KR850008344A - 일가의 카르복실 이오노포르와 거대분자가 공유결합에 의해 결합된 접합체의 제조방법 - Google Patents

일가의 카르복실 이오노포르와 거대분자가 공유결합에 의해 결합된 접합체의 제조방법 Download PDF

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Publication number
KR850008344A
KR850008344A KR1019850003565A KR850003565A KR850008344A KR 850008344 A KR850008344 A KR 850008344A KR 1019850003565 A KR1019850003565 A KR 1019850003565A KR 850003565 A KR850003565 A KR 850003565A KR 850008344 A KR850008344 A KR 850008344A
Authority
KR
South Korea
Prior art keywords
macromolecule
thiol group
ionophore
antibody
compound
Prior art date
Application number
KR1019850003565A
Other languages
English (en)
Korean (ko)
Inventor
잔센 프란쯔 (외 1)
Original Assignee
미쉘 드 아스
소시에떼 아노님 사노피
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 미쉘 드 아스, 소시에떼 아노님 사노피 filed Critical 미쉘 드 아스
Publication of KR850008344A publication Critical patent/KR850008344A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817—Toxins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1019850003565A 1984-05-23 1985-05-23 일가의 카르복실 이오노포르와 거대분자가 공유결합에 의해 결합된 접합체의 제조방법 KR850008344A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8408073A FR2564839B1 (fr) 1984-05-23 1984-05-23 Conjugues associant par liaison covalente un ionophore carboxylique monovalent et une macromolecule et leur utilisation comme agents potentialisateurs des immunotoxines
FR8408073 1984-05-23

Publications (1)

Publication Number Publication Date
KR850008344A true KR850008344A (ko) 1985-12-16

Family

ID=9304319

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850003565A KR850008344A (ko) 1984-05-23 1985-05-23 일가의 카르복실 이오노포르와 거대분자가 공유결합에 의해 결합된 접합체의 제조방법

Country Status (4)

Country Link
JP (1) JPS6156198A (fr)
KR (1) KR850008344A (fr)
FR (1) FR2564839B1 (fr)
ZA (1) ZA853793B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018094035A2 (fr) * 2016-11-16 2018-05-24 Purdue Research Foundation Conjugués ligand-ionophore

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5764617A (en) * 1980-10-08 1982-04-19 Teijin Ltd Cytotoxic proteinic complex and its preparation
FR2516794B1 (fr) * 1981-11-20 1985-10-25 Sanofi Sa Nouveaux medicaments anticancereux pour le traitement des leucemies t constitues de la chaine a de la ricine et d'un anticorps monoclonal specifique
FR2521010B1 (fr) * 1982-02-09 1985-07-19 Sanofi Sa Medicaments comportant en tant qu'association au moins une immunotoxine et au moins un ionophore carboxylique monovalent
JPS58167519A (ja) * 1982-03-30 1983-10-03 Teijin Ltd 細胞毒性複合体及びその製造法
JPS5942323A (ja) * 1982-09-02 1984-03-08 Teijin Ltd 選択的殺細胞性蛋白複合体及びその製造方法

Also Published As

Publication number Publication date
FR2564839A1 (fr) 1985-11-29
ZA853793B (en) 1986-01-29
JPS6156198A (ja) 1986-03-20
FR2564839B1 (fr) 1986-11-14

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