KR880003957A - Method for preparing cephalosporin derivative - Google Patents

Method for preparing cephalosporin derivative Download PDF

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Publication number
KR880003957A
KR880003957A KR1019860008168A KR860008168A KR880003957A KR 880003957 A KR880003957 A KR 880003957A KR 1019860008168 A KR1019860008168 A KR 1019860008168A KR 860008168 A KR860008168 A KR 860008168A KR 880003957 A KR880003957 A KR 880003957A
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KR
South Korea
Prior art keywords
group
formula
compound
methyl
aminothiazol
Prior art date
Application number
KR1019860008168A
Other languages
Korean (ko)
Other versions
KR890001285B1 (en
Inventor
고문규
신재무
김동수
김덕희
Original Assignee
우대규
한일약품공업 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 우대규, 한일약품공업 주식회사 filed Critical 우대규
Priority to KR1019860008168A priority Critical patent/KR890001285B1/en
Publication of KR880003957A publication Critical patent/KR880003957A/en
Application granted granted Critical
Publication of KR890001285B1 publication Critical patent/KR890001285B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

내용 없음No content

Description

세팔로스포린 유도체의 제조방법Method for preparing cephalosporin derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (2)

다음 일반식(Ⅱ)의 유기산과 다음 일반식(Ⅲ)의 화합물을 반응시켜 다음 일반식(Ⅳ)의 화합물을 제조한 다음 이를 다음 일반식(Ⅴ)의 화합물과 반응시킴을 특징으로 하는 다음 일반식(Ⅰ)의 화합물의 제조방법.Next, a compound of Formula (IV) is prepared by reacting an organic acid of Formula (II) with a compound of Formula (III), and then reacting it with a compound of Formula (V) Process for the preparation of a compound of formula (I). [상기 일반식에서 R1은 2-(2-아미노티아졸-4-일)-2-신-메톡시이미노아세틸기, 2-(2-아미노티아졸-4-일)-2-신-(2-카르복시프로프-2-옥시이미노아세틸기, 또는 2-(2-아미노티아졸-4-일)-2-신-(2-t-부톡시카르보닐프로프-2-옥시이미노)아세틸기와 D-(-)--(4-히드록시-6-메틸피리딘-3-카르복스아미도)--(4-히드록시페닐)아세틸기를 나타내고, R2는 아세톡시메틸기, (2,5-디히드로-6-히드록시-2-메틸-5-옥소-1,2,4-트리아진)-3-일]티오메틸기, (1-메틸피롤리딘이 오메틸기, (1-피리딘이움)메틸기와[(1-메틸-1H-테트라졸)-5-일]티오메틸기를 나타내고, M은 수소나 나트륨원자를 나타내고, X,Y는 각각 염소원자 또는 수소원자를 나타낸다.[Wherein R 1 is 2- (2-aminothiazol-4-yl) -2-cin-methoxyiminoacetyl group, 2- (2-aminothiazol-4-yl) -2-cin- ( 2-carboxyprop-2-oxyiminoacetyl group, or 2- (2-aminothiazol-4-yl) -2-cin- (2-t-butoxycarbonylprop-2-oxyimino) acetyl Tile D-(-)- -(4-hydroxy-6-methylpyridine-3-carboxamido)- A-(4-hydroxyphenyl) acetyl group, R 2 is an acetoxymethyl group, (2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazine)- 3-yl] thiomethyl group, (1-methylpyrrolidin represents a 5-methyl group, (1-pyridinium) methyl group [[1-methyl-1H-tetrazol) -5-yl] thiomethyl group, M is Hydrogen or sodium, and X and Y each represent a chlorine atom or a hydrogen atom. 제1항에서 일반식(Ⅳ)의 활성에스테르를 한용기내의 반응으로 제조함을 특징으로 하는 제조방법.A process according to claim 1, wherein the active ester of general formula (IV) is prepared by reaction in a single container. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019860008168A 1986-09-29 1986-09-29 Process for preparing cephalosporin derivatives KR890001285B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019860008168A KR890001285B1 (en) 1986-09-29 1986-09-29 Process for preparing cephalosporin derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019860008168A KR890001285B1 (en) 1986-09-29 1986-09-29 Process for preparing cephalosporin derivatives

Publications (2)

Publication Number Publication Date
KR880003957A true KR880003957A (en) 1988-05-31
KR890001285B1 KR890001285B1 (en) 1989-04-28

Family

ID=19252553

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860008168A KR890001285B1 (en) 1986-09-29 1986-09-29 Process for preparing cephalosporin derivatives

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KR (1) KR890001285B1 (en)

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Publication number Publication date
KR890001285B1 (en) 1989-04-28

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