KR840001999A - 벤조퀴놀리진의 제조방법 - Google Patents

벤조퀴놀리진의 제조방법 Download PDF

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Publication number
KR840001999A
KR840001999A KR1019820004513A KR820004513A KR840001999A KR 840001999 A KR840001999 A KR 840001999A KR 1019820004513 A KR1019820004513 A KR 1019820004513A KR 820004513 A KR820004513 A KR 820004513A KR 840001999 A KR840001999 A KR 840001999A
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KR
South Korea
Prior art keywords
quinolizine
hexahydro
benzo
methyl
addition salt
Prior art date
Application number
KR1019820004513A
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English (en)
Other versions
KR880002004B1 (ko
Inventor
레흡 아아키벨드 죤 (외 1)
Original Assignee
데이비드 이. 지벤스
죤 와이어스 앤드 브러더 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 데이비드 이. 지벤스, 죤 와이어스 앤드 브러더 리미티드 filed Critical 데이비드 이. 지벤스
Publication of KR840001999A publication Critical patent/KR840001999A/ko
Application granted granted Critical
Publication of KR880002004B1 publication Critical patent/KR880002004B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

벤조퀴놀리진의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 이소부탄설폰산의 반응성 유도체를 2β-메틸아미노-1,3,4,6,7,11b-헥사하이드로-2H-벤조[a] 퀴놀리진과 반응시키거나 또는 N-메틸-N-(1,3,4,6,7,11bα-헥사하이드로-2H-벤조[a] 퀴놀리진-2β-일)-2-메틸-2-프로펜-1-설폰아미드 또는 기의 산부가염을 접촉 환원하고 필요하다면 유리염기를 약제학적으로 무독한 산부가염으로 전환시킴을 특징으로 하여, N-메틸-N-(1,3,4,6,7,11b α-헥사하이드로-2H-벤조[a]-퀴놀리진-2β-일)-이소-부탄설폰아미드 또는 그의 약제학적으로 무독한 산부가염을 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8204513A 1981-10-07 1982-10-07 벤조퀴놀리진의 제조방법 KR880002004B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP8130350 1981-10-07
GB30350 1981-10-07
GB8130350 1981-10-07

Publications (2)

Publication Number Publication Date
KR840001999A true KR840001999A (ko) 1984-06-11
KR880002004B1 KR880002004B1 (ko) 1988-10-11

Family

ID=10525019

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8204513A KR880002004B1 (ko) 1981-10-07 1982-10-07 벤조퀴놀리진의 제조방법

Country Status (12)

Country Link
EP (1) EP0079123B1 (ko)
JP (1) JPS5872581A (ko)
KR (1) KR880002004B1 (ko)
AT (1) ATE15371T1 (ko)
AU (1) AU554777B2 (ko)
CA (1) CA1173038A (ko)
DE (1) DE3266047D1 (ko)
DK (1) DK159443C (ko)
GR (1) GR78037B (ko)
IE (1) IE54048B1 (ko)
PH (1) PH17333A (ko)
ZA (1) ZA826826B (ko)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1513824A (en) * 1975-05-22 1978-06-14 Wyeth John & Brother Ltd 1,3,4,6,7,11b-hexahydro-2h-benzo(a)quinolizine derivative
GB1577187A (en) * 1977-12-14 1980-10-22 Wyeth John & Brother Ltd 2-sulphamamido-1,3,4,6,7,11b-hexahydro-2h-benzo(a)quinolizimes
ZA815420B (en) * 1980-08-28 1983-03-30 Wyeth John & Brother Ltd Benzoquinolizines
IE51467B1 (en) * 1980-08-28 1986-12-24 Wyeth John & Brother Ltd Benzoquinolizines

Also Published As

Publication number Publication date
GR78037B (ko) 1984-09-26
KR880002004B1 (ko) 1988-10-11
IE822240L (en) 1983-04-07
EP0079123B1 (en) 1985-09-04
ATE15371T1 (de) 1985-09-15
DE3266047D1 (de) 1985-10-10
JPS5872581A (ja) 1983-04-30
DK159443C (da) 1991-04-02
CA1173038A (en) 1984-08-21
ZA826826B (en) 1984-04-25
AU8842682A (en) 1983-04-14
DK159443B (da) 1990-10-15
PH17333A (en) 1984-08-01
EP0079123A1 (en) 1983-05-18
DK442782A (da) 1983-04-08
AU554777B2 (en) 1986-09-04
IE54048B1 (en) 1989-05-24

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