KR900007776A - Method for preparing naphthalene derivative - Google Patents

Method for preparing naphthalene derivative Download PDF

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Publication number
KR900007776A
KR900007776A KR1019890017218A KR890017218A KR900007776A KR 900007776 A KR900007776 A KR 900007776A KR 1019890017218 A KR1019890017218 A KR 1019890017218A KR 890017218 A KR890017218 A KR 890017218A KR 900007776 A KR900007776 A KR 900007776A
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KR
South Korea
Prior art keywords
compound
formula
lower alkyl
lithium
methyl
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KR1019890017218A
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Korean (ko)
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KR950013084B1 (en
Inventor
다카시 스즈키
미네히코 야마무라
신이치 야마다
Original Assignee
치바타 이치로
다나베 세이야쿠 가부시끼가이샤
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Publication of KR900007776A publication Critical patent/KR900007776A/en
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Publication of KR950013084B1 publication Critical patent/KR950013084B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C67/347—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings

Abstract

내용 없음No content

Description

나프탈렌 유도체의 제조방법Method for preparing naphthalene derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (10)

일반식(Ⅱ)의 화합물을 일반식(Ⅲ)의 화합물과 반응시켜 일반식(Ⅳ)의 화합물을 수득한 후, 일반식(Ⅳ)의 화합물 또는 이의 염을 일반식(Ⅴ)의 화합물과 반응시키고, 경우에 따라, 추가로 생성물을 약제학적으로 허용되는 이의 염으로 전환시키는 단계를 포함함을 특징으로 하여, 일반식(Ⅰ)의 나프탈렌 유도체 또는 약제학적으로 허용되는 이의 염을 제조하는 방법.The compound of formula (II) is reacted with a compound of formula (III) to obtain a compound of formula (IV), and then the compound of formula (IV) or a salt thereof is reacted with a compound of formula (V). And optionally converting the product into a pharmaceutically acceptable salt thereof, wherein the naphthalene derivative of formula (I) or a pharmaceutically acceptable salt thereof is prepared. 상기식에서,In the above formula, R1, R2, R3, R4, R5, R6, R7및 R8은 저급 알킬 그룹이다.R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are lower alkyl groups. 제1항에서, 일반식(Ⅱ)의 화합물과 일반식(Ⅲ)이 화합물의 반응을 유기 리튬 화합물의 존재하에서 수행하는 방법.The process according to claim 1, wherein the reaction of the compound of general formula (II) with the compound of general formula (III) is carried out in the presence of an organolithium compound. 제2항에 있어서, 유기 리튬 화합물이 저급 알킬 리튬, 알릴 리튬 디-저급 알킬 아미드인 방법.The method of claim 2 wherein the organolithium compound is lower alkyl lithium, allyl lithium di-lower alkyl amide. 제2항에 있어서, 유기 리튬 화합물이 n-부틸 리튬인 방법.The method of claim 2, wherein the organolithium compound is n-butyl lithium. 제2항에 있어서, R1및 R2가 메틸 또는 에틸이고, R3및 R4가 메틸, 에틸 또는 이소프로필이며, R5, R6, R7및 R8이 메틸인 방법.The method of claim 2, wherein R 1 and R 2 are methyl or ethyl, R 3 and R 4 are methyl, ethyl or isopropyl, and R 5 , R 6 , R 7 and R 8 are methyl. 일반식(Ⅱ)의 화합물을 일반식(Ⅲ)의 화합물과 반응시키는 단계를 포함함을 특징으로 하여, 일반식(Ⅳ)의 화합물을 제조하는 방법.A method of preparing a compound of formula (IV), comprising reacting a compound of formula (II) with a compound of formula (III). 상기식에서,In the above formula, R3, R4, R5, R6, R7및 R8은 저급 알킬 그룹이다.R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are lower alkyl groups. 제6항에 있어서, 일반식(Ⅱ)이 화합물과 일반식(Ⅲ)의 화합물의 반응을 유기 리튬 화합물의 존재하에서 수행하는 방법.The process according to claim 6, wherein the general formula (II) is carried out in the presence of an organolithium compound. 제7항에 있어서, 유기 리튬 화합물이 저급 알킬 리튬, 아릴 리튬 또는 리튬 디-저급 알킬 아미드인 방법.8. The method of claim 7, wherein the organolithium compound is lower alkyl lithium, aryl lithium or lithium di-lower alkyl amide. 제7항에 있어서, 유기 리튬 화합물이 n-부틸 리튬인 방법.8. The method of claim 7, wherein the organolithium compound is n-butyl lithium. 제7항에 있어서, R3및 R4가 메틸, 에틸 또는 이소프로필이며, R5, R6, R7및 R8이 메틸인 방법.8. The method of claim 7, wherein R 3 and R 4 are methyl, ethyl or isopropyl and R 5 , R 6 , R 7 and R 8 are methyl. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019890017218A 1988-11-29 1989-11-27 Process for preparing a naphthalene derivative KR950013084B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP63303335A JPH02149546A (en) 1988-11-29 1988-11-29 Preparation of naphthalene derivative
JP63-303335 1988-11-29
JP88-303335 1988-11-29

Publications (2)

Publication Number Publication Date
KR900007776A true KR900007776A (en) 1990-06-01
KR950013084B1 KR950013084B1 (en) 1995-10-24

Family

ID=17919736

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890017218A KR950013084B1 (en) 1988-11-29 1989-11-27 Process for preparing a naphthalene derivative

Country Status (16)

Country Link
US (1) US5066825A (en)
EP (1) EP0371484A3 (en)
JP (1) JPH02149546A (en)
KR (1) KR950013084B1 (en)
CN (1) CN1043932A (en)
BG (1) BG50500A3 (en)
CA (1) CA2002612A1 (en)
DK (1) DK599689A (en)
FI (1) FI895652A0 (en)
HU (1) HU204023B (en)
IE (1) IE893631L (en)
IL (1) IL92303A0 (en)
NO (1) NO170010C (en)
PH (2) PH26342A (en)
PT (1) PT92413A (en)
ZA (1) ZA898900B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6680344B1 (en) 1999-06-01 2004-01-20 The University Of Texas Southwestern Medical Center Method of treating hair loss using diphenylmethane derivatives
US6646005B1 (en) 1999-06-01 2003-11-11 The University Of Texas Southwestern Medical Center Method of treating hair loss using sulfonyl thyromimetic compounds
MXPA01012493A (en) 1999-06-01 2003-09-10 Univ Texas Southwestern Med Ct Method of treating hair loss using diphenylether derivatives.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8705837A1 (en) * 1985-01-10 1987-05-16 Tanabe Seiyaku Co Naphthalene derivatives, process for the preparation thereof and pharmaceutical composition containing same.

Also Published As

Publication number Publication date
PT92413A (en) 1990-05-31
EP0371484A2 (en) 1990-06-06
IL92303A0 (en) 1990-07-26
ZA898900B (en) 1990-08-29
IE893631L (en) 1990-05-29
NO894737L (en) 1990-05-30
EP0371484A3 (en) 1991-04-10
KR950013084B1 (en) 1995-10-24
FI895652A0 (en) 1989-11-27
CA2002612A1 (en) 1990-06-29
AU613250B2 (en) 1991-07-25
PH26342A (en) 1992-04-29
NO894737D0 (en) 1989-11-28
DK599689A (en) 1990-05-30
PH26331A (en) 1992-04-29
HUT53060A (en) 1990-09-28
US5066825A (en) 1991-11-19
JPH02149546A (en) 1990-06-08
DK599689D0 (en) 1989-11-28
HU896312D0 (en) 1990-02-28
NO170010B (en) 1992-05-25
CN1043932A (en) 1990-07-18
AU4551389A (en) 1990-06-07
BG50500A3 (en) 1992-08-14
NO170010C (en) 1992-09-02
HU204023B (en) 1991-11-28

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