KR840007554A - 결정성 이부프로펜의 제조방법 - Google Patents

결정성 이부프로펜의 제조방법 Download PDF

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Publication number
KR840007554A
KR840007554A KR1019840000801A KR840000801A KR840007554A KR 840007554 A KR840007554 A KR 840007554A KR 1019840000801 A KR1019840000801 A KR 1019840000801A KR 840000801 A KR840000801 A KR 840000801A KR 840007554 A KR840007554 A KR 840007554A
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ibuprofen
solvent
liquid
mixture
solution
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KR1019840000801A
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KR900003298B1 (ko
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고오든(외 1) 로저유우진
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케네스 엠 사이러스
디 엎죤 캄파니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

내용 없음.

Description

결정성 이부프로펜의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 온도에 대한 각종 용매중에서 용해도를 나타낸 그래프이다.

Claims (11)

  1. 약 20-60℃ 온도에서 이부프로펜을 적어도 약 10용량%의 δH8 액체 용매를 함유하는 액체용매에 용해시켜 용액을 생성한 후; 이부프로펜:δH8 용매용액의 온도를 그안에 함유된 이부프로펜 성분이 실질적으로 완전히 용해된 용액으로 되게하기 위해 포화점까지 필요한 만큼 조절하고; 결과 생성된 δH8 용매중 이부프로펜 용액을 약 0-3시간에 걸쳐 0∼-20℃로 냉각하여 이 용액으로부터 이부프로펜이 결정화되고 침전되게 한 후; 냉각된 이부프로펜:δH8 용매혼합물을 충분한 시간동안 진탕하여 혼합물중 고체/액체 평형 상태를 얻은 후; 혼합물의 액체 성분으로 부터 결정성 이부프로펜을 분리하는 것으로 구성된 결정성 이부프로펜의 제조방법.
  2. 제1항에 있어서, 이부프로펜의 δH8 액체 혼합물중 과포하 용액을 고체 이부프로펜으로 접종하여 뒤이은 냉각 조작중에 결정화가 유발되게 하는 방법.
  3. 제1항에 있어서 δH8 용매성분을 메탄올, 에탄올, 이소프로판올 및 그 혼합물로 구성된 군으로부터 선택하는 방법.
  4. 제2항에 있어서 결과 생성된 이부프로펜/δH8 용매 액체 혼합물에 이부프로펜의 용해도를 감소시키는 액체를 혼합하는 단계를 더 포함하여 결과 생성된 혼합물로부터 이부프로펜의 결정화 및 침전이 일어나게 하는 방법.
  5. 제4항에 있어서 이부프로펜/δH8 액체와 혼합되는 용해도 감소액체가 물, 헥산, 헵탄, 톨루엔, 초산에틸, 에틸렌글리콜, 프로필렌글리콜, 글리세린 및 그 혼합물로 구성된 군으로부터 선택되는 방법.
  6. 제1항에 있어서 결정화될 이부프로펜이 δH8 용매성분과 비-C1-C3용매 성분의 액체 용매 혼합물중에 함유되어 있으며 여기서 비-δH8 용매 액체 성분은 극성이 적으며 C1-C3-알카놀 보다 이부프로펜에 대한 수소결합 능력이 적은 방법.
  7. 제6항에 있어서 δH8 용매 액체 성분이 C1-C3-알카놀인 방법.
  8. 제1항에 있어서 결정화될 이부프로펜이 용매액체 혼합물중 물을 90%까지 함유하는 δH8 용매 액체/물 혼합물인 방법.
  9. 제8항에 있어서 δH8 용매액체 성분이 C1-C3-알카놀인 방법.
  10. 이부프로펜을 수소결합매개변수[δH]가 약 8힐데브란드 단위보다 큰 액체 용매중의 그의 용액으로부터 결정화하는 것으로 구성된 실질적으로 등방정 또는 육방정 형상의 결정습성을 가진 이부프로펜을 제조하는 방법.
  11. 제1항에 있어서 이부프로펜을 약 10용량%의 물을 함유하는 에탄올 용액으로 구성된 용매 혼합물로부터 결정화하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840000801A 1983-02-28 1984-02-20 결정성 이부프로펜의 제조방법 KR900003298B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US47082083A 1983-02-28 1983-02-28
US470820 1983-02-28
US06/517,116 US4476248A (en) 1983-02-28 1983-07-25 Crystallization of ibuprofen
US517116 1983-07-25

Publications (2)

Publication Number Publication Date
KR840007554A true KR840007554A (ko) 1984-12-08
KR900003298B1 KR900003298B1 (ko) 1990-05-14

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Country Link
US (1) US4476248A (ko)
EP (1) EP0120587B1 (ko)
JP (1) JPH0623126B2 (ko)
KR (1) KR900003298B1 (ko)
AU (1) AU567125B2 (ko)
CA (1) CA1212693A (ko)
DE (1) DE3460098D1 (ko)
ES (1) ES530082A0 (ko)
MX (1) MX161333A (ko)
PH (1) PH20032A (ko)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8606762D0 (en) * 1986-03-19 1986-04-23 Boots Co Plc Therapeutic agents
US5015646A (en) * 1987-08-28 1991-05-14 Bristol-Myers Squibb Co. Pharmaceutically useful polymorphic modification of buspirone
US4810789A (en) * 1987-08-28 1989-03-07 Bristol-Myers Company Process for buspirone hydrochloride polymorphic crystalline form conversion
SE463541B (sv) 1987-08-31 1990-12-10 Lejus Medical Ab Granulaer produkt oeverdragen av en smaelta av sig sjaelv samt foerfarande foer dess framstaellning
ATE121619T1 (de) * 1990-04-11 1995-05-15 Upjohn Co Verfahren zum geschmacksabdecken von ibuprofen.
US5151551A (en) * 1990-09-06 1992-09-29 Hoechst Celanese Corporation Method for purification of ibuprofen comprising mixtures
WO1992008686A1 (en) * 1990-11-19 1992-05-29 Ethyl Corporation Process for improving flow characteristics of crystalline ibuprofen
US5191114A (en) * 1991-10-09 1993-03-02 Sage Pharmaceuticals, Inc. Process for enhancing the flow characteristics of ibuprofen
US5300301A (en) * 1992-12-02 1994-04-05 Hoechst Celanese Corporation Isolation of ibuprofen from tablets
AT401871B (de) * 1994-01-28 1996-12-27 Gebro Broschek Gmbh Verfahren zur herstellung von s(+)-ibuprofen- partikeln mit verbesserten fliesseigenschaften und deren verwendung zur arzneimittelherstellung
US5608048A (en) * 1995-06-05 1997-03-04 Bristol-Myers Squibb Company d4 T polymorphic Form 1 process
US5922695A (en) * 1996-07-26 1999-07-13 Gilead Sciences, Inc. Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability
GB2315661B (en) * 1996-07-26 2000-05-03 Unilever Plc Frozen food product
TR199902202T2 (xx) * 1997-03-14 1999-12-21 Unilever N.V. Dondurulmu� g�da �r�n�.
US5935946A (en) * 1997-07-25 1999-08-10 Gilead Sciences, Inc. Nucleotide analog composition and synthesis method
ZA986614B (en) 1997-07-25 1999-01-27 Gilead Sciences Nucleotide analog composition
FI122018B (fi) * 2000-01-31 2011-07-29 Danisco Menetelmä betaiinin kiteyttämiseksi
HRP20000328A2 (en) * 2000-05-19 2002-02-28 Pliva Farmaceutska Ind Dionik Novel polymorph v of torasemide
CA2788498C (en) * 2001-03-01 2016-02-16 Gilead Sciences, Inc. Polymorphic and other crystalline forms of cis-ftc
PL367262A1 (en) * 2001-04-26 2005-02-21 Bristol-Myers Squibb Company A pharmaceutical tablet having a high api content
DE10153934A1 (de) * 2001-11-06 2003-05-22 Basf Ag Verfahren zur Kristallisation von Profenen
DE602004014470D1 (de) 2003-01-14 2008-07-31 Gilead Sciences Inc Zusammensetzungen und verfahren zur antiviralen kombinationstherapie
ATE442352T1 (de) * 2003-05-16 2009-09-15 Cephalon France Verfahren zur herstellung von modafinil
FR2857253B1 (fr) * 2003-07-07 2007-02-09 Ethypharm Sa Installation comprenant une machine de fabrication de comprimes en particulier a usage therapeuthique
US20050137262A1 (en) * 2003-12-22 2005-06-23 Hu Patrick C. Highly concentrated pourable aqueous solutions of potassium ibuprofen, their preparation and their uses
US20080247582A1 (en) 2004-09-09 2008-10-09 Guenther Godehard A Loudspeaker and Systems
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
CL2007002425A1 (es) * 2006-08-22 2008-06-27 Albermarle Corp Procedimiento de preparacion controlado de sal sodica de ibuprofeno de tamano de particula mediano; y dichas particulas de sal sodica.
US8189840B2 (en) 2007-05-23 2012-05-29 Soundmatters International, Inc. Loudspeaker and electronic devices incorporating same
JP2011500724A (ja) * 2007-10-19 2011-01-06 パーデュ リサーチ ファンデーション 結晶性化合物の固体製剤
EP2445486B1 (en) * 2009-06-22 2017-11-08 Wyeth LLC Sodium ibuprofen tablets and methods of manufacturing pharmaceutical compositions including sodium ibuprofen
CN103221391B (zh) 2010-01-27 2018-07-06 艾尼纳制药公司 (R)-2-(7-(4-环戊基-3-(三氟甲基)苄基氧基)-1,2,3,4-四氢环戊二烯并[b]吲哚-3-基)乙酸及其盐的制备方法
JP5821247B2 (ja) * 2010-04-07 2015-11-24 大正製薬株式会社 イブプロフェンの昇華抑制方法
CN102311335B (zh) * 2010-06-29 2013-12-11 山东新华制药股份有限公司 高松密度布洛芬的制备工艺
KR101324862B1 (ko) * 2011-07-12 2013-11-01 (주)에이에스텍 클로피도그렐 황산수소염의 구형 입자, 이를 포함하는 약학적 조성물 및 이의 제조방법
CN102936194A (zh) * 2012-11-14 2013-02-20 陕西合成药业有限公司 一种高纯度的布洛芬的精制方法
US10301262B2 (en) 2015-06-22 2019-05-28 Arena Pharmaceuticals, Inc. Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta [b]indol-3-yl)acetic acid(Compund1) for use in SIPI receptor-associated disorders
EP3582772A1 (en) 2017-02-16 2019-12-25 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of primary biliary cholangitis
MA47503A (fr) 2017-02-16 2021-04-21 Arena Pharm Inc Composés et méthodes pour le traitement de maladies inflammatoires chroniques de l'intestin avec manifestations extra-intestinales
CN113200846B (zh) * 2021-04-23 2022-04-22 浙江新和成股份有限公司 一种高松密度布洛芬球形晶体的制备方法及其产品

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB971700A (en) * 1961-02-02 1964-09-30 Boots Pure Drug Co Ltd Anti-Inflammatory Agents
IT1059677B (it) * 1974-03-22 1982-06-21 Neopharmed Spa Sale di lisina ad azione terapeutica
JPS553336B2 (ko) * 1974-04-11 1980-01-24
CA1062721A (en) * 1975-12-15 1979-09-18 Anthony A. Sinkula Propionic acid derivatives
US4189596A (en) * 1976-05-24 1980-02-19 The Upjohn Company Preparing 2-arylalkanoic acid derivatives

Also Published As

Publication number Publication date
JPS59167536A (ja) 1984-09-21
EP0120587A1 (en) 1984-10-03
MX161333A (es) 1990-09-10
ES8504658A1 (es) 1985-05-01
AU2377184A (en) 1984-09-06
CA1212693A (en) 1986-10-14
AU567125B2 (en) 1987-11-12
ES530082A0 (es) 1985-05-01
JPH0623126B2 (ja) 1994-03-30
PH20032A (en) 1986-09-04
US4476248A (en) 1984-10-09
DE3460098D1 (en) 1986-05-28
KR900003298B1 (ko) 1990-05-14
EP0120587B1 (en) 1986-04-23

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