KR870007932A - 1-아미노 인단을 분해하는 진보된 방법 - Google Patents

1-아미노 인단을 분해하는 진보된 방법 Download PDF

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Publication number
KR870007932A
KR870007932A KR870000811A KR870000811A KR870007932A KR 870007932 A KR870007932 A KR 870007932A KR 870000811 A KR870000811 A KR 870000811A KR 870000811 A KR870000811 A KR 870000811A KR 870007932 A KR870007932 A KR 870007932A
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South Korea
Prior art keywords
hydrogen
lower alkyl
alcohol
dissolve
advanced method
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KR870000811A
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English (en)
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프라카쉬 괼 옴
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크리스틴 에이. 트라우트웨인
워너-램버트 컴패니
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Application filed by 크리스틴 에이. 트라우트웨인, 워너-램버트 컴패니 filed Critical 크리스틴 에이. 트라우트웨인
Publication of KR870007932A publication Critical patent/KR870007932A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

내용 없음

Description

1-아미노 인단을 분해하는 진보된 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. (a) 알콜내의 R-N-아세틸-3,4-디메톡시페닐알라닌을 하기 구조식 화합물의 (R,S) 혼합물과 반응시키고;
    (b) 침전된 (R,S) 염을 제거하고;
    (c) (R,R) 염을 포함하는 여과물을 농축하고, 염기로 처리하고, 하기 화합물의 원하는 R 이성체를 공지 방법에 따라 분리하는 것으로 구성되는, 다음 구조식 화합물의 R 이성체를 제조하는 방법.
    식중,
    X는 수소, 저급 알킬 또는 하드록시, 저급 알콕시 또는 카보닐로 말단이 치환된 저급 알킬,
    Y는 수소, 저급 알킬 또는 하이드록시, 저급 알콕시, R이 수소인 OR, 저급 알킬, 저급 알카노일 또는 벤조일로 말단이 치환된 저급 알킬,
    Z 및 Z'는 각각 독립적으로 수소, 할로겐, 니트로, 트리플루오로메틸, 저급 알킬, 하이드록시 또는 저급 알콕시,
    R3는 수소 또는 저급 알킬.
  2. 제 1 항에 있어서, 단계 (a)에서 알콜이 저급 알칸올인 방법.
  3. 제 2 항에 있어서, 단계 (a)에서 알콜이 메탄올인 방법.
  4. 제 1 항에 있어서, X,Y,Z 및 Z'가 수소인 화합물의 R 형태가 생성된 방법.
  5. 제 4 항에 있어서, R3가 수소인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR870000811A 1986-02-03 1987-02-02 1-아미노 인단을 분해하는 진보된 방법 KR870007932A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/824,988 US4833273A (en) 1986-02-03 1986-02-03 Process for the resolution of 1-aminoindanes
US824,988 1986-02-03

Publications (1)

Publication Number Publication Date
KR870007932A true KR870007932A (ko) 1987-09-23

Family

ID=25242822

Family Applications (1)

Application Number Title Priority Date Filing Date
KR870000811A KR870007932A (ko) 1986-02-03 1987-02-02 1-아미노 인단을 분해하는 진보된 방법

Country Status (17)

Country Link
US (1) US4833273A (ko)
EP (1) EP0235590A3 (ko)
JP (1) JPS62185058A (ko)
KR (1) KR870007932A (ko)
AU (1) AU592143B2 (ko)
CA (1) CA1282080C (ko)
DK (1) DK52587A (ko)
FI (1) FI870425A (ko)
HU (1) HU200159B (ko)
IE (1) IE870189L (ko)
IL (1) IL81432A (ko)
NO (1) NO165490C (ko)
NZ (1) NZ219137A (ko)
OA (1) OA08476A (ko)
PH (1) PH22740A (ko)
PT (1) PT84233B (ko)
ZA (1) ZA8719B (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877218A (en) * 1994-01-10 1999-03-02 Teva Pharmaceutical Industries, Ltd. Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives
PT966435E (pt) 1996-12-18 2005-06-30 Yissum Res Dev Co Derivados aminoindano
US6737547B1 (en) 1998-12-31 2004-05-18 Teva Pharmaceutical Industries, Ltd. Compositions containing and methods of using N-acyl-1H-aminoindenes
IL141690A (en) * 2001-02-27 2004-06-20 Isp Finetech Ltd Process for preparation of rasagiline and its salts
US20040010038A1 (en) * 2002-02-27 2004-01-15 Eran Blaugrund Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective MAO inhibitors
JP2009518433A (ja) * 2005-12-09 2009-05-07 イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブライ ユニバーシティー オブ エルサレム 神経保護用の低用量ラドスチギルの使用
TW200744576A (en) * 2006-02-24 2007-12-16 Teva Pharma Propargylated aminoindans, processes for preparation, and uses thereof
CN101062897B (zh) * 2006-04-25 2011-11-23 重庆医药工业研究院有限责任公司 一种制备2，3-二氢-1h-茚-1-胺及其衍生物的改进方法
CN103896779B (zh) * 2008-06-02 2015-12-30 基因里克斯(英国)有限公司 用于制备对映异构纯胺的方法
EP2181980A1 (en) 2008-10-28 2010-05-05 Chemo Ibérica, S.A. A process for the preparation of (R)-1-aminoindanes
EP2681186B1 (en) 2011-03-03 2016-05-11 Synthon BV Process of resolution of 1-aminoindan
WO2016116607A1 (en) * 2015-01-22 2016-07-28 Farma Grs D.O.O. Process and intermediates for the racemization of enantiomerically enriched 1-aminoindane
US10570086B2 (en) 2016-03-17 2020-02-25 Fmc Corporation Process for converting S-enantiomer to its racemic form

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3028430A (en) * 1955-03-28 1962-04-03 Parke Davis & Co Process for the production of optically active isomers of amphetamine
US3167566A (en) * 1961-10-18 1965-01-26 Abbott Lab Resolution of dl-tryptophane and dl-alpha-phenylethylamine
CH505056A (de) * 1968-12-27 1971-03-31 Hoffmann La Roche Verfahren zur Herstellung von L-3-(3',4'-Dihydroxyphenyl)-alanin
US3734952A (en) * 1968-12-27 1973-05-22 Hoffmann La Roche Preparation of l-dopa
US3919316A (en) * 1974-08-05 1975-11-11 Lilly Co Eli 2-Aminodichlorotetralins
US4132737A (en) * 1978-02-27 1979-01-02 Eli Lilly And Company Trifluoromethyl substituted 1-aminoindanes
US4501735A (en) * 1983-12-05 1985-02-26 Warner-Lambert Company N6-(1- and 2-benzocycloalkyl) adenosines

Also Published As

Publication number Publication date
NZ219137A (en) 1990-02-26
DK52587D0 (da) 1987-02-02
AU592143B2 (en) 1990-01-04
PT84233B (pt) 1989-09-14
PH22740A (en) 1988-11-28
FI870425A (fi) 1987-08-04
IL81432A (en) 1990-07-26
IE870189L (en) 1987-08-03
AU6750687A (en) 1987-08-06
NO165490B (no) 1990-11-12
NO870409D0 (no) 1987-02-02
CA1282080C (en) 1991-03-26
DK52587A (da) 1987-08-04
NO870409L (no) 1987-08-04
IL81432A0 (en) 1987-08-31
PT84233A (en) 1987-03-01
EP0235590A2 (en) 1987-09-09
HUT47074A (en) 1989-01-30
JPS62185058A (ja) 1987-08-13
US4833273A (en) 1989-05-23
NO165490C (no) 1991-02-20
EP0235590A3 (en) 1989-08-16
FI870425A0 (fi) 1987-01-30
HU200159B (en) 1990-04-28
ZA8719B (en) 1988-07-04
OA08476A (en) 1988-07-29

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