KR860001122A - 신규한 베클로 메타손 17,21-디프로피오네이트의 용매화물(solvates)의 제조 및 그 사용 - Google Patents

신규한 베클로 메타손 17,21-디프로피오네이트의 용매화물(solvates)의 제조 및 그 사용 Download PDF

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Publication number
KR860001122A
KR860001122A KR1019850005290A KR850005290A KR860001122A KR 860001122 A KR860001122 A KR 860001122A KR 1019850005290 A KR1019850005290 A KR 1019850005290A KR 850005290 A KR850005290 A KR 850005290A KR 860001122 A KR860001122 A KR 860001122A
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KR
South Korea
Prior art keywords
dipropionate
beclomethasone
preparation
solvate
isopropyl ether
Prior art date
Application number
KR1019850005290A
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English (en)
Other versions
KR880001237B1 (ko
Inventor
로날드 페이지 필립 (외 1)
Original Assignee
엘리쟈베드 발더
호비온 인터 리미티드
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Publication date
Priority claimed from PT7897284A external-priority patent/PT78972A/pt
Priority claimed from PT8079685A external-priority patent/PT80796B/pt
Application filed by 엘리쟈베드 발더, 호비온 인터 리미티드 filed Critical 엘리쟈베드 발더
Publication of KR860001122A publication Critical patent/KR860001122A/ko
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Publication of KR880001237B1 publication Critical patent/KR880001237B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Otolaryngology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Glass Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

신규한 베클로 메탄손 17,21-디프로피오네이트의 용매화물(solvates)의 제조 및 그 사용
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 베클로 메타손 17,21-디프로피오네이트를 유기용매에 용해시킨 후 디-이소프로필 에테르를 가해침전시키는 것을 특징으로 하는 베클로메타손 17,21-디프로피오네이트의 디-이소프로필 에테르용매화물의 제조방법
  2. 제1항에 있어서, 유기용매는 할로겐화된 하이드로 카본류와 에테르류에서 선택한다는 것
  3. 제2항에 있어서, 할로겐화된 하이드로 카본은 클로로 포름 또는 디클로로 메탄이라는 것
  4. 제2항에 있어서, 에테르는 테트라하이드로 푸란 또는 디옥산이라는 것
  5. 제1항에 있어서, 용매화물은 약 10%의 용매화물질(solvating substance)을 포함한다는 것
  6. 분무가스로 트리클로로플루오로메탄 또는 디클로로 디플루오로메탄을 사용하고 베틀로메타손 17,21-디프로피오네이트의 디-이소프로필에테르 용매화합물을 에어로졸 흡입기/카니스테에 넣은 것을 특징으로 하는 안정한 에어로졸의 제조방법
  7. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850005290A 1984-07-25 1985-07-24 베클로메타손 17,21-디프로피오네이트의 용매화합물의 제조방법 KR880001237B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PT7897284A PT78972A (en) 1984-07-25 1984-07-25 Preparation process of a 17,21-dipropionate beclomethasona di-isopropylic ether solution and its utilization
PT78972 1984-07-25
PT80796 1985-07-11
PT8079685A PT80796B (pt) 1985-07-11 1985-07-11 Processo para a preparacao de solvatos etoericos de beclometasona 17,21-dipropionato e utilizacao dos mesmos

Publications (2)

Publication Number Publication Date
KR860001122A true KR860001122A (ko) 1986-02-22
KR880001237B1 KR880001237B1 (ko) 1988-07-12

Family

ID=26653439

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850005290A KR880001237B1 (ko) 1984-07-25 1985-07-24 베클로메타손 17,21-디프로피오네이트의 용매화합물의 제조방법

Country Status (12)

Country Link
US (1) US4913892A (ko)
EP (1) EP0172672B1 (ko)
KR (1) KR880001237B1 (ko)
AU (1) AU566318B2 (ko)
CA (1) CA1274503A (ko)
DE (1) DE3561321D1 (ko)
DK (1) DK336485A (ko)
HK (1) HK58789A (ko)
IE (1) IE59086B1 (ko)
IL (1) IL75903A (ko)
NO (1) NO163899C (ko)
NZ (1) NZ212877A (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR890000664B1 (ko) * 1981-10-19 1989-03-22 바리 안소니 뉴우샘 미분된 베클로메타손 디프로피오네이트 일수화물의 제조방법
PT78973A (en) * 1984-07-25 1984-08-01 Joao Emerico Villax New preparation process of the 9alpha-fluoro 17,21-acylates or hidroxilades in 17 and 21 chloro-corticosteroid
GB8432063D0 (en) * 1984-12-19 1985-01-30 Riker Laboratories Inc Physically modified steroids
MX9203481A (es) 1990-10-18 1992-07-01 Minnesota Mining & Mfg Formulaciones.
US7101534B1 (en) 1991-12-18 2006-09-05 3M Innovative Properties Company Suspension aerosol formulations
MX9304585A (es) 1992-07-31 1994-03-31 Glaxo Group Ltd Formulacion farmaceutica en aerosol, lata adecuada para liberar la formulacion e inhalador de dosis dosificada que comprende la lata.
JP4228116B2 (ja) * 1996-05-09 2009-02-25 ゼニス・オペレイションズ・プロプライエタリー・リミテッド 喘息および気道の疾患の治療
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
US8148377B2 (en) 2007-02-11 2012-04-03 Map Pharmaceuticals, Inc. Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4044126A (en) * 1972-04-20 1977-08-23 Allen & Hanburys Limited Steroidal aerosol compositions and process for the preparation thereof
ATE3774T1 (de) * 1980-05-02 1983-06-15 Schering Corporation Beclomethason-ester-solvate, verfahren zu ihrer herstellung und herstellung einer formulierung.
GB2107715B (en) * 1981-10-19 1985-11-13 Glaxo Group Ltd Micronised beclomethasone dipropionate monohydrate and powder inhalation compositions containing it

Also Published As

Publication number Publication date
NO163899B (no) 1990-04-30
DK336485D0 (da) 1985-07-24
EP0172672B1 (en) 1988-01-07
US4913892A (en) 1990-04-03
IL75903A (en) 1989-10-31
HK58789A (en) 1989-07-28
IE59086B1 (en) 1994-01-12
EP0172672A1 (en) 1986-02-26
NO163899C (no) 1990-08-08
IL75903A0 (en) 1985-12-31
NZ212877A (en) 1988-03-30
NO852948L (no) 1986-01-27
AU566318B2 (en) 1987-10-15
AU4530585A (en) 1986-01-30
DE3561321D1 (en) 1988-02-11
KR880001237B1 (ko) 1988-07-12
DK336485A (da) 1986-01-26
CA1274503A (en) 1990-09-25

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