KR860007267A - Simple Manufacturing Method of Cemfe derivatives - Google Patents

Simple Manufacturing Method of Cemfe derivatives Download PDF

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Publication number
KR860007267A
KR860007267A KR1019850001654A KR850001654A KR860007267A KR 860007267 A KR860007267 A KR 860007267A KR 1019850001654 A KR1019850001654 A KR 1019850001654A KR 850001654 A KR850001654 A KR 850001654A KR 860007267 A KR860007267 A KR 860007267A
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KR
South Korea
Prior art keywords
formula
compound
cemfe
derivatives
reacting
Prior art date
Application number
KR1019850001654A
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Korean (ko)
Other versions
KR870001984B1 (en
Inventor
임성기
문순구
이관순
Original Assignee
임성기
한미약품공업 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 임성기, 한미약품공업 주식회사 filed Critical 임성기
Priority to KR1019850001654A priority Critical patent/KR870001984B1/en
Priority to IT67781/85A priority patent/IT1189604B/en
Priority to JP22109685A priority patent/JPS61186391A/en
Publication of KR860007267A publication Critical patent/KR860007267A/en
Application granted granted Critical
Publication of KR870001984B1 publication Critical patent/KR870001984B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

내용 없음No content

Description

세펨유도체의 간단한 제조방법Simple Manufacturing Method of Cemfe derivatives

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (1)

구조식(Ⅳ)의 디알킬(또는 디아릴) 클로로치오포스페이트와 구조식(Ⅴ)의 1-하이드록시벤조트리아졸을 반응시켜 신규의 구조식(Ⅵ) 화합물을 제조하고, 이 화합물과 구조식(Ⅱ)의 유기산을 반응시켜 얻어진 구조식(Ⅲ)의 반응성 아마이드의 용매화물을 구조식(Ⅲ) 화합물과 아실화 반응을 시켜서 구조식(Ⅰ) 화합물을 제조하는 방법.By reacting the dialkyl (or diaryl) chlorothio phosphate of formula (IV) with 1-hydroxybenzotriazole of formula (V), a novel compound of formula (VI) was prepared, and the compound of formula (II) A process for preparing a compound of formula (I) by subjecting a solvate of a reactive amide of formula (III) obtained by reacting an organic acid to an acylation reaction with a compound of formula (III). 상기식에서,In the above formula, R1은 수소 또는 알카리금속 또는 알카리토류금속 ;R 1 is hydrogen or an alkali metal or an alkaline earth metal; R2는 수소, 메틸, 아세톡시에틸, 또는 -CH2-S-R3기, 여기에서 R3는 1내지 4의 헤테로 원자를 함유하고 또한 저급알킬기로 치환될 수도 있는 5원 또는 6원의 복소환기를 의미한다.R 2 is hydrogen, methyl, acetoxyethyl, or —CH 2 —SR 3 group, wherein R 3 is a 5 or 6 membered heterocyclic group containing 1 to 4 hetero atoms and which may be substituted with lower alkyl groups Means. R4는 에틸 또는 페닐을 의미한다.R 4 means ethyl or phenyl. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019850001654A 1984-11-03 1985-03-14 Process for preparing cephem derivatives KR870001984B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
KR1019850001654A KR870001984B1 (en) 1985-03-14 1985-03-14 Process for preparing cephem derivatives
IT67781/85A IT1189604B (en) 1984-11-03 1985-09-16 PREPARATION PROCEDURE FOR CEFEM DERIVATIVES
JP22109685A JPS61186391A (en) 1984-11-03 1985-10-03 Manufacture of cephem derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019850001654A KR870001984B1 (en) 1985-03-14 1985-03-14 Process for preparing cephem derivatives

Publications (2)

Publication Number Publication Date
KR860007267A true KR860007267A (en) 1986-10-10
KR870001984B1 KR870001984B1 (en) 1987-10-24

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850001654A KR870001984B1 (en) 1984-11-03 1985-03-14 Process for preparing cephem derivatives

Country Status (1)

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KR (1) KR870001984B1 (en)

Also Published As

Publication number Publication date
KR870001984B1 (en) 1987-10-24

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Free format text: OPPOSITION NUMBER: 001987000233001987000540; OPPOSITION DATE: 26230127