FR2564839B1 - Conjugues associant par liaison covalente un ionophore carboxylique monovalent et une macromolecule et leur utilisation comme agents potentialisateurs des immunotoxines - Google Patents
Conjugues associant par liaison covalente un ionophore carboxylique monovalent et une macromolecule et leur utilisation comme agents potentialisateurs des immunotoxinesInfo
- Publication number
- FR2564839B1 FR2564839B1 FR8408073A FR8408073A FR2564839B1 FR 2564839 B1 FR2564839 B1 FR 2564839B1 FR 8408073 A FR8408073 A FR 8408073A FR 8408073 A FR8408073 A FR 8408073A FR 2564839 B1 FR2564839 B1 FR 2564839B1
- Authority
- FR
- France
- Prior art keywords
- potentializers
- immunotoxins
- macromolecule
- covalent binding
- monovalent carboxylic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (22)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8408073A FR2564839B1 (fr) | 1984-05-23 | 1984-05-23 | Conjugues associant par liaison covalente un ionophore carboxylique monovalent et une macromolecule et leur utilisation comme agents potentialisateurs des immunotoxines |
CA000481505A CA1314245C (fr) | 1984-05-23 | 1985-05-14 | Methode de preparation de conjugues formes d'un ionophore carboxylique monovalent associe par une liaison de covalence a une macromolecule et utiles comme agents de potentialisation d'immunotoxines |
IL8913885A IL89138A (en) | 1984-05-23 | 1985-05-17 | Activated carboxylic ionophores containing a thiol group |
IL75228A IL75228A (en) | 1984-05-23 | 1985-05-17 | Conjugates in which certain nonovalent carboxylic ionophores are covalently bonded to a macromolecule,their preparation and pharmaceutical compositions containing them as immunotoxin potentiators |
ZA853793A ZA853793B (en) | 1984-05-23 | 1985-05-20 | Conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule,their use as immunotoxin potentiators and the intermediate activated ionophores |
GR851229A GR851229B (fr) | 1984-05-23 | 1985-05-20 | |
NZ212118A NZ212118A (en) | 1984-05-23 | 1985-05-20 | Conjugate of macromolecule and ionophore; use as immunotoxin potentiator |
NZ22798585A NZ227985A (en) | 1984-05-23 | 1985-05-20 | Intermediate activated ionophores carrying a thiol group |
DE8585400998T DE3571928D1 (en) | 1984-05-23 | 1985-05-21 | Conjugates associated with a covalent bond to a monovalent carboxylic ionophore and a macromolecule, their use as potentializers of immunotoxines and the activated intermediate ionophores |
DK224785A DK164457C (da) | 1984-05-23 | 1985-05-21 | Konjugater, hvor en monovalent carboxylionophor ved hjaelp af en kovalent binding er knyttet til et makromolekyle, fremgangsmaade til fremstilling af konjugaterne og disses anvendelse som immunotoksinpotentiatorer |
PT80501A PT80501B (fr) | 1984-05-23 | 1985-05-21 | Procede pour l'obtention de conjugues associant par liaison covalente un ionophore carboxylique monovalent et une macromolecule utiles comme agents potentialiseurs des immunotoxines |
AT85400998T ATE45092T1 (de) | 1984-05-23 | 1985-05-21 | Conjugierte derivate, assoziiert durch covalente bindungen mit einem monovalenten carbonylionophor, ihre verwendung als potentialisatoren von immunotoxinen und activierte ionophore zwischenverbindungen. |
EP85400998A EP0162781B1 (fr) | 1984-05-23 | 1985-05-21 | Conjugués associant par liaison covalente un ionophore carboxylique monovalent et une macromolécule, leur utilisation comme agents potentialisateurs des immunotoxines et les ionophores activés intermédiaires |
IE127985A IE58480B1 (en) | 1984-05-23 | 1985-05-22 | Conjugates of monovalent carboxylic ionophores and macromolecules |
ES543367A ES8604228A1 (es) | 1984-05-23 | 1985-05-22 | Procedimiento para la obtencion de un conjugado entre un io-nofero carboxilico monovalente y una macromolecula |
AU42793/85A AU600651B2 (en) | 1984-05-23 | 1985-05-23 | Conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule, their use as immunotoxin potentiators and the intermediate activated ionophores |
JP60111285A JPS6156198A (ja) | 1984-05-23 | 1985-05-23 | イオノフオアと高分子とをカツプリングさせた包合体およびその使用法 |
KR1019850003565A KR850008344A (ko) | 1984-05-23 | 1985-05-23 | 일가의 카르복실 이오노포르와 거대분자가 공유결합에 의해 결합된 접합체의 제조방법 |
US07/034,712 US4919928A (en) | 1984-05-23 | 1987-04-06 | Conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule, their use as immunotoxin potentiators and the intermediate activated ionophores |
IL89138A IL89138A0 (en) | 1984-05-23 | 1989-02-01 | Activated carboxylic ionophores containing a thiol group |
US07/457,858 US4977280A (en) | 1984-05-23 | 1989-12-27 | Conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule, their use as immunotoxin potentiators and the intermediate activated ionophores |
US07/458,444 US5144009A (en) | 1984-05-23 | 1989-12-28 | Conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule, their use as immunotoxin potentiators and the intermediate activated inophores |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8408073A FR2564839B1 (fr) | 1984-05-23 | 1984-05-23 | Conjugues associant par liaison covalente un ionophore carboxylique monovalent et une macromolecule et leur utilisation comme agents potentialisateurs des immunotoxines |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2564839A1 FR2564839A1 (fr) | 1985-11-29 |
FR2564839B1 true FR2564839B1 (fr) | 1986-11-14 |
Family
ID=9304319
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8408073A Expired FR2564839B1 (fr) | 1984-05-23 | 1984-05-23 | Conjugues associant par liaison covalente un ionophore carboxylique monovalent et une macromolecule et leur utilisation comme agents potentialisateurs des immunotoxines |
Country Status (4)
Country | Link |
---|---|
JP (1) | JPS6156198A (fr) |
KR (1) | KR850008344A (fr) |
FR (1) | FR2564839B1 (fr) |
ZA (1) | ZA853793B (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018094035A2 (fr) * | 2016-11-16 | 2018-05-24 | Purdue Research Foundation | Conjugués ligand-ionophore |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5764617A (en) * | 1980-10-08 | 1982-04-19 | Teijin Ltd | Cytotoxic proteinic complex and its preparation |
FR2516794B1 (fr) * | 1981-11-20 | 1985-10-25 | Sanofi Sa | Nouveaux medicaments anticancereux pour le traitement des leucemies t constitues de la chaine a de la ricine et d'un anticorps monoclonal specifique |
FR2521010B1 (fr) * | 1982-02-09 | 1985-07-19 | Sanofi Sa | Medicaments comportant en tant qu'association au moins une immunotoxine et au moins un ionophore carboxylique monovalent |
JPS58167519A (ja) * | 1982-03-30 | 1983-10-03 | Teijin Ltd | 細胞毒性複合体及びその製造法 |
JPS5942323A (ja) * | 1982-09-02 | 1984-03-08 | Teijin Ltd | 選択的殺細胞性蛋白複合体及びその製造方法 |
-
1984
- 1984-05-23 FR FR8408073A patent/FR2564839B1/fr not_active Expired
-
1985
- 1985-05-20 ZA ZA853793A patent/ZA853793B/xx unknown
- 1985-05-23 JP JP60111285A patent/JPS6156198A/ja active Pending
- 1985-05-23 KR KR1019850003565A patent/KR850008344A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
FR2564839A1 (fr) | 1985-11-29 |
ZA853793B (en) | 1986-01-29 |
KR850008344A (ko) | 1985-12-16 |
JPS6156198A (ja) | 1986-03-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |