ZA853793B - Conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule,their use as immunotoxin potentiators and the intermediate activated ionophores - Google Patents

Conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule,their use as immunotoxin potentiators and the intermediate activated ionophores

Info

Publication number
ZA853793B
ZA853793B ZA853793A ZA853793A ZA853793B ZA 853793 B ZA853793 B ZA 853793B ZA 853793 A ZA853793 A ZA 853793A ZA 853793 A ZA853793 A ZA 853793A ZA 853793 B ZA853793 B ZA 853793B
Authority
ZA
South Africa
Prior art keywords
potentiators
immunotoxin
macromolecule
conjugates
covalent bond
Prior art date
Application number
ZA853793A
Other languages
English (en)
Inventor
Franz Jansen
Pierre Gros
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of ZA853793B publication Critical patent/ZA853793B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817—Toxins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ZA853793A 1984-05-23 1985-05-20 Conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule,their use as immunotoxin potentiators and the intermediate activated ionophores ZA853793B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8408073A FR2564839B1 (fr) 1984-05-23 1984-05-23 Conjugues associant par liaison covalente un ionophore carboxylique monovalent et une macromolecule et leur utilisation comme agents potentialisateurs des immunotoxines

Publications (1)

Publication Number Publication Date
ZA853793B true ZA853793B (en) 1986-01-29

Family

ID=9304319

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA853793A ZA853793B (en) 1984-05-23 1985-05-20 Conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule,their use as immunotoxin potentiators and the intermediate activated ionophores

Country Status (4)

Country Link
JP (1) JPS6156198A (xx)
KR (1) KR850008344A (xx)
FR (1) FR2564839B1 (xx)
ZA (1) ZA853793B (xx)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3541403A4 (en) * 2016-11-16 2020-08-12 Purdue Research Foundation LIGAND-IONOPHORE CONJUGATES

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5764617A (en) * 1980-10-08 1982-04-19 Teijin Ltd Cytotoxic proteinic complex and its preparation
FR2516794B1 (fr) * 1981-11-20 1985-10-25 Sanofi Sa Nouveaux medicaments anticancereux pour le traitement des leucemies t constitues de la chaine a de la ricine et d'un anticorps monoclonal specifique
FR2521010B1 (fr) * 1982-02-09 1985-07-19 Sanofi Sa Medicaments comportant en tant qu'association au moins une immunotoxine et au moins un ionophore carboxylique monovalent
JPS58167519A (ja) * 1982-03-30 1983-10-03 Teijin Ltd 細胞毒性複合体及びその製造法
JPS5942323A (ja) * 1982-09-02 1984-03-08 Teijin Ltd 選択的殺細胞性蛋白複合体及びその製造方法

Also Published As

Publication number Publication date
JPS6156198A (ja) 1986-03-20
KR850008344A (ko) 1985-12-16
FR2564839A1 (fr) 1985-11-29
FR2564839B1 (fr) 1986-11-14

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