JPS56152498A - Production of steroid aldehyde - Google Patents
Production of steroid aldehydeInfo
- Publication number
- JPS56152498A JPS56152498A JP5464280A JP5464280A JPS56152498A JP S56152498 A JPS56152498 A JP S56152498A JP 5464280 A JP5464280 A JP 5464280A JP 5464280 A JP5464280 A JP 5464280A JP S56152498 A JPS56152498 A JP S56152498A
- Authority
- JP
- Japan
- Prior art keywords
- solvent
- steroid
- dimethylsulfonium
- oxidized
- bringing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Steroid Compounds (AREA)
Abstract
PURPOSE: A steroid alcohol is oxidized in a solvent by bringing it into contact with dimethylsulfonium ion to produce the titled compound used as a synthetic intermediate of gestogen and adrenal cortical hormone practically in high yield.
CONSTITUTION: A steroid alcohol of formula I (the dotted line between he 1 and 2 positions in the ring A means a single or double bond) is oxidized in a solvent by bringing it into contact with dimethylsulfonium ion which has been prepared in an aromatic hydrocarbon solvent to give a steroid aldehyde of formula II. The solvent is preferably a halogenated hydrocarbon such as dichloromethane or chloroform and a cyclic ether such as tetrahydrofurn or dioxane. Their combination also may be employed wherein the ratio of the aromatic hydrocarbon : the halogenated hydrocarbon : the cyclic ether is preferably 1:(1W4):1, much preferably 1.5:(1W2.5):1 by volume.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5464280A JPS56152498A (en) | 1980-04-24 | 1980-04-24 | Production of steroid aldehyde |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5464280A JPS56152498A (en) | 1980-04-24 | 1980-04-24 | Production of steroid aldehyde |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS56152498A true JPS56152498A (en) | 1981-11-26 |
JPS632280B2 JPS632280B2 (en) | 1988-01-18 |
Family
ID=12976423
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5464280A Granted JPS56152498A (en) | 1980-04-24 | 1980-04-24 | Production of steroid aldehyde |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56152498A (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995016698A1 (en) * | 1993-12-17 | 1995-06-22 | The Upjohn Company | Conversion of bisnoralcohol to bisnoraldehyde |
US6608220B1 (en) * | 1994-10-27 | 2003-08-19 | Pharmacia & Upjohn Company | Conversion of bisnoralcohol to bisnoraldehyde |
JP2008148318A (en) * | 2006-12-11 | 2008-06-26 | Siemens Audiologische Technik Gmbh | Hearing device with transponder identification, and control method thereof |
CN104109183A (en) * | 2014-07-04 | 2014-10-22 | 湖北葛店人福药业有限责任公司 | New technique for synthesizing progesterone |
CN106589037A (en) * | 2016-12-22 | 2017-04-26 | 浙江仙琚制药股份有限公司 | Method for preparing progesterone and derivatives thereof |
CN117801044A (en) * | 2024-02-29 | 2024-04-02 | 天津凯莱英医药科技发展有限公司 | Continuous production method and device for progesterone |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0528629Y2 (en) * | 1986-07-23 | 1993-07-22 | ||
JPH0544936Y2 (en) * | 1986-07-28 | 1993-11-16 |
-
1980
- 1980-04-24 JP JP5464280A patent/JPS56152498A/en active Granted
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995016698A1 (en) * | 1993-12-17 | 1995-06-22 | The Upjohn Company | Conversion of bisnoralcohol to bisnoraldehyde |
US6608220B1 (en) * | 1994-10-27 | 2003-08-19 | Pharmacia & Upjohn Company | Conversion of bisnoralcohol to bisnoraldehyde |
JP2008148318A (en) * | 2006-12-11 | 2008-06-26 | Siemens Audiologische Technik Gmbh | Hearing device with transponder identification, and control method thereof |
CN104109183A (en) * | 2014-07-04 | 2014-10-22 | 湖北葛店人福药业有限责任公司 | New technique for synthesizing progesterone |
CN106589037A (en) * | 2016-12-22 | 2017-04-26 | 浙江仙琚制药股份有限公司 | Method for preparing progesterone and derivatives thereof |
CN117801044A (en) * | 2024-02-29 | 2024-04-02 | 天津凯莱英医药科技发展有限公司 | Continuous production method and device for progesterone |
Also Published As
Publication number | Publication date |
---|---|
JPS632280B2 (en) | 1988-01-18 |
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