KR880009007A - 퀴놀린 카복실산의 제조방법 및 그의 중간체 - Google Patents
퀴놀린 카복실산의 제조방법 및 그의 중간체 Download PDFInfo
- Publication number
- KR880009007A KR880009007A KR1019880000331A KR880000331A KR880009007A KR 880009007 A KR880009007 A KR 880009007A KR 1019880000331 A KR1019880000331 A KR 1019880000331A KR 880000331 A KR880000331 A KR 880000331A KR 880009007 A KR880009007 A KR 880009007A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- hydrogen atom
- general formula
- lower alkyl
- compound
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
내용 없음.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (4)
- (a) 일반식 (II)의 벤조일아세트산 유도체를 일반식 (III)의 피롤리딘 유도체와 반응시켜 일반식 (IV)의 화합물을 수득하고 ; (b) 일반식 (IV)의 화합물을 에틸 오르토포르메이트 및 아세트산 무수물, 또는 디메틸포름아미드 디메틸아세탈과 반응시켜 축합된 화합물을 생성한 다음, 축합된 화합물을 사이클로프로필아민으로 처리하여 일반식 (V)의 아크릴산 유도체를 수득하고 ; (c) 일반식 (V)의 아크릴산 유도체를 염기 촉매의 존재하에 폐환시키고, R이 저급 알킬그룹이고/이거나, R′ 또는 R2가 아미노 보로그룹인 반응 생성물이 수득되는 경우 수득된 생성물을 산 또는 염기로 처리하고/하거나 환원적 분해시킴을 특징으로하여, 구조식 (I)의 화합물을 제조하는 방법.상기식에서, R은 수소원자 또는 저급 알킬그룹이고, X는 할로겐원자이고, R′ 및 R2는 각각 독립적으로 수소원자 또는 아미노그룹에 대한 보호그룹이거나, R1이 R2와 함께 보호그룹이다.
- 제1항에 있어서, R1및 R2는 각각 독립적으로 수소원자, 저급 알킬그룹 또는 알콕시카보닐그룹이거나, R1이 R2와 함께 프탈로일그룹인 방법.
- 일반식 (IV)의 벤조일아세트산 유도체.상기식에서, R은 수소원자 또는 저급 알킬그룹이고, X는 할로겐원자이고, R1및 R2는 각각 독립적으로 수소원자 또는 아미노그룹에 대한 보호그룹이거나, R1이 R2와 함께 보호그룹이다.
- 일반식 (V)의 벤조일아크릴산 유도체.상기식에서, R은 수소원자 또는 저급 알킬그룹이고, X는 할로겐원자이고, R1및 R2는 각각 독립적으로 수소원자 또는 아미노그룹에 대한 보호그룹이거나, R1이 R2와 함께 보호그룹이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP?62-11907 | 1987-01-21 | ||
JP62011907A JPS63179856A (ja) | 1987-01-21 | 1987-01-21 | キノロンカルボン酸誘導体の製造方法並びにその中間体 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR880009007A true KR880009007A (ko) | 1988-09-13 |
Family
ID=11790793
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880000331A KR880009007A (ko) | 1987-01-21 | 1988-01-18 | 퀴놀린 카복실산의 제조방법 및 그의 중간체 |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0275971A1 (ko) |
JP (1) | JPS63179856A (ko) |
KR (1) | KR880009007A (ko) |
CN (1) | CN88100318A (ko) |
AU (1) | AU594858B2 (ko) |
HU (1) | HU198200B (ko) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5173484A (en) * | 1988-02-05 | 1992-12-22 | Bayer Aktiengesellschaft | Quinolone- and naphthyridone carboxylic acid derivatives, process for their production, antibacterial compositions and feed additives containing them |
DE3906365A1 (de) * | 1988-07-15 | 1990-01-18 | Bayer Ag | 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe |
EP0486687A4 (en) * | 1989-07-21 | 1992-06-17 | Iolab Corporation | Quinolonecarboxylic acid derivatives |
IT1248011B (it) * | 1991-06-07 | 1995-01-05 | Mediolanum Farmaceutici Spa | Procedimento per la preparazione dell'acido 9-fluoro-10- (4-metil-1-piperazinil)-7-oxo-2,3-diidro-7h-pirido (1,2,3-de) (1,4)benzotiadin-6-carbossilico cloridrato. |
DE4342186A1 (de) * | 1993-12-10 | 1995-06-14 | Bayer Ag | Eintopfverfahren zur Herstellung von 3-Chinoloncarbonsäurederivaten |
DE10026903A1 (de) * | 2000-06-03 | 2002-01-10 | Cpc Cellular Process Chemistry | Verfahren zur Herstellung von Chinolon-3-carbonsäuren |
DE10162684A1 (de) | 2001-12-19 | 2003-07-10 | Bayer Ag | Verfahren zur Herstellung von Aminen |
AU2003234810A1 (en) * | 2002-05-17 | 2003-12-02 | Daiichi Pharmaceutical Co., Ltd. | Process for producing quinolonecarboxylic acid derivative |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL56517A0 (en) * | 1978-02-02 | 1979-03-12 | American Cyanamid Co | Novel 4-(cycloalkyl or cyclalkenyl substituted) amino, alkylamino or alkenylamino benzoic acids, salts and derivatives |
IN162769B (ko) * | 1984-11-13 | 1988-07-09 | Kyorin Seiyaku Kk | |
HUT40639A (en) * | 1985-03-08 | 1987-01-28 | Kyorin Seiyaku Kk | Process for producing quinolon-carboxylic acid derivative and pharmaceutical composition containing them |
-
1987
- 1987-01-21 JP JP62011907A patent/JPS63179856A/ja active Pending
-
1988
- 1988-01-18 KR KR1019880000331A patent/KR880009007A/ko not_active Application Discontinuation
- 1988-01-19 EP EP88100683A patent/EP0275971A1/en not_active Withdrawn
- 1988-01-20 AU AU10639/88A patent/AU594858B2/en not_active Ceased
- 1988-01-20 HU HU88215A patent/HU198200B/hu not_active IP Right Cessation
- 1988-01-21 CN CN198888100318A patent/CN88100318A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
AU1063988A (en) | 1988-07-28 |
AU594858B2 (en) | 1990-03-15 |
EP0275971A1 (en) | 1988-07-27 |
CN88100318A (zh) | 1988-08-03 |
HU198200B (en) | 1989-08-28 |
JPS63179856A (ja) | 1988-07-23 |
HUT45985A (en) | 1988-09-28 |
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Legal Events
Date | Code | Title | Description |
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WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |