A (en) * | 1989-04-10 | 1992-08-04 | Behringwerke Aktiengesellschaft | Process for removing toxins from protein solutions |
DE3911629A1 (de) * | 1989-04-10 | 1990-10-11 | Behringwerke Ag | Verfahren zur abtrennung von toxinen aus proteinloesungen |
DE3939169A1 (de) * | 1989-11-27 | 1991-05-29 | Behringwerke Ag | Verfahren zur reinigung von lipocortinen |
DE4003773A1 (de) * | 1990-02-08 | 1991-08-14 | Behringwerke Ag | Verfahren zur reinigung von lipocortinen |
BE1004336A3 (fr) * | 1991-01-15 | 1992-11-03 | Analis Sa | Procede de separation et de quantification de l'hemoglobine glycosylee hb a1c. |
US5968477A (en) | 1994-01-24 | 1999-10-19 | Neorx Corporation | Radiolabeled annexin conjugates with hexose and a chelator |
US20030220233A1 (en) | 1994-01-24 | 2003-11-27 | Neorx Corporation | Radiolabeled annexins |
WO1999010405A1 (en) * | 1997-08-26 | 1999-03-04 | Ranbar Electrical Materials, Inc. | Varnished compositions, methods of making and components made therefrom |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ187246A (en) * | 1976-03-04 | 1980-05-27 | New Zealand Dev Finance | Hydrophilic hydroxy c2-c4 alkylated crosslinked regenerated cellulose |
DE3315000A1 (de) * | 1983-04-26 | 1984-10-31 | Behringwerke Ag, 3550 Marburg | Gewebeprotein pp(pfeil abwaerts)4(pfeil abwaerts), verfahren zu seiner gewinnung sowie seine verwendung |
NZ208241A (en) * | 1984-05-22 | 1987-09-30 | John Stephen Ayers | Purification of blood plasma or serum: selective removal of (very) low density lipoproteins (ldl and vldl) |
DE3533516A1 (de) * | 1984-09-21 | 1986-04-03 | Boehringer Ingelheim KG, 6507 Ingelheim | Blutgerinnungshemmende proteine, verfahren zur herstellung sowie deren verwendung |
DE3519011A1 (de) * | 1985-05-25 | 1986-11-27 | Behringwerke Ag, 3550 Marburg | Verfahren zur herstellung eines materials zur affinitaetschromatographie |
CA1265446A (en) * | 1985-09-30 | 1990-02-06 | Masahiro Maki | Anticoagulating substance, process for preparing same and anticoagulant comprising same as an effective component |
-
1987
- 1987-07-25 DE DE19873724726 patent/DE3724726A1/de not_active Withdrawn
-
1988
- 1988-07-19 ES ES198888111576T patent/ES2038721T3/es not_active Expired - Lifetime
- 1988-07-19 DE DE8888111576T patent/DE3878075D1/de not_active Expired - Fee Related
- 1988-07-19 AT AT88111576T patent/ATE85344T1/de not_active IP Right Cessation
- 1988-07-19 EP EP88111576A patent/EP0301374B1/de not_active Expired - Lifetime
- 1988-07-21 FI FI883450A patent/FI90553C/fi not_active IP Right Cessation
- 1988-07-22 AU AU19735/88A patent/AU620553B2/en not_active Ceased
- 1988-07-22 DK DK411088A patent/DK411088A/da not_active Application Discontinuation
- 1988-07-22 US US07/222,998 patent/US4990597A/en not_active Expired - Fee Related
- 1988-07-22 PT PT88067A patent/PT88067B/pt not_active IP Right Cessation
- 1988-07-22 JP JP63181948A patent/JP2511500B2/ja not_active Expired - Lifetime
- 1988-07-23 KR KR1019880009268A patent/KR970001810B1/ko not_active IP Right Cessation
- 1988-07-25 CA CA000572953A patent/CA1327675C/en not_active Expired - Fee Related
-
1993
- 1993-04-09 GR GR930400521T patent/GR3007613T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
FI90553B (fi) | 1993-11-15 |
DE3878075D1 (de) | 1993-03-18 |
DK411088D0 (da) | 1988-07-22 |
PT88067A (pt) | 1989-06-30 |
CA1327675C (en) | 1994-03-08 |
EP0301374A2 (de) | 1989-02-01 |
DK411088A (da) | 1989-01-26 |
ATE85344T1 (de) | 1993-02-15 |
PT88067B (pt) | 1995-03-01 |
ES2038721T3 (es) | 1993-08-01 |
DE3724726A1 (de) | 1989-02-02 |
EP0301374A3 (en) | 1990-01-31 |
AU1973588A (en) | 1989-01-27 |
JP2511500B2 (ja) | 1996-06-26 |
KR970001810B1 (ko) | 1997-02-15 |
JPS6435000A (en) | 1989-02-06 |
US4990597A (en) | 1991-02-05 |
FI883450A (fi) | 1989-01-26 |
FI883450A0 (fi) | 1988-07-21 |
FI90553C (fi) | 1994-02-25 |
AU620553B2 (en) | 1992-02-20 |
EP0301374B1 (de) | 1993-02-03 |
GR3007613T3 (ko) | 1993-08-31 |
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