KR850004387A - 유효 화합물 방출 조성체의 제조방법 - Google Patents

유효 화합물 방출 조성체의 제조방법 Download PDF

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Publication number
KR850004387A
KR850004387A KR1019840008335A KR840008335A KR850004387A KR 850004387 A KR850004387 A KR 850004387A KR 1019840008335 A KR1019840008335 A KR 1019840008335A KR 840008335 A KR840008335 A KR 840008335A KR 850004387 A KR850004387 A KR 850004387A
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weight
compound
polymer component
layer
resin
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KR1019840008335A
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본 비테라 미크로스
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에리히 데브리쯔, 요아힘 그렘
바이엘 악티 엔게젤샤프트
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Application filed by 에리히 데브리쯔, 요아힘 그렘, 바이엘 악티 엔게젤샤프트 filed Critical 에리히 데브리쯔, 요아힘 그렘
Publication of KR850004387A publication Critical patent/KR850004387A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Botany (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Control Of Motors That Do Not Use Commutators (AREA)
  • Control Of Eletrric Generators (AREA)
  • Liquid Developers In Electrophotography (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • External Artificial Organs (AREA)

Abstract

내용 없음

Description

유효 화합물 방출 조성체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명의 치료 조성체 제조용 장치의 개략도임, 제2도는 본 발명 완성 제품의 단면 도식임.

Claims (10)

  1. 유효화합물에 본질적으로 침투되지 않는 피복층, 유효화합물 축적층 및 필요에 따라 박리시킬 수 있고, 유효화합물에 본질적으로 침투되지 않는 보호층으로 되는 치료 조성체의 제조방법에 있어서, 적어도 30%이상의 시스―1,4―결합을 갖고, 무늬 점도 20―100(100℃에서 작동시간 1+4분)을 갖는 디엔고무로되고, 그 자체 또는 폴리이소부틸렌 중합체 성분 70중량% 이하의 혼합물로 랜덤하게 또는 블록형태로 결합된 비닐방향족 화합물 50중량% 이하를 함유한 중합체 성분, 1이사의 비말동반제 및 1이상의 수지를 용매중에 용해시키고, 유효화합물로서 중합체 성분의 혼합물 중량에 기초해서 1―30중량%의 소염제, 비말 동반제 및 수지를 또한 용매중에 용해시키고, 이용액들을 혼합시켜서 얻은 혼합용액을 유효화합물에 본질적으로 침추되지 않ㄴ느 필름)피복층)에 고르게 사요하고, 필름으로 인발시키고, 피복시킨 필름 (피복층)을 처음에 실온에서 건조시킨 다음 50℃ 이하에서 건조시키고 필요에 따라서 건조시킨 필름 (피복층)의 피복측에, 유효 화합물에 본질적으로 침투되지 않고 박리시킬 수 있는 보호층을 제고함을 특징으로 하는 치료 조성체 제조방법.
  2. 제1항에 있어서, 하기 일반식(Ⅰ) 및 (또는) 일반식(Ⅱ)의 소염제가 유효 화합물인 방법.
    상기식에서, R1―R5는 동일하거나 서로 다른 것으로서, 수소 할로겐, 저급알킬 또는 치환알킬이고, X는 N 또는 CH이고, Y는 수소, 금속이온, 알킬 또는 치환알킬이고, R은 수소, 저급알킬 또는 치환알킬이고, Ar은 아릴, 헤테로아릴, 치환아릴 또는 치환헤테로 알릴이고, n+m은 정수로서 0,1 또는 2의 값을 갖고, p는 0 또는 1임. 단 n,m 및 p가 0인 경우에 Ar는 아릴 또는 헤테로아릴을 나타내지 않는다.
  3. 제1항또는 2항에 있어서, 하기 일반식의 화합물이 유기 화합물로 사용되는 방법.
  4. 제1,2 또는 3항에 있어서, 유효 화합물 축적층 제조에 있어서, 중합체 성분 30―60중량%, 비말동반제 30―60중량% 및 점착성 개선용 수지 2―40중량%를 사용하고, 이 3성분의 합량이 100중량%인 방법.
  5. 제1,2,3 및 4항에 있어서, 랜덤하게 또는 블록형으로 비닐―방향족 화합물 50중량% 이하로 공중합될 수 있는 부타디엔 및 (또는) 이소프렌의 디엔고무가 중합체 성분에서 사용되는 방법.
  6. 제1,2,3,4 및 5항에 있어서, 중합체 성분에서 시스―1,4 결합 ε0―40중량%와 트란스 1,4결합 40―60중량% 및 무늬점도 30―50인 폴리부타디엔 고무가 사용되는 방법.
  7. 제1,2,3,4,5 및 6항에 있어서, 중합체 성분에서 중합체내에 스티렌 15―30중량%와 무늬 점도 30―50를 갖는 스티렌부타디엔 고무가 사용되는 방법.
  8. 제1,2,3,4,5,6 및 7항에 있어서, 유효 화합물 측적층이 사용된 필름(피복층)이 흡창성 굴요성재 또는 비굴요성재 되는 방법.
  9. 제1,2,3,4,5,6,7 및 8항에 있어서, 폴리테르펜 수지 또는 이 수지의 변형 글리세롤 에스테르가 유효 화합물 축적용수지로 사용되고, 오일류, 지방산 에스테르류, 트리글리세리드류, 알코올류 및 (또는) 지방산류가 유효화합물 축적용 비말동반제로 사용되는 방법.
  10. 제1,2,3,4,5,6,7,8 및 9항에 있어서, 유효 화합물 축적층 제조를 위해 분자량 분포 Mw/Mn 1.5―3.5이고, 분자량의 점도 평균차가 30,000―40,000g/mol인 폴리이소부틸렌이 사용되는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840008335A 1983-12-28 1984-12-26 유효 화합물 방출 조성체의 제조방법 KR850004387A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19833347278 DE3347278A1 (de) 1983-12-28 1983-12-28 Wirkstoffabgabesysteme
DEP3347278.5 1983-12-28

Publications (1)

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KR850004387A true KR850004387A (ko) 1985-07-15

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ID=6218284

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KR1019840008335A KR850004387A (ko) 1983-12-28 1984-12-26 유효 화합물 방출 조성체의 제조방법

Country Status (19)

Country Link
US (1) US4627852A (ko)
EP (1) EP0150428B1 (ko)
JP (1) JPS60158111A (ko)
KR (1) KR850004387A (ko)
AT (1) ATE53304T1 (ko)
AU (1) AU566414B2 (ko)
CA (1) CA1229044A (ko)
DE (2) DE3347278A1 (ko)
DK (1) DK625984A (ko)
ES (1) ES8605684A1 (ko)
FI (1) FI845132L (ko)
GR (1) GR82619B (ko)
HU (1) HU193075B (ko)
IL (1) IL73935A (ko)
NO (1) NO162496B (ko)
NZ (1) NZ210690A (ko)
PH (1) PH22901A (ko)
PT (1) PT79764B (ko)
ZA (1) ZA8410058B (ko)

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Publication number Priority date Publication date Assignee Title
DE3344691A1 (de) * 1983-12-10 1985-06-20 Bayer Ag, 5090 Leverkusen Wirkstoffabgasesysteme
EP0204968B1 (de) * 1985-05-24 1989-09-27 Beiersdorf Aktiengesellschaft Nitro-Pflaster
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EP0356382B1 (de) * 1988-08-02 1994-02-16 Ciba-Geigy Ag Mehrschichtiges Pflaster
US5332577A (en) * 1988-12-27 1994-07-26 Dermamed Transdermal administration to humans and animals
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DE10003767A1 (de) 2000-01-28 2001-10-04 Beiersdorf Ag Hautfreundliches Wirkstoffpflaster zur transdermalen Verabreichung nichtsteroidaler Antirheumatika
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DE10056009A1 (de) * 2000-11-11 2002-05-16 Beiersdorf Ag Hautfreundliches Wirkstoffpflaster zur transdermalen Verabreichung hyperämisierender Wirkstoffe
US7097850B2 (en) * 2002-06-18 2006-08-29 Surmodics, Inc. Bioactive agent release coating and controlled humidity method
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Publication number Publication date
HUT36706A (en) 1985-10-28
CA1229044A (en) 1987-11-10
HU193075B (en) 1987-08-28
ATE53304T1 (de) 1990-06-15
FI845132A0 (fi) 1984-12-27
DK625984D0 (da) 1984-12-21
ES538863A0 (es) 1986-04-01
EP0150428A3 (en) 1986-01-15
EP0150428A2 (de) 1985-08-07
DK625984A (da) 1985-06-29
EP0150428B1 (de) 1990-06-06
NZ210690A (en) 1988-08-30
US4627852A (en) 1986-12-09
DE3482407D1 (de) 1990-07-12
FI845132L (fi) 1985-06-29
AU566414B2 (en) 1987-10-22
ZA8410058B (en) 1985-08-28
GR82619B (en) 1985-05-02
PT79764B (en) 1986-10-21
NO845002L (no) 1985-07-01
IL73935A0 (en) 1985-03-31
IL73935A (en) 1989-12-15
NO162496B (no) 1989-10-02
PH22901A (en) 1989-01-24
PT79764A (en) 1985-01-01
DE3347278A1 (de) 1985-07-11
ES8605684A1 (es) 1986-04-01
JPS60158111A (ja) 1985-08-19
AU3664984A (en) 1985-07-04

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