KR850004545A - 혈장분획을 열처리 하는 방법 - Google Patents

혈장분획을 열처리 하는 방법 Download PDF

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KR850004545A
KR850004545A KR1019840007603A KR840007603A KR850004545A KR 850004545 A KR850004545 A KR 850004545A KR 1019840007603 A KR1019840007603 A KR 1019840007603A KR 840007603 A KR840007603 A KR 840007603A KR 850004545 A KR850004545 A KR 850004545A
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organic liquid
biological material
hours
suspension
virus
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KR1019840007603A
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KR890000165B1 (ko
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마이클 헬데브란트 챨스
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원본미기재
알파 쎄러퓨틱 코포레이션
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0023—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/04—Heat
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

혈장분획을 열처리 하는 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (24)

  1. 생물학적 물질을 건조분말의 형태로 준비하고; 건조 생물학적 물질 분말을 유기 액체에 혼합시켜 액체 중 분말 현탁액을 생성하고; 상기 생성된 현탁액을 선택된 온도로 선택된 시간 동안 가열하여 생물학적 물질의 생물학적 활성을 실질적으로 유지시키면서 생물학적 물질에 결합된 모든 바이러스를 불활성화시키고; 현탁된 생물학적 물질을 유기액체로 부터 분리하여 생물학적 물질을 회수함을 특징으로한 생물학적 물질에 결합된 바이러스를 불활성화시키는 방법.
  2. 제1항에 있어서, 현탁액을 약 60℃ 내지 약 100℃ 범위내의 선택된 온도로 가열하는 방법
  3. 제2항에 있어서, 선택된 시간이 약 5분 내지 30시간인 방법.
  4. 제1항에 있어서, 유기액체를 알칸, 케톤 및 과불소시약으로 구성된 그룹으로 부터 선택하는 방법.
  5. 제1항에 있어서, 유기 액체가 헵탄인 방법.
  6. 제1항에 있어서, 유기 액체가 헥산인 방법.
  7. 제1항에 있어서, 유기 액체가 아세톤인 방법.
  8. 제1항에 있어서, 유기 액체가 퍼플루오로트리프로필-아민인 방법.
  9. 제1항에 있어서, 선택된 온도가 약 60℃이고, 선택된 시간이 약 10시간 내지 약 30시간인 방법.
  10. 제1항에 있어서, 현탁액을 약 95℃ 내지 약 100℃ 범위 내의 선택된 온도로 가열하며, 선택된 시간이 약 30분 내지 약 10시간인 방법.
  11. 제1항에 있어서, 생물학적 물질이 인체 혈장으로 부터 분리된 적어도 하나의 단백질 분획으로 구성되는 방법.
  12. 제1항에 있어서, 생물학적 물질를 알부민, 안티-트롬빈Ⅲ, 피브리노오겐, 인자Ⅷ, 프로프롬빈 복합체 및 이들의 혼합물로 구성되는 그룹으로 부터 선택하는 방법.
  13. 제1항에 있어서, 생물학적 물질에 인체 혈장으로 부터 분리된 인자 Ⅷ이 포함되는 방법.
  14. 제1항에 있어서, 바이러스가 B형 간염 바이러스인 방법.
  15. 혈장 분획을 건조 분말의 형태로 준비하고; 건조 혈장 분획 분말을 유기액체에 혼합시켜 액체중 분말 현탁액을 생성하고; 상기 생성된 현탁액을 약 60℃ 내지 약 100℃ 범위내의 온도로 선택된 시간동안 가열하여 실질적으로는 혈장 분획 중에 함유된 인자 Ⅷ의 생물학적 활성을 유지시키면서 혈장분획에 결합된 모든 바이러스를 불활성화시키고; 현탁된 혈장 분획을 유기 액체로부터 분리하여 혈장분획을 회수함을 특징으로 한, 인자 Ⅷ을 함유하는 혈장분획에 결합된 바이러스를 불활성화시키는 방법.
  16. 제15항에 있어서, 선택된 시간이 약 5준 내지 약 30시간인 방법.
  17. 제15항에 있어서, 유기 액체를 알칸, 케논 및 과불소시약으로 구성된 그룹으로 부터 선택하는 방법.
  18. 제15항에 있어서, 유기액체가 헵탄인 방법.
  19. 제15항에 있어서, 유기 액체가 헥산인 방법.
  20. 제15항에 있어서, 유기 액체가 아세톤인 방법.
  21. 제15항에 있어서, 유기 액체가 퍼플루오로트리프로필-아민인 방법.
  22. 제15항에 있어서, 현탁액을 약 60℃로 가열하며, 선택된 시간이 약 10시간 내지 약 30시간인 방법.
  23. 제15항에 있어서, 현탁액을 약 95℃ 내지 약 100℃ 범위내의 온도로 가열하며, 선택된 시간이 약 30분 내지 약 10시간인 방법.
  24. 제15항에 있어서, 바이러스가 B형 간염 바이러스인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840007603A 1983-12-02 1984-12-01 혈장분획을 열처리하는 방법 KR890000165B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US557,665 1983-12-02
US06/557,665 US4490361A (en) 1983-12-02 1983-12-02 Virus inactivating heat treatment of plasma fractions
US557665 1983-12-02

Publications (2)

Publication Number Publication Date
KR850004545A true KR850004545A (ko) 1985-07-25
KR890000165B1 KR890000165B1 (ko) 1989-03-09

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US (1) US4490361A (ko)
EP (1) EP0144709B1 (ko)
JP (1) JPS60132919A (ko)
KR (1) KR890000165B1 (ko)
CA (1) CA1238580A (ko)
DE (2) DE144709T1 (ko)
ES (2) ES537379A0 (ko)

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Publication number Publication date
ES8603950A1 (es) 1986-01-01
EP0144709A2 (en) 1985-06-19
KR890000165B1 (ko) 1989-03-09
EP0144709B1 (en) 1988-10-19
ES8605036A1 (es) 1986-02-16
ES537379A0 (es) 1986-01-01
DE144709T1 (de) 1985-12-19
DE3474635D1 (en) 1988-11-24
JPS60132919A (ja) 1985-07-16
ES546920A0 (es) 1986-02-16
US4490361A (en) 1984-12-25
EP0144709A3 (en) 1985-07-03
CA1238580A (en) 1988-06-28

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