KR870008842A - N-[2-{[(2- 히드록시 페닐)(페닐)메틸렌]아미노}에틸]아세트아미드 유도체, 그의 제법 및 치료에의 응용 - Google Patents
N-[2-{[(2- 히드록시 페닐)(페닐)메틸렌]아미노}에틸]아세트아미드 유도체, 그의 제법 및 치료에의 응용 Download PDFInfo
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- KR870008842A KR870008842A KR870002176A KR870002176A KR870008842A KR 870008842 A KR870008842 A KR 870008842A KR 870002176 A KR870002176 A KR 870002176A KR 870002176 A KR870002176 A KR 870002176A KR 870008842 A KR870008842 A KR 870008842A
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- piperazinyl
- piperidyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (6)
- 일반식(Ⅰ)에 해당하는 것을 특징으로 하는 순수한 광학 이성질체 또는 공학 이성질체의 혼합물 형태의 화합물, 뿐만 아니라 약리적으로 허용되는 산과의 그의 부과염.상기식에서,A와 B는 각각 수소원자를 나타내거나 또는 다르게는 함께 탄소-질소 결합을 나타내며,X1은 수소 또는 할로겐원자 또는(C1-C4) 알킬기를 나타내고,X2는 수소 또는 할로겐원자 또는 메틸기를 나타내며,X3는 수소 또는 할로겐원자 또는 히드록실기를 나타내고,X4는 수소 또는 할로겐원자를 나타내며,X5는 수소 또는 할로겐원자 또는 메틸 또는(C1-C4) 알킬술포닐기, 또는 할로겐원자 또는 메톡시기로 임의적으로 파라 치환된 벤질술포닐기를 나타내고,R은 1-모르폴리닐, 4-히드록시-1-피페리딜, 4-아미노 카르보닐-1-피페리딜, 4-히드록시-4-페닐-1-피페리딜, 4-(1-피페리딜)-1-피페리딜, 4-(2-옥소-1-벤조이미다졸리닐)-1-피페리딜, 1-피페라지닐, 4-메틸-1-피페라지닐, 4-에톡시카르보닐-1-피페라지닐, 4-페닐-1-피페라지닐, 4-클로로페닐-1-피페라지닐, 4-메틸페닐-1-피페라지닐, 또는4-(2-피리딜)-1-피페라지닐기를 나타낸다.
- 제 1 항에 있어서, A와 B는 함께 탄소-질소결합을 나타내고 R은 4-히드록시 피페리딜기를 나타내는 것을 특징으로 하는 화합물.
- 제 1 항과 제 2 항 중 어느 하나에 있어서, X1,X4및 X5는 각각 수소원자를 나타내고, X2는 염소원자 또는 메틸기를 나타내며,X3는 염소원자를 나타내는 것을 특징으로 하는 화합물.
- 일반식(Ⅱ)(여기서 X1,X2,X3,X4및 X5는 제 1 항에 기재된 바와 같다)의 벤조페논을 클로로포름과 같은 용매에서 및 환류온도에서 과량의 에틸렌 디아민과 반응시킨 다음, 얻은 화합물을 실온에서 염기의 존재하에 염화 2-클로로 아세틸과 반응시키고,다음에, 일반식(Ⅲ)의 얻은 화합물을 실온에서 또는 온화하게 가열하면서 저급알코올과 같은 용매에서 및 임의적으로 염기의 존재하에 일반식 RH(여기서 R은 제 1 항에 정의한 바와 같다)의 아민과 반응시키며, 만일 일반식(Ⅰ)에서, A와 B가 각각 수소원자를 나타낸다면 얻은 화합물을 실온에서 및 저급알코올과 같은 용매에서 알칼리금속의 수소화 붕소화물에 의해 환원시키는 것을 특징으로 하는 제 1 항에 정의된 화합물의 제조방법.
- 제 1 항 내지 제 3 항 중 어느 하나에 따르는 화합물로 구성되는 것을 특징으로 하는 의약 조성물.
- 제 1 항 내지 제 3 항 중 어느 하나에 따르는 화합물을 제약부형제와 조합하여 포함하는 것을 특징으로 하는 제약 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR86.03489 | 1986-03-12 | ||
FR8603489A FR2595695B1 (fr) | 1986-03-12 | 1986-03-12 | Derives de n-(((hydroxy-2 phenyl) (phenyl) methylene) amino-2) ethyl) acetamide, leur preparation et leur application en therapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
KR870008842A true KR870008842A (ko) | 1987-10-21 |
Family
ID=9333030
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR870002176A KR870008842A (ko) | 1986-03-12 | 1987-03-11 | N-[2-{[(2- 히드록시 페닐)(페닐)메틸렌]아미노}에틸]아세트아미드 유도체, 그의 제법 및 치료에의 응용 |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0239461A1 (ko) |
JP (1) | JPS62230767A (ko) |
KR (1) | KR870008842A (ko) |
AU (1) | AU6991087A (ko) |
DK (1) | DK123987A (ko) |
FI (1) | FI871067A (ko) |
FR (1) | FR2595695B1 (ko) |
HU (1) | HUT43820A (ko) |
IL (1) | IL81858A0 (ko) |
NO (1) | NO870998L (ko) |
PT (1) | PT84452B (ko) |
ZA (1) | ZA871766B (ko) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CS103091A3 (en) * | 1991-04-12 | 1992-10-14 | Ustav Organicke Chemie A Bioch | Protected substituted benzhydrylamines as shoulders for the synthesis ofpeptides on solid phase, process of their preparation and use |
ES2165880T3 (es) * | 1993-06-21 | 2002-04-01 | Selectide Corp | Conectores segmentables selectivamente basados en enlaces ester de acido iminodiacetico. |
US6063794A (en) * | 1996-10-11 | 2000-05-16 | Cor Therapeutics Inc. | Selective factor Xa inhibitors |
US6262047B1 (en) | 1996-10-11 | 2001-07-17 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6194435B1 (en) | 1996-10-11 | 2001-02-27 | Cor Therapeutics, Inc. | Lactams as selective factor Xa inhibitors |
US6369080B2 (en) | 1996-10-11 | 2002-04-09 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
AU747531B2 (en) * | 1997-04-14 | 2002-05-16 | Millennium Pharmaceuticals, Inc. | Selective factor Xa inhibitors |
EP0975659A1 (en) * | 1997-04-14 | 2000-02-02 | Cor Therapeutics, Inc. | SELECTIVE FACTOR Xa INHIBITORS |
JP2001523226A (ja) | 1997-04-14 | 2001-11-20 | シーオーアール セラピューティクス インコーポレイテッド | 選択的Xa因子阻害剤 |
JP2002514214A (ja) | 1997-04-14 | 2002-05-14 | シーオーアール セラピューティクス インコーポレイテッド | 選択的Xa因子阻害剤 |
US6218382B1 (en) | 1997-08-11 | 2001-04-17 | Cor Therapeutics, Inc | Selective factor Xa inhibitors |
US6333321B1 (en) | 1997-08-11 | 2001-12-25 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6228854B1 (en) | 1997-08-11 | 2001-05-08 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
JP2006522742A (ja) * | 2003-04-08 | 2006-10-05 | ニューロームド テクノロジーズ、インク. | ピペラジンから距離をおいて配置したベンズヒドリル基から成る一群のカルシウムチャンネル阻害剤 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2319338A1 (fr) * | 1975-08-01 | 1977-02-25 | Synthelabo | Nouveaux derives de a- phenyl benzylideniques des acides amines, leur preparation et les medicaments qui en contiennent |
FR2516509B1 (fr) * | 1981-11-18 | 1985-07-26 | Synthelabo | Derives benzylideniques, leur preparation et leur application en therapeutique |
-
1986
- 1986-03-12 FR FR8603489A patent/FR2595695B1/fr not_active Expired
-
1987
- 1987-03-10 IL IL81858A patent/IL81858A0/xx unknown
- 1987-03-11 NO NO870998A patent/NO870998L/no unknown
- 1987-03-11 AU AU69910/87A patent/AU6991087A/en not_active Abandoned
- 1987-03-11 JP JP62057891A patent/JPS62230767A/ja active Pending
- 1987-03-11 DK DK123987A patent/DK123987A/da not_active Application Discontinuation
- 1987-03-11 FI FI871067A patent/FI871067A/fi not_active Application Discontinuation
- 1987-03-11 EP EP87400531A patent/EP0239461A1/fr not_active Withdrawn
- 1987-03-11 KR KR870002176A patent/KR870008842A/ko not_active Application Discontinuation
- 1987-03-11 HU HU871055A patent/HUT43820A/hu unknown
- 1987-03-11 ZA ZA871766A patent/ZA871766B/xx unknown
- 1987-03-11 PT PT84452A patent/PT84452B/pt unknown
Also Published As
Publication number | Publication date |
---|---|
HUT43820A (en) | 1987-12-28 |
AU6991087A (en) | 1987-09-17 |
FI871067A (fi) | 1987-09-13 |
DK123987A (da) | 1987-09-13 |
FR2595695B1 (fr) | 1988-12-02 |
NO870998L (no) | 1987-09-14 |
PT84452B (fr) | 1989-03-17 |
JPS62230767A (ja) | 1987-10-09 |
EP0239461A1 (fr) | 1987-09-30 |
FI871067A0 (fi) | 1987-03-11 |
IL81858A0 (en) | 1987-10-20 |
FR2595695A1 (fr) | 1987-09-18 |
DK123987D0 (da) | 1987-03-11 |
NO870998D0 (no) | 1987-03-11 |
PT84452A (fr) | 1987-04-01 |
ZA871766B (en) | 1987-09-01 |
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