KR880000106A - 지속적으로 방출하는 제약학적 제제 - Google Patents

지속적으로 방출하는 제약학적 제제 Download PDF

Info

Publication number
KR880000106A
KR880000106A KR870005994A KR870005994A KR880000106A KR 880000106 A KR880000106 A KR 880000106A KR 870005994 A KR870005994 A KR 870005994A KR 870005994 A KR870005994 A KR 870005994A KR 880000106 A KR880000106 A KR 880000106A
Authority
KR
South Korea
Prior art keywords
particulate material
group
ion exchange
acidic
polymer
Prior art date
Application number
KR870005994A
Other languages
English (en)
Other versions
KR950003609B1 (ko
Inventor
게브르 셀타시 이삭
제이알. 러셀 네스티르
아이어 유마
비. 파우지 마디
Original Assignee
원본 미기재
워너-람버트 컴퍼니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 원본 미기재, 워너-람버트 컴퍼니 filed Critical 원본 미기재
Publication of KR880000106A publication Critical patent/KR880000106A/ko
Application granted granted Critical
Publication of KR950003609B1 publication Critical patent/KR950003609B1/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B33/00—After-treatment of single crystals or homogeneous polycrystalline material with defined structure

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

내용 없음

Description

지속적으로 방출하는 제약학적 제제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
본 도면은 실시예에 기재된 환약의 방출 양상을 표시한다.

Claims (10)

  1. a) 최소 하나의 활성 물질을 최소 하나의 이온적으로 중성 중합체 또는 최소 하나의 이온성 미립자재료와 접촉시키고 ;
    b) 이온쌍이 활성 물질은 미립자 재료에 결합시키고 중심을 중합체의 중성 피복물로 피복하여 막을 형성시킨 중성 중합체, 미립자 재료 및 활성 물질의 합성물을 생성 시키고 ; 및
    c)단꼐 (b)의 생성물을 회수하는 단계로 구성되는, 생물학적 활성 물질을 처리하는 방법.
  2. 제 1 항에 있어서, 미립자 재료가 단계 (a)전에 산성 또는 염기성 특성인 방법.
  3. 제 2 항에 있어서, 미립자 재료가 카올린, 비카올린 도로, 산성 또는 염기성 특성을 갖는 이온 교환수지 및 그것의 혼합물로 구성되는 그룹으로부터 선택된 방법
  4. 제 1 항에 있어서, 미립자 재료가 카올린인 방법.
  5. 제 1 항에 있어서, 중성 중합체 결합체가 셀룰로스 에테르 아크릴수지, 및 폴리비닐 에스테르로 구성되는 그룹으로부터 선택된 방법.
  6. 제 4 항에 있어서, 중성 중합체가 아크릴 수지, 셀룰로스 유도체, 및 폴리비닐 에스테르로 구성되는 그룹으로부터 선택된, 물에 불용성인 수성 중합체인 방법.
  7. 제 6 항에 있어서, 중합제가 아크릴 에스테르, 메트아크릴 에스테르, 및 그것의 혼합물로부터 선택된 단량체로부터 유쾌한 공중합체를 포함하는 수성 분산물로서 공급되는 방법.
  8. 제 1 항에 있어서, 미립자 재료가 산성 또는 염기성 특성을 갖는 이온 교환 수지인 방법.
  9. 제 8 항에 있어서, 이온 교환 수지가 설포네이트, 카복실레이트, 4차 암모늄 그룹, 아민 그룹, 및 그것의 혼합물로 구성되는 그룹으로부터 선택된 최소 하나의 이온성 그룹을 포함하는 방법.
  10. 제 9 항에 있어서, 이온 교환 수지가 강 산성인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870005994A 1986-06-17 1987-06-13 지속적 방출성의 제약학적 제제의 제조방법 KR950003609B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US875,146 1986-06-17
US875146 1986-06-17
US06/875,146 US4810501A (en) 1986-06-17 1986-06-17 Sustained release pharmaceutical preparations

Publications (2)

Publication Number Publication Date
KR880000106A true KR880000106A (ko) 1988-03-23
KR950003609B1 KR950003609B1 (ko) 1995-04-17

Family

ID=25365278

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870005994A KR950003609B1 (ko) 1986-06-17 1987-06-13 지속적 방출성의 제약학적 제제의 제조방법

Country Status (17)

Country Link
US (1) US4810501A (ko)
EP (1) EP0249949B1 (ko)
JP (1) JPS63258406A (ko)
KR (1) KR950003609B1 (ko)
AT (1) ATE83649T1 (ko)
AU (1) AU611085B2 (ko)
CA (1) CA1297016C (ko)
DE (1) DE3783163T2 (ko)
DK (1) DK305287A (ko)
ES (1) ES2053470T3 (ko)
FI (1) FI872652A (ko)
GR (1) GR3006981T3 (ko)
NO (1) NO872499L (ko)
NZ (1) NZ220722A (ko)
PH (1) PH24152A (ko)
PT (1) PT85105B (ko)
ZA (1) ZA873851B (ko)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8707416D0 (en) * 1987-03-27 1987-04-29 Wellcome Found Pharmaceutical formulations
US4996047A (en) * 1988-11-02 1991-02-26 Richardson-Vicks, Inc. Sustained release drug-resin complexes
US4999189A (en) * 1988-11-14 1991-03-12 Schering Corporation Sustained release oral suspensions
US5186930A (en) * 1988-11-14 1993-02-16 Schering Corporation Sustained release oral suspensions
GB9025372D0 (en) * 1990-11-22 1991-01-09 Nat Res Dev Pharmaceutical dosage forms
US5683719A (en) * 1990-11-22 1997-11-04 British Technology Group Limited Controlled release compositions
US5358723A (en) * 1991-11-26 1994-10-25 Warner-Lambert Company Process and composition for the development of controlled release gemfibrozil dosage form
US5472712A (en) * 1991-12-24 1995-12-05 Euroceltique, S.A. Controlled-release formulations coated with aqueous dispersions of ethylcellulose
US5681585A (en) 1991-12-24 1997-10-28 Euro-Celtique, S.A. Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
US5968551A (en) * 1991-12-24 1999-10-19 Purdue Pharma L.P. Orally administrable opioid formulations having extended duration of effect
US5348747A (en) * 1992-03-05 1994-09-20 American Home Products Corporation Pharmaceutical coating sugars
US5429822A (en) * 1992-03-13 1995-07-04 Cambridge Scientific, Inc. Biodegradable bursting release system
ES2194863T3 (es) * 1992-11-30 2003-12-01 Kv Pharm Co Materiales farmaceuticos con enmascarado de sabor.
US5456917A (en) * 1993-04-12 1995-10-10 Cambridge Scientific, Inc. Method for making a bioerodible material for the sustained release of a medicament and the material made from the method
FR2723846B1 (fr) * 1994-08-24 1997-06-13 Hi Pharmtech Forme pharmaceutique solide pour l'administration d'une substance active liquide liposoluble
US7008668B2 (en) * 1995-05-09 2006-03-07 Phoqus Pharmaceuticals Limited Powder coating composition for electrostatic coating of pharmaceutical substrates
ATE293440T1 (de) * 1995-05-09 2005-05-15 Phoqus Pharmaceuticals Ltd Pulverbeschichtungszusammensetzung für elektrostatische beschichtung von pharmazeutischen substraten
GB9623634D0 (en) * 1996-11-13 1997-01-08 Bpsi Holdings Inc Method and apparatus for the coating of substrates for pharmaceutical use
US6479082B1 (en) 1996-12-23 2002-11-12 Wm. Wrigley, Jr. Co. Process of increasing flavor release from chewing gum using hydroxypropyl cellulose and product thereof
JP3739410B2 (ja) 1997-07-02 2006-01-25 ユーロ−セルティーク エス．エイ． 安定化された徐放性トラマドール製剤
EP0943341A1 (en) * 1998-02-18 1999-09-22 Oscar Gold Procedure to prepare granulated compositions that contain erythromycin macrolides and procedure to prepare pharmaceutical compositions that contain said macrolides
WO2000059314A1 (en) 1999-04-01 2000-10-12 Wm. Wrigley Jr. Company Long flavor duration releasing structures for chewing gum
GB0002305D0 (en) * 2000-02-01 2000-03-22 Phoqus Limited Power material for electrostatic application
FR2807771A1 (fr) * 2000-04-12 2001-10-19 Atofina Procede de modification hydrophile d'un substrat mettant en jeu un traitement en milieu aqueux par un polymere soluble dans l'eau et thermosensible
WO2003020242A1 (en) * 2001-08-29 2003-03-13 Srl Technologies, Inc. Sustained release preparations
GB2402895B (en) * 2003-06-18 2006-08-23 Phoqus Pharmaceuticals Ltd Method and apparatus for the application of powder material to substrates
GB0330171D0 (en) * 2003-12-30 2004-02-04 Phoqus Pharmaceuticals Ltd Method and apparatus for the application of powder material to substrates
GB0407312D0 (en) * 2004-03-31 2004-05-05 Phoqus Pharmaceuticals Ltd Method and apparatus for the application of powder material to substrates
US20050265955A1 (en) * 2004-05-28 2005-12-01 Mallinckrodt Inc. Sustained release preparations
MX2008001468A (es) * 2005-06-30 2008-04-07 Sod Conseils Rech Applic Composiciones farmaceuticas del peptido similar al glucagon-1.
PL1915137T3 (pl) 2005-08-10 2014-03-31 Add Advanced Drug Delivery Tech Ltd Preparat doustny o kontrolowanym uwalnianiu
KR101402592B1 (ko) * 2006-03-06 2014-06-17 에스케이바이오팜 주식회사 피록시캄-무기물 복합체를 포함하는 경피투여 조성물 및이를 이용한 패치시스템
US20080081067A1 (en) * 2006-10-03 2008-04-03 Gupta Manishkumar Sustained release pharmaceutical compositions of venlafaxine and process for preparation thereof
WO2015159394A1 (ja) * 2014-04-16 2015-10-22 株式会社小松製作所 アイドラ、履帯式走行装置及び摩耗プレート

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2897121A (en) * 1957-06-04 1959-07-28 Upjohn Co Pharmaceutical composition
US3119738A (en) * 1962-04-12 1964-01-28 Wisconsin Alumni Res Found Medication for ruminants
US3594470A (en) * 1968-02-19 1971-07-20 Abbott Lab Chewable tablets including coated particles of pseudoephedrine-weak cation exchange resin
FR2183546B1 (ko) * 1972-05-10 1975-06-20 Servier Lab
US4011061A (en) * 1975-03-20 1977-03-08 Minnesota Mining And Manufacturing Company Articles providing sustained release and method of making
US4284444A (en) * 1977-08-01 1981-08-18 Herculite Protective Fabrics Corporation Activated polymer materials and process for making same
DE2908794C2 (de) * 1978-03-09 1984-09-13 Japan Atomic Energy Research Institute, Tokio/Tokyo Verfahren zur Herstellung eines eine physiologisch aktive Substanz enthaltenden Polymerpräparates
US4221778A (en) * 1979-01-08 1980-09-09 Pennwalt Corporation Prolonged release pharmaceutical preparations
US4308251A (en) * 1980-01-11 1981-12-29 Boots Pharmaceuticals, Inc. Controlled release formulations of orally-active medicaments
IT1176853B (it) * 1984-10-02 1987-08-18 Eurand Spa Procedimento per ottenere una formulazione a rilascio controllato di componenti solubili in acqua
US4600645A (en) * 1985-01-31 1986-07-15 Warner-Lambert Company Process for treating dosage forms

Also Published As

Publication number Publication date
DK305287D0 (da) 1987-06-16
ES2053470T3 (es) 1994-08-01
FI872652A (fi) 1987-12-18
PH24152A (en) 1990-03-22
AU611085B2 (en) 1991-06-06
ATE83649T1 (de) 1993-01-15
KR950003609B1 (ko) 1995-04-17
PT85105B (pt) 1990-03-08
NO872499L (no) 1987-12-18
DE3783163D1 (de) 1993-02-04
EP0249949B1 (en) 1992-12-23
DE3783163T2 (de) 1993-04-22
EP0249949A3 (en) 1988-03-16
NZ220722A (en) 1990-06-26
ZA873851B (en) 1987-11-25
DK305287A (da) 1987-12-18
JPS63258406A (ja) 1988-10-25
NO872499D0 (no) 1987-06-16
PT85105A (en) 1987-07-01
CA1297016C (en) 1992-03-10
FI872652A0 (fi) 1987-06-15
US4810501A (en) 1989-03-07
EP0249949A2 (en) 1987-12-23
AU7419687A (en) 1987-12-24
GR3006981T3 (ko) 1993-06-30

Similar Documents

Publication Publication Date Title
KR880000106A (ko) 지속적으로 방출하는 제약학적 제제
ES2052573T3 (es) Particulas polimericas, su fabricacion y utilizaciones.
ATE29220T1 (de) Verfahren zur herstellung von unloeslichen, nur wenig quellbaren polymerisaten von basischen vinylheterocyclen und deren verwendung.
KR860003044A (ko) 복합 다공성물질, 그의 제조방법, 및 금속원소의 분리방법
ATE207742T1 (de) Heterodisperse hydrogelsysteme zur verzögerten freisetzung unlöslicher arzneistoffe
ATE60997T1 (de) Vernetzte poroese polymere fuer eine kontrollierte wirkstoffabgabe.
FR2292732A1 (fr) Procede de fabrication de polymeres sous forme de particules spheriques ou perles a partir de solutions polymeres
FI20001106A (fi) Poly(vinyyliamiini) -pohjaiset superabsorbentit geelit ja menetelmä niiden valmistamiseksi
DK1227802T3 (da) Filmformigt præparat til bifase-frigivelse af farmakologisk aktive substanser eller andre substanser
DE69023068D1 (de) Isolierung von Polymeren aus deren Lösung mit der Hilfe von einem Extruder.
DE68907687D1 (de) In einer zur erhoehung ihrer loeslichkeitsrate geeigneten form auf polymere substanzen aufgebrachte schwerloesliche arzneistoffe.
ES2009461A6 (es) Procedimiento para prepara granulos a base de polimeros hidrofilos que permiten una distribucion facil y regular de un principio activo fitosanitario o farmaceutico.
DK1083196T3 (da) Undervandsgranulering af aktivstofholdige smeltemasser
JPS55165906A (en) Preparation of acrylamide polymer
JPS55129442A (en) Water-containing gel material
JPS5668647A (en) Waterrsoluble ionic crossslinkable bifunctional monomer* ion exchange polymer produced therefrom and manufacture thereof
IT1243097B (it) Agenti addensanti,loro preparazione ed uso, a base di derivati di polimeri o copolimeri reticolati dell'acido acrilico
JPS5533425A (en) Production of gradually releasing preparation
DE3856181D1 (de) Prägezusammenstellung zur herstellung von texturierten polymermaterialien
ATE426002T1 (de) Umwandlung von pulverfírmigen polymeren
JPS57147429A (en) Microcapsule
JPS641710A (en) Water absorbing polymer and production thereof
Noguchi et al. Size-Exclusion Chromatography of Poly (Vinyl Acetate) and Poly (Vinyl Alcohol) on Eluent-Interchangeable Columns
RU93031660A (ru) Способ получения полимерного материала для мягких контактных линз
JPS57121012A (en) Preparation of anion exchange material

Legal Events

Date Code Title Description
A201 Request for examination
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
NORF Unpaid initial registration fee