KR850006131A - 안정화된 제약 조성물 - Google Patents

안정화된 제약 조성물 Download PDF

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Publication number
KR850006131A
KR850006131A KR1019850001346A KR850001346A KR850006131A KR 850006131 A KR850006131 A KR 850006131A KR 1019850001346 A KR1019850001346 A KR 1019850001346A KR 850001346 A KR850001346 A KR 850001346A KR 850006131 A KR850006131 A KR 850006131A
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KR
South Korea
Prior art keywords
pharmaceutical composition
imidazolium
carbamoyl
oleate
acid
Prior art date
Application number
KR1019850001346A
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English (en)
Inventor
케이이치(외 2) 가토오
Original Assignee
구로다 요시히로
스미토모 세이야쿠 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 구로다 요시히로, 스미토모 세이야쿠 가부시키가이샤 filed Critical 구로다 요시히로
Publication of KR850006131A publication Critical patent/KR850006131A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

안정화된 제약 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 해리상수 4이하인 산성물질과 4-카르바모일-이미다졸륨-5-올레이트 또는 그의 염 또는 그의 수화물로 구성되는, 안정화된 제약조성물.
  2. 산성물질이 인산 또는 염산인, 청구범위 제1항의 안정화된 제약 조성물.
  3. 산성물질이 구연산, 주석산, 능금산 또는 푸마르산인, 청구범위 제1항의 안정화된 제약 조성물.
  4. 산성물질이 산성 코우팅제인, 청구범위 제1항의 안정화된 제약 조성물.
  5. 산성 물질의 함량이 4-카르바모일-이미다졸륨-5-올레이트 또는 그의 염 또는 그의 수화물에 대해 몰비로 0.001-0.5인, 청구범위 제1항, 제2항 또는 제3항의 안정화된 제제의 안정화법.
  6. 해리상수 4이하인 산성 물질을 제제 내에 공존시킴을 특징으로 하는, 활성 성분으로서 4-카르바모일-이미다졸륨-5-올레이트 또는 그 염 또는 그의 수화물을 함유하는 제제의 안정화법.
  7. 4-카르바모일-이미다졸륨-5-올레이트 또는 그 염 또는 그의 수화믈을 활성성분으로 함유하는 제약 조성물의 제조에 있어서 산성 물질을 분말 상태로 첨가 혼합함을 특징으로 하는, 안정화된 제약 조성물의 제조방법.
  8. 4-카르바모일-이미다졸륨-5-올레이트 또는 그 염 또는 그의 수화물을 활성성분으로 함유하는 제약조성물의 제조에 있어서 산성 물질을 액체 상태 또는 용매내에 상기 산성물질이 용해되거나 분산되어 있 는 상태로 첨가 혼합함을 특징으로 하는,안정화된 제약 조성물의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850001346A 1984-03-05 1985-03-04 안정화된 제약 조성물 KR850006131A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP59043265A JPS60185727A (ja) 1984-03-05 1984-03-05 ４−カルバモイルイミダゾリウム−５−オレ−ト製剤の安定化法
JP43265 1984-03-05

Publications (1)

Publication Number Publication Date
KR850006131A true KR850006131A (ko) 1985-10-02

Family

ID=12659008

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850001346A KR850006131A (ko) 1984-03-05 1985-03-04 안정화된 제약 조성물

Country Status (5)

Country Link
EP (1) EP0159777A1 (ko)
JP (1) JPS60185727A (ko)
KR (1) KR850006131A (ko)
CA (1) CA1235065A (ko)
ES (1) ES8700936A1 (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR950010150B1 (ko) * 1986-01-14 1995-09-11 쥬우가이세이야꾸 가부시끼가이샤 니코란딜 함유 주사제의 안정화 방법
JP5266010B2 (ja) * 2007-09-14 2013-08-21 富士フイルム株式会社 ４−カルバモイル−５−ヒドロキシ−イミダゾール誘導体のスルホン酸塩化合物
JP5458777B2 (ja) 2009-09-28 2014-04-02 株式会社ジェイテクト ダブルカルダンジョイントのカップリングヨーク
JP2013082706A (ja) * 2011-09-28 2013-05-09 Fujifilm Corp ５−ヒドロキシ−１ｈ−イミダゾール−４−カルボキサミド水和物の結晶
WO2013047758A1 (ja) * 2011-09-28 2013-04-04 富士フイルム株式会社 ５－ヒドロキシ－１ｈ－イミダゾール－４－カルボキサミド水和物の結晶及び５－ヒドロキシ－１ｈ－イミダゾール－４－カルボキサミド・３／４水和物の結晶及びその製造方法
TWI594988B (zh) * 2011-09-28 2017-08-11 富士軟片股份有限公司 ５－羥基－１ｈ－咪唑－４－甲醯胺．３／４水合物及其結晶之製造方法
CN104903299B (zh) * 2013-01-15 2018-10-16 富士胶片株式会社 5-羟基-1h-咪唑-4-甲酰胺的硫酸盐
BR112014026250A2 (pt) 2013-01-15 2017-06-27 Fujifilm Corp preparação de produto sólido embalado contendo 5-hidroxi-1h-imidazola-4-carboxamida ou sal do mesmo, ou hidrato dos mesmos
LT2946780T (lt) 2013-01-15 2017-06-12 Fujifilm Corporation Tabletė, turinti 5-hidroksi-1h-imidazol-4-karboksamido
EP3686189B1 (en) * 2017-10-27 2021-09-01 FUJIFILM Corporation Production method for 5-hydroxy-1h-imidazole-4-carboxamide-3/4hydrate

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4181731A (en) * 1976-09-07 1980-01-01 Sumitomo Chemical Company, Limited Novel therapeutic application of 4-carbamoyl-5-hydroxyimidazole
EP0051962B1 (en) * 1980-11-05 1988-08-24 Sumitomo Chemical Company, Limited Pharmaceutical composition comprising 4-carbamoyl-imidazolium-5-olate

Also Published As

Publication number Publication date
CA1235065A (en) 1988-04-12
EP0159777A1 (en) 1985-10-30
ES8700936A1 (es) 1986-11-16
JPS60185727A (ja) 1985-09-21
ES540907A0 (es) 1986-11-16
JPH0137376B2 (ko) 1989-08-07

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