KR870007426A - 모노클로날항체및 이를 이용한 글루콕실화 단백질의 측정방법과 측정기기 - Google Patents

모노클로날항체및 이를 이용한 글루콕실화 단백질의 측정방법과 측정기기 Download PDF

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Publication number
KR870007426A
KR870007426A KR870000516A KR870000516A KR870007426A KR 870007426 A KR870007426 A KR 870007426A KR 870000516 A KR870000516 A KR 870000516A KR 870000516 A KR870000516 A KR 870000516A KR 870007426 A KR870007426 A KR 870007426A
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KR
South Korea
Prior art keywords
glucoxylated
reduced
proteins
lysine residue
monoclonal antibody
Prior art date
Application number
KR870000516A
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English (en)
Inventor
야스오 오헤
마쓰우라마끼꼬
후미오 시미즈
요시또 나까지마
사다히또 신
겐지 시마
Original Assignee
오스까 아끼히꼬
오스까 세이야꾸 가부시기가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP5882886A external-priority patent/JPH0674278B2/ja
Application filed by 오스까 아끼히꼬, 오스까 세이야꾸 가부시기가이샤 filed Critical 오스까 아끼히꼬
Publication of KR870007426A publication Critical patent/KR870007426A/ko

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

내용 없음

Description

모노클로날항체 및 이를 이용한 글루콕실화 단백질의 측정방법과 측정기기
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 이 발명에 따르는 글루시돌-라이신 유도체(I)의 피엠알(PMR) 스텍트럼이다.
제2도는 이 발명의 항체의 특이성을 보여주는 그래프이다.

Claims (7)

  1. 환원형 글루콕실화 라이신 잔기를 에피토프로 하는 모노클로날 항체.
  2. 시료를 환원처리하고 환원형 글루콕실화 라이신 잔기를 에피토프로하는 모노클로날 항체를 사용하여 면역 검정법에 의하여 하나 이상의 환원 글루콕실화 라이신 잔기를 함유하는 화합물을 검출하는 시료중의 글루콕실화 단백질 측정방법.
  3. 제2항에 있어서 시료가 체액의 단백질 유분이며 상기 유분은 단백-흡착 담체를 갖는 체액의 흡착처리에 의해 얻어지는 것인 방법.
  4. 제3항에 있어서 체액이 혈액인 방법.
  5. 제3항에 있어서 단백-흡착담체가 쿠마시 브릴리언트불루 G250 또는 시바크론 불루-불용성 담체인 방법.
  6. 환원형 글루콕실화 라이신 잔기를 에피토프로하는 모노클로날 항체를 함유하는 당뇨병 진단용 킷트.
  7. 일반식(I)
    으로 표시하는 글루신톨 라이신 유도체의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR870000516A 1986-01-20 1987-01-20 모노클로날항체및 이를 이용한 글루콕실화 단백질의 측정방법과 측정기기 KR870007426A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP1075886 1986-01-20
JP10758 1986-01-20
JP5882886A JPH0674278B2 (ja) 1986-03-17 1986-03-17 グルシト−ルリジン誘導体
JP58828 1986-03-17

Publications (1)

Publication Number Publication Date
KR870007426A true KR870007426A (ko) 1987-08-19

Family

ID=26346080

Family Applications (1)

Application Number Title Priority Date Filing Date
KR870000516A KR870007426A (ko) 1986-01-20 1987-01-20 모노클로날항체및 이를 이용한 글루콕실화 단백질의 측정방법과 측정기기

Country Status (4)

Country Link
US (1) US4837170A (ko)
EP (1) EP0230934A3 (ko)
KR (1) KR870007426A (ko)
DK (1) DK26587A (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5173422A (en) * 1986-08-22 1992-12-22 Miles Inc. Monoclonal antibodies specific for human glycoalbumin
ES2046187T3 (es) * 1986-08-22 1994-02-01 Miles Inc Anticuerpos para uso en la determinacion de la glucoalbumina humana.
US5223392A (en) * 1988-01-25 1993-06-29 Exocell, Inc. Monoclonal antibodies against glycated albumin, hybrid cell lines producing these antibodies, and use therefore
US5484735A (en) * 1989-08-23 1996-01-16 Northwestern University Immunoassay of glycosylated proteins employing antibody directed to reductively glycosylated N-terminal amino acids
US5183739A (en) * 1990-02-27 1993-02-02 Exocell, Inc. Monoclonal antibodies specific for non-a1c glycated hemoglobin and immunoassay methods
WO1994000592A1 (en) * 1992-06-26 1994-01-06 Exocell, Inc. Monoclonal antibodies against glycated low density lipoprotein
US6043043A (en) * 1993-04-02 2000-03-28 Bayer Corporation Method for the determination of hemoglobin adducts
US7071298B2 (en) * 1997-02-05 2006-07-04 Fox Chase Cancer Center Compounds and methods for treating glycogen storage disease and other pathological conditions resulting from formation of age-proteins
US6410692B2 (en) * 1998-02-02 2002-06-25 Novadx, Inc. Removal of abundant interfering proteins from a liquid sample using a collapsible affinity matrix
US7087435B2 (en) * 2001-04-30 2006-08-08 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 2753 daltons
US7343841B2 (en) * 2002-02-15 2008-03-18 Black & Decker Inc. Blade clamp assembly
WO2004073864A2 (en) * 2003-02-13 2004-09-02 Becton, Dickinson And Company Devices for component removal during blood collection, and uses thereof
US20060089316A1 (en) * 2004-10-25 2006-04-27 Brown Truman R Method for reducing a susceptibility to tumor formation induced by 3-deoxyglucosone and precursors thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4247533A (en) * 1978-05-01 1981-01-27 The Rockefeller University Hemoglobin A1c radioimmunoassay
US4371374A (en) * 1980-11-17 1983-02-01 The Rockefeller University Monitoring metabolic control in diabetic patients by measuring glycosylated amino acids and peptides in urine
DE3141146A1 (de) * 1981-10-16 1983-04-28 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und reagens zur bestimmung von glykosiliertem haemoglobin
US4629692A (en) * 1982-12-06 1986-12-16 Miles Laboratories, Inc. Immunoassay for nonenzymatically glucosylated proteins and protein fragments an index of glycemia
SE434680B (sv) * 1983-01-21 1984-08-06 Karl Arne Lundblad Anvendning av en saltlosning av monoklonala antikroppar med relativt hog salthalt vid blodgruppsbestemning
US4474892A (en) * 1983-02-16 1984-10-02 Board Of Trustees Of The Leland Stanford Junior University Two-site immunoassays using monoclonal antibodies of different classes or subclasses and test kits for performing same
JPS61230058A (ja) * 1985-04-04 1986-10-14 Susumu Kogyo Kk アルブミンの定量法

Also Published As

Publication number Publication date
DK26587A (da) 1987-07-21
EP0230934A3 (en) 1989-09-06
EP0230934A2 (en) 1987-08-05
DK26587D0 (da) 1987-01-19
US4837170A (en) 1989-06-06

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