KR860001215B1 - 안지오텐신-전환 효소 억제제의 제조방법 - Google Patents

안지오텐신-전환 효소 억제제의 제조방법 Download PDF

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Publication number
KR860001215B1
KR860001215B1 KR1019830003852A KR830003852A KR860001215B1 KR 860001215 B1 KR860001215 B1 KR 860001215B1 KR 1019830003852 A KR1019830003852 A KR 1019830003852A KR 830003852 A KR830003852 A KR 830003852A KR 860001215 B1 KR860001215 B1 KR 860001215B1
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KR
South Korea
Prior art keywords
factor
medium
formula
proline
toxic salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019830003852A
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English (en)
Korean (ko)
Other versions
KR840005743A (ko
Inventor
스튜어트 민더스 존
오 코노 센크리스토퍼
미쯔오 나가주까사 왈터
Original Assignee
일라이 릴리 앤드 캄파니
아더 알. 웨일
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/409,765 external-priority patent/US4404281A/en
Priority claimed from US06/409,764 external-priority patent/US4404282A/en
Priority claimed from US06/409,763 external-priority patent/US4508901A/en
Application filed by 일라이 릴리 앤드 캄파니, 아더 알. 웨일 filed Critical 일라이 릴리 앤드 캄파니
Publication of KR840005743A publication Critical patent/KR840005743A/ko
Application granted granted Critical
Publication of KR860001215B1 publication Critical patent/KR860001215B1/ko
Expired legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • C12P17/04Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D455/00Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465Streptomyces

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1019830003852A 1982-08-19 1983-08-18 안지오텐신-전환 효소 억제제의 제조방법 Expired KR860001215B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US409765 1982-08-19
US06/409,765 US4404281A (en) 1982-08-19 1982-08-19 Process for enzyme inhibitors
US06/409,764 US4404282A (en) 1982-08-19 1982-08-19 Process for enzyme inhibitor
US409764 1982-08-19
US409763 1982-08-19
US06/409,763 US4508901A (en) 1982-08-19 1982-08-19 Quiuolizine and indolizine enzyme inhibitors

Publications (2)

Publication Number Publication Date
KR840005743A KR840005743A (ko) 1984-11-15
KR860001215B1 true KR860001215B1 (ko) 1986-08-27

Family

ID=27410818

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830003852A Expired KR860001215B1 (ko) 1982-08-19 1983-08-18 안지오텐신-전환 효소 억제제의 제조방법

Country Status (15)

Country Link
EP (1) EP0103403B1 (enExample)
KR (1) KR860001215B1 (enExample)
AU (1) AU560417B2 (enExample)
DD (1) DD218389A5 (enExample)
DE (1) DE3381244D1 (enExample)
DK (1) DK377883A (enExample)
ES (1) ES8505721A1 (enExample)
FI (1) FI832960A7 (enExample)
GB (1) GB2126217B (enExample)
GR (1) GR78665B (enExample)
IL (1) IL69474A (enExample)
NZ (1) NZ205245A (enExample)
PL (1) PL243461A1 (enExample)
PT (1) PT77190B (enExample)
SU (1) SU1403991A3 (enExample)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4316906A (en) * 1978-08-11 1982-02-23 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of substituted prolines
US4316905A (en) * 1980-07-01 1982-02-23 E. R. Squibb & Sons, Inc. Mercaptoacyl derivatives of various 4-substituted prolines

Also Published As

Publication number Publication date
GB2126217B (en) 1986-04-03
EP0103403B1 (en) 1990-02-28
DD218389A5 (de) 1985-02-06
GB2126217A (en) 1984-03-21
AU560417B2 (en) 1987-04-09
FI832960L (fi) 1984-02-20
NZ205245A (en) 1987-01-23
FI832960A0 (fi) 1983-08-18
PT77190A (en) 1983-09-01
DE3381244D1 (de) 1990-04-05
FI832960A7 (fi) 1984-02-20
DK377883D0 (da) 1983-08-18
IL69474A (en) 1986-11-30
ES524874A0 (es) 1985-06-01
EP0103403A3 (en) 1986-07-02
GR78665B (enExample) 1984-09-27
SU1403991A3 (ru) 1988-06-15
PT77190B (en) 1986-03-20
AU1790483A (en) 1984-02-23
IL69474A0 (en) 1983-11-30
GB8321679D0 (en) 1983-09-14
PL243461A1 (en) 1985-01-02
KR840005743A (ko) 1984-11-15
ES8505721A1 (es) 1985-06-01
DK377883A (da) 1984-02-20
EP0103403A2 (en) 1984-03-21

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A201 Request for examination
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Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19830818

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G160 Decision to publish patent application
PG1605 Publication of application before grant of patent

Comment text: Decision on Publication of Application

Patent event code: PG16051S01I

Patent event date: 19860726

O035 Opposition [patent]: request for opposition

Free format text: OPPOSITION NUMBER: 001986001365; OPPOSITION DATE: 19861011

PO0301 Opposition

Comment text: Request for Opposition

Patent event code: PO03011R01D

Patent event date: 19861011

Opposition date: 19861011

Opposition identifier: 001986001365

O073 Decision to grant registration after opposition [patent]: decision to grant registration
PO0701 Decision to grant registration after opposition

Comment text: Decision to Grant Registration

Patent event code: PO07011S01D

Patent event date: 19870219