KR880010767A - 비스테로이드성 소염제를 함유하는 약제학적 제제 - Google Patents

비스테로이드성 소염제를 함유하는 약제학적 제제 Download PDF

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Publication number
KR880010767A
KR880010767A KR1019880002422A KR880002422A KR880010767A KR 880010767 A KR880010767 A KR 880010767A KR 1019880002422 A KR1019880002422 A KR 1019880002422A KR 880002422 A KR880002422 A KR 880002422A KR 880010767 A KR880010767 A KR 880010767A
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South Korea
Prior art keywords
pharmaceutical formulation
pharmaceutical
inflammatory agent
nonsteroidal anti
acid
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Application number
KR1019880002422A
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English (en)
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KR960016204B1 (ko
Inventor
다께오 이이지마
마사끼 오따기리
데쭈 미요시
마사오 우에노
Original Assignee
후가와 히데아끼
니씬 가가꾸 가부시끼가이샤
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Priority claimed from JP5205487A external-priority patent/JPH0768120B2/ja
Priority claimed from JP63027791A external-priority patent/JPH01203335A/ja
Application filed by 후가와 히데아끼, 니씬 가가꾸 가부시끼가이샤 filed Critical 후가와 히데아끼
Publication of KR880010767A publication Critical patent/KR880010767A/ko
Application granted granted Critical
Publication of KR960016204B1 publication Critical patent/KR960016204B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/01—Hydrolysed proteins; Derivatives thereof
    • A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2063—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

내용 없음

Description

비스테로이드성 소염제를 함유하는 약제학적 제제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 아이부프로펜(ibuprofen) 고체 제제를 개에 경구 투여할 경우 혈청증 아이부프로펜 농도의 시간에 따른 변화를 나타내는 그래프, 제2도는 아이부프로펜 제제를 개에 경구 투여할 경우 혈청 중 아이부프포펜 농도의 시간에 따른 변화를 나태내는 그래프

Claims (9)

  1. (a) 평균분자크기가 약 100 m이하인 산성 비스테로이드성 소염제 및 (b) 평균분자량이 4,000 내지 12,000인 단백질 가수분해물 도는 폴리팹타이드를 함유하는 경구 투여용 약제학적 제제
  2. 제1항에 있어서, 부형제, 붕해제, 윤활제 등과 같은 약제학적 제제용으로 알려진 첨가제를 추가로 함유하는 약제학적 제제.
  3. 제1항에 있어서, 성분(a)가 아이부프로펜, 케토 프로펜, 나프록센, 톨메틴, 푸라비프로펜 또는 알클로페낙과 같은 페닐프로피온산 계열의 비스테로이드성 소염제;아스피린과 같은 살리실란 계열의 비스테로이드성 소염제;메페님산 또는 플루페남산과 같은 안트라닐산 계열의 비스테로이드성 소염제;또는 인도메타신인 약제학적 제제.
  4. 제1항에 있어서, 성분(b)가 젤라틴 또는 카세인의 가수분해물인 약제학적 제제.
  5. 제1항에 있어서, 성분(b)가 성분(a)의 중량을 기준으로 하여 0 내지 10중량배의 양으로 존재하는 약제학적 제제.
  6. 제1항에 있어서, 정제형태의 약제학적 제제.
  7. 제1항에 있어서, 과립제 형태의 약제학적 제제.
  8. 제1항에 있어서, 캅셀제 형태의 약제학적 제제.
  9. 제1항에 있어서, 무수 시럽제 형태의 약제학적 제제.
    ※참고사항;최초출원 내용에 의하여 공개하는 것임.
KR1019880002422A 1987-03-09 1988-03-09 비스테로이드성 소염제를 함유하는 약제학적 제제 KR960016204B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP52054/1987 1987-03-09
JP62-52054 1987-03-09
JP5205487A JPH0768120B2 (ja) 1987-03-09 1987-03-09 非ステロイド性抗炎症薬経口投与用組成物
JP27791/1988 1988-02-10
JP63027791A JPH01203335A (ja) 1988-02-10 1988-02-10 非ステロイド性抗炎症薬含有固形製剤

Publications (2)

Publication Number Publication Date
KR880010767A true KR880010767A (ko) 1988-10-24
KR960016204B1 KR960016204B1 (ko) 1996-12-06

Family

ID=26365771

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880002422A KR960016204B1 (ko) 1987-03-09 1988-03-09 비스테로이드성 소염제를 함유하는 약제학적 제제

Country Status (5)

Country Link
US (1) US5080907A (ko)
EP (1) EP0282020B1 (ko)
KR (1) KR960016204B1 (ko)
CA (1) CA1324083C (ko)
DE (1) DE3882157T2 (ko)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2623976B1 (fr) * 1987-12-08 1994-02-25 So Ge Val Comprime pour animal domestique
FR2650502B1 (fr) * 1989-08-07 1994-05-27 Delagrange Laboratoires Nouvelle forme galenique orale ameliorant la biodisponibilite
DE4140179C2 (de) * 1991-12-05 1995-12-21 Alfatec Pharma Gmbh Akutform für ein Ibuprofen enthaltendes Arzneimittel
US5932245A (en) * 1991-12-05 1999-08-03 Alfatec Pharma Gmbh Gelatin or collagen hydrolysate containing drug formulation that provides for immediate release of nanoparticle drug compounds
DE4140172C2 (de) * 1991-12-05 1995-12-21 Alfatec Pharma Gmbh Retardform für ein Ibuprofen enthaltendes Arzneimittel
DE4140194C2 (de) * 1991-12-05 1998-02-19 Alfatec Pharma Gmbh Ein Dihydropyridinderivat in Nanosolform enthaltendes Arzneimittel und seine Herstellung
DE4140184C2 (de) * 1991-12-05 1995-12-21 Alfatec Pharma Gmbh Akutform für ein Flurbiprofen enthaltendes Arzneimittel
DE4140192C2 (de) * 1991-12-05 1996-02-29 Alfatec Pharma Gmbh Sol-gesteuerte Thermokolloidmatrix auf Gelatinebasis für perorale Retardformen
DE4140183C2 (de) * 1991-12-05 1995-12-21 Alfatec Pharma Gmbh Retardform für ein Flurbiprofen enthaltendes Arzneimittel
DE4140178C2 (de) * 1991-12-05 1998-02-19 Alfatec Pharma Gmbh Akutform für ein Indolylessigsäurederivat enthaltendes Arzneimittel und seine Herstellung
DE4140185C2 (de) * 1991-12-05 1996-02-01 Alfatec Pharma Gmbh Ein 2-Arylpropionsäurederivat in Nanosolform enthaltendes Arzneimittel und seine Herstellung
DE4221880A1 (de) * 1992-07-03 1994-01-05 Alfatec Pharma Gmbh Feste und flüssige Lösungen von schwer wasserlöslichen Arzneistoffen
DK138592D0 (da) * 1992-11-17 1992-11-17 Nycomed Dak As Tabletter
WO1999003451A1 (en) * 1997-07-16 1999-01-28 Antrin Research Limited Pharmaceutical formulations for oral administration
US6197347B1 (en) 1998-06-29 2001-03-06 Andrx Pharmaceuticals, Inc. Oral dosage for the controlled release of analgesic
US20040132823A1 (en) * 2001-11-02 2004-07-08 Leo Pavliv Pharmaceutical composition of 2-(4-isobutylphenyl) propionic acid
DE10158039A1 (de) * 2001-11-27 2003-07-03 Kosmas Kg Antiphlogistisches Mittel und dessen Verwendung
EP1744757A4 (en) * 2004-05-04 2009-04-22 Equitech Corp IMPROVED ENHANCED COMPOSITION
US7582679B2 (en) * 2006-02-03 2009-09-01 Pharmaceutics International Incorporated Compositions containing solid ibuprofen concentrates and methods of making solid ibuprofen concentrates
US20070190130A1 (en) * 2006-02-16 2007-08-16 Mark William A Protein hydrolysate excipients

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL291817A (ko) * 1900-01-01
NL291819A (ko) *
DE2843963A1 (de) * 1978-10-09 1980-04-24 Merck Patent Gmbh Im koerper resorbierbare geformte masse auf basis von kollagen und ihre verwendung in der medizin
DK150008C (da) * 1981-11-20 1987-05-25 Benzon As Alfred Fremgangsmaade til fremstilling af et farmaceutisk oralt polydepotpraeparat
CA1208558A (en) * 1982-10-07 1986-07-29 Kazuo Kigasawa Soft buccal
US4474766A (en) * 1983-06-27 1984-10-02 Merck & Co., Inc. Anti-inflammatory/analgesic combination of cyclo-(N-methyl-Ala-Tyr-D-Trp-Lys-Val-Phe) and a selected non-steroidal anti-inflammatory drug (NSAID)

Also Published As

Publication number Publication date
EP0282020A2 (en) 1988-09-14
EP0282020B1 (en) 1993-07-07
US5080907A (en) 1992-01-14
CA1324083C (en) 1993-11-09
DE3882157D1 (de) 1993-08-12
EP0282020A3 (en) 1990-02-28
DE3882157T2 (de) 1993-11-11
KR960016204B1 (ko) 1996-12-06

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