KR840002254B1 - Discrete tupe automated chemical analytic apparatus - Google Patents

Abstract

In the appts. a specimen discharge nozzle is supported on a carrier member in a vertically movable state. The carrier member can be moved to any desired extent in the direction in which a conveyor carrying linearly arranged reaction tubes is driven. That is the direction in which a reaction line extends, and also crosswise of the reaction line, namely, at right angles to the direction in which the conveyor is driven, the carrier member is rendered freely movable everywhere along a two-dimensional plane. A mechanism for effecting the crosswise movement of the specimen carrier member is supported on a mechanism for carrying out the longitudinal movment of the specimen carrier member.

Description

Automation analysis device

1 is a schematic view showing an example of a conventional apparatus.

2 is a system configuration diagram showing one embodiment of the apparatus of the present invention.

3 is a longitudinal sectional view showing an example of a mobile block structure used in the apparatus of the present invention.

4 is a block diagram of one embodiment of a pulse count type pump used in the present invention.

The present invention relates to an automated analysis device for measuring desired items by dispensing samples and reagents in a plurality of reaction tubes arranged in parallel arranged in a reaction line for intermittent movement.

In recent years, the importance of examinations for the diagnosis of diseases has increased, and the number of examinations and the number of examination items has increased. In this situation, for example, in the laboratory and the examination center of a hospital, the inspection automation has emerged as an important problem in order to cope with such a situation. In such a case, the following points should be considered in order to improve the automation analysis device that provides an analysis result that is a critical judgment data relating to human life in a limited number of people and places such as a hospital.

That is, firstly, it is necessary to be able to perform analysis with extremely small amount of sample and trace amount of reagent and even lower analysis cost in order not to cause pain to the patient. The organization should be able to analyze and report more quickly. Thirdly, it should be equipped with the simplicity of analyzing a large number of items and specimens with a limited number of people. Because it is providing data, it must be accurate and reliable, and fifthly, it must be small enough to be used in smaller spaces.

Even in the conventional automated analysis apparatus, there have been remarkable improvements in these five items. In particular, the advancement and development of the micronization and the rapidity has been made by the adoption of automation. However, there is no satisfactory point in terms of simplicity. Also, in terms of accuracy, there were many items affected by reaction conditions and low degrees of freedom in the automation stage.

However, in the conventional automated analysis apparatus, the dispensing position of the specimen and the dispensing position of the visual field are fixed or semi-fixed, and are often dispensed at a position corresponding to one-to-one in the dispensing pump according to the measurement item. In this case, in order to take the necessary reaction time for the item to be measured and the reagent, the operator had to manually set the reagent nozzle or sampling nozzle to a specific position in advance. In addition, when a large number of items are carried out in a limited reaction line, a large number of reagent nozzles are set in a necessary position in advance, so that a waste of time is required for piping of a reagent tube, or a complicated operation may be caused. there was. In this conventional method, any reagent amount cannot be dispensed on the reaction line, and a predetermined amount of reagent is dispensed at a predetermined position, in particular, a fixed method (a method in which the reagent position does not move at all). In the case of), the degree of freedom in use is weakened, an excessive reaction is forced, and the reliability of the measurement result is greatly reduced, and in the case of a semi-fixed method (a method in which the reagent position can be moved manually), Whenever an item was changed, there was a defect that a setting position and the like had to be changed by a person. In addition, since it is set mechanically also in the liquid amount setting of a reagent pump, it was impossible to change automatically and arbitrarily about an item and the reagent used.

Therefore, it is impossible to set automatically and arbitrarily even at the dispensing position of the reagent and the dispensing liquid amount, and since there is no method for the manual switching, the large limit that limits the full automation in the automation analysis device It was a factor.

Moreover, since the apparatus which tried to automate reagent dispensing for the purpose of simplifying control of an automation analysis apparatus is disclosed (examined-Japanese-Patent No. 54-5790), the outline is demonstrated with reference to FIG.

The apparatus is provided with a nozzle mechanism 124 and a contact wall cleaning tank 122, and the pipette mechanism 123 for serum dispensing 123 which repeats the same operation every cycle irrespective of the sample information and the sample information. And a turntable (125A), a nozzle mechanism (124A) and an outer wall cleaning tank (122A), operated according to instructions from the main computer (105) according to the present invention, and having a first reagent container (126A) disposed thereon. The first reagent dispensing pipette mechanism 123A repeats the same operation every cycle irrespective of the information, and is operated by the instructions from the main computer 105 according to the sample information, and the second reagent container 126B is operated. A second reagent dispensing pipette mechanism 123B including a turntable 126B, a nozzle mechanism 12B, and a contact wall cleaning tank 122B, and repeating the same operation every cycle regardless of the specimen information. It is composed mainly of a, and, for example, the reagent container 101 of serum on the sample device 120 When the serum suction position is reached, the transfer of the sample device stops while the reaction line 108, the pitching device 123, the 123A, and the 123B perform a predetermined step operation, and in the meantime, Serum in the vessel is dispensed by the pipette mechanism 123 and diluted in a predetermined reaction vessel 103 while being diluted with distilled water, and when each reaction vessel is continuously transferred to reach the position of the nozzle 124A, 125A) rotates and stops according to the sample information, and upon this stop, the first reagent in the reagent vessel 126A at the suction position on the turntable is sucked by the pipette mechanism 123A and added into the reaction vessel. When the reaction vessel after the addition of the first reagent reaches the position of the nozzle 124B, the second reagent is added at this time by the operation of the pipette mechanism 123B. Such a device eliminates the need for reagent replacement, and facilitates the suction and dispensing of serum and reagents, thereby simplifying the instrument and control systems and ensuring high reliability. Has the effect of.

However, in the above-described conventional apparatus, since the dispensing (sampling) position of the serum, the suction and dispensing positions of the reagents are fixed (or semi-fixed), there is a big drawback in that the time from sampling to analysis cannot be adjusted. In other words, even in the case of urgent specimens and the reaction time may be short, the time is regulated by a measurement item with a long set reaction time, and there is a drawback that there is no so-called freedom of application, and for the same reason, It is impossible to adjust the addition time of, so for example, even in the case of a measurement item having a short reaction time, the same time as the item requiring the maximum reaction time should be consumed, and a disadvantage that the measurement is inaccurate due to an unnecessary reaction is generated. have.

Moreover, since it has a structure which arrange | positions a plurality of rotary cables above a reaction line, there exists also a fault which causes the increase of occupied area and the miniaturization of the whole apparatus is inhibited.

The present invention has been studied in consideration of the above circumstances, and it is possible to adjust the reaction time according to the measurement item, to increase the degree of freedom of application, to be excellent in operability, and to secure the promptness. It is an object of the present invention to provide an automated analysis device that solves the shortcomings of the conventional device.

The present invention will be described in detail with reference to the following Examples.

2 is a system configuration diagram including a perspective view showing one embodiment of the device of the present invention. The apparatus comprises three units which are movable in the reaction line 1 and the traveling direction (time axis direction) of the reaction line, that is, the first reagent nozzle dispensing position moving unit (hereinafter referred to as a first reagent dispensing mechanism moving unit) ( 2) and a sampling cassette capable of moving along the longitudinal direction of the reaction line 1 and the sampling position moving unit 3 and the second reagent nozzle dispensing position moving unit (hereinafter referred to as the second reagent dispensing mechanism moving unit) 4. 5), the pump mechanism 6, the nozzle swing mechanism 7, the photometric part 8, and various control block groups 25-31.

The reaction line 1 is constituted by an endless chain conveyor 1b in which a plurality of reaction tubes 1a are arranged in a row in parallel. In this example, six rows of reaction tubes are placed in the front-rear direction and extended in the longitudinal direction, that is, six channel reaction lines are shown. This chain cone wire 1b is intermittently driven in the direction of arrow A by the drive mechanism not shown in figure, and the reaction tube 1a is intermittently conveyed by this accordingly. In addition, a drain (discharge tank) is disposed in the front portion of the chain cone air 1b along the longitudinal direction, and a washing mechanism including a washing nozzle 1a is disposed in the lower direction of the reaction line 1. . Moreover, a hot air mechanism (not shown) is provided in a part of the inner surface of the chain conveyor 1b, and the mold temperature of the liquid in a reaction tube is achieved.

Each of the moving units 2 to 4 is inserted into the reaction line 1, and is formed in a long series in a direction orthogonal to the longitudinal direction of the reaction line 1, and has a substantially U-shape having side walls at both ends. The support plates 2a, 3a, 4a, guide shafts 2b, 3b, 4b, which are supported between the opposite side sides and located in the upper direction of the reaction line 1, and can be moved on the respective guide shafts. The movable blocks 9a, 9b, 9c arranged so as to be provided, the guide pulleys 10a, 10b, 10c outside the front side portions of each support plate, and the pulse motors 11a, 11b supported outside the rear side wall portions of each support plate. , 11c and wires 13a, 13b, 13c spanned between the guide pulleys 10a, 10b, 10c at positions opposite to the pulleys 12a, 12b, 12c of each pulse motor.

Part of each of the wires 13a, 13b, and 13c is fixed to the side portions of the correspondingly arranged movable blocks 9a, 9b, and 9c, whereby the rotation of the pulse motors 11a-11c is performed. The guide shafts 2b, 3b, and 4b are moved as the wires 13a to 13c move. In addition, guide rollers (or bearings) 14 are attached to both front and rear ends of each of the supporting plates 2a, 3a, and 4a, and each of the two guide rails is arranged in series in the direction orthogonal to the supporting plate. 14a, 14b). In addition, three rows of belts 16a-16c are arranged in parallel with the front guide rails 15c, and these belts are driven by three pulse motors 17a-17c, respectively.

A part of each of the belts 16a-16c is fixed to a part of the bottom of the support plates 2a, 3a, 4a, respectively, and each support plate 2a, 3a, 4a is individually reacted with the movement of each belt. It can move about the direction of the time axis.

Moreover, the 1st reagent container 18a and the 2nd reagent container 18b are arrange | positioned on the side end part of the support plates 2a and 4a, respectively.

Next, an embodiment of a specific structure of the moving blocks 9a-9c will be described with reference to FIG. This fine movement block has a box 20 formed by dividing the hollow portion 20a and the hollow portion 20b, and an elliptical through hole 20a ₁ is provided at the center of the hollow portion 20c. In the through hole 20a ₁ , the guide shaft 2b slides freely, and an attachment protrusion 20c for inserting and fixing the wire 13a is provided on the side of the hollow portion 20a. The guide shaft 2b is formed in a shape (for example, elliptical shape) that prevents the block from rotating. In addition, the guide shaft 21 is provided in the substantially center part in the hollow part 20b, and the small block 22 applied to the downward direction by the pressing spring 23 is used for the shanghai-dong. The small reagent 22 is supported and fixed to this small block 22.

The upper end of the first reagent nozzle 19a protrudes to the outside through a through hole 20d formed in the upper box 20, and is connected to the tub 19a ₁ , and the lower end of the nozzle is the box 20. It protrudes outside through the through-hole 20e formed in the inside. In addition, the inlet end of the wire 24a is fixed to the upper side of the small block 22, and the wire 24a is cut outward through the through-hole 20f formed in the box 20, and the spring It is guided by and connected to the operating piece 7c of the two nozzle swing mechanism 7 in detail later. In addition, since the wire 24 is normally pulled upward by the nozzle shank moving mechanism 7 (arrow C direction), the wire 24 is supported by the small block 22 and this in response to the convenience force of the pressing hanger 23. It moves in the upper direction (arrow direction) of the first reagent nozzle 19a, and during operation, by releasing the operation of the nozzle up / down mechanism 7 by the pressing pressure of the pressing spring 23, the negative direction ( Arrow B ₂ direction). With such a mechanism structure, even if the relative position between the nozzle up-and-down movement mechanism 7 and the nozzle changes, it is possible to easily move the nozzle up and down by remote operation (release method). The moving block having such a configuration is also attached to the other guide shafts 3b and 4b, and the moving block moves along the guide shaft by the movement of the wires 13a-13c according to the driving of the pulse motors 11a-11b. do. In this case, the nozzles 19b and 19c supported by the other moving blocks 9b and 9c are used for sampling and for the second reagent, respectively.

The sample cassette 5 contains a plurality of sample containers 5a (including samples, serum, etc.), and is arranged to hold an equal height at the upper side of the reaction line 1, and parallel to the bottom thereof. It is arrange | positioned and fixed to a part on 2 rows of belts 5b and 5c in series. One end (right end) of these two rows of belts 5c and 5c is wound around two drive pulleys 34a and 34c in which pulse motors 34 arranged in the vicinity thereof are arranged in parallel, respectively, and the other end (illustrated). The left end) is respectively wound around two guide pulleys which omit illustration.

For this reason, when the belts 5b and 5c are driven simultaneously by driving the pulse motor 34, the sample cassette 5 attached thereto is reciprocated along the longitudinal direction of the reaction line 1.

The pump mechanism 6 is composed of three syringes 6a-6c and a drive mechanism 6d for driving them, and the tip of each syringe is respectively an electromagnetic valve 32a-32c. Are connected to the tubs 19a ₁ , 19b ₁ , and 19c ₁ connected to the respective nozzles 19a-19c via. The drive mechanism 6d is composed of a nut 6d ₁ , a lead screw 6d ₂ , and a pulse motor 6d ₃ . Specifically, as shown in FIG. 4, for example, a nut 6d ₁ is connected to the piston of the syringe 6a, and the nut 6d ₁ is screwed into the lead screw 6d ₂ . the combination is, the lead screw crying pulse is connected to the axis of rotation of Motor (6d ₃₎ and, eongyeol a nozzle inserted into the other side of the entrance vessel 33 containing the distilled water of the solenoid valve (32a) tube probe (19a ₂ ) Is connected.

In this way, a pulse count type pump is configured. Moreover, three drive mechanisms 6d which drive each syringe may be provided corresponding to each syringe, and may be comprised so that switching drive is possible with one.

Such a pump operates even when the operation of the pulse motor 6d ₃ is converted to the vertical movement of the piston via the lead screw 6d ₄ and the nut 6d ₁ .

For example, by operating the solenoid valve 32a when the syringe 6a performs the suction operation (downward movement operation), distilled water in the distillation container 33 is sucked into the syringe 6a, and then the solenoid valve 32a. ), The piston is moved upward, and the suctioned distillation reaches the tip of the nozzle 19a via the nozzle tubing 16a ₁ . A reagent isolation bubble should be formed at the tip of 19a) to prepare for the next inhalation. When the suction and dispensing of the reagent are performed, the predetermined amount of the reagent is aspirated by controlling the movement of the syringe 6a. This control can be easily set by a program that puts the pulse motor driving signal from the control circuit described later into a computer for controlling.

The nozzle swing mechanism 7 is constituted by a pulse motor 7a, a rotating disc 7b, and an operating piece 7c protruding from a portion of the upper surface of the rotating disc 7b. The tip ends of the wires 24a to 24c are attached, and the wires 24a to 24c are pulled or returned to their original positions by motor driving.

The light metering portion 8 is constituted by a flow cell 8a for storing a sample, a light source 8b and a detector 8c which are arranged around the flow cell, and are suction nozzles.

The sample in the reaction tube that reaches the suction position by (8d) is sucked into the flow cell 8a, the absorbance is measured, and the result can be output to the outside.

The control block group includes an operation panel 25 including each key electrode, a control circuit 27 for outputting various control signals, an interface circuit 28 for interfacing the control circuit with the operation panel, and A log converter 29 for converting the sample information signal V ₈ obtained from the photometric unit ₈ into a processing signal, an A / D converter 30 for converting the output of the log converter into a digital signal, and various measurement items. A plurality of programs are stored, and are composed of a computer (CPT) 26 for driving the chair circuit 27 and a pruner 31 for frit-out the sample information signal. From the control circuit 27, signals V ₂ -V ₄ for driving various mobile units 2-4, drive signals V ₅ of the sample cassette ₅ , various solenoid valve drive signals V _32a -V _32c , various The pump drive signals V _6a- V _6c , the _{shank east} drive signals V _19a- V _19o , and the various block reciprocating drive signals V ₉₁ -V _9c are outputted in accordance with the program of the CPU 26.

Next, the operation of the apparatus will be described. In practice, six items are simultaneously measured in the six-channel reaction line, and correspondingly, reagents disposed on the plates of the first reagent transfer unit 2 and the second reagent transfer unit 4 are also measured. Although various types are used here, for convenience of explanation, the first reagent container 18a and the second reagent container 18b are disposed on the flat plates of the reagent transfer units 2 and 4, respectively. A description will be given of a series of operations in the case of using a reaction tube aligned with a straight line of. In addition, this apparatus performs various operations corresponding to each measurement item, but here, for example, the case where the GOT is measured will be described.

Therefore, the GOT measurement program stored in advance by the CPU 26 is selected by pressing an item selection key button (not shown) on the operation panel, and various control signals are generated by the control circuit 27. In this case, in the various moving blocks 9a-9c, the tip ends of the nozzles 19a-19c are positioned in a straight line in the upper direction of the drain 1c (initial state).

First, the pump driving signals V _6a- V _6c and the solenoid valve driving signals V _32a- V _32o are outputted from the control circuit 27 so that the pump mechanism 6 operates as described above, and the respective nozzles 19a-19c operate. Distilled water is filled, and a sample and a reagent containment bubble are formed at the tip. Next, various mobile unit drive signals V ₂ -V ₄ are output from the control circuit 27, whereby the pulse motors 17a-17c are driven to position the various mobile units 2-4. At this time, when the dispensing position corresponding to the reaction time of each reagent in the measurement of the GOT, for example, the sampling mechanism moving unit 3 is almost the center, the first reagent dispensing mechanism moving unit 2 at substantially equal intervals on the left and right sides thereof. And the position of the second reagent dispensing mechanism moving unit 4 is arranged. Simultaneously with this, the sample cassette drive signal V5 is output from the control circuit 27, whereby the sample cassette ₅ , in which the pulse motor 34 is rotated and placed and fixed on the belts 5b and 5c, is sampled. The position is determined by moving directly under the guide shaft 3b of the mechanism moving unit 3.

Next, various moving block drive signals V _{9a to} V _9C are output from the control circuit 27, and the respective pulse motors 11a to 11c rotate to move the respective wire blocks 13a to 13c. 9a-9c are moved along the guide shafts 2b, 3b and 4b in a direction perpendicular to the direction of the time axis of the reaction line 1. And the tip of each nozzle (19a-19c) is respectively the first reagent

(18a), the position is determined on the target sample container 5a and the second reagent container 18b. Then, the nozzle swing mechanism driving signals V _19a -V _19c are output from the control circuit 27, and the pulse motor 7a in the nozzle up / down mechanism 7 is driven to wire 24a- connected to each nozzle. The tip of each nozzle 19a-19c is inserted in the 1st reagent container 18a, the sample container 5a, and the 2nd reagent container 18b, respectively, in order to operate 24c back to the place. Immediately thereafter, the pump driving signals V _6a- V _6c are output from the control circuit 27 so that the pump mechanism 6 is operated so that the appropriate amount of the first reagent, the sample, and the second reagent are stored in the nozzles 19a-19c. Inhale. After the end of the suction operation, the nozzle Shanghai driving mechanism drive signals V _19a -V _19c are again output from the control circuit 27 so that the pulse motor 7a reverses and pulls the wires 24a-24c. 19a-19c move upward and return to their original position. Then, the moving block drive signals V _9a- V _9c are output from the control circuit 27 so that the pulse motors 12a-12c rotate simultaneously, so that each of the moving blocks 9a-gc is simultaneously used as a target wiki (for example, The position is determined in the reaction tube row of the center reaction line row). At this stage, the pump driving signals V _6a- V _6c are again output from the control circuit 27 so that the pump discharge operation is performed, so that the first and second reagents and the samples in the nozzles are discharged into the reaction tubes at the corresponding positions. (Busy)

After the above-described series of operations, the moving block drive signals V _9a- V ₉ are output from the control circuit 27 to return each of the moving blocks 9a-9c to the initial position (drain 1C phase). Then, the pump driving signals V _6a- V _6o are output from the control circuit 27 to discharge the pump, and the reagents and samples remaining in the nozzles 19a-19c are discharged in the drain 1C. . This discharge is pushed out by the distilled water contained in the syringe in each pump, so that the nozzle inner wall portion is automatically cleaned. In this case, the nozzle outer wall is also cleaned by dividing the cleaning tank into the drain 1C so that each nozzle is lowered. After cleaning, each solenoid valve

(32 _a- 32 _c ) is switched to fill the nozzle with distilled water again, and then the solenoid valve is switched to inhale a small amount of sequestered air bubble and ready for the next measurement operation.

Incidentally, during the series of operations, the intermittent transfer operation of the reaction line is stopped, and of course, the predetermined interval is moved after the operation ends. In addition, the movement of each unit, the movement of each block, the movement of each nozzle, the movement of suction and the like, etc. may be performed separately, or the order thereof may be arbitrarily performed.

After the above-described series of operations are repeated for each sample, when the reaction tube containing the sample subjected to the predetermined reaction reaches the photometric portion (suction position), an inhalation mechanism (not shown) is operated to perform the suction nozzle ( 8d), a predetermined amount of the sample is guided into the plucell and absorbance measurement is performed at the photometric section 8, so that the measurement result signal _V8 passes through the log converter 29 and the A / D converter 30. At the same time, the result of analysis is transferred to the printer 31 via the interface circuit 28 and printed out.

When changing the measurement item at first, select the target item by operating the keyboard on the operation panel 25 so that the reagent nozzle is moved to the position of the reagent corresponding to it. Then, the corresponding program is selected and automatically thereafter. Measurement and analysis are performed.

In addition, when measuring items not memorized in a computer, a program corresponding to them may be input.

In addition, although not shown in figure, only the number corresponding to the number of suction nozzles is provided, and the light metering part 8 is arrange | positioned by this, and six items of measurement results are acquired simultaneously.

In this case, after all the adjustments are made to one sample, the measurement is made on another sample. In this case, the control circuit 27 generates a signal V ₅ for driving the pulse motor 34 to generate a sample cassette ( 5) is intermittently moved to position the target sample under the moving range of the sampling nozzle 19b. Then, the sampling nozzle is moved onto the target sample to suck a predetermined amount of sample, and then the sampling nozzle is moved on the reaction tube, and the predetermined amount of sample is sequentially fed to the reaction tube aligned in a direction orthogonal to the time axis of the reaction line. Will be busy. As described above, the measurement of a plurality of items for a plurality of samples is automatically performed sequentially in accordance with a set program.

According to the apparatus described in detail above, the following various effects can be obtained.

Since the sample cassette, the sampling mechanism, the reagent, and the reagent dispensing apparatus can be freely moved in the direction of the time axis of the reaction line, there is no need to set manually every time as in the prior art, and the automatic setting by the program is possible. Moreover, since the reagent addition time (or dispensing position) can be arbitrarily adjusted according to the reagent reaction time of the measurement item, the degree of freedom of application is increased, and the measurement density can be improved.

Sampling nozzles and reagent nozzles can be moved in the direction of the time axis of the reaction line, and can be moved in the direction orthogonal to them, so that even when a special item and a plurality of reagents are required, Depending on the number of reagents, a large number of sampling nozzles and reagent nozzles are not required, thus reducing tubing piping and the like and improving workability.

In addition, since the sample cassette, the sampling nozzle, or the reagent and the dispensing mechanism are always located in the vicinity of each other, the moving distance between the sampling nozzle and the reagent nozzle is short, and the dispensing operation can be speeded up. In addition, even when used for a plurality of channels, it is sufficient to use a single sampling nozzle and reagent nozzle, and the device can be miniaturized and simplified.

Since the sampling position (sample dispensing position) can be adjusted arbitrarily, there is no need to wait for a certain time like a conventional fixed method or semi-fixed method for a reaction tube driven at a constant speed. For this reason, for example, it is extremely convenient in the case of urgent inspection, and the speed of operation (or inspection) is remarkable.

In addition, when the pump is adopted with a pulse count method, the inspection item is switched, so that the cumbersome work of cutting reagents and the work of having to enact a syringe like the conventional method each time are not necessary. Since the time loss in the preparation step is completely eliminated, and expensive reagents are not discarded as in the prior art, it is economically improved.

The present invention is not limited to the above embodiments, and various modifications can be made. For example, in the above embodiment, the case where two reagent dispensing mechanism moving units were used was described. However, a larger number should be provided to further increase the degree of freedom of use. In addition, the structure of the said moving block is not limited to the said embodiment, For example, in the case of a multiple channel, you may arrange | position a nozzle for a channel in one block at regular intervals. The drive mechanism of other parts is not limited to the above embodiment.

Of course, the present invention can be applied to the case of a single channel method.

According to the present invention described in detail above, it is possible to arbitrarily adjust the reaction time and the reagent addition time according to the measurement item, and to provide an automated analysis device excellent in the degree of freedom of use and excellent in operability and speed.

Claims (1)

In an automated analysis device for measuring desired items by dispensing samples and reagents in a plurality of reaction tubes 1a arranged in parallel in a row in a reaction line 1 for intermittent movement, Sample, nozzle 19b and reagent dispensing mechanism constituting the sampling mechanism 3 while the sample cassette 5 and the sampling mechanism 3 can move simultaneously or separately with respect to the time axis direction of the reaction line 1. Reagent nozzles 19a and 19c constituting (2, 4) can be moved in a direction intersecting with respect to the time axis direction of the reaction line 1, respectively, and reagent containers 18a and 18b and reagent dispensing mechanism (2.4). ) Can be moved relative to the time axis direction of the reaction line (1).

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