KR860004068A - Simple Manufacturing Method of Cemfe derivatives - Google Patents

Simple Manufacturing Method of Cemfe derivatives Download PDF

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Publication number
KR860004068A
KR860004068A KR1019840006886A KR840006886A KR860004068A KR 860004068 A KR860004068 A KR 860004068A KR 1019840006886 A KR1019840006886 A KR 1019840006886A KR 840006886 A KR840006886 A KR 840006886A KR 860004068 A KR860004068 A KR 860004068A
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KR
South Korea
Prior art keywords
formula
compound
cemfe
derivatives
simple manufacturing
Prior art date
Application number
KR1019840006886A
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Korean (ko)
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KR870001333B1 (en
Inventor
임성기
Original Assignee
임성기
한미약품공업 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 임성기, 한미약품공업 주식회사 filed Critical 임성기
Priority to KR1019840006886A priority Critical patent/KR870001333B1/en
Priority to IT67781/85A priority patent/IT1189604B/en
Priority to JP22109685A priority patent/JPS61186391A/en
Publication of KR860004068A publication Critical patent/KR860004068A/en
Application granted granted Critical
Publication of KR870001333B1 publication Critical patent/KR870001333B1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

내용 없음No content

Description

세펨유도체의 간단한 제조방법Simple Manufacturing Method of Cemfe derivatives

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (1)

구조식(IV)의 디알킬(또는 디아릴)클로로포스페이트와 구조식(V)의 1-하이드록시벤조트리아졸을 반응시켜 신규의 구조식(VI)화합물을 제조하고 이 화합물과 구조식(II)의 유기산을 반응시켜 얻어진 구조식(III)의 반응성 아마이드의 용매화물을 구조식(III)화합물과 아실화 반응을 시켜서 구조식(I)화합물을 제조하는 방법.By reacting the dialkyl (or diaryl) chlorophosphate of formula (IV) with 1-hydroxybenzotriazole of formula (V), a novel compound of formula (VI) is prepared and the organic acid of formula (II) A process for preparing a compound of formula (I) by subjecting a solvate of a reactive amide of formula (III) to acylation with a compound of formula (III). 상기식에서, R1은 수소, 또는 알칼리금속 또는 알카리 토류금속; R2는 수소, 메틸, 아세톡시에틸, 또는 -CH2-S-R3기, 여기에서 R3는 1 내지 4의 헤테로 원자를 함유하고 또한 저급알킬기로 치환될 수 있는 5원 또는 6원 복소환기를 의미한다. R4는 에틸 또는 에틸 또는 페닐을 의미한다.Wherein R 1 is hydrogen or an alkali metal or alkaline earth metal; R 2 is hydrogen, methyl, acetoxyethyl, or —CH 2 —SR 3 group, wherein R 3 is a 5 or 6 membered heterocyclic group containing 1 to 4 hetero atoms and which may be substituted with lower alkyl groups it means. R 4 means ethyl or ethyl or phenyl. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019840006886A 1984-11-03 1984-11-03 Process for preparing cephem derivatives KR870001333B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
KR1019840006886A KR870001333B1 (en) 1984-11-03 1984-11-03 Process for preparing cephem derivatives
IT67781/85A IT1189604B (en) 1984-11-03 1985-09-16 PREPARATION PROCEDURE FOR CEFEM DERIVATIVES
JP22109685A JPS61186391A (en) 1984-11-03 1985-10-03 Manufacture of cephem derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019840006886A KR870001333B1 (en) 1984-11-03 1984-11-03 Process for preparing cephem derivatives

Publications (2)

Publication Number Publication Date
KR860004068A true KR860004068A (en) 1986-06-16
KR870001333B1 KR870001333B1 (en) 1987-07-18

Family

ID=19236056

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840006886A KR870001333B1 (en) 1984-11-03 1984-11-03 Process for preparing cephem derivatives

Country Status (1)

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KR (1) KR870001333B1 (en)

Also Published As

Publication number Publication date
KR870001333B1 (en) 1987-07-18

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