KR840006492A - Process for preparing platinum-diamine complex - Google Patents

Process for preparing platinum-diamine complex Download PDF

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Publication number
KR840006492A
KR840006492A KR1019830004987A KR830004987A KR840006492A KR 840006492 A KR840006492 A KR 840006492A KR 1019830004987 A KR1019830004987 A KR 1019830004987A KR 830004987 A KR830004987 A KR 830004987A KR 840006492 A KR840006492 A KR 840006492A
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formula
compound
platinum
prepared
producing
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KR1019830004987A
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KR910002536B1 (en
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베르빅(외2) 프랑소와
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원본미기재
네덜란드즈 센트랄 오르가니세티 보르 퇴게파스트-네툴베텐 샤펠리젝 온더죅
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

내용 없음No content

Description

플라티늄-디아민 착화물의 제조 방법Process for preparing platinum-diamine complex

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (24)

암의 치료를 위한 플라티늄-(Ⅱ)-디아민 착화물로서 하기 일반식(Ⅰ)의 화합물을 사용하는 것을 특징으로 하는, 플라티늄-(Ⅱ)-디아민 착화물로 구성되는 의약적 조성물의 제조방법.A method for producing a pharmaceutical composition composed of a platinum- (II) -diamine complex, characterized by using a compound of the general formula (I) as a platinum- (II) -diamine complex for the treatment of cancer. 상기식에서, R1과 R2는 각각 에틸기이거나 또는 두기가 함께 탄소와 결합되어 시클로헥실기를 형성하며, R3와 R4는 각각 수소원자이며, X는 말로네이트기, 에틸말로네이트기, 히드록 시말로네이트기, 카르복시프탈레이트기, 비슬클로로 아세테이트기, 시클로부탄-1.1-디카르복시레이트기, 디니트레이트기 또는 옥사레이트기이거나 상술된 기들의 나트륨염이다.Wherein R 1 and R 2 are each an ethyl group or both groups are bonded to carbon together to form a cyclohexyl group, each of R 3 and R 4 is a hydrogen atom, X is a malonate group, an ethyl malonate group, a hydroxide Or a sodium salt of the groups described above, or a oxymalonate group, a carboxyphthalate group, a bischloro acetate group, a cyclobutane-1.1-dicarboxylate group, a dinitrate group or an oxalate group. 제 1항에 있어서, 플라티늄-(Ⅱ)-디아민 착화물로서 하기식(4), 화합물을 사용하는 것을 특징으로하는 의약적 조성물의 제조방법.The method for producing a pharmaceutical composition according to claim 1, wherein the following formula (4) and a compound are used as the platinum- (II) -diamine complex. 제 1항에 있어서, 플라티늄-(Ⅱ)-디아민 착화물로서 하기식(5)의 화합물을 사유하는 것을 특징으로하는 의약적 조성물의 제조방법.The method for producing a pharmaceutical composition according to claim 1, wherein the compound of formula (5) is used as a platinum- (II) -diamine complex. 제 1항에 있어서, 플라티늄-(Ⅱ)-디아민 착화물로서 하기식(6)의 화합물을 사용하는 것을 특징으로 하는 의약적 조성물의 제조방법.The method for producing a pharmaceutical composition according to claim 1, wherein a compound of formula (6) is used as the platinum- (II) -diamine complex. 제 1항에 있어서, 플라티늄-(Ⅱ)디아민 착화물로서 하기식(7)의 화합물을 사용하는 것을 특징으로 하는 의야적 조성물의 제조방법.The method for producing a prosthetic composition according to claim 1, wherein a compound of formula (7) is used as the platinum- (II) diamine complex. 제 1항에 있어서, 플라티늄-(Ⅱ)-디아민 착화물로서 하기식(8)의 화합물을 사용하는 것을 특징으로하는 의약적 조성물의 제조방법.The method for producing a pharmaceutical composition according to claim 1, wherein a compound of formula (8) is used as the platinum- (II) -diamine complex. 제 1항에 있어서, 플라티늄-(Ⅱ)-디아민 착화물로서 하기식(9)의 화합물을 사용하는 것을 특징으로 하는 의약적 조성물의 제조방법.The method for producing a pharmaceutical composition according to claim 1, wherein a compound of formula (9) is used as the platinum- (II) -diamine complex. 제 1항에 있어서, 플라티늄-(Ⅱ)-디아민 착화물로서 하기식(10)의 화합물을 사용하는 것을 특징으로 하는 의약적 조성물의 제조방법.The method for producing a pharmaceutical composition according to claim 1, wherein a compound of formula (10) is used as the platinum- (II) -diamine complex. 제 1항에 있어서, 플라티늄-(Ⅱ)-디아민 착화물로서 하기식(11)의 화합물을 사용하는 것을 특징으로 하는 의약적 조성물의 제조방법.The method for producing a pharmaceutical composition according to claim 1, wherein a compound of formula (11) is used as the platinum- (II) -diamine complex. 제 1항에 있어서, 플라티늄-(Ⅱ)-디아민 착화물로서 하기식(12)의 화합물을 사용하는 것을 특징으로 하는 의약적 조성물의 제조방법.The method for producing a pharmaceutical composition according to claim 1, wherein a compound of formula (12) is used as the platinum- (II) -diamine complex. 제 1항에 있어서, 플라티늄 -(Ⅱ)-디아미 착화물로 하기식(13)의 화합물을 사용하는 것을 특징으로 하는 의약적 조성물의 제조방법.The method of producing a pharmaceutical composition according to claim 1, wherein the compound of formula (13) is used as the platinum- (II) -diami complex. 제 1항에 있어서, 플라티늄-(Ⅱ)-디아미 착화물로서 하기식(14)의 화합물을 사용하는 것을 특징으로 하는 의약적 조성물의 제조방법.The method for producing a pharmaceutical composition according to claim 1, wherein a compound of formula (14) is used as the platinum- (II) -diami complex. 상기 일반식(Ⅰ)의 플라티늄-(Ⅱ)-디아민 착화물을 공지된 방법에 따라 제조되는 것을 특징으로하는 제 14∼제 24항에 따른 방법에 사용되는 플라티늄-(Ⅱ)-디아민 착화물의 제조방법.Preparation of the platinum- (II) -diamine complex for use in the process according to claims 14 to 24, wherein the platinum- (II) -diamine complex of formula (I) is prepared according to a known method. Way. 제 13항에 있어서 상기 식(4)의 화합물을 제조하는 것을 특징으로 하는 제조방법.The production method according to claim 13, wherein the compound of formula (4) is prepared. 제 13항에 있어서, 상기 식(5)의 화합물을 제조하는 것을 특징으로 하는 제조방법.A process according to claim 13, wherein the compound of formula (5) is prepared. 제 14항에 있어서, 상기 식(6)의 화합물을 제조하는 것을 특징으로 하는 제조방법.The production method according to claim 14, wherein the compound of formula (6) is prepared. 제 13항에 있어서, 상기 식(7)의 화합물을 제조하는 것을 특징으로 하는 제조방법.The process according to claim 13, wherein the compound of formula (7) is prepared. 제 13항에 있어서, 상기 식(8)의 화합물을 제조하는 것을 특징으로 하는 제조방법.A process according to claim 13, wherein the compound of formula (8) is prepared. 제 13항에 있어서, 상기 식(9)의 화합물을 제조하는 것을 특징으로 하는 제조방법.A process according to claim 13, wherein the compound of formula (9) is prepared. 제 13항에 있어서, 상기 식(10)의 화합물을 제조하는 것을 특징으로 하는 제조방법.The process according to claim 13, wherein the compound of formula (10) is prepared. 제 13항에 있어서, 상기 식(11)의 화합물을 제조하는 것을 특징으로 하는 제조방법.A process according to claim 13, wherein the compound of formula (11) is prepared. 제 13항에 있어서, 상기 식(12)의 화합물을 제조하는 것을 특징으로 하는 제조방법.A process according to claim 13, wherein the compound of formula (12) is prepared. 제 13항에 있어서, 상기 식(13)의 화합물을 제조하는 것을 특징으로 하는 제조방법.A process according to claim 13, wherein the compound of formula (13) is prepared. 제 13항에 있어서, 상기 식(14)의 화합물을 제조하는 것을 특징으로 하는 제조방법.A process according to claim 13, wherein the compound of formula (14) is prepared. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019830004987A 1982-10-21 1983-10-21 Preparation method of plantinum-diamine complexes KR910002536B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL8204067 1982-10-21
NL8204067A NL8204067A (en) 1982-10-21 1982-10-21 PLATINUM DIAMINE COMPLEXES, METHOD FOR PREPARING THE SAME, METHOD FOR PREPARING A MEDICINAL PRODUCT USING SUCH PLATINADIAMINE COMPLEX FOR THE TREATMENT OF CANCER, PREVENTLY PREVENTED.

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KR840006492A true KR840006492A (en) 1984-11-30
KR910002536B1 KR910002536B1 (en) 1991-04-23

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JP (1) JPS5993091A (en)
KR (1) KR910002536B1 (en)
AT (1) AT390610B (en)
AU (1) AU562964B2 (en)
BE (1) BE898058A (en)
CA (1) CA1229618A (en)
CH (1) CH658244A5 (en)
CS (1) CS242888B2 (en)
DD (1) DD217522A5 (en)
DE (1) DE3337333A1 (en)
DK (2) DK483083A (en)
ES (1) ES8406498A1 (en)
FI (1) FI76351C (en)
FR (1) FR2534907B1 (en)
GB (1) GB2128615B (en)
GR (1) GR79652B (en)
HU (1) HU188035B (en)
IE (1) IE56124B1 (en)
IT (1) IT1169858B (en)
LU (1) LU85054A1 (en)
NL (1) NL8204067A (en)
NO (1) NO171276C (en)
NZ (1) NZ206018A (en)
PH (1) PH24077A (en)
PT (1) PT77542B (en)
SE (1) SE8305783L (en)
YU (1) YU43554B (en)
ZA (1) ZA837857B (en)

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US4786725A (en) * 1982-06-28 1988-11-22 Engelhard Corporation Solubilized platinum (II) complexes
US4661516A (en) * 1983-06-20 1987-04-28 Research Corporation Diaminocyclohexane platinum complexes
US4758588A (en) * 1983-06-20 1988-07-19 Research Corporation Technologies Diaminocyclohexane platinum complexes
EP0169645A1 (en) * 1984-06-27 1986-01-29 Johnson Matthey Public Limited Company Platinum co-ordination compounds
DE3432320A1 (en) * 1984-09-03 1986-03-13 Behringwerke Ag, 3550 Marburg CIS-PLATINUM COMPLEXES WITH A PENTAERYTHRITE DERIVATIVE AS A LIGAND, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENT CONTAINING THESE COMPOUNDS
HU193809B (en) * 1984-09-12 1987-12-28 Chugai Pharmaceutical Co Ltd Process for producing new platinum complexes
US4737589A (en) * 1985-08-27 1988-04-12 Nippon Kayaku Kabushiki Kaisha Platinum Complexes
US4760157A (en) * 1986-01-31 1988-07-26 American Cyanamid Company (2,2,-bis(aminomethyl)-1,3-propanediol-N,N')platinum complexes
US4880790A (en) * 1986-01-31 1989-11-14 American Cyanamid Company (Gem-heterocyclodimethanamine-N,N')platinum complexes
DE3630497A1 (en) * 1986-09-08 1988-03-10 Behringwerke Ag CIS-PLATINUM COMPLEXES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS
ATE53217T1 (en) * 1986-10-03 1990-06-15 Asta Pharma Ag DIAMININE-PLATINUM (II) COMPLEX COMPOUNDS WITH A HYDROXYLATED 2-PHENYL-INDOLE RING.
JPS63203692A (en) * 1987-02-19 1988-08-23 Nippon Kayaku Co Ltd Novel platinum complex
AT390065B (en) * 1987-10-08 1990-03-12 Behringwerke Ag cis-Platinum complexes, process for their preparation and pharmaceutical compositions containing these compounds
NL8802150A (en) * 1988-08-31 1990-03-16 Tno PLATINUM (II) DIAMINE COMPLEX, PROCESS FOR PREPARING THIS COMPOUND, PREPARATION WITH ANTI-TUMOR EFFECT, CONTAINING THIS COMPOUND AND FORMED PREPARATIONS WITH ANTI-TUMOR EFFECT.
NL8802149A (en) * 1988-08-31 1990-03-16 Tno PLATINUM (IV) DIAMINE COMPLEX, METHOD FOR PREPARING THIS COMPOUND, PREPARATION WITH ANTI-TUMOR EFFECT, CONTAINING AT LEAST A PLATINUM COMPOUND, AND FORMED PREPARATIONS WITH ANTI-TUMOR EFFECT.
CN102924528B (en) * 2012-10-29 2015-04-15 东南大学 Anti-tumor bivalent platinum complex and preparation method for complex and ligand of complex

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US4115418A (en) * 1976-09-02 1978-09-19 Government Of The United States Of America 1,2-diaminocyclohexane platinum (ii) complexes having antineoplastic activity
US4206226A (en) * 1977-08-29 1980-06-03 The United States Of America As Represented By The Department Of Health, Education And Welfare Use of 4-carboxy-phthalato-(1,2-diaminocyclohexane)-platinum(II) and alkali metal salts thereof in alleviating L1210 murine leukemia
NL7807334A (en) * 1978-07-06 1980-01-08 Tno PLATINUM DIAMINE COMPLEXES, METHOD FOR PREPARING THE SAME, METHOD FOR PREPARING A MEDICINAL PRODUCT USING SUCH A PLATINUM DIAMOND COMPLEX FOR THE TREATMENT OF CANCER, SO PREVENTLY DRIVED.
NL189358C (en) * 1978-07-06 1993-03-16 Tno PROCESS FOR PREPARING A MEDICINE FOR THE TREATMENT OF CANCER, AND AN PLATINUM-DIAMMINE COMPLEX DERIVED FROM A 1,3-ALKANE DIAMINE.
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NZ206018A (en) 1986-02-21
ES526670A0 (en) 1984-07-01
NO833825L (en) 1984-04-24
LU85054A1 (en) 1984-03-22
BE898058A (en) 1984-04-24
IT8323359A0 (en) 1983-10-19
JPS5993091A (en) 1984-05-29
GB8328084D0 (en) 1983-11-23
CA1229618A (en) 1987-11-24
NO171276C (en) 1993-02-17
CH658244A5 (en) 1986-10-31
FI76351B (en) 1988-06-30
ZA837857B (en) 1984-06-27
KR910002536B1 (en) 1991-04-23
PT77542B (en) 1986-02-12
ES8406498A1 (en) 1984-07-01
IT1169858B (en) 1987-06-03
SE8305783L (en) 1984-04-22
AT390610B (en) 1990-06-11
JPH0244479B2 (en) 1990-10-04
GR79652B (en) 1984-10-31
SE8305783D0 (en) 1983-10-20
FI833842A (en) 1984-04-22
ATA373083A (en) 1989-11-15
YU43554B (en) 1989-08-31
AU2027583A (en) 1984-05-03
YU210783A (en) 1986-08-31
GB2128615B (en) 1986-07-16
IE56124B1 (en) 1991-04-24
HU188035B (en) 1986-03-28
DE3337333A1 (en) 1984-04-26
NL8204067A (en) 1984-05-16
DK483083A (en) 1984-04-22
PH24077A (en) 1990-03-05
AU562964B2 (en) 1987-06-25
FI76351C (en) 1988-10-10
DK483083D0 (en) 1983-10-20
FR2534907B1 (en) 1988-08-19
CS775283A2 (en) 1985-08-15
FI833842A0 (en) 1983-10-20
DD217522A5 (en) 1985-01-16
PT77542A (en) 1983-11-01
FR2534907A1 (en) 1984-04-27
IE832459L (en) 1984-04-21
NO171276B (en) 1992-11-09
DK75592D0 (en) 1992-06-09
DK75592A (en) 1992-06-09
CS242888B2 (en) 1986-05-15
GB2128615A (en) 1984-05-02

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