KR840002256B1 - Discrete type automated chemical analytic apparatus - Google Patents

Abstract

A discrete type automated chemical analytic apparatus, wherein a carrier member reciprocatable in parallel with a reaction line constituted by those of the reaction tubes linearly arranged on an endless belt which are set on the top run of the endless belt supports two reagent-pipetting nozzles in a vertically movable state. The corresponding reagent containers are disposed on an extension of the reaction lione. The nozzles through which the reagent is sucked from the reagent containers pipette the sucked reagent into the corresponding reaction tubes at predetermined points on the reaction line in accordance with the movement of the carrier member.

Description

Automation analysis device

1 is a schematic view showing one example of a conventional apparatus.

2 is a system configuration diagram showing an embodiment of the apparatus of the present invention.

3 and 4 are perspective and side views showing one embodiment of a moving block used in the apparatus of the present invention.

5 is an explanatory diagram showing an example of a reagent cassette moving mechanism;

6 is a schematic diagram showing an operating state of the nozzle.

7 is a schematic side view of a moving block used in another embodiment of the present invention.

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an automated analysis device, and more particularly, to a discrete automated analysis device for continuously measuring a plurality of items by a single reaction channel.

In recent years, the importance of the test in the diagnosis of a disease is increasing, and the number of tests and the number of test items are also increasing.

In such a situation, for example, in an examination room and an inspection center of a hospital, the inspection automation has emerged as an important problem in order to cope with such a situation. In this case, in order to improve the automation analysis device that provides the analysis result which is the critical judgment data deeply related to the life of a person in a limited number of people and places such as a hospital, the following points should be considered. In other words, in order not to cause pain to patients, it should be possible to analyze with very small amount of sample and trace amount of reagent, and even lower analysis cost. Secondly, a number of specimens should be analyzed more quickly and have the promptness to report more quickly. Third, a limited number of people should have simplicity to make mistakes in analyzing multiple items and samples. Fourth, because it provides important diagnostic data related to human life, it must be accurate and reliable. Fifth, it should be a small thing that can be used in a smaller space.

Even in the conventional automation analysis device, there have been remarkable developments regarding the improvement of these five items. In particular, in the case of miniaturization and rapidization, great advances and developments have been made by employing automation, but in terms of simplicity, satisfactory things have not yet appeared. Also, in terms of clarity, there are many items affected by reaction conditions and low degrees of freedom at the automation stage.

By the way, in the conventional well-known automated analysis device, the dispensing position of the sample and the dispensing position of the reagent are fixed or semi-fixed, and are often dispensed at a position corresponding to one to one in the corresponding dispensing pump according to the measurement item. . In this case, in order to take the required reaction time for the items and reagents to be measured, it was necessary for the operator to manually set the reagent nozzles or sampling nozzles in a specific position in advance. In addition, when a large number of items are carried out in a limited reaction line, a large number of reagent nozzles are set in a required position in advance, which may lead to time-consuming and complicated pipework of reagent tubes, which may cause operational errors. . Such a conventional method is a method of dispensing any reagent amount at an arbitrary position on a reaction line, and dispensing a reagent of a liquid amount set at a predetermined position, particularly in the case of a fixed method. The degree of freedom of the phase is restricted, which imposes an unreasonable response, and causes a drastic decrease in the reliability of the measurement results. In the case of the semi-fixed method, the setting position is changed by intervening each time an item is changed. There was inconvenience to do. In addition, since it is set mechanically also in the liquid amount setting of a reagent pump, it was impossible to change automatically and arbitrarily about an item and the reagent used.

Therefore, in the past, the automatic and random setting of the reagent at the dispensing position of the reagent and the dispensing liquid amount was not possible, and since there was no method except for manual switching, a large factor for limiting the full automation in the automation analysis device was found. Was becoming.

Moreover, since the apparatus which tried to automate the dispensing of reagents for the purpose of simplifying the control of an automation analysis apparatus is described (Patent No. 54-5790), the outline is shown in FIG. The apparatus includes a nozzle mechanism 124 and an outer wall cleaning tank 122, and a blood dispensing mechanism 123 for repeating the same operation every cycle regardless of the sample information, and the main computer 105 according to the sample information. And a rotary tackle 125A on which the first reagent container 126A is placed, a nozzle mechanism 124A, and an outer wall cleaning tank 11A, and 1 regardless of the sample information. The rotating table on which the first reagent dispensing pipette mechanism 123A repeats the same operation every cycle and the main comparator 105 according to the sample information, and the second reagent container 126B are mounted. 125B), a nozzle mechanism 124B, and an outer wall cleaning tank 122B, and a second reagent dispensing pipette mechanism 123B which repeats the same operation every cycle irrespective of the sample information. For example, the serum sample container 101 reaches the serum suction position on the sampler instrument 120. In this case, the transfer of the sampler mechanism is stopped while the conveying line 108 and the pipette mechanisms 123, 123A, and 123B perform a predetermined step operation, and the serum of the container bovine in the suction position is in between. By diluting with suction and distilled water by means of dispensing into a predetermined reaction vessel 103, each reaction vessel is transferred again to reach the position of the nozzle 124A, the rotary table 125A rotates and stops according to the sample information At this stop, the first reagent in the reagent container 16A at the suction position on the rotary table is sucked in, following the pipette mechanism 123A, added to the reaction vessel, and the reaction vessel after the first reagent addition is added to the nozzle 124B. ), The second reagent is added this time by the operation of the pipette mechanism 123B. According to such an apparatus, the replacement of patented reagents is unnecessary, and the suction and dispensing of serum and reagents can be automated, so that the instrument system and the control system can be simplified, and high reliability can be secured. .

However, even in the above-mentioned conventional apparatus, since the suction and dispensing positions of the reagents are fixed (or semi-fixed), there is a big drawback that it is impossible to adjust the reaction time or the addition time of the reagent depending on the measurement item. That is, since the adjustment time of the reagent addition cannot be adjusted, for example, even in the case of measurement items having a short reaction time, the same time as the item requiring the maximum reaction time should be consumed. There is a drawback to being accurate (in the case of fixed methods) In addition, even in a method (semi-fixed method) in which the reagent dispensing position can be adjusted by manual setting, there is a disadvantage in that the position of each measurement item is reduced in size.

The present invention has been studied in view of the above circumstances, and an object of the present invention is to provide an automated analysis device that is excellent in operability and simplicity and can achieve miniaturization of a device by automatically adjusting reagent addition time according to measurement items. It is.

According to the following Examples, the present invention will be described in detail.

2 is a system configuration diagram showing an embodiment of the apparatus of the present invention. The apparatus comprises a reaction line (7), a nozzle moving mechanism (6) disposed on the reaction line, an isoblock (16) for moving the nozzle by the nozzle mechanism, and various nozzles in the moving block (16). Measuring the absorbance of the sample and the sampling pump (1), the first reagent pump (2), the second reagent pump (3) for performing suction and dispensing of the various nozzles Serum (sample) cassette 13 (sampler having a sample container 13a) positioned below the photometric unit 8 and the nozzle moving mechanism 6 and disposed on the side of the reaction line 7 And a reagent cassette 14 (having a first reagent container 10 and a second reagent container 11) and control blocks 17-22 for automatically controlling various devices and instruments. In addition, a nozzle cleaning drain 15 is disposed on the side of the reagent cassette 14.

The reaction line 7 has an endless chain conveyor 12 in which a plurality of reaction tubes 7a are arranged in a straight line at regular intervals, and the chain conveyor 12 is interposed through a rotating member 7a. The reaction tube 7b is intermittently moved in the counterclockwise direction (shown by the arrow A direction) by a drive mechanism (not shown). Further, below the reaction line 7, a washing mechanism including a washing nozzle 32 is provided. In addition, (7c) is a thermostat and is used to cause a predetermined reaction.

The nozzle moving mechanism 6 is arranged in the longitudinal direction of the reaction line 7 and has a timing belt 6a attached with a moving block 16, and B ₁ , B which displays the timing belt 6a in the drawing. _The pulse motor 6b for moving in _two directions and the guide pulley 6c and timing belt 6a which guide the timing belt 6a on the opposite side of the pulse motor 6b are arranged in parallel, and are moved. It is comprised as the guide rail 6d which guides the block 16. As shown in FIG.

Next, a configuration of one embodiment of the moving block 16 will be described with reference to FIG. 3 and FIG. The movable block 16 has a supporting member having an inverted (c) shape in cross section by the flat plate portion 41 and the parallel protrusions 42 and 43, and makes a predetermined distance to the flat plate portion 41 of this member. Two long guide holes 45a and 45b are formed, and a pair of small blocks 16a and 16b are provided at both ends of the connecting shaft 16d which slides smoothly into the guide holes 45a and 45b. 16a 'and 16b' are attached, nozzles 46a and 46b are inserted into and supported in the front small blocks 16a and 16b, respectively, and the rear small blocks 16a 'and 16b' are respectively supported. ) Is slidably attached to two guide shafts 44 supported at both ends by the parallel protrusions 42 and 43, and on the rear side of the upper protrusion 42, a guide block 42a and an attachment portion 42b. Is connected, the attachment portion 42b is fixed to a part of the timing belt 6a, and the guide block 42a is slid to the guide shaft 6d 'disposed along the timing belt 6a. A plurality of guide bearings 43a protrude from the rear side of the lower protrusion 43, and the guide bearing 43a is configured to be movable on the guide rail 6d. . In addition, the opposite small blocks 16a 'and 16b' connected to the small blocks 16a and 16b through which the various nozzles 46a and 46b are inserted through the through holes 42c formed in the upper protruding block 42 are provided. It is attached to the distal end of the wire 47 guided to the spring extending in the outer upper direction, and the wire 47 is pulled upward in the upper direction (arrow C direction) by the solenoid mechanism 5 disposed correspondingly. Direction of movement, and during operation, the solenoid mechanism 5 is released to move downward by the pressing force of the pressing spring 48.

With such a structure, even if the state positions of the solenoid and the nozzle change, it is possible to move the shanghai copper by remote operation (release method).

According to the operation of the small blocks 16a 'and 16b', various nozzles 16a 'and 16b' are made to be movable, and the upper end of these various nozzles is described later in detail through a flexible pipe. It is connected to various pumps 1-3. For example, the nozzle 46a is used as the first reagent nozzle 46b as the second reagent nozzle. The interval 1 between the first reagent nozzle 46a and the second reagent nozzle 46b is set so as to correspond to the distance between the reagent containers 10 and 11.

合)하는 너트(1c, 2c, 3,)와 이 너트의 피스톤이 연결된 시린지(1d, 2d, 3d) 및, 시린지의 출력부가 연결되는 전자밸브(31a-31c)(31a, 31b)는 시약펌프용, 31c는 샘플링펌프용)와, 샘플링노즐(46c)의 구동기구(27)에 의하여 구성되어 있고, 제1시약 펌프(2)내의 전자밸브(31a)의 한쪽에는 상기 제1시약용노즐(46a)에 접속된 파이프의 선단이 연결되고, 제2시약 펌프(3)내의 전자밸브(31b)의 한쪽에는 상기 제2시약용노즐(46b)에 접속된 파이프의 선단이 연결되어 있고, 각 전자밸브(31a, 31b)의 다른 쪽에는 일단이 증류수 용기(9) 내에 삽입된 파이프의 다른쪽 단이 공통으로 연결된다. 또, 샘플링펌프(1) 내의 전자밸브(31c)의 한쪽에 상기 샘플링노즐(4Cc)에 접속된 파이프의 일단이, 다른 쪽에는 증류수 용기(9)내에 일단이 삽입된 파이프의 타단이 연결된다. 이와 같이 해서, 펄스 카운트방식의 펌프가 구동된다. 또, 샘플링노즐(46c)의 선단은 통상 샘플러(13) 내의 1개의 샘플용기(13a)상에 위치하고 있고, 구동기구(27)에 의하여 상하이동을 하고, 샘플의 흡입을 하는 동시에 진동 동작을하고, 목적반응관(35)의 위치(36c'로 표시)와, 드레인(15')의 위치(46c"로 표시)를 이동하도록 되어 있다.The various pumps 1-3 are combined with lead screws 1b, 2b and 3b connected to pulse motors 1a, 2a and 3a, respectively.

Nuts 1c, 2c, and 3 to be combined with the syringes 1d, 2d and 3d to which the pistons of the nuts are connected, and solenoid valves 31a to 31c and 31a and 31b to which the outputs of the syringes are connected are reagent pumps. And 31c are used for the sampling pump) and the drive mechanism 27 of the sampling nozzle 46c, and one of the solenoid valves 31a in the first reagent pump 2 is provided with the first reagent nozzle (1). The tip of the pipe connected to 46a) is connected, and the tip of the pipe connected to the second reagent nozzle 46b is connected to one of the solenoid valves 31b in the second reagent pump 3, and each electron The other end of the pipe, one end of which is inserted into the distilled water container 9, is commonly connected to the other side of the valves 31a and 31b. In addition, one end of the pipe connected to the sampling nozzle 4Cc is connected to one of the solenoid valves 31c in the sampling pump 1, and the other end of the pipe having one end inserted into the distilled water container 9 is connected to the other. In this way, the pump of a pulse count system is driven. In addition, the tip of the sampling nozzle 46c is normally located on one sample container 13a in the sampler 13, and is moved by the drive mechanism 27 to inhale and inhale the sample and at the same time vibrate. The position of the target reaction tube 35 (indicated by 36c ') and the position of the drain 15' (indicated by 46c ") are moved.

The photoluminescent part 8 is comprised by the flow cell 8a which accommodates a sample, the light source 8b and the detector 8c which were arrange | positioned centering around this flow cell, and are comprised by the suction nozzle 8d. A sample in the reaction tube that reaches the suction device SU is sucked and sent to the flow cell 8d to output the absorbance measurement result signal 29 to the outside.

The reagent cassette 14 is intermittently movable in the front-rear direction (the direction orthogonal to the time axis direction of the reaction tube) shown by the mechanism as shown in FIG. In other words, the drive mechanism includes a chain 52 installed on two opposite sprockets 51a and 51b, guide protrusions 52a and 52a attached to a part of the chain 52, and one sprocket 51b. And a plurality of reagent containers 11a-11d disposed on a cassette 14 fitted on the guide protrusion 52a, the pulse motor 54 being connected via a belt 53 to the guide protrusion 52a. The other reagent containers 10a-10d are arranged behind), the pulse motor 54 is driven by the drive signal 34, and the cassette 14 is moved in the directions of the arrows C ₁ and C ₂ . It is. The sampler 13 also moves intermittently in a direction orthogonal to the time axis direction of the reaction line by the above mechanism.

The control block group is responsible for the interface between the operation panel 17 including various key boards, the control block 18 for outputting various control signals, and the operation panel 17 and the control block 18. The interface circuit 19, the log converter 20 for converting the sample information signal 29 obtained from the photometric unit 8 into a processing signal, and the output of the log converter is converted into a digital signal 29 ' A / D converter 21 for inputting into the interface circuit 19, a computer (CUP) 22 for controlling the operation of the interface circuit 19 and storing data, and receiving and printing out the sample information signal. It is comprised by the printer 23. From the control block 18, sampling pump drive signals 25, first and second reagent pump drive signals 24a and 24b, nozzle nozzle drive signals 26a and 26b for various reagents, and sampling nozzle drive mechanisms. The operation signal 30c, the sampler drive signal 28, the field cassette drive signal 34, and the pulse motor drive signal 30 for the nozzle moving mechanism are outputted, respectively.

Next, the operation of the apparatus will be described. In addition, in the following operation | movement description, the advancing direction (arrow A direction) of the reaction line 7 is demonstrated as a time-axis direction.

, 24b)가 여러 펌프(1-3)에 공급되기 때문에 펌프내의 펄스모우터(1a, 2a, 3a)가 동작하고, 리이드 스크루우(1b, 2b, 3b) 및 너트(1c, 2c, 3c)를 개재하여 시린지(1d, 2d, 3d)가 흡입동작을 실시하는 동시에 전자밸브(31a-31c)가 동작하여 증류수(9)가 흡입되고, 다음에 전자 밸브(31a-31c)를 절환하여 시린지(1d, 2d, 3d)를 다시 약간의 흡입동작을 하게 함으로서, 예를 들면 제6도에서 보는바와 같이 노즐(46a-46c) 내에는 증류수(9) 및 샘플 및 시약 격리용기포 Y가 형성된다. 그후, 제어블록(18)에서 샘플링 노즐구동기구 동작신호(30c)가 출력되어 샘플링 노즐 구동기구(27)가 동작하여 일련의 샘플링이 실행된다. 즉, 샘플링노즐(46c)이 하강 동작하여 샘플용기(13a) 내에 삽입되는데, 이 단계에서 샘플링펌프(1)가 동작하여 소정량의 샘플을 노즐내로 흡입하고, 그 다음에 샘플링노즐(46c)이 상승하여 진동동작에 의하여 소정의 위치에 있는 반응관(35)상에 이동하여 이 반응관 내(35)에 소정량의 시료를 배출한다. 소정량을 배출한 후, 재차 진동동작에 의하여 드레인(15')상에 이동하여, 남은 샘플을 배출하고, 세정을 한다. 그 후에 샘플링노즐(46c)은 원위치에 복귀하게 된다.First, a plurality of samples (e.g., containers 13a) containing the first sample are set in the sampler 13, and a plurality of samples for which these inspection items are used on the reagent cassette 14 is used. Reagent containers (eg, two containers 10 and 11 for the first and second reagents) are set. At this time, the moving block 16 having various nozzles is set at the position S on the drain 15. Next, a signal to select the target sample container 13a in the sampler 13 and the target reagent containers 10 and 11 on the reagent cassette 14 is supplied by operating with a key board on the operation panel 17. At the same time, setting signals such as reagent information, target measurement items, and measurement time are supplied. Then, the control block 18 is operated via the interface circuit 19 to output the sampler position control signal 28 and the reagent cassette denture control signal 34, and the sample container 13a is generated by the respective control signals. The first and second reagent containers 10 and 11 are driven to be located directly under the nozzle driving mechanism 6. After that, the following operation is automatically executed according to the set program. First, various nozzles in the moving block 16 waiting at the initial position S are filled with distilled water (the sampling pump 1 also operates simultaneously). That is, in this step, the distilled water suction signal 25,

Since 24b is supplied to several pumps 1-3, the pulse motors 1a, 2a, 3a in the pump operate, and lead screws 1b, 2b, 3b and nuts 1c, 2c, 3c. The syringes 1d, 2d, and 3d perform the suction operation via the valve, and the solenoid valves 31a to 31c operate to suck the distilled water 9, and then the solenoid valves 31a to 31c are switched to the syringe ( By slightly injecting 1d, 2d, and 3d, distilled water 9 and sample and reagent isolation bubbles Y are formed in the nozzles 46a-46c, for example, as shown in FIG. Then, the sampling nozzle drive mechanism operation signal 30c is output from the control block 18 so that the sampling nozzle drive mechanism 27 is operated to perform a series of sampling. That is, the sampling nozzle 46c moves downward and is inserted into the sample container 13a. At this stage, the sampling pump 1 operates to suck a predetermined amount of sample into the nozzle, and then the sampling nozzle 46c Ascends and moves on the reaction tube 35 at a predetermined position by vibrating operation, and discharges a predetermined amount of sample into the reaction tube 35. After discharging the predetermined amount, it moves on the drain 15 'by vibrating operation again, discharges the remaining sample, and washes. Thereafter, the sampling nozzle 46c returns to its original position.

Next, a signal 30 for driving the pulse motor 6b of the nozzle moving mechanism from the control block 18 is outputted, and the moving block 16 waiting at the initial position S moves to the right, and each reagent Dragon nozzles 46a and 46b stop in position on reagent containers 10 and 11 (position of moving block 16A shown).

Solenoid on at this stage. Since the off signals 26a and 26b are output and the solenoids 5a and 5b are turned off, the sampling nozzles are operated in the same manner, so that the first and second reagent nozzles 46a and 46b are lowered to operate the nozzle tip. The first and second reagent pumps 2 and 3 operate in response to the drive signals 24a and 24b from the control block 18 in the step of being inserted into the first and second reagents, so that a predetermined amount of reagent suction is carried out. Is executed and the solenoid on after the suction operation is completed. By the off signals 26a and 26b, the solenoids 5a and 5b are turned on so that the nozzles 46 and 46b return to the home position in detail.

In this case, since the relative spacing (ι _{1 in} FIG. 3) of the first and second reagent nozzles 46a and 46b is configured to coincide with the spacing of the first and second reagent periods, Suction operation is carried out smoothly. In this way, the moving block 16 on which the nozzles 46a and 46b, which respectively inhale the first and second reagents, is held by the pulse motor driving signal 30 from the control block 18, is shown on the left side. Direction (B direction), and stops when the second reagent nozzle 46b is positioned on the target reaction tube (for example, 7a ') on the reaction line 7 (shown in the moving block 16B). ). Then, the liquid in the second reagent nozzle 46b is discharged into the reaction tube 7a '. That is, the pump 3 causes the discharge operation (the operation of pushing the piston of the syringe 3d upward) by the signal 24b from the control block 18, whereby the second reagent at the tip of the nozzle reacts. It is discharged in the tube 7a '. Then, the moving block 16 is moved slightly to the left (shown in B ₁ ) by the output signal 30 of the control block 18 so that the first reagent nozzle 46a is positioned on the reaction tube 7a '. Let's do it. Then, the first reagent pump 2 is discharged by the pump driving signal 24a from the control block 18, and the second reagent is discharged into the reaction tube 7a '. Thereafter, the movable block 16 is moved by the pulse motor driving signal 30 in the control block 18 to return to the initial position S. FIG. At this time, the first reagent nozzle 46a discharges the first reagent remaining in the nozzle at the stage located on the drain 15, and the second reagent nozzle 46b is disposed at the drain 15. The second reagent remaining in the nozzle is discharged. This discharge is carried out by pushing out by distilled water contained in the syringes 1d, 2d, and 3d in each of the pumps 2 and 3, so that the nozzle wall portion is automatically cleaned. In this case, when the cleaning tank is provided next to the drain 15 to clean the nozzle outer wall, the cleaning effect is further improved. At the end of the cleaning, the solenoid valves 31a-31c are switched to inhale a certain amount of distilled water 9 into the nozzle. Then, the solenoid valve is switched to suck a small amount of isolation vessel (Y in FIG. 6). Be prepared for the measurement operation. Moreover, of course, the intermittent transfer operation of the reaction line 7 is stopped during the above operation.

After the above-described series of operations are repeated for each sample, when the reaction tube reaches the light metering portion (suction position), a suction pump (not shown) is operated, and the suction nozzle 8d carries out a predetermined amount of sample. Absorbance measurement is performed by inducing in the flow cell 8a, and the measurement result signal 29 is sent to the interface circuit 19 via the log converter 20 and the A / D converter 21, and again the printer 23 To be printed out.

Next, when changing the measurement item, the reagent cassette supplies a driving signal 34 so that the reagent used therein is located directly under the moving block 16, and at the same time, each reagent is supplied to the reaction tube of the target position according to the required reaction time. In order to supply the signal 30 for moving the moving block 16 to be discharged to the key board, the key board is operated to change the measurement program. As a result, various operations are performed by the new program, and the desired item is measured. At this time, since the moving block 16 equipped with the reagent nozzle can move freely in the direction of the time axis of the reaction line, it is possible to control the reagent discharge position.

Having the apparatus as described above in detail can achieve various effects as follows.

Firstly, the position of the reagent dispensing nozzle (especially the discharging position) does not need to be manually set at each time, and automatic setting is possible by a program, and since a plurality of reagent nozzles need not be set, The tubing is very simple and the workability is remarkably improved.

Secondly, when switching inspection items, the cumbersome operation of the reagent switching operation, in particular, the work that had to be cleaned at each time in the syringe as in the conventional method, is completely eliminated, and the reagents are simply placed at a designated position. .

Third, since the preparation work, the item switching, etc. are remarkably simplified, it is possible to shorten the item switching operation, which was required for more than a few minutes, in seconds, and furthermore, it is extremely effective when achieving full automation.

Fourth, the reagents do not take the path of the reagent suction nozzle → syringe → discharge nozzle as in the prior art, and share the suction nozzle and the discharge nozzle so that the reagent does not enter the syringe. Not only does the waste of time required to be eliminated completely eliminates the need for operations such as cleaning, but also eliminates expensive reagents as in the prior art, resulting in economical improvement.

Fifthly, the first and second reagents can dispense any amount in any order and at any position, and have extremely high degree of freedom in adaptation, and thus, the optimum conditions for carrying out the adaptation of many items. Measurements can be made to achieve high analytical precision.

In addition, this invention is not limited to the said Example, A various deformation | transformation is possible. For example, in the structure of the moving block 16, the spacing and operation of each nozzle are not limited to the above embodiment. In addition, the structure may not necessarily be a structure in which various nozzles are integrally supported. For example, as shown in FIG. 7, the moving block 16 is divided into two blocks 16-1 and 16-2. The nozzles 4a and 46b are disposed in each of the divided blocks so as to be individually driven by a corresponding timing belt and a pulse motor. You may make it adhere freely. In this case, the tip of each nozzle is preferably bent so as to be concentrated at one point or in the range of the diameter of the reaction vessel, the reagent vessel and the group). Moreover, of course, you may increase or decrease the number of each nozzle according to the number of target reagents. In addition, the specific structure of the drive mechanism of each part is not limited to the said embodiment.

In addition, in the above embodiment, the reaction line uses a chain conveyor method as an example, but any of the discrete analysis automation apparatuses may be applied.

According to the present invention as described above, it is possible to provide an automated analysis device that can freely adjust the addition time of the reagent according to the measurement item, which is excellent in operability and simplicity and which can achieve miniaturization of the device. .

Claims (1)

In an automated analysis device for dispensing samples and reagents in a plurality of reaction tubes 7a arranged in parallel in parallel with a reaction line 7 for intermittent movement, a desired item is measured. Reagent nozzles 46a and 46b, one end of which is connected to the pumps 2 and 3 by the pulse count method, are installed in the movable block 16 which is movable on the reaction line 7 in the time axis direction. An automation analysis device, characterized in that the nozzle for moving in the time axis direction.

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