KR830009116A - Method for preparing cephalosporin derivative - Google Patents

Method for preparing cephalosporin derivative Download PDF

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Publication number
KR830009116A
KR830009116A KR1019820001180A KR820001180A KR830009116A KR 830009116 A KR830009116 A KR 830009116A KR 1019820001180 A KR1019820001180 A KR 1019820001180A KR 820001180 A KR820001180 A KR 820001180A KR 830009116 A KR830009116 A KR 830009116A
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KR
South Korea
Prior art keywords
general formula
compound
following general
acid addition
active derivative
Prior art date
Application number
KR1019820001180A
Other languages
Korean (ko)
Inventor
노부하루 카께야
카즈히꼬 키다오
Original Assignee
키다오 세이지로오
쿄오또 야꾸힝 고오교 가부시기 가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 키다오 세이지로오, 쿄오또 야꾸힝 고오교 가부시기 가이샤 filed Critical 키다오 세이지로오
Publication of KR830009116A publication Critical patent/KR830009116A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음No content

Description

세팔로스포린 유도체의 제조방법Method for preparing cephalosporin derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (2)

다음의 일반구조식(II)의 화합물 또는 그 활성화 유도체를 다음 일반구조식(III)의 화합물 또는 그 활성유도체와 반응시키고, R2가 보호기인 때에는 그 보호기를 제거하거나, 또는 다음 일반구조식(IV)의 화합물 또는 그 활성유도체를 다음 일반구조식(V)의 화합물과 반응시켜서 얻어진 생성물을 임의로 산부가염으로 전환시키고, 임의로 최종생성물을 수용매, 염산수용액 또는 유기용매 중에서 최종생성물을 재결정하여, 다음 일반구조식(I)의 화합물, 그 약학적으로 사용 가능한 산부가염 및 이들의 결정성 하이드레이트를 제조하는 방법.A compound of the following general formula (II) or an active derivative thereof is reacted with a compound of the following general formula (III) or an active derivative thereof, and when R 2 is a protecting group, the protecting group is removed or the following general formula (IV) The product obtained by reacting a compound or an active derivative thereof with a compound of the following general formula (V) is optionally converted to an acid addition salt, and optionally, the final product is recrystallized from an aqueous solvent, an aqueous hydrochloric acid solution or an organic solvent, and the following general formula ( A process for producing the compound of I), pharmaceutically usable acid addition salts thereof and crystalline hydrates thereof. 상기식에서, R1은 저급 알킬기이며, R2는 수소 또는 아미노 보호기이며, X는 카복실기와 반응할 수 있는 원자 또는 기이다.Wherein R 1 is a lower alkyl group, R 2 is a hydrogen or amino protecting group and X is an atom or group capable of reacting with a carboxyl group. 다음 일반구조식(I)의 세팔로스포린 유도체 또는 그 산부가염 유기산화 혼합함을 특징으로 하는 박테리아 원인의 감염성 질환 치료용 경구투여할 수 있는 약학적 제제의 제조방법.A method for preparing orally administrable pharmaceutical preparations for treating infectious diseases of bacterial causes, characterized in that the cephalosporin derivatives of the general formula (I) or acid addition salts thereof are mixed organically. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019820001180A 1981-10-01 1982-03-19 Method for preparing cephalosporin derivative KR830009116A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP156466 1981-10-01
JP56156466A JPS5857385A (en) 1981-10-01 1981-10-01 Hydrated compound, its preparation, and remedy for bacteriosis

Publications (1)

Publication Number Publication Date
KR830009116A true KR830009116A (en) 1983-12-17

Family

ID=15628358

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019820001180A KR830009116A (en) 1981-10-01 1982-03-19 Method for preparing cephalosporin derivative

Country Status (2)

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JP (1) JPS5857385A (en)
KR (1) KR830009116A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6114431B1 (en) 2016-04-01 2017-04-12 株式会社アマダホールディングス Laser processing machine

Also Published As

Publication number Publication date
JPS5857385A (en) 1983-04-05

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